64% buyers of institutions opening or closing positions this quarter
21 more new buyers than exits, ownership fell 20.83 percentage points vs the prior quarter, and 1 well-known fund manager in the top 25.
64% buyers of institutions opening or closing positions this quarter
114.8% institutional ownership
TRV GP IV, portfolio allocation
Institutional ownership vs Biotechnology peers
No Form 4 insider transactions on file
Latest positioning in MAZE across 13F flow, ownership shift, marquee holders, and holder-count growth.
Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in MAZE held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 4.6M | $136.3M | 0.0% | 8.252% | 3.51% |
| 2 | TRV GP IV, LLC | 4.5M | $133.5M | 0.0% | 8.084% | 50.04% |
| 3 | ARCH Venture Management, LLC | 4.1M | $123.0M | 0.0% | 7.444% | 18.16% |
| 4 | Deep Track Capital, LP | 3.5M | $103.8M | -18.1% | 6.283% | 1.70% |
| 5 | JANUS HENDERSON GROUP PLC | 2.9M | $85.3M | -9.0% | 5.165% | 0.04% |
| 6 | Paradigm Biocapital Advisors LP | 2.7M | $81.9M | — | 4.959% | 1.67% |
| 7 | BlackRock, Inc. | 2.6M | $76.7M | +12.4% | 4.644% | 0.00% |
| 8 | a16z Capital Management, L.L.C. | 1.7M | $50.8M | 0.0% | 3.076% | 3.94% |
| 9 | VR Adviser, LLC | 1.6M | $47.8M | +3.5% | 2.895% | 1.78% |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 1.4M | $42.9M | — | 2.594% | 0.00% |
| 11 | Alphabet Inc. | 1.4M | $41.4M | 0.0% | 2.509% | 1.03% |
| 12 | Logos Global Management LP | 1.2M | $36.9M | +30.0% | 2.231% | 1.84% |
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.2M | $35.2M | — | 2.128% | 0.05% |
| 14 | General Catalyst Group Management, LLC | 1.0M | $30.9M | 0.0% | 1.872% | 16.85% |
| 15 | TRV GP V, LLC | 951K | $28.4M | 0.0% | 1.718% | 7.08% |
| 16 | FMR LLC | 864K | $25.8M | +18.6% | 1.562% | 0.00% |
| 17 | CITADEL ADVISORS LLC | 809K | $24.2M | +80.5% | 1.462% | 0.00% |
| 18 | ArrowMark Colorado Holdings LLC | 767K | $22.9M | 0.0% | 1.387% | 0.61% |
| 19 | Casdin Capital, LLC | 759K | $22.7M | 0.0% | 1.371% | 1.72% |
| 20 | Cormorant Asset Management, LP | 750K | $22.4M | — | 1.355% | 1.12% |
| 21 | Woodline Partners LP | 650K | $19.4M | -37.2% | 1.175% | 0.07% |
| 22 | STATE STREET CORP | 637K | $19.0M | +19.5% | 1.150% | 0.00% |
| 23 | DRIEHAUS CAPITAL MANAGEMENT LLC | 636K | $19.0M | +68.3% | 1.149% | 0.14% |
| 24 | Caligan Partners LP | 615K | $18.4M | +11.8% | 1.111% | 1.22% |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 600K | $17.9M | +13.8% | 1.084% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in MAZE — a direct measure of their conviction.
Filings activity in MAZE during Q1 2026, grouped by how each filer changed its position.
5 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 163 | +15% | 114.83% | 20.83 pp | $1.53B | 23% |
| Q4 2025 | 142 | +54% | 135.66% | +60.15 pp | $1.98B | +80% |
| Q3 2025 | 92 | +23% | 75.51% | +43.24 pp | $1.10B | +134% |
| Q2 2025 | 75 | +8.7% | 32.27% | 3.22 pp | $471M | 0.6% |
| Q1 2025 | 69 | — | 35.49% | — | $473M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
No recent Form 4 insider transactions on file for MAZE.
Quick answers to the most common questions about buying MAZE stock.
Based on Q1 2026 13F filings, institutional ownership of Maze Therapeutics, Inc. stands at 114.8%, held across 163 reporting institutions.
Frazier Life Sciences Management, L.P. is the largest reported institutional holder of MAZE, with approximately 4,567,274 shares worth $0.14B as of Q1 2026.
Yes — 1 widely-followed marquee investor appear among the top 25 institutional holders of MAZE, including CITADEL ADVISORS LLC.
Our composite Smart Money Score for MAZE is 43 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
49 institutions opened new positions in MAZE during Q1 2026, while 28 fully exited. 25 added to existing positions and 89 trimmed.
MAZE institutional ownership fell by 20.83 percentage points quarter-over-quarter, with a net change of +21 holders.
The top 10 institutions account for 57.6% of all reported 13F value in MAZE, and the top 25 account for 82.7%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.