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XENE
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XENEXenon Pharmaceuticals Inc.
$39.09$3.8B
Overview & Tools
OverviewChart Terminal ↗Visualize
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Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
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XENE logo

Xenon Pharmaceuticals Inc.

XENE
NASDAQ · Biotechnology
$39.09
At close - Sep 22, 4:00 PM EDT - USD
Market Cap$3.78B
P/E-9.0x
52W High$72.66
Volume2.34M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

R&D Escalation Deepens Cash Burn, Equity Dilution Looms

Xenon Pharmaceuticals is a pre-revenue clinical-stage biotech with a promising pipeline but a rapidly accelerating cash burn. R&D expenses grew 124% from $44.2M in 2024Q1 to $99.2M in 2026Q2, driving operating losses to -$123.2M in 2026Q2. The company's cash p...

GrowthDecelerating
ProfitabilityNegative
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

XENE price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

8/12 Beats

EPS beat 8 of last 12 quarters

02

Valuation risk

-144% Peers

P/E is 144% below peer median

03

Market leadership

RS 14 · Lag

Laggard (Underperforming 86% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystEstimated earnings · Nov 6

Market performance

Price History →

Trailing total returns as of 9/23/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
XENE-12.14%
S&P 500 (^GSPC)+13.20%
1-Year Return
XENE+4.66%
S&P 500 (^GSPC)+15.98%
3-Year Return
XENE+11.15%
S&P 500 (^GSPC)+82.63%
5-Year Return
XENE+144.01%
S&P 500 (^GSPC)+74.16%

Growth & profitability

Annual revenue & EPS trend
Revenue
$8M
Net income
-$346M-47.6% YoY
Free cash flow
-$280M-51.7% YoY
Operating margin
-4974.3%
ROIC (TTM)-55.3%
Avg ROIC 5Y-
ROE (TTM)-51.8%
Piotroski Score4 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate8/12 (67%)
Revenue Beat Rate2/12 (100%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 6, 2026
-$1.11+2.6%
vs -$1.14
—
vs $2M
Q2 2026
May 7, 2026
-$1.17+0.0%
vs -$1.17
—
vs $1M
Q1 2026
Feb 26, 2026
-$1.31-9.2%
vs -$1.20
—
vs $178,571
Q4 2025
Nov 3, 2025
-$1.15+0.9%
vs -$1.16
—
vs —
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
GlobeNewsWire·Sep 3, 2026
Xenon to Present at Wells Fargo Healthcare Conference

VANCOUVER, BC and BOSTON, MA, Sept. 03, 2026 (GLOBE NEWSWIRE) -- Xenon Pharmaceuticals Inc. (Nasdaq: XENE), a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development and commercialization of life-changing therapeutics for patients in need, today announced that the company will present at an upcoming investor conference:

GlobeNewsWire·Aug 28, 2026
Xenon Pharmaceuticals Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

VANCOUVER, BC and BOSTON, MA, Aug. 28, 2026 (GLOBE NEWSWIRE) -- Xenon Pharmaceuticals Inc. (Nasdaq: XENE), a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need, today announced equity inducement grants to five new non-officer employees consisting of an aggregate of 13,450 share options and 7,850 restricted share units (RSUs). All of the foregoing share options and RSUs were approved by the Compensation Committee of the Company's Board of Directors with an effective date of August 27, 2026 and were granted as inducements material to the employees entering into employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4).

GlobeNewsWire·Aug 26, 2026
Xenon to Highlight Phase 3 X-TOLE2 Clinical Data and Rational Polytherapy Potential for Azetukalner at EEC 2026

VANCOUVER, BC and BOSTON, MA, Aug. 26, 2026 (GLOBE NEWSWIRE) -- Xenon Pharmaceuticals Inc. (Nasdaq: XENE), a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need, today announced multiple data presentations at the upcoming 16th European Epilepsy Congress (EEC), taking place September 5-9, 2026, in Athens, Greece.

Defense World·Aug 25, 2026
BlackRock Inc. Invests $454.06 Million in Xenon Pharmaceuticals Inc. $XENE

BlackRock Inc. bought a new position in shares of Xenon Pharmaceuticals Inc. (NASDAQ: XENE) during the undefined quarter, according to its most recent 13F filing with the Securities and Exchange Commission. The fund bought 7,522,482 shares of the biopharmaceutical company's stock, valued at approximately $454,057,000. BlackRock Inc. owned about 7.78% of Xenon Pharmaceuticals

Filtered for Xenon Pharmaceuticals Inc.More Headlines
04

Compare before deciding

Benchmark XENE against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Xenon Pharmaceuticals Inc. (XENE)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
XENE logoXENEXenon Pharmaceuticals Inc.Current
$39.09$3.78B-8.97—-4612.13%-51.76%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$300.65$8.38B-22.30-100%—-34.15%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$26.41$4.52B11.5311.87%33.42%32.39%—
PTCT logoPTCTPTC Therapeutics, Inc.
$65.96$5.47B8.48114.51%-3.8%——
ARVN logoARVNArvinas, Inc.
$8.51$549.08M-6.65-0.3%2.94%1.91%—
OVID logoOVIDOvid Therapeutics Inc.
$2.76$515.13M-11.501181.27%-2178.9%-23.64%—

Compare XENE vs Peers

Xenon Pharmaceuticals Inc. (XENE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs PRAX

Most directly comparable listed peer for XENE.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare XENE against a more recognizable public peer.

Peer Set

Compare Top 5

vs PRAX, ACAD, PTCT, ARVN

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

XENE SEC Filings & Documents

Xenon Pharmaceuticals Inc. (XENE) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

May 7, 2026·SEC

Material company update

Apr 13, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 29, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 3, 2025·SEC

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XENE Frequently Asked Questions

Xenon Pharmaceuticals Inc. (XENE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Xenon Pharmaceuticals Inc.'s revenue?

Xenon Pharmaceuticals Inc. (XENE) reported $7.5M in revenue for fiscal year 2025. This represents a 48% decrease from $14.3M in 2012.

Is XENE profitable?

Xenon Pharmaceuticals Inc. (XENE) reported a net loss of $409.2M for fiscal year 2025.

Dividend & Returns
What is XENE's return on equity?

Xenon Pharmaceuticals Inc. (XENE) has a return on equity (ROE) of -51.8%. Negative ROE indicates the company is unprofitable.

What is Xenon Pharmaceuticals Inc.'s free cash flow?

Xenon Pharmaceuticals Inc. (XENE) had negative free cash flow of $427.6M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in XENE back in 2012?

Total return calculator · dividends reinvested · 14+ years of data

See returns →