Free cash flow remains robust, evidenced by a peak margin of 48.5% in 2025Q4, despite quarterly volatility driven by working capital fluctuations.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 | Dec'01 | Dec'00 | Dec'99 | Dec'98 | Dec'97 | Dec'96 |
|---|
| Cash from Operations | 863.7M | 782.7M | 595.4M | 389.9M | 339.4M | 256.5M | 228.5M | 147M | 101.4M | -94.33M | -106.18M | -38M | -47.14M | -29.61M | -35.29M | -698K | 49.94M | -53.09M | -74.17M | -59.33M | -99.33M | -30.79M | -99.99M | 37.13M | -79.36M | -21.86M | -18.64M | -10.3M | -10.7M | 11M | 6.7M |
| Operating CF Margin % | - | 27.36% | 25.28% | 20.66% | 22.8% | 22.63% | 21.85% | 18.65% | 22.47% | -58.36% | -707.87% | -192.21% | - | -1014.29% | -66.42% | -0.9% | 149.08% | -1798% | -1865.79% | -4847.55% | -253.18% | -24.86% | -117.39% | 26.7% | -439.82% | -52.99% | -127.81% | -61.31% | -66.88% | 42.15% | 34.9% |
| Operating CF Growth % | 287.05% | 31.46% | 52.71% | 14.88% | 32.32% | 12.25% | 55.44% | 44.97% | 207.49% | 11.16% | -179.45% | 19.4% | -59.22% | 16.11% | -4956.45% | -101.4% | 194.06% | 28.41% | -25% | 40.27% | -222.58% | 69.2% | -369.31% | 146.78% | -263.13% | -17.22% | -81.02% | 3.74% | -197.27% | 64.18% | - |
| Net Income | 668.6M | 478.6M | 341.3M | 249.7M | 154.5M | 89.6M | 407.3M | 37M | 21.1M | -142.54M | -141.09M | -88.93M | -60.54M | -46.09M | 5.03M | 37.57M | -7.97M | -51.04M | -88.61M | -207.3M | -107.2M | -22.19M | -45.77M | -30.26M | -94.54M | -36.91M | -28.81M | -16.8M | -20M | 5.1M | 5.9M |
| Depreciation & Amortization | 29.8M | 30.1M | 27.1M | 21.3M | 15.6M | 10.9M | 8.6M | 7.4M | 4M | 2.4M | 1.45M | 1.01M | 827K | 671K | 657K | 694K | 1.44M | 3.18M | 7.61M | 9.4M | 10.57M | 10.09M | 7.08M | 3.69M | 3.1M | 2.65M | 2.2M | 2.1M | 1.7M | 1.3M | 1M |
| Stock-Based Compensation | 222.3M | 217.9M | 195.5M | 194.3M | 173.1M | 134.2M | 100M | 75.3M | 58.1M | 42.52M | 28.46M | 28.39M | 10.38M | 6.82M | 5.48M | 2.92M | 3.13M | 5.54M | 7.99M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Taxes | 118M | 165.4M | -123.1M | -56.7M | 19.1M | 4.3M | -310.7M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | -317.9M | 19.5M | 173.8M | -46.9M | 44.5M | 800K | 61.2M | 32.1M | 19.9M | 12.1M | -789K | 12.83M | 584K | -3.1M | -32.78M | -37.37M | 62.51M | 2.4M | 11.33M | 121.68M | 8.35M | -21.99M | -36.36M | 46.71M | -1.43M | 10.56M | 7.53M | 2.2M | 9.9M | 2.8M | 500K |
| Working Capital Changes | 142.9M | -128.8M | -19.2M | 28.2M | -67.4M | 16.7M | -37.9M | -4.8M | -1.7M | -8.81M | 5.78M | 8.7M | 1.61M | 12.1M | -13.67M | -4.52M | -9.16M | -13.18M | -12.48M | 16.88M | -11.05M | 3.3M | -24.93M | 16.98M | 13.51M | 1.85M | 433K | 2.2M | -2.3M | 1.8M | -700K |
| Change in Receivables | -255M | -210.5M | -39.8M | -89.3M | -162.2M | -28.4M | -30.5M | -69.2M | -25.1M | -31.13M | 0 | 0 | -1.67M | 13.53M | -12.88M | 2.81M | -4.28M | 2.45M | 2.43M | 7.49M | -4.81M | 6.44M | 5.96M | -15.21M | 8.15M | -3.8M | -4.02M | -800K | -2.9M | 900K | -900K |
| Change in Inventory | -9.3M | -15.3M | -19.1M | 5.4M | -2.6M | -2.5M | -10.7M | -6.4M | -3.5M | -1.02M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 133.5M | 160.2M | 29M | 64.3M | 114.6M | 56.8M | 26.9M | 0 | 0 | 27.34M | 4.4M | 9.84M | 3.7M | -949K | 0 | 149K | 985K | 0 | 0 | 9.87M | -5.71M | -3.9M | -31.15M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Investing | -784.8M | -264.4M | -126.8M | -467.1M | -177.1M | -130.2M | 4.1M | -211.1M | -242.9M | -251.25M | 112.95M | -195.81M | -105.37M | 5.34M | -34.76M | -3.53M | -54.7M | 12.06M | 44.42M | 20.84M | 120.28M | 9.38M | 18.47M | -186.65M | -46.02M | -16.64M | -75.67M | -21.2M | 4.7M | -7.2M | -48.6M |
| Capital Expenditures | -32.4M | -34M | -38.2M | -28.3M | -16.5M | -23.4M | -10.9M | -14.7M | -24.8M | -6.94M | -4.11M | -1.93M | -1.61M | -545K | -971K | -750K | -315K | -35K | -1.32M | -624K | -3.11M | -7.24M | -53.15M | -50.44M | -5.3M | -3.81M | -2.44M | -2.1M | -3.7M | -6.4M | -2.3M |
| CapEx % of Revenue | 1.04% | 1.19% | 1.62% | 1.5% | 1.11% | 2.06% | 1.04% | 1.87% | 5.5% | 4.29% | 27.39% | 9.78% | - | 18.67% | 1.83% | 0.97% | 0.94% | 1.19% | 33.26% | 50.98% | 7.93% | 5.84% | 62.4% | 36.27% | 29.37% | 9.23% | 16.73% | 12.5% | 23.13% | 24.52% | 11.98% |
| Acquisitions | 0 | 0 | 0 | 0 | -42.7M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 63.2M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7K | 13K | 49K | -343K | -68K | 3K | 2.04M | 559K | 1.28M | 596K | -1.03M | 525K | -525K | 20.29M | 11.6M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Financing | -6.5M | -38.3M | -486.7M | 65.3M | -234.3M | 27.4M | -157.8M | 32.4M | 29.5M | 516.65M | 2.39M | 276.99M | 138.73M | 5.3M | 83.7M | 286K | 21.48M | 9.9M | -1.45M | 57.18M | 10.09M | 10.33M | 36.69M | 211.06M | 5.81M | 181.3M | 94.13M | 41M | 1.9M | 700K | 46.8M |
| Debt Issued (Net) | 0 | 0 | -308.8M | 0 | -279M | -100K | -186.9M | 0 | 0 | 502.78M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1.49M | 56.59M | -5.76M | -6.64M | 29.69M | 14.45M | 2.25M | 1.82M | 757K | 0 | 1.5M | -100K | -700K |
| Equity Issued (Net) | 79.6M | -38.3M | -177.9M | 65.3M | 44.7M | 27.5M | 29.1M | 27.31M | 29.53M | 13.87M | 2.39M | 276.99M | 138.73M | 5.3M | 83.7M | 286K | 21.48M | 9.9M | 34K | 591K | 15.85M | 16.97M | 7M | 196.61M | 3.46M | 179.49M | 93.36M | 41M | 400K | 700K | 47.5M |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | -71.7M | -167.7M | -300M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | -86.1M | 0 | 0 | 0 | 0 | 0 | 0 | 5.09M | -30K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 236K | 0 | 104K | 0 | 15K | 0 | 0 | 100K | 0 |
| Net Change in Cash | 72.4M | 480M | -18.1M | -11.6M | -73.3M | 153.7M | 74.8M | -31.7M | -112M | 171.06M | 9.16M | 43.18M | -13.78M | -18.96M | 13.65M | -3.94M | 16.72M | -31.14M | -31.2M | 18.68M | 31.03M | -11.08M | -44.83M | 61.54M | -119.58M | 142.81M | -187K | 9.6M | -4.1M | 4.5M | -6.4M |
| Free Cash Flow | 831.3M | 748.7M | 557.2M | 361.6M | 322.9M | 233.1M | 217.6M | 132.3M | 76.6M | -101.27M | -110.29M | -39.93M | -48.75M | -30.15M | -36.27M | -1.45M | 49.63M | -53.13M | -75.49M | -59.96M | -102.44M | -38.03M | -153.13M | -13.31M | -84.67M | -25.66M | -21.09M | -12.4M | -14.4M | 4.6M | 4.4M |
| FCF Margin % | 26.8% | 26.17% | 23.66% | 19.16% | 21.69% | 20.56% | 20.8% | 16.79% | 16.98% | -62.66% | -735.26% | -201.99% | - | -1032.96% | -68.24% | -1.87% | 148.14% | -1799.19% | -1899.04% | -4898.53% | -261.11% | -30.7% | -179.79% | -9.57% | -469.19% | -62.22% | -144.54% | -73.81% | -90% | 17.62% | 22.92% |
| FCF Growth % | 68.89% | 34.37% | 54.09% | 11.99% | 38.52% | 7.12% | 64.47% | 72.72% | 175.64% | 8.18% | -176.2% | 18.09% | -61.69% | 16.86% | -2404.49% | -102.92% | 193.41% | 29.62% | -25.9% | 41.47% | -169.38% | 75.17% | -1050.44% | 84.28% | -229.94% | -21.7% | -70.04% | 13.89% | -413.04% | 4.55% | - |
| FCF per Share | 8.04 | 7.30 | 5.37 | 3.58 | 3.26 | 2.38 | 2.22 | 1.38 | 0.80 | -1.15 | -1.27 | -0.47 | -0.65 | -0.45 | -0.54 | -0.03 | 0.94 | -1.36 | -1.96 | -1.58 | -2.72 | -1.00 | -4.23 | -0.41 | -2.78 | -0.99 | -0.95 | -0.65 | -0.79 | 0.25 | 0.27 |
| FCF Conversion (FCF/Net Income) | 1.24x | 1.64x | 1.74x | 1.56x | 2.20x | 2.86x | 0.56x | 3.97x | 4.80x | 0.66x | 0.75x | 0.43x | 0.78x | 0.64x | -7.02x | -0.02x | -6.27x | 1.04x | 0.84x | 0.29x | 0.93x | 1.39x | 2.18x | -1.23x | 0.84x | 0.59x | 0.65x | 0.61x | 0.54x | 2.16x | 1.14x |
| Interest Paid | 0 | 0 | 1.6M | 3.8M | 6.6M | 8.6M | 11.6M | 11.6M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 80.8M | 81.4M | 217.5M | 51.5M | 14.4M | 5.1M | 15.3M | 500K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Single product revenue concentration
As reported in recent financial filings, NBIX exhibits significant quarterly volatility in its operating cash flow to net income ratio, which reached a high of 8.20 in 2025Q1, suggesting that GAAP earnings often fail to capture the full cash-generating potential of the Ingrezza franchise.
The frequent divergence between net income and operating cash flow suggests that non-cash items and working capital fluctuations play a disproportionate role in reported profitability. Investors should monitor whether this conversion gap stabilizes as the company matures, as the current reliance on non-cash adjustments may mask the underlying cash-generating efficiency of the business.
Based on the provided cash flow data, NBIX has demonstrated a volatile but generally positive free cash flow trajectory, with margins peaking at 48.5% in 2025Q4, indicating that the company is successfully converting its high-margin revenue into substantial discretionary capital for future investment or strategic deployment.
The wide variance in FCF margins, ranging from 9.0% to 48.5% over the last ten quarters, highlights the impact of lumpy R&D spending and working capital timing on cash availability. While the trend appears favorable, the sustainability of these margins warrants further investigation into how future clinical trial costs might compress cash flow in the coming fiscal years.
According to the company's cash flow statements, working capital changes have been a primary driver of quarterly cash flow swings, with a notable $119.2 million inflow in 2025Q4, reflecting the inherent complexity of managing inventory and receivables within the specialty pharmacy distribution channel.
The significant shifts in working capital suggest that NBIX is susceptible to timing differences in collections and inventory stocking patterns. Analysts should interpret these fluctuations as operational noise rather than structural weakness, though persistent negative working capital cycles in certain quarters may indicate potential pressure on cash conversion efficiency.
Based on reported figures, NBIX has utilized its robust cash position to execute significant share repurchases, including a $300 million buyback in 2024Q4, signaling management's confidence in the long-term value of the equity despite the ongoing need for heavy R&D investment in the pipeline.
The company's capital deployment strategy appears focused on balancing shareholder returns with the necessity of funding late-stage clinical programs. This approach suggests a management team that is comfortable with its current liquidity position, though investors should monitor whether these buybacks continue to be prioritized over potential external acquisitions.
As indicated in the quarterly cash flow data, stock-based compensation has remained a consistent and material non-cash expense, averaging over $50 million per quarter, which effectively obscures the true cash-generating power of the core neurology business when viewed through the lens of GAAP net income.
The persistent use of stock-based compensation as a primary form of employee incentive warrants careful scrutiny, as it represents a real economic cost to shareholders that is often excluded from non-GAAP performance metrics. This practice may lead to an overstatement of the company's operational efficiency if the dilutive impact is not fully accounted for in valuation models.
Quick answers to the most common questions about buying NBIX stock.
Neurocrine Biosciences, Inc. (NBIX) generated $782.7M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Neurocrine Biosciences, Inc. (NBIX) generated $748.7M in free cash flow in 2025. Free cash flow is the cash left over after capital expenditures, which can be used to pay dividends, repurchase shares, or pay down debt.
Neurocrine Biosciences, Inc. (NBIX) spent $34.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.
In 2025, Neurocrine Biosciences, Inc. (NBIX) spent $167.7M on share repurchases. This shows the company's commitment to returning capital to its equity investors.