Revenue and operating margin have improved strongly, with quarterly revenue reaching $1.1B and operating margin rising to 29.5% in 2026Q3, although the trend has been volatile, with margin dipping to 4.1% in 2025Q1.
Neurocrine Biosciences, Inc. (NBIX) annual income statement — 30-year revenue, gross profit & net income history
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 | Dec'01 | Dec'00 | Dec'99 | Dec'98 | Dec'97 | Dec'96 |
|---|
| Sales/Revenue | 3.7B | 2.86B | 2.36B | 1.89B | 1.49B | 1.13B | 1.05B | 788.1M | 451.2M | 161.63M | 15M | 19.77M | 0 | 2.92M | 53.14M | 77.41M | 33.5M | 2.95M | 3.98M | 1.22M | 39.23M | 123.89M | 85.18M | 139.08M | 18.05M | 41.24M | 14.59M | 16.8M | 16M | 26.1M | 19.2M |
| Revenue Growth % | 37.98% | 21.45% | 24.81% | 26.76% | 31.34% | 8.38% | 32.71% | 74.67% | 179.16% | 977.51% | -24.12% | - | -100% | -94.51% | -31.36% | 131.08% | 1034.47% | -25.71% | 224.75% | -96.88% | -68.33% | 45.45% | -38.76% | 670.73% | -56.25% | 182.71% | -13.17% | 5% | -38.7% | 35.94% | - |
| Cost of Goods Sold | 81.2M | 52.1M | 34M | 39.7M | 23.2M | 14.3M | 10.1M | 7.4M | 4.9M | 1.25M | 0 | 0 | 14.4M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2.2M | -2.1M | -1.7M | -1.3M | -1M |
| COGS % of Revenue | - | 1.82% | 1.44% | 2.1% | 1.56% | 1.26% | 0.97% | 0.94% | 1.09% | 0.78% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -15.07% | -12.5% | -10.63% | -4.98% | -5.21% |
| Gross Profit | 3.62B | 2.81B | 2.32B | 1.85B | 1.47B | 1.12B | 1.04B | 780.7M | 446.3M | 160.37M | 15M | 19.77M | -14.4M | 0 | 0 | 77.41M | 33.5M | 2.95M | 3.98M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16.79M | 18.9M | 17.7M | 27.4M | 20.2M |
| Gross Margin % | 97.81% | 98.18% | 98.56% | 97.9% | 98.44% | 98.74% | 99.03% | 99.06% | 98.91% | 99.22% | 100% | 100% | - | - | - | 100% | 100% | 100% | 100% | - | - | - | - | - | - | - | 115.07% | 112.5% | 110.63% | 104.98% | 105.21% |
| Gross Profit Growth % | - | 20.98% | 25.65% | 26.06% | 30.94% | 8.05% | 32.68% | 74.93% | 178.29% | 969.15% | -24.12% | 237.28% | - | - | -100% | 131.08% | 1034.47% | -25.71% | - | - | - | - | - | - | - | -100% | -11.19% | 6.78% | -35.4% | 35.64% | - |
| Operating Expenses | 2.74B | 2.19B | 1.75B | 1.6B | 1.22B | 1.02B | 872.8M | 708.4M | 409.5M | 291.73M | 162.37M | 113.97M | 64.41M | 52.6M | 51.69M | 43.49M | 47.22M | 56.62M | 91.27M | 213.47M | 152.55M | 148.96M | 137.51M | 197.87M | 121.66M | 85.12M | 52.39M | 38.8M | 30.1M | 26.9M | 17.3M |
| OpEx % of Revenue | - | 76.54% | 74.33% | 84.6% | 81.72% | 89.7% | 83.45% | 89.89% | 90.76% | 180.5% | 1082.48% | 576.51% | - | 1801.88% | 97.28% | 56.18% | 140.96% | 1917.47% | 2296.18% | 17440.03% | 388.82% | 120.24% | 161.44% | 142.27% | 674.2% | 206.4% | 359.11% | 230.95% | 188.13% | 103.07% | 90.1% |
| Selling, General & Admin | 1.43B | 1.16B | 1.01B | 887.6M | 752.7M | 583.3M | 433.3M | 354.1M | 248.93M | 169.91M | 68.08M | 32.48M | 17.99M | 13.35M | 13.44M | 12.46M | 16.07M | 14.83M | 20.24M | 37.48M | 54.87M | 42.33M | 22.44M | 20.59M | 12.72M | 10.86M | 9.96M | 7.5M | 6.6M | 5.7M | 3.7M |
| SG&A % of Revenue | - | 40.42% | 42.76% | 47.04% | 50.56% | 51.46% | 41.43% | 44.93% | 55.17% | 105.12% | 453.87% | 164.3% | - | 457.31% | 25.29% | 16.09% | 47.97% | 502.17% | 509.18% | 3062.17% | 139.86% | 34.17% | 26.35% | 14.81% | 70.5% | 26.33% | 68.29% | 44.64% | 41.25% | 21.84% | 19.27% |
| Research & Development | 1.23B | 1.02B | 731.1M | 565M | 463.8M | 328.1M | 275M | 200M | 155.8M | 91.83M | 94.29M | 81.49M | 46.42M | 39.25M | 37.16M | 30.95M | 31.15M | 33.72M | 55.54M | 81.98M | 97.68M | 106.63M | 115.07M | 177.27M | 108.94M | 74.27M | 40.23M | 29.2M | 21.8M | 19.9M | 12.6M |
| R&D % of Revenue | - | 35.51% | 31.04% | 29.94% | 31.15% | 28.95% | 26.29% | 25.38% | 34.53% | 56.81% | 628.61% | 412.22% | - | 1344.57% | 69.93% | 39.98% | 92.99% | 1141.96% | 1397.33% | 6698.12% | 248.96% | 86.07% | 135.09% | 127.46% | 603.71% | 180.08% | 275.75% | 173.81% | 136.25% | 76.25% | 65.63% |
| Other Operating Expenses | 3M | 17.4M | 12.5M | 143.9M | 0 | 105.3M | 164.5M | 154.3M | 4.8M | 30M | 0 | 0 | 18K | 0 | 1.09M | 82K | 2.8M | 2.56M | 2.05M | 94M | 0 | 0 | 0 | 0 | 0 | 0 | 2.2M | 2.1M | 1.7M | 1.3M | 1M |
| Operating Income | 881.2M | 619.1M | 570.5M | 250.9M | 249M | 102.5M | 163M | 72.3M | 36.8M | -131.36M | -147.37M | -94.2M | -64.41M | -49.68M | 1.45M | 33.92M | -13.72M | -53.67M | -87.3M | -212.24M | -113.32M | -25.07M | -52.33M | -58.79M | -103.61M | -43.88M | -35.6M | -19.9M | -12.4M | 500K | 2.9M |
| Operating Margin % | 23.81% | 21.64% | 24.22% | 13.3% | 16.73% | 9.04% | 15.58% | 9.17% | 8.16% | -81.27% | -982.48% | -476.51% | - | -1701.88% | 2.72% | 43.82% | -40.96% | -1817.47% | -2196.18% | -17340.03% | -288.82% | -20.24% | -61.44% | -42.27% | -574.2% | -106.4% | -244.04% | -118.45% | -77.5% | 1.92% | 15.1% |
| Operating Income Growth % | - | 8.52% | 127.38% | 0.76% | 142.93% | -37.12% | 125.45% | 96.47% | 128.01% | 10.86% | -56.44% | -46.25% | -29.66% | -3530.8% | -95.73% | 347.21% | 74.43% | 38.52% | 58.87% | -87.3% | -351.97% | 52.09% | 10.98% | 43.26% | -136.12% | -23.26% | -78.9% | -60.48% | -2580% | -82.76% | - |
| EBITDA | 964.8M | 649.2M | 597.6M | 272.2M | 264.6M | 113.4M | 171.6M | 79.7M | 40.8M | -128.96M | -145.92M | -93.19M | -63.58M | -49.01M | 2.1M | 34.62M | -12.29M | -50.49M | -79.69M | -202.84M | -102.75M | -14.98M | -45.25M | -55.09M | -100.52M | -41.23M | -33.4M | -17.8M | -10.7M | 1.8M | 3.9M |
| EBITDA Margin % | 26.06% | 22.7% | 25.37% | 14.42% | 17.77% | 10% | 16.41% | 10.11% | 9.04% | -79.79% | -972.79% | -471.41% | - | -1678.9% | 3.96% | 44.72% | -36.67% | -1709.82% | -2004.73% | -16571.73% | -261.89% | -12.09% | -53.13% | -39.61% | -557.04% | -99.97% | -228.98% | -105.95% | -66.88% | 6.9% | 20.31% |
| EBITDA Growth % | 66.37% | 8.63% | 119.54% | 2.87% | 133.33% | -33.92% | 115.31% | 95.34% | 131.64% | 11.62% | -56.58% | -46.57% | -29.74% | -2428.12% | -93.92% | 381.75% | 75.67% | 36.64% | 60.71% | -97.41% | -586.01% | 66.9% | 17.86% | 45.19% | -143.79% | -23.43% | -87.66% | -66.36% | -694.44% | -53.85% | - |
| D&A (Non-Cash Add-back) | 83.6M | 30.1M | 27.1M | 21.3M | 15.6M | 10.9M | 8.6M | 7.4M | 4M | 2.4M | 1.45M | 1.01M | 827K | 671K | 657K | 694K | 1.44M | 3.18M | 7.61M | 9.4M | 10.57M | 10.09M | 7.08M | 3.69M | 3.1M | 2.65M | 2.2M | 2.1M | 1.7M | 1.3M | 1M |
| EBIT | 863M | 636.5M | 612.6M | 394.8M | 221M | 127.2M | 139.5M | 78.5M | 52.3M | -123.02M | -141.09M | -88.93M | -64.41M | -49.68M | 1.45M | 33.92M | -13.72M | -51.11M | -81.59M | -212.24M | -113.32M | -25.07M | -52.33M | -58.79M | -103.61M | -43.88M | -35.6M | -19.9M | -12.4M | 500K | 2.9M |
| Net Interest Income | -17.9M | 90.3M | -35.6M | -4.6M | 4.1M | -25.8M | -32.8M | -32M | -30.5M | -19.52M | 2.84M | 1.93M | 0 | 400K | 489K | 435K | 397K | 691K | -7.03M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interest Income | -14.7M | 90.3M | 91M | 0 | 11.2M | 0 | 0 | 0 | 0 | 0 | 2.84M | 1.93M | 629K | 400K | 489K | 435K | 397K | 691K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interest Expense | 3.2M | 0 | 126.6M | 4.6M | 7.1M | 25.8M | 32.8M | 32M | 30.53M | 19.52M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.03M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Income/Expense | 50.9M | 86.3M | -84.5M | 81.2M | -35.1M | -1.1M | -56.3M | -25.8M | -15.05M | -11.18M | 6.28M | 5.27M | 3.87M | 3.59M | 3.58M | 3.65M | 5.75M | 2.63M | -1.31M | 4.94M | 6.11M | 2.88M | 6.64M | 28.69M | 9.08M | 7.09M | 7.09M | 200K | -7.4M | 4.8M | 3.2M |
| Pretax Income | 932.1M | 705.4M | 486M | 332.1M | 213.9M | 101.4M | 106.7M | 46.5M | 21.84M | -142.54M | -141.09M | -88.93M | -60.54M | -46.09M | 5.03M | 37.57M | -7.97M | -88.61M | -88.61M | -207.3M | -107.2M | -22.19M | -45.69M | -30.1M | -94.54M | -36.79M | -28.51M | -19.7M | -19.8M | 5.3M | 6.1M |
| Pretax Margin % | 25.18% | 24.66% | 20.63% | 17.6% | 14.37% | 8.95% | 10.2% | 5.9% | 4.84% | -88.19% | -940.6% | -449.84% | - | -1578.97% | 9.46% | 48.53% | -23.78% | -3000.78% | -2229.26% | -16936.19% | -273.25% | -17.91% | -53.65% | -21.64% | -523.89% | -89.21% | -195.41% | -117.26% | -123.75% | 20.31% | 31.77% |
| Income Tax | 229.6M | 226.8M | 144.7M | 82.4M | 59.4M | 11.8M | -300.6M | 9.5M | 730K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 173K | 0 | 0 | 0 | 0 | 79K | 158K | 0 | 120K | 302K | -3.1M | 7.6M | 200K | 200K |
| Effective Tax Rate % | 24.63% | 32.15% | 29.77% | 24.81% | 27.77% | 11.64% | -281.72% | 20.43% | 3.34% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | -0.2% | 0% | 0% | 0% | 0% | -0.17% | -0.52% | 0% | -0.33% | -1.06% | 15.74% | -38.38% | 3.77% | 3.28% |
| Net Income | 702.5M | 478.6M | 341.3M | 249.7M | 154.5M | 89.6M | 407.3M | 37M | 21.11M | -142.54M | -141.09M | -88.93M | -60.54M | -46.09M | 5.03M | 37.57M | -7.97M | -51.04M | -88.61M | -207.3M | -107.2M | -22.19M | -45.77M | -30.26M | -94.54M | -36.91M | -28.81M | -16.8M | -20M | 5.1M | 5.9M |
| Net Margin % | 18.98% | 16.73% | 14.49% | 13.23% | 10.38% | 7.9% | 38.94% | 4.69% | 4.68% | -88.19% | -940.6% | -449.84% | - | -1578.97% | 9.46% | 48.53% | -23.78% | -1728.34% | -2229.26% | -16936.19% | -273.25% | -17.91% | -53.74% | -21.75% | -523.89% | -89.5% | -197.48% | -100% | -125% | 19.54% | 30.73% |
| Net Income Growth % | 64.14% | 40.23% | 36.68% | 61.62% | 72.43% | -78% | 1000.81% | 75.26% | 114.81% | -1.03% | -58.65% | -46.89% | -31.36% | -1017.21% | -86.63% | 571.52% | 84.39% | 42.4% | 57.25% | -93.37% | -383.1% | 51.52% | -51.29% | 68% | -156.13% | -28.12% | -71.48% | 16% | -492.16% | -13.56% | - |
| Net Income (Continuing) | 702.5M | 478.6M | 341.3M | 249.7M | 154.5M | 89.6M | 407.3M | 37M | 21.11M | -142.54M | -141.09M | -88.93M | -60.54M | -46.09M | 5.03M | 37.57M | -7.97M | -51.04M | -88.61M | -207.3M | -107.2M | -22.19M | -45.77M | -30.26M | -94.54M | -36.91M | -28.81M | -16.8M | -20M | 5.1M | 5.9M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | 6.68 | 4.67 | 3.29 | 2.47 | 1.56 | 0.92 | 4.16 | 0.39 | 0.22 | -1.62 | -1.63 | -1.05 | -0.81 | -0.69 | 0.08 | 0.67 | -0.15 | -1.30 | -2.30 | -5.45 | -2.84 | -0.58 | -1.26 | -0.93 | -3.10 | -1.42 | -1.30 | -0.88 | -1.10 | 0.28 | 0.36 |
| EPS Growth % | 61.24% | 41.95% | 33.2% | 58.33% | 69.57% | -77.88% | 966.67% | 77.27% | 113.58% | 0.61% | -55.24% | -29.63% | -17.39% | -1018.77% | -88.79% | 546.67% | 88.46% | 43.48% | 57.8% | -91.9% | -389.66% | 53.97% | -35.48% | 70% | -118.31% | -9.23% | -47.73% | 20% | -492.86% | -22.22% | - |
| EPS (Basic) | - | 4.81 | 3.40 | 2.56 | 1.61 | 0.95 | 4.37 | 0.40 | 0.22 | -1.62 | -1.63 | -1.05 | -0.81 | -0.69 | 0.08 | 0.68 | -0.15 | -1.30 | -2.30 | -5.45 | -2.84 | -0.60 | -1.26 | -0.93 | -3.10 | -1.42 | -1.30 | -0.88 | -1.10 | 0.30 | 0.39 |
| Diluted Shares Outstanding | 105.2M | 102.5M | 103.7M | 101M | 98.9M | 97.9M | 97.8M | 95.73M | 95.4M | 88.09M | 86.71M | 84.5M | 74.58M | 66.99M | 66.95M | 56.35M | 52.82M | 39.14M | 38.45M | 38.01M | 37.72M | 37.99M | 36.2M | 32.37M | 30.49M | 26.03M | 22.12M | 19.07M | 18.14M | 18.21M | 16.39M |
| Basic Shares Outstanding | 101.6M | 99.5M | 100.4M | 97.7M | 95.8M | 94.6M | 93.1M | 91.63M | 95.4M | 87.99M | 86.56M | 84.5M | 74.58M | 66.8M | 65.62M | 55.18M | 52.82M | 39.14M | 38.45M | 38.01M | 37.72M | 36.76M | 36.2M | 32.37M | 30.49M | 26.03M | 22.12M | 19.07M | 18.14M | 17M | 15.13M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Quick answers to the most common questions about buying NBIX stock.
For fiscal year 2025, Neurocrine Biosciences, Inc. (NBIX) reported total revenue of $2.86B. This represents a 14798.4% increase compared to $19.2M in 1996.
Neurocrine Biosciences, Inc. (NBIX) is profitable, generating $478.6M in net income for the fiscal year ending 2025 with a net profit margin of 16.7%.
Neurocrine Biosciences, Inc. (NBIX) reported an operating income of $619.1M, resulting in an operating profit margin of 21.6%. This margin reflects the operational efficiency of the business before interest and taxes.
Neurocrine Biosciences, Inc. (NBIX) generated $2.81B in gross profit for the year, representing a gross profit margin of 98.2%. This demonstrates the company's core pricing power and production efficiency.
Key Metrics
Top Statement Risk
Quarterly operating margin volatility
Metrics are mathematically derived from official filings.
Revenue Growth Sustained at Double Digits
Based on reported quarterly figures, NBIX revenue rose 41.2% year over year to $1.1B in 2026Q3, following 39.5% growth in Q2, suggesting the commercial expansion has durable momentum rather than a single-quarter spike.
The jump from roughly $622M in 2024Q3 to $1.1B in 2026Q3 indicates a sustained compounding trajectory rather than a one-time catalyst. Investors should monitor whether the growth rate can hold above 30% as the comparison base becomes more demanding in the coming periods. The lumpiness between quarters, such as the 2025Q1 slowdown to 11.1%, suggests revenue timing remains sensitive to product launch cadence and reporting periods.
Gross Margin Near-Saturation Constrains Upside
As reported in financial statements, NBIX gross margin has held between 97.6% and 98.7% across the ten quarters, leaving limited room for further expansion and making operating margin the more meaningful profitability lever.
Gross margins at this level reflect a high-value, low-cost-of-goods product profile typical of specialty pharmaceuticals, so the margin itself is not a differentiator within the period. The quarterly erosion in gross margin toward 97.6% in 2026Q2 and 2026Q3 is modest but may warrant monitoring for early signs of pricing or mix pressure. The analytical focus should therefore shift to how efficiently revenue converts into operating income.
Operating Leverage Visible but Uneven
Based on NBIX's reported figures, operating margin moved from 22.6% in 2024Q4 to 29.5% in 2026Q3, indicating that operating income has generally scaled faster than revenue, although the trend is not linear.
The 2026Q2 operating margin contraction to 15.8% despite 39.5% revenue growth shows SG&A rising to $439.7M and overwhelming the gross profit gain. This pattern suggests overhead efficiency depends heavily on commercial spending timing rather than on steady structural improvement. Investors may wish to examine whether SG&A intensity normalizes or continues to swing with launch activity.
Net Income Diverges from Operating Trends
As reported in financial statements, NBIX's 2026Q1 net income of $197.9M exceeded its operating income of $186.0M, and 2025Q1 net income of $7.9M sat far below operating income of $23.6M, indicating non-operating items materially affect reported earnings.
The gap between operating and net income in several quarters suggests tax effects, interest income, or other non-operating items play a meaningful role in reported EPS. The 2025Q1 EPS of $0.08 versus 2025Q3 EPS of $2.04 illustrates how sensitive per-share results are to these items. Stock-based compensation of roughly $41M to $66M per quarter should also be considered when assessing the underlying earnings base.
Peer-Relative Margin Gap Warrants Scrutiny
Based on peer context, NBIX's 2026Q3 operating margin of 29.5% trails the 49.5% reported by PTCT and the 38.5% reported by INVA, which may suggest the company's cost base is heavier than some specialty biotech comparables.
A bear case would emphasize that SG&A of $366M to $440M per quarter absorbs a large share of revenue and could pressure margins if competitive launches intensify. The quarterly volatility in operating margin, ranging from 4.1% to 30.1% over the period, may indicate that earnings are less durable than the headline revenue growth implies. These observations are analytical inferences from reported figures and warrant further investigation into the drivers of cost intensity.