Orchestra BioMed Holdings, Inc. (OBIO) Revenue History
Annual and quarterly revenue from 2020 to 2025
Compound Annual Growth Rate (CAGR)
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OBIO Revenue Growth
Revenue Breakdown (FY 2025)
OBIO's revenue distribution by segment and geography for fiscal year 2025
By Product/Segment
OBIO Revenue Analysis (2020–2025)
As of May 8, 2026, Orchestra BioMed Holdings, Inc. (OBIO) generated trailing twelve-month (TTM) revenue of $33.5 million, reflecting explosive growth of +12120.2% year-over-year. The most recent quarter (Q4 2025) recorded $30.9 million in revenue, up 3490.8% sequentially.
Looking at the longer-term picture, OBIO's 5-year compound annual growth rate (CAGR) stands at +42.5%, indicating outstanding long-term growth trajectory. The company achieved its highest annual revenue of $33.5 million in 2025, representing a new all-time high.
Revenue diversification analysis shows OBIO's business is primarily driven by Product (100%). With over half of revenue concentrated in Product, the company maintains significant focus in this area while developing other growth vectors.
When compared to Healthcare sector peers including NVCR (+8.5% YoY), XTNT (+16.9% YoY), and BSX (+19.9% YoY), OBIO has outperformed the peer group in terms of revenue growth. Compare OBIO vs NVCR →
OBIO Revenue vs Peers
Revenue metrics vs comparable public companies
| Company | TTM Revenue | YoY Growth | 5Y CAGR | Op. Margin | Compare |
|---|---|---|---|---|---|
| OBIOCurrent | $33M | +12120.2% | +42.5% | -154.7% | |
 NVCR | $655M | +8.5% | +5.8% | -23.5% | |
 XTNT | $117M | +16.9% | +12.6% | -10.3% | |
 BSX | $20.1B | +19.9% | +15.2% | 19.8% | |
 MDT | $33.5B | +6.9% | +3.0% | 17.8% | |
 ABT | $42.0B | +6.4% | +5.6% | 16.3% |
OBIO Historical Revenue Data (2020–2025)
| Year | Revenue | YoY % | Gross Profit | Gross Margin | Op. Income | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | $33.5M | +1169.2% | $33.3M | 99.4% | $-51,807,000 | -154.7% |
| 2024 | $2.6M | -4.4% | $2.4M | 92.3% | $-64,301,000 | -2437.5% |
| 2023 | $2.8M | -21.9% | $2.6M | 93.3% | $-51,506,000 | -1866.2% |
| 2022 | $3.5M | +551.8% | $3.2M | 90.9% | $-32,657,000 | -924.3% |
| 2021 | $-782,000 | -113.7% | $-981,000 | 125.4% | $-21,799,000 | 2787.6% |
| 2020 | $5.7M | - | $5.6M | 97.5% | $-18,752,000 | -328.8% |
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Start ComparisonOBIO — Frequently Asked Questions
Quick answers to the most common questions about buying OBIO stock.
Is OBIO's revenue growth accelerating or slowing?
OBIO revenue is accelerating at +12120.2% year-over-year, exceeding the 5-year CAGR of +42.5%. TTM revenue reached $33M. Growth momentum has increased versus prior periods.
What is OBIO's long-term revenue growth rate?
Orchestra BioMed Holdings, Inc.'s 5-year revenue CAGR of +42.5% reflects the sustained expansion pattern. Current YoY growth of +12120.2% is above this long-term average.
How is OBIO's revenue distributed by segment?
OBIO reports revenue by product line and geographic region. Annual and quarterly breakdowns from 2020-2025 are available for download. Segment mix reveals concentration and diversification trends.