Last 48 quarters of trend data · Healthcare · Medical - Devices
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -0.77 | — | — | — | — | — | 59.42 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 2.72 | 2.71 | 3.16 | 2.50 | 2.34 | 2.36 | 3.58 | 2.90 | 2.59 | 6.51 | 11.23 | 9.56 | 17.48 |
| — | +15.2% | -11.7% | -13.7% | -9.7% | -63.8% | -68.1% | -69.6% | -85.2% | -63.8% | -33.6% | -5.5% | +149.9% | |
| P/B Ratio | 78.51 | 170.61 | 105.55 | 10.67 | 6.05 | 3.82 | 1.11 | 1.02 | 0.76 | 1.56 | 3.74 | 2.79 | 5.18 |
| — | +4363.2% | +9420.8% | +942.1% | +699.2% | +145.4% | -70.3% | -63.3% | -85.4% | -61.5% | +13.7% | +33.7% | +256.0% | |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | 54.13 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Pacific Biosciences of California, Inc.'s operating margin was -102.0% in Q1 2026, down 9.7 pp QoQ and up 1052.5 pp YoY. Gross margin expanded 1036.0% YoY, indicating pricing power or improving input costs.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 31.7% | 34.5% | 37.5% | 39.2% | 36.9% | -3.7% | 25.6% | 25.0% | 16.5% | 29.1% | 16.4% | 32.1% | 32.7% |
| — | +1036.0% | +46.3% | +56.6% | +124.0% | -112.7% | +56.3% | -22.1% | -49.5% | +15.9% | -12.7% | -23.3% | -28.4% | |
| Operating Margin | -348.5% | -102.0% | -92.3% | -101.0% | -112.8% | -1154.5% | -390.1% | -160.3% | -488.3% | -209.6% | -150.0% | -148.1% | -153.8% |
| — | +91.2% | +76.3% | +37.0% | +76.9% | -450.7% | -160.1% | -8.2% | -217.4% | +10.6% | +52.9% | +35.9% | +19.7% | |
| Net Margin | -341.5% | -22.3% | -90.4% | -98.9% | -105.4% | -1146.8% | 6.0% | -151.9% | -481.3% | -201.4% | -140.5% | -120.1% | -146.8% |
| — | +98.1% | -1595.9% | +34.9% | +78.1% | -469.3% | +104.3% | -26.5% | -227.9% | +11.0% | +54.4% | +49.6% | +27.1% |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -213.5% | -214.5% | -194.8% | -77.9% | -54.8% | -142.4% | 0.5% | -12.8% | -30.4% | -11.6% | -11.2% | -9.5% | -10.5% |
| — | -50.6% | -39534.4% | -506.6% | -80.4% | -1130.2% | +104.4% | -35.0% | -190.0% | +17.4% | +21.1% | +19.1% | -3.9% | |
| ROA | -53.4% | -1.1% | -5.1% | -4.7% | -5.0% | -40.2% | 0.2% | -4.1% | -10.9% | -4.6% | -4.5% | -3.6% | -3.7% |
| — | +97.4% | -3008.5% | -13.7% | +54.4% | -777.6% | +103.9% | -14.9% | -192.3% | +4.7% | +4.4% | +14.3% | +0.4% | |
| ROIC | -45.8% | -4.2% | -4.5% | -4.2% | -4.7% | -34.7% | -9.5% | -3.7% | -9.3% | -4.1% | -4.7% | -4.6% | -4.1% |
| — | +87.9% | +52.9% | -14.0% | +50.0% | -740.5% | -100.0% | +20.2% | -126.0% | +25.6% | +10.8% | -6.8% | -4.7% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has weakened 15.4% YoY to 5.65x, tightening the short-term liquidity position. Debt/Equity has risen for 6 consecutive quarters, indicating increasing financial leverage that investors should watch closely.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 141.98 | 297.29 | 141.98 | 19.48 | 11.37 | 7.63 | 1.33 | 2.03 | 1.88 | 1.44 | 1.33 | 1.22 | 1.46 |
| — | +3796.8% | +10596.6% | +858.7% | +505.7% | +431.6% | -0.3% | +65.9% | +28.5% | +5.1% | -21.0% | -19.1% | +4.8% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 6.89 | 5.65 | 6.89 | 6.24 | 6.92 | 6.68 | 7.48 | 9.74 | 8.01 | 9.28 | 7.81 | 4.80 | 3.45 |
| — | -15.4% | -7.8% | -35.9% | -13.7% | -28.0% | -4.3% | +103.0% | +132.5% | +151.3% | +141.3% | -57.2% | -70.0% | |
| Quick Ratio | 5.99 | 4.87 | 5.99 | 5.40 | 6.02 | 5.87 | 6.59 | 8.64 | 7.14 | 8.36 | 7.21 | 4.43 | 3.20 |
| — | -17.0% | -9.2% | -37.6% | -15.7% | -29.8% | -8.6% | +95.3% | +123.2% | +141.6% | +136.9% | -58.5% | -71.1% | |
| Interest Coverage | -77.52 | -21.79 | -22.09 | -22.32 | -23.11 | -244.47 | 1.97 | -16.16 | -47.93 | -20.87 | -22.17 | -20.62 | -18.65 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 48 years · Updated daily
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Quick answers to the most common questions about buying PACB stock.
Pacific Biosciences of California, Inc.'s current P/E is -0.8x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Pacific Biosciences of California, Inc.'s current operating margin is -348.5%. Margins have been expanding over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Pacific Biosciences of California, Inc.'s business trajectory between earnings reports.