Ranked by reported Q4 2025 13F market value
Share of total reported institutional value in RPTX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 10.3M | $26.9M | 0.0% | 24.040% | 0.90% |
| 2 | Blue Owl Capital Holdings LP | 3.4M | $9.0M | 0.0% | 8.011% | 0.67% |
| 3 | ORBIMED ADVISORS LLC | 3.3M | $8.6M | 0.0% | 7.729% | 0.18% |
| 4 | Redmile Group, LLC | 1.6M | $4.1M | 0.0% | 3.690% | 0.30% |
| 5 | Rangeley Capital, LLC | 1.3M | $3.3M | +99.4% | 2.996% | 3.09% |
| 6 | MARSHALL WACE, LLP | 1.1M | $2.9M | β | 2.596% | 0.00% |
| 7 | RENAISSANCE TECHNOLOGIES LLC | 981K | $2.6M | +35.5% | 2.283% | 0.00% |
| 8 | JANE STREET GROUP, LLC | 372K | $967K | β | 0.865% | 0.00% |
| 9 | TWO SIGMA INVESTMENTS, LP | 334K | $868K | +2942.7% | 0.776% | 0.00% |
| 10 | Yakira Capital Management, Inc. | 267K | $693K | β | 0.620% | 0.23% |
| 11 | NORTHERN TRUST CORP | 260K | $677K | -0.7% | 0.606% | 0.00% |
| 12 | BlackRock, Inc. | 144K | $375K | -1.6% | 0.335% | 0.00% |
| 13 | Militia Capital Partners, LP | 119K | $310K | 0.0% | 0.277% | 0.12% |
| 14 | XTX Topco Ltd | 117K | $304K | +145.9% | 0.272% | 0.01% |
| 15 | Walleye Capital LLC | 107K | $277K | β | 0.248% | 0.00% |
| 16 | BANK OF MONTREAL /CAN/ | 105K | $273K | 0.0% | 0.244% | 0.00% |
| 17 | TWO SIGMA ADVISERS, LP | 54K | $141K | +95.7% | 0.126% | 0.00% |
| 18 | Point72 Asset Management, L.P. | 51K | $133K | β | 0.119% | 0.00% |
| 19 | Quinn Opportunity Partners LLC | 40K | $104K | 0.0% | 0.093% | 0.00% |
| 20 | NewEdge Wealth, LLC | 33K | $86K | 0.0% | 0.077% | 0.00% |
| 21 | Squarepoint Ops LLC | 14K | $38K | -77.8% | 0.034% | 0.00% |
| 22 | OCCUDO QUANTITATIVE STRATEGIES LP | 14K | $35K | β | 0.032% | 0.00% |
| 23 | HARBOURVEST PARTNERS LLC | 12K | $32K | 0.0% | 0.029% | 0.02% |
| 24 | Engineers Gate Manager LP | 12K | $30K | +1.1% | 0.027% | 0.00% |
| 25 | BANK OF AMERICA CORP /DE/ | 11K | $28K | -16.5% | 0.025% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in RPTX β a direct measure of their conviction.
Filings activity in RPTX during Q4 2025, grouped by how each filer changed its position.
Institutions that opened a new RPTX position in Q4 2025
Institutions that fully closed their RPTX position in Q4 2025
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q4 2025 | 44 | 2.2% | 55.18% | +13.94 pp | $63M | +34% |
| Q3 2025 | 45 | 12% | 41.24% | +8.19 pp | $47M | +25% |
| Q2 2025 | 51 | +2.0% | 33.05% | +8.89 pp | $38M | +37% |
| Q1 2025 | 50 | 11% | 24.16% | 10.44 pp | $28M | 30% |
| Q4 2024 | 56 | +1.8% | 34.60% | 60.70 pp | $39M | 64% |
| Q3 2024 | 55 | 9.8% | 95.30% | 14.02 pp | $109M | 13% |
| Q2 2024 | 61 | 14% | 109.32% | 34.34 pp | $125M | 24% |
| Q1 2024 | 71 | β | 143.66% | β | $164M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying RPTX stock.
Based on Q4 2025 13F filings, institutional ownership of Repare Therapeutics Inc. stands at 55.2%, held across 44 reporting institutions.
BVF INC/IL is the largest reported institutional holder of RPTX, with approximately 10,333,600 shares worth $0.03B as of Q4 2025.
Yes β 5 widely-followed marquee investors appear among the top 25 institutional holders of RPTX, including RENAISSANCE TECHNOLOGIES LLC, JANE STREET GROUP, LLC, TWO SIGMA INVESTMENTS, LP, TWO SIGMA ADVISERS, LP, Point72 Asset Management, L.P..
Our composite Smart Money Score for RPTX is 72 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
12 institutions opened new positions in RPTX during Q4 2025, while 13 fully exited. 28 added to existing positions and 3 trimmed.
RPTX institutional ownership rose by 13.94 percentage points quarter-over-quarter, with a net change of -1 holders.
The top 10 institutions account for 95.3% of all reported 13F value in RPTX, and the top 25 account for 99.8%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Repare Therapeutics Inc. (RPTX) Institutional Ownership