Free cash flow burn improved 58% from -$81.5M in 2024Q1 to -$34.4M in 2026Q2, but cumulative operating outflows of $437.1M over ten quarters exceed cash on hand, and no capital returns signal pure survival mode.
Sana Biotechnology, Inc. (SANA) cash flow statement — 8-year operating, investing & financing cash flows
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 |
|---|
| Cash from Operations | -132.24M | -143.83M | -223.15M | -253.58M | -290.05M | -251.05M | -137.98M | -85.5M | -13.49M |
| Operating CF Margin % | - | - | - | - | - | - | - | - | - |
| Operating CF Growth % | 98.11% | 35.55% | 12% | 12.57% | -15.53% | -81.95% | -61.37% | -533.6% | - |
| Net Income | -211.82M | -244.17M | -266.76M | -283.25M | -269.48M | -355.93M | -285.31M | -130.78M | -13.25M |
| Depreciation & Amortization | 10.87M | 12.75M | 17.39M | 24.56M | 15.63M | 11.07M | 5.92M | 1.83M | 1K |
| Stock-Based Compensation | 22.82M | 25.46M | 37.68M | 35.53M | 38.34M | 22.36M | 5.83M | 1.5M | 118K |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7.55M | 0 |
| Other Non-Cash Items | 46.77M | 72.24M | -10.28M | -49.03M | -82.08M | 61.64M | 129.42M | 38.97M | -228K |
| Working Capital Changes | -878K | -10.11M | -1.19M | 18.61M | 7.54M | 9.8M | 6.16M | 10.53M | -308K |
| Change in Receivables | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | -943K | -3.54M | 1.38M | 1.03M | 1.06M | -266K | 1.98M | -421K | 289K |
| Cash from Investing | -102.6M | -40.24M | 17.45M | 172.01M | 210.56M | -245.8M | -252.56M | -87.86M | -780K |
| Capital Expenditures | -2.82M | -938K | -33.43M | -20.03M | -20.88M | -29.86M | -23.87M | -26.18M | -460K |
| CapEx % of Revenue | - | - | - | - | - | - | - | - | - |
| Acquisitions | 883K | 1.43M | 0 | -192.04K | -231.44K | 0 | 0 | -3.19M | 0 |
| Investments | - | - | - | - | - | - | - | - | - |
| Other Investing | 185K | 0 | 17.45M | 192.04K | 231.44K | -4.57M | 0 | 59K | -320K |
| Cash from Financing | 220.64M | 128.73M | 199.75M | 31.65M | 4.91M | 631.75M | 435.69M | 223.73M | 45.72M |
| Debt Issued (Net) | -89K | -347K | 7.74M | 0 | 0 | 0 | 0 | 0 | 0 |
| Equity Issued (Net) | 221M | 129.08M | 181M | 31.65M | 4.91M | 631.75M | 435.54M | 223.74M | 45.72M |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | -271K | 0 | 11.01M | 0 | 0 | 0 | 149K | -14K | 0 |
| Net Change in Cash | -14.2M | -55.33M | -5.95M | -49.92M | -74.58M | 134.9M | 45.14M | 50.36M | 31.45M |
| Free Cash Flow | -135.06M | -144.77M | -256.58M | -273.61M | -310.93M | -280.92M | -161.85M | -111.69M | -13.96M |
| FCF Margin % | - | - | - | - | - | - | - | - | - |
| FCF Growth % | 27.11% | 43.58% | 6.22% | 12% | -10.68% | -73.56% | -44.92% | -700.34% | - |
| FCF per Share | -0.46 | -0.57 | -1.11 | -1.41 | -1.65 | -1.69 | -0.86 | -0.60 | -0.07 |
| FCF Conversion (FCF/Net Income) | 0.64x | 0.59x | 0.84x | 0.90x | 1.08x | 0.71x | 0.48x | 0.65x | 1.02x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quick answers to the most common questions about buying SANA stock.
Sana Biotechnology, Inc. (SANA) generated $-143.8M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Sana Biotechnology, Inc. (SANA) reported negative free cash flow of $144.8M in 2025, indicating capital requirements exceeded cash from operations.
Sana Biotechnology, Inc. (SANA) spent $0.9M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.
Key Metrics
Top Statement Risk
Cash runway and dilution risk
Metrics are mathematically derived from official filings.
Cash Conversion Diverges from Losses
Operating cash outflows averaged $43.7M per quarter over the last ten quarters, consistently less than net losses, indicating non-cash charges like SBC and D&A cushion the reported burn.
The OCF/NI ratio has ranged from 0.35 to 1.16, with 2024Q2 showing cash burn exceeding net loss (ratio 1.16) due to working capital swings. Recent quarters (2026Q2 ratio 0.52) show cash burn moderating relative to losses, but this is largely because SBC and D&A (totaling ~$7.5M quarterly) are non-cash. Investors should focus on the cash burn rate, not net loss, as the true liquidity drain.
FCF Burn Stabilizes at Lower Level
Free cash flow improved from -$81.5M in 2024Q1 to -$34.4M in 2026Q2, a 58% reduction, reflecting strategic cost cuts and lower capex, but remains deeply negative with no revenue.
The FCF trajectory shows a clear pivot to conserve cash, with quarterly burn settling in the $30-40M range since 2025Q3. However, this stabilization is not a sign of health but a survival measure, as the company still has zero revenue and must fund all operations externally. The improvement is driven by reduced R&D and capex, not by any operational cash generation.
Minimal Capex Signals R&D Focus
Capital expenditures have collapsed from $15.8M in 2024Q1 to $1.6M in 2026Q2, indicating a shift away from infrastructure investment toward clinical trial funding, consistent with a cash preservation strategy.
Capex now represents a negligible portion of total cash outflows, suggesting the company is not investing in manufacturing capacity or lab expansion. This may limit future scalability if clinical trials succeed, but it is a rational choice given the liquidity constraints. The low capital intensity reflects a virtual company model, relying on external partners for manufacturing.
Working Capital Swings Provide Minor Relief
Working capital changes have been volatile, ranging from -$10.9M to +$4.3M quarterly, but have contributed a net positive $1.5M in 2026Q2, offering slight cash flow support amid ongoing losses.
The working capital fluctuations appear driven by timing of payables and receivables, not by operational efficiency, as there is no revenue to drive a traditional cycle. Positive changes in some quarters (e.g., 2025Q4 +$3.4M) may indicate delayed payments to vendors, which could strain relationships. These swings are immaterial relative to the $30-40M quarterly burn and do not alter the fundamental cash drain.
No Capital Returns, Only Cash Consumption
Sana has paid no dividends and made no buybacks over the last ten quarters, with all cash directed to R&D and operations, reflecting a pure survival mode with no shareholder returns.
The absence of capital returns is expected for a pre-revenue biotech, but the lack of any acquisition activity (except minor $248K and $635K in 2026Q1 and 2025Q4) suggests management is not pursuing inorganic growth. The only deployment is operational burn, which is unsustainable given the $71.9M cash balance. This underscores the imminent need for external financing, likely dilutive.
Cumulative Losses Exceed Cash Burn
Over the last ten quarters, cumulative net losses totaled $621.8M while operating cash outflows were $437.1M, a $184.7M gap driven by non-cash charges, indicating reported losses overstate actual cash consumption.
The divergence between net income and operating cash flow is significant, with SBC and D&A accounting for the majority of the gap. This suggests that while the company is burning cash rapidly, the economic reality is slightly less severe than the income statement implies. However, the cumulative cash burn of $437M still far exceeds the current cash balance, highlighting the critical need for additional capital.
What Could Invalidate the Base Case
The reported cash position of $71.9M may understate liquidity if short-term investments or partnership milestones are excluded, but the absence of guidance in the latest earnings report suggests management is deferring commitments amid uncertainty.
The cash flow statement obscures potential non-dilutive funding sources, such as partnership upfronts or R&D tax credits, which could extend the runway beyond the apparent two quarters. However, the lack of updated guidance from the 2026-08-11 earnings report may indicate that management itself is uncertain about near-term financing, warranting close monitoring of any capital raise terms.