Revenue growth has been erratic, with 2026Q2 up 7.5% year-over-year, while gross margin of 55.1% and operating margin of -70.6% reflect persistent unprofitability despite a $6.0M net income aided by non-operating gains.
Schrödinger, Inc. (SDGR) annual income statement — 9-year revenue, gross profit & net income history
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 |
|---|
| Sales/Revenue | 259.04M | 255.87M | 207.54M | 216.67M | 180.96M | 137.93M | 108.09M | 85.54M | 66.64M | 55.69M |
| Revenue Growth % | 8.88% | 23.29% | -4.21% | 19.73% | 31.19% | 27.6% | 26.36% | 28.37% | 19.65% | - |
| Cost of Goods Sold | 111.72M | 113.25M | 75.46M | 75.97M | 79.93M | 72.31M | 44.62M | 36.45M | 23.7M | 15.89M |
| COGS % of Revenue | - | 44.26% | 36.36% | 35.07% | 44.17% | 52.43% | 41.28% | 42.61% | 35.57% | 28.54% |
| Gross Profit | 147.31M | 142.61M | 132.08M | 140.69M | 101.02M | 65.62M | 63.47M | 49.09M | 42.94M | 39.8M |
| Gross Margin % | 56.87% | 55.74% | 63.64% | 64.94% | 55.83% | 47.57% | 58.72% | 57.39% | 64.43% | 71.46% |
| Gross Profit Growth % | - | 7.97% | -6.12% | 39.27% | 53.95% | 3.38% | 29.29% | 14.34% | 7.88% | - |
| Operating Expenses | 300.76M | 309.51M | 341.38M | 318.14M | 247.84M | 177.06M | 124.39M | 87.81M | 70.91M | 58.82M |
| OpEx % of Revenue | - | 120.96% | 164.49% | 146.83% | 136.96% | 128.37% | 115.07% | 102.65% | 106.4% | 105.62% |
| Selling, General & Admin | 131.78M | 136.37M | 139.59M | 136.37M | 121.47M | 86.16M | 59.69M | 48.4M | 36.38M | 31.15M |
| SG&A % of Revenue | - | 53.3% | 67.26% | 62.94% | 67.13% | 62.47% | 55.22% | 56.58% | 54.6% | 55.94% |
| Research & Development | 168.98M | 173.14M | 201.78M | 181.77M | 126.37M | 90.9M | 64.69M | 39.4M | 34.52M | 27.67M |
| R&D % of Revenue | - | 67.67% | 97.23% | 83.89% | 69.84% | 65.91% | 59.85% | 46.06% | 51.81% | 49.68% |
| Other Operating Expenses | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Operating Income | -153.44M | -166.9M | -209.3M | -177.45M | -146.82M | -111.44M | -60.92M | -38.72M | -27.97M | -19.02M |
| Operating Margin % | -59.24% | -65.23% | -100.85% | -81.9% | -81.13% | -80.8% | -56.35% | -45.26% | -41.97% | -34.15% |
| Operating Income Growth % | - | 20.26% | -17.95% | -20.86% | -31.74% | -82.95% | -57.34% | -38.42% | -47.04% | - |
| EBITDA | -98.49M | -160.87M | -203.14M | -171.9M | -142.47M | -108.6M | -57.26M | -35.08M | -25.07M | -17.34M |
| EBITDA Margin % | -38.02% | -62.87% | -97.88% | -79.34% | -78.73% | -78.73% | -52.97% | -41% | -37.63% | -31.13% |
| EBITDA Growth % | 47.19% | 20.81% | -18.17% | -20.65% | -31.2% | -89.66% | -63.24% | -39.88% | -44.64% | - |
| D&A (Non-Cash Add-back) | 6.06M | 6.02M | 6.16M | 5.55M | 4.34M | 2.85M | 3.66M | 3.64M | 2.89M | 1.69M |
| EBIT | -51.93M | -102.33M | -185.71M | 42.92M | -149.12M | -100.81M | -60.92M | -38.72M | -27.97M | -19.02M |
| Net Interest Income | 0 | 0 | 0 | 0 | 3.95M | 1.06M | 2.25M | 1.88M | 433K | 359K |
| Interest Income | 0 | 0 | 0 | 0 | 3.95M | 1.06M | 2.25M | 1.88M | 433K | 359K |
| Interest Expense | 0 | 0 | 0 | 0 | 3K | 0 | 0 | 0 | 0 | 0 |
| Other Income/Expense | 101.51M | 64.57M | 23.59M | 220.37M | -2.31M | 10.63M | 34.62M | 12.74M | -379K | 1.96M |
| Pretax Income | -51.93M | -102.33M | -185.71M | 42.92M | -149.12M | -100.81M | -26.29M | -25.97M | -28.35M | -17.06M |
| Pretax Margin % | -20.05% | -39.99% | -89.48% | 19.81% | -82.41% | -73.09% | -24.32% | -30.36% | -42.54% | -30.63% |
| Income Tax | 2.4M | 939K | 1.41M | 2.2M | 63K | 411K | 345K | -291K | 77K | 332K |
| Effective Tax Rate % | -4.63% | -0.92% | -0.76% | 5.12% | -0.04% | -0.41% | -1.31% | 1.12% | -0.27% | -1.95% |
| Net Income | -54.34M | -103.27M | -187.12M | 40.72M | -149.19M | -100.39M | -24.46M | -24.57M | -28.43M | -17.39M |
| Net Margin % | -20.98% | -40.36% | -90.16% | 18.79% | -82.44% | -72.78% | -22.63% | -28.72% | -42.66% | -31.23% |
| Net Income Growth % | 70.04% | 44.81% | -559.54% | 127.29% | -48.6% | -310.39% | 0.44% | 13.56% | -63.44% | - |
| Net Income (Continuing) | -54.34M | -103.27M | -187.12M | 40.72M | -149.19M | -101.22M | -26.64M | -25.68M | -28.43M | -17.39M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 11K | 14K | 4K | 41K | 0 | 0 |
| EPS (Diluted) | -0.72 | -1.41 | -2.57 | 0.54 | -2.10 | -1.43 | -0.44 | -0.41 | -0.59 | -3.07 |
| EPS Growth % | 70.16% | 45.14% | -575.93% | 125.71% | -46.85% | -225% | -7.32% | 30.51% | 80.78% | - |
| EPS (Basic) | - | -1.41 | -2.57 | 0.57 | -2.10 | -1.43 | -0.44 | -0.41 | -0.59 | -3.07 |
| Diluted Shares Outstanding | 75.77M | 73.44M | 72.67M | 74.99M | 71.17M | 70.59M | 60.02M | 63.27M | 48.47M | 5.67M |
| Basic Shares Outstanding | 74.71M | 73.44M | 72.67M | 71.78M | 71.17M | 70.59M | 60.02M | 63.27M | 48.47M | 5.67M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - |
Quick answers to the most common questions about buying SDGR stock.
For fiscal year 2025, Schrödinger, Inc. (SDGR) reported total revenue of $255.9M. This represents a 359.4% increase compared to $55.7M in 2017.
Schrödinger, Inc. (SDGR) reported a net loss of $103.3M for the fiscal year ending 2025.
Schrödinger, Inc. (SDGR) reported an operating income of $-166.9M, resulting in an operating profit margin of -65.2%. This margin reflects the operational efficiency of the business before interest and taxes.
Schrödinger, Inc. (SDGR) generated $142.6M in gross profit for the year, representing a gross profit margin of 55.7%. This demonstrates the company's core pricing power and production efficiency.
Key Metrics
Top Statement Risk
Persistent operating losses
Metrics are mathematically derived from official filings.
Revenue Volatility Masks Underlying Growth
Revenue growth swung from -43.5% in 2024Q1 to +53.9% in 2025Q3, with 2026Q2 up 7.5% year-over-year, indicating lumpy demand rather than a stable trajectory.
The quarterly revenue pattern shows extreme volatility, with 2024Q4 and 2025Q4 both spiking above $87M, likely reflecting large software or collaboration deals, while intervening quarters hovered in the $35-60M range. This suggests revenue is driven by discrete events rather than recurring subscription growth, making the underlying growth rate difficult to discern. The 2026Q2 growth of 7.5% is modest and may indicate a normalization after the 2025Q3 spike.
Gross Margin Instability Reflects Mix Shifts
Gross margin ranged from 47.8% in 2025Q2 to 72.6% in 2024Q4, with 2026Q2 at 55.1%, indicating significant variability likely tied to product mix between software and services.
The wide swings in gross margin suggest that revenue composition varies substantially quarter to quarter, with higher-margin software sales likely driving the peaks and lower-margin services or collaborations compressing margins in other periods. The 2026Q2 gross margin of 55.1% is below the 2024Q4 peak but above the 2025Q2 trough, implying a mixed environment. Investors should monitor whether the company can stabilize gross margins as it scales, as the current volatility complicates forecasting.
Operating Leverage Absent as Costs Outpace Revenue
Operating income remained deeply negative across all quarters, with operating margin improving from -193.9% in 2024Q3 to -70.6% in 2026Q2, yet still far from breakeven.
Despite revenue growth in some quarters, operating expenses (R&D and SG&A) have remained elevated, with R&D consistently above $40M and SG&A above $30M. The operating loss narrowed in 2026Q2 to -$41.5M from -$52.9M a year earlier, but this was driven by revenue growth rather than cost discipline. The lack of operating leverage is evident as revenue increases have not translated into proportional improvements in operating income, suggesting that the company is still in a heavy investment phase.
Net Income Distorted by Non-Operating Items
Net income swung from -$60.0M in 2026Q1 to +$6.0M in 2026Q2, with EPS of $0.08, despite an operating loss of -$41.5M, indicating significant non-operating gains.
The positive net income in 2026Q2 and 2025Q4, despite substantial operating losses, suggests that investment gains or other non-operating items are masking the underlying operational performance. For instance, 2026Q2 net income of $6.0M on an operating loss of -$41.5M implies a non-operating gain of roughly $47.5M, likely from changes in fair value of equity investments. This volatility in net income makes it an unreliable indicator of core profitability, and investors should focus on operating metrics.
R&D and SG&A Remain Sticky
R&D expenses have stayed above $40M per quarter for the last ten quarters, while SG&A has hovered around $33-36M, indicating a fixed cost base that does not flex with revenue.
The consistency of R&D spending, which ranged from $41.0M to $51.0M, and SG&A, which stayed between $31.2M and $36.2M, suggests that the company is maintaining a high level of investment regardless of revenue fluctuations. This cost stickiness explains the persistent operating losses and implies that significant revenue growth is needed to achieve breakeven. The slight decline in R&D in 2026Q2 to $41.0M may indicate early cost discipline, but it is too soon to call a trend.
Path to Profitability Remains Elusive
Despite revenue growth, operating losses have persisted for ten consecutive quarters, with cumulative operating losses exceeding $400M, raising questions about the sustainability of the business model.
The company has not demonstrated an ability to convert revenue growth into operating income, and the reliance on non-operating gains for positive net income in some quarters is a red flag. With R&D and SG&A costs running at roughly $75M per quarter, the company would need to nearly double revenue from current levels just to break even, assuming no cost increases. The high stock-based compensation, averaging over $10M per quarter, further dilutes shareholders and adds to the cash burn, making the path to profitability uncertain.