Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in SKYE held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | 5AM Venture Management, LLC | 9.7M | $6.0M | 0.0% | 27.549% | 1.65% |
| 2 | Versant Venture Management, LLC | 2.0M | $1.2M | 0.0% | 5.713% | 0.87% |
| 3 | BAKER BROS. ADVISORS LP | 1.6M | $968K | +8.6% | 4.482% | 0.01% |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 764K | $470K | — | 2.175% | 0.00% |
| 5 | SPHERA FUNDS MANAGEMENT LTD. | 679K | $417K | +41.8% | 1.932% | 0.07% |
| 6 | BlackRock, Inc. | 286K | $176K | +1.5% | 0.814% | 0.00% |
| 7 | GEODE CAPITAL MANAGEMENT, LLC | 277K | $170K | +31.9% | 0.789% | 0.00% |
| 8 | MILLENNIUM MANAGEMENT LLC | 258K | $159K | -32.1% | 0.735% | 0.00% |
| 9 | PLATINUM INVESTMENT MANAGEMENT LTD | 233K | $143K | 0.0% | 0.663% | 0.04% |
| 10 | VANGUARD FIDUCIARY TRUST CO | 104K | $64K | — | 0.297% | 0.00% |
| 11 | STATE STREET CORP | 75K | $46K | 0.0% | 0.214% | 0.00% |
| 12 | UBS Group AG | 46K | $28K | +244.4% | 0.130% | 0.00% |
| 13 | XTX Topco Ltd | 41K | $25K | -22.9% | 0.116% | 0.00% |
| 14 | TWO SIGMA INVESTMENTS, LP | 26K | $16K | -50.3% | 0.073% | 0.00% |
| 15 | Engineers Gate Manager LP | 20K | $12K | -12.7% | 0.057% | 0.00% |
| 16 | NORTHERN TRUST CORP | 20K | $12K | 0.0% | 0.057% | 0.00% |
| 17 | BARCLAYS PLC | 18K | $11K | -14.9% | 0.052% | 0.00% |
| 18 | GROUP ONE TRADING, L.P. | 7K | $4K | -59.3% | 0.021% | 0.00% |
| 19 | Vanguard Global Advisers, LLC | 5K | $3K | — | 0.013% | 0.00% |
| 20 | MORGAN STANLEY | 3K | $2K | -40.3% | 0.007% | 0.00% |
| 21 | FEDERATED HERMES, INC. | 1K | $712 | 0.0% | 0.003% | 0.00% |
| 22 | ADVISOR GROUP HOLDINGS, INC. | 600 | $364 | +29900.0% | 0.002% | 0.00% |
| 23 | NATIONAL BANK OF CANADA /FI/ | 400 | $242 | 0.0% | 0.001% | 0.00% |
| 24 | TD Waterhouse Canada Inc. | 79 | $51 | +216.0% | 0.000% | 0.00% |
| 25 | Zurcher Kantonalbank (Zurich Cantonalbank) | 52 | $32 | 0.0% | 0.000% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in SKYE — a direct measure of their conviction.
Filings activity in SKYE during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 38 | 24% | 35.84% | 7.74 pp | $10M | 18% |
| Q4 2025 | 50 | 7.4% | 43.58% | 156.41 pp | $12M | 84% |
| Q3 2025 | 54 | 6.9% | 199.99% | +0.00 pp | $77M | 9.8% |
| Q2 2025 | 58 | 23% | 199.99% | +57.89 pp | $85M | +117% |
| Q1 2025 | 75 | +2.7% | 142.10% | 57.89 pp | $39M | 44% |
| Q4 2024 | 73 | +1.4% | 199.99% | +0.00 pp | $70M | 29% |
| Q3 2024 | 72 | +18% | 199.99% | +0.00 pp | $99M | 49% |
| Q2 2024 | 61 | — | 199.99% | — | $194M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying SKYE stock.
Based on Q1 2026 13F filings, institutional ownership of Skye Bioscience, Inc. stands at 35.8%, held across 38 reporting institutions.
5AM Venture Management, LLC is the largest reported institutional holder of SKYE, with approximately 9,681,763 shares worth $0.01B as of Q1 2026.
Yes — 2 widely-followed marquee investors appear among the top 25 institutional holders of SKYE, including MILLENNIUM MANAGEMENT LLC, TWO SIGMA INVESTMENTS, LP.
Our composite Smart Money Score for SKYE is 33 out of 100 (Bearish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
5 institutions opened new positions in SKYE during Q1 2026, while 17 fully exited. 5 added to existing positions and 23 trimmed.
SKYE institutional ownership fell by 7.74 percentage points quarter-over-quarter, with a net change of -12 holders.
The top 10 institutions account for 98.4% of all reported 13F value in SKYE, and the top 25 account for 100.0%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Skye Bioscience, Inc. (SKYE) Institutional Ownership