Spruce Biosciences, Inc. (SPRB) P/E Ratio History
Insufficient DataInsufficient historical P/E data to classify valuation. · Data 2026–2026
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P/E Ratio Analysis
As of June 29, 2026, Spruce Biosciences, Inc. (SPRB) trades at a price-to-earnings ratio of -1.1x, with a stock price of $55.11 and trailing twelve-month earnings per share of $-27.11.
Compared to the Healthcare sector median P/E of 23.0x, SPRB trades at a 105% discount to its sector peers. The sector includes 231 companies with P/E ratios ranging from 0.0x to 191.4x.
Relative to the broader market, SPRB trades at a notable discount to the S&P 500 median P/E of 25.3x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our SPRB DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
SPRB Cross-Benchmark Valuation
How does the current P/E compare to sector peers and the broader market?
SPRB P/E vs Peers
Commercial Rare Disease Biopharma peers sorted by market cap
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $9B | 106.5 | - | -33% | |
| $2B | 13.1Lowest | - | +8%Best | |
| $32B | 24.4 | 0.60Best | +5% |
Lower P/E can signal a discount or weaker growth expectations; PEG adds growth context.
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
DCA Calculator
See how regular investing compounds over time.
Peer Comparison
Compare growth, multiples, and margins vs sector.
SPRB — Frequently Asked Questions
Quick answers to the most common questions about buying SPRB stock.
What is SPRB's P/E ratio?
Spruce Biosciences, Inc. (SPRB) trailing twelve-month P/E ratio is -1.1x, based on TTM diluted EPS of $-27.11. The 5-year average P/E is N/A and the historical range spans N/A to N/A.
Is SPRB stock overvalued or undervalued?
SPRB current P/E: -1.1x. 5-year average P/E: N/A. Percentile: N/A.
Is SPRB stock expensive?
SPRB is fairly valued relative to its own history. The current P/E of -1.1x is near the 5-year average of N/A (N/A percentile of historical range).
What is SPRB's historical P/E range?
Over the past 5 years, SPRB's P/E ratio has ranged from N/A to N/A, with a median of N/A and an average of N/A. The current P/E of -1.1x places the stock at the N/A percentile of this range. Full historical data spans 2026–2026.
How does SPRB's P/E compare to the S&P 500?
SPRB trades at -1.1x P/E versus the S&P 500 median of 25.3x. The 104% discount to the market suggests lower growth expectations or perceived higher risk.
How does SPRB's valuation compare to Healthcare peers?
Spruce Biosciences, Inc. P/E of -1.1x compares to the Healthcare sector median of 23.0x. The discount suggests lower growth expectations, weaker margins, or higher perceived risk relative to peers. See the peer comparison table on this page for ticker-by-ticker P/E and PEG.
What is SPRB's PEG ratio?
SPRB PEG ratio is N/A, based on a P/E of -1.1x and EPS growth of 47.5%. PEG normalises P/E by growth and helps compare stocks with different earnings trajectories.
What is SPRB's earnings yield?
SPRB earnings yield is N/A, the inverse of its -1.1x P/E ratio. Earnings yield represents the percentage of each dollar invested that the company earns. It can be compared directly to bond yields to assess relative attractiveness of stocks versus fixed income.