The firm's financial position appears increasingly precarious, evidenced by a debt-to-equity ratio that spiked to 8.77 in 2025Q4 alongside a current ratio of 0.76.
| Metric | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 | Dec'01 | Dec'00 | Dec'99 | Dec'98 |
|---|
| Total Current Assets | 8.55M | 7.51M | 7.34M | 24.28M | 48.68M | 70.18M | 1.14M | 6.9M | 1.81M | 5.02M | 9.25M | 2.46M | 126K | 27K | 462K | 184.92K | 166K | 221K | 953K | 873K | 1.25M | 1.94M | 1.48M | 678K | 1.42M | 2.61M | 236K | 753K |
| Cash & Short-Term Investments | 4.01M | 3.72M | 1.18M | 18.12M | 42.19M | 65.82M | 153K | 5.29M | 48K | 4.7M | 8.9M | 2.27M | 76K | 20K | 455K | 70.25K | 30K | 25K | 588K | 508K | 941K | 771K | 996K | 543K | 1.1M | 2.38M | 157K | 563K |
| Cash Only | 4.01M | 3.72M | 1.18M | 18.12M | 42.19M | 65.82M | 153K | 5.29M | 48K | 4.7M | 8.9M | 2.27M | 61K | 4K | 33K | 70.25K | 30K | 25K | 588K | 508K | 941K | 771K | 996K | 7K | 1.1M | 2.18M | 157K | 563K |
| Short-Term Investments | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 15K | 16K | 422K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 536K | 0 | 200K | 0 | 0 |
| Accounts Receivable | 4.26M | 3.69M | 6.05M | 5.86M | 5.27M | 3.78M | 1.29M | 1.29M | 1.55M | 93.59K | 272.29K | 100.01K | 0 | 0 | 0 | 77.73K | 52.53K | 86.8K | 260.15K | 265.52K | 172.39K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Sales Outstanding | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 151.45 | 342.41 | 344.37 | 1.48K | 239.3 | 542.44 | - | - | - | - | - | - | - |
| Inventory | 0 | 0 | 0 | 0 | 0 | -2.28K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 38K | 29K | 7K | 20K | 4K | 1K | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Inventory Outstanding | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.26K | 529.25 | 106.46 | 34.93 | 36.5 | 8.11 | - | - | - | - | - | - |
| Other Current Assets | 0 | 0 | 0 | 0 | 0 | 193K | -294.01K | 313.52K | 215.11K | 226.41K | 74.71K | 93.99K | 50K | 7K | 7K | 36.95K | 45.47K | 80.2K | 97.85K | 79.48K | 137.61K | 1.16M | 484K | 135K | 325K | 230K | 79K | 190K |
| Total Non-Current Assets | 2.94M | 3.78M | 4.85M | 2.19M | 147K | 480K | 664K | 6.99K | 18K | 28K | 0 | 0 | 0 | 69K | 163K | 1.02M | 1.56M | 1.76M | 1.95M | 2.29M | 2.19M | 2.21M | 1.83M | 1.89M | 1.9M | 1.89M | 2.11M | 1.92M |
| Property, Plant & Equipment | 499K | 187K | 293K | 389K | 17K | 359.51K | 334K | 6.99K | 18K | 28K | 0 | 0 | 0 | 0 | 0 | 0 | 158K | 1K | 3K | 26K | 21K | 19K | 4K | 24K | 38K | 73K | 3K | 2K |
| Fixed Asset Turnover | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.35x | 92.00x | 21.33x | 15.58x | 5.52x | 5.21x | - | - | - | - | - | - |
| Goodwill | 0 | 0 | 0 | 0 | 0 | -35.59K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 485.28K | 0 | 965K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 | 130K | 132.59K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 426.25K | 1.56M | 794K | 1.95M | 2.26M | 2.17M | 2.19M | 1.82M | 1.86M | 1.86M | 1.82M | 2.11M | 1.92M |
| Long-Term Investments | 2.44M | 3.59M | 4.55M | 1.81M | 0 | 0 | 149.7K | 0 | 0 | 0 | 0 | 0 | 0 | 53K | -259K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Assets | 0 | 0 | 0 | 0 | 0 | 23.49K | 180.3K | 0 | 0 | 0 | 0 | 0 | 0 | 16K | 389K | 108.46K | -188K | -25K | -588K | -508K | -941K | -771K | -996K | -7K | -1.1M | -2.18M | -157K | -563K |
| Total Assets | 11.49M | 11.28M | 12.18M | 26.48M | 48.83M | 70.66M | 1.81M | 6.91M | 1.83M | 5.05M | 9.25M | 2.46M | 126K | 96K | 625K | 1.02M | 1.73M | 1.98M | 2.9M | 3.16M | 3.44M | 4.14M | 3.31M | 2.56M | 3.33M | 4.5M | 2.35M | 2.67M |
| Asset Turnover | - | - | - | - | - | - | - | - | - | - | - | - | 0.02x | - | -0.13x | 0.18x | 0.03x | 0.05x | 0.02x | 0.13x | 0.03x | 0.02x | - | - | - | - | - | - |
| Asset Growth % | 1.87% | -7.39% | -53.98% | -45.77% | -30.9% | 3807.96% | -73.83% | 277.28% | -63.75% | -45.39% | 276.02% | 1852.38% | 31.25% | -84.64% | -38.73% | -41.04% | -12.67% | -31.74% | -8.16% | -8.22% | -16.92% | 25.23% | 29.06% | -22.89% | -26.11% | 91.49% | -12.05% | - |
| Total Current Liabilities | 11.21M | 7.35M | 6.54M | 6.66M | 7.55M | 7.98M | 5.58M | 6.74M | 3.51M | 1.74M | 746K | 683K | 272K | 136K | 100K | 416K | 417K | 541K | 362K | 632K | 618K | 601K | 282K | 359K | 363K | 493K | 366K | 419K |
| Accounts Payable | 7.17M | 5.58M | 4.14M | 4.96M | 4.41M | 3.37M | 4.05M | 3.84M | 2.77M | 1.21M | 314K | 63.93K | 25K | 124K | 88K | 558.77K | 500.23K | 602.86K | 422.86K | 564.26K | 425.12K | 423.8K | 142K | 178K | 179K | 177K | 349K | 379K |
| Days Payables Outstanding | 11.19K | - | - | - | - | - | 5.92K | 87.59K | 94.67K | 50.36K | - | - | - | - | - | 723.1 | 16.6K | 11K | 6.43K | 985.43 | 3.88K | 3.44K | - | - | - | - | - | - |
| Short-Term Debt | 0 | 0 | 0 | 0 | 1.35M | 2.31M | 878.31K | 309.46K | 234K | 225K | 216K | 206K | 230K | 0 | 0 | 0 | 49K | 52K | 51K | 72K | 77K | 101K | 0 | 69K | 0 | 0 | 0 | 0 |
| Deferred Revenue (Current) | 530K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Current Liabilities | -3K | 12K | 14K | 9K | -1.34M | 590.59K | 644.46K | 161.52K | 5.2K | 0 | 0 | 0 | 17K | 12K | 12K | 54.86K | 56.88K | 70K | -111.86K | -4.26K | 115.88K | 279K | 140K | 112K | 184K | 316K | 17K | 40K |
| Current Ratio | 0.76x | 1.02x | 1.12x | 3.64x | 6.45x | 8.79x | 0.21x | 1.02x | 0.52x | 2.89x | 12.40x | 3.60x | 0.46x | 0.20x | 4.62x | 0.44x | 0.40x | 0.41x | 2.63x | 1.38x | 2.03x | 3.22x | 5.25x | 1.89x | 3.92x | 5.29x | 0.64x | 1.80x |
| Quick Ratio | 0.76x | 1.02x | 1.12x | 3.64x | 6.45x | 8.79x | 0.21x | 1.02x | 0.52x | 2.89x | 12.40x | 3.60x | 0.46x | 0.20x | 4.62x | 0.44x | 0.31x | 0.35x | 2.61x | 1.35x | 2.02x | 3.22x | 5.25x | 1.89x | 3.92x | 5.29x | 0.64x | 1.80x |
| Cash Conversion Cycle | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -15K | -10.13K | -4.84K | -711.21 | -3.3K | - | - | - | - | - | - | - |
| Total Non-Current Liabilities | 234K | 0 | 109K | 243K | 0 | 290K | 411K | 3.94M | 3.01M | 1.44M | 530K | 247K | 255K | 124K | 88K | 341K | 100K | 100K | 100K | 100K | 325K | 322K | 142K | 247K | 179K | 177K | 349K | 379K |
| Long-Term Debt | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Capital Lease Obligations | 234K | 0 | 109K | 243K | 0 | 289.79K | 544.47K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 0 | 0 | 0 | 0 | 0 | 207 | 411K | 3.94M | 3.01M | 1.44M | 530K | 247K | 255K | 124K | 88K | 341K | 100K | 100K | 100K | 100K | 325K | 322K | 142K | 247K | 179K | 177K | 349K | 379K |
| Total Liabilities | 11.44M | 7.35M | 6.65M | 6.91M | 7.55M | 8.27M | 5.99M | 6.39M | 3.51M | 1.74M | 746K | 683K | 272K | 136K | 100K | 416K | 517K | 641K | 462K | 732K | 618K | 601K | 282K | 359K | 363K | 493K | 366K | 419K |
| Total Debt | 456K | 106K | 247K | 365K | 1.35M | 555K | 1.42M | 309.46K | 234K | 225K | 216K | 206K | 230K | 0 | 0 | 0 | 49K | 52K | 51K | 72K | 77K | 101K | 0 | 69K | 0 | 0 | 0 | 0 |
| Net Debt | -3.55M | -3.62M | -936K | -17.76M | -40.83M | -65.27M | 1.27M | -4.99M | 186K | -4.48M | -8.69M | -2.06M | 169K | -4K | -33K | -70.25K | 19K | 27K | -537K | -436K | -864K | -670K | -996K | 62K | -1.1M | -2.18M | -157K | -563K |
| Debt / Equity | 8.77x | 0.03x | 0.04x | 0.02x | 0.03x | 0.01x | - | 0.60x | - | 0.07x | 0.03x | 0.12x | - | - | - | - | 0.04x | 0.04x | 0.02x | 0.03x | 0.03x | 0.03x | - | 0.03x | - | - | - | - |
| Debt / EBITDA | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Net Debt / EBITDA | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Interest Coverage | -1182.44x | -2790.00x | -1723.20x | -2198.70x | -150.46x | -87.43x | -106.48x | -827.27x | -943.91x | -736.98x | -478.58x | -184.29x | - | - | - | -611.09x | -188.50x | -502.33x | -516.20x | -285.75x | -221.30x | -299.40x | -248.00x | -1184.50x | -602.50x | - | - | - |
| Total Equity | 52K | 3.94M | 5.54M | 19.57M | 41.28M | 45.71M | -4.18M | 518.1K | -1.68M | 3.31M | 8.5M | 1.78M | -146K | -40K | 525K | 604K | 1.21M | 1.34M | 2.44M | 2.43M | 2.83M | 3.54M | 3.03M | 2.21M | 2.96M | 4.01M | 1.99M | 2.25M |
| Equity Growth % | -98.68% | -28.9% | -71.71% | -52.59% | -9.69% | 1193.52% | -906.79% | 130.78% | -150.78% | -61.03% | 378.56% | 1317.12% | -265% | -107.62% | -13.08% | -50.21% | -9.48% | -45.08% | 0.49% | -14.05% | -20.27% | 17.05% | 37.28% | -25.56% | -26.08% | 101.86% | -11.93% | - |
| Book Value per Share | 0.00 | 0.07 | 0.11 | 0.39 | 0.84 | 0.94 | -0.06 | 0.01 | -0.03 | 0.06 | 0.18 | 0.31 | -0.01 | -0.04 | 0.80 | 1.72 | 11.71 | 40.96 | 138.10 | 191.35 | 346.50 | 640.34 | 647.07 | 957.86 | 2829.04 | 4892.55 | 2391.57 | 2627.04 |
| Total Shareholders' Equity | 52K | 3.94M | 5.54M | 19.57M | 41.28M | 45.71M | -4.18M | 518.1K | -1.68M | 3.31M | 8.5M | 1.78M | -146K | -40K | 525K | 604K | 1.21M | 1.34M | 2.44M | 2.43M | 2.83M | 3.54M | 3.03M | 2.21M | 2.96M | 4.01M | 1.99M | 2.25M |
| Common Stock | 121K | 111K | 103K | 102K | 102K | 97K | 4.1M | 8.58M | 3.75M | 2.83M | 9.38M | 9.14M | 6.66M | 6.65M | 6.64M | 6.61M | 6.61M | 6.61M | 6.32M | 5.99M | 5.8M | 5.64M | 5.56M | 4.66M | 3.35M | 2.63M | 1.68M | 1.6M |
| Retained Earnings | -44.41M | -144.83M | -133.68M | -116.26M | -108.06M | -84.65M | -43.15M | -50.54M | -29.75M | 11.04M | -12.24M | -3.59M | -21.43M | -21.14M | -20.49M | -21.31M | -20.41M | -19.68M | -18.12M | -15.82M | -13.65M | -11.51M | -10.13M | -8.16M | -5.86M | -3.53M | -826K | -272K |
| Treasury Stock | 0 | 0 | -1.57M | -1.32M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accumulated OCI | 9.68M | 116.99M | 117.06M | 115.57M | 119.15M | -52K | -35K | -38.93K | -19K | -8K | -9.26M | 0 | 0 | 0 | 0 | 0 | 266.9K | -151K | -149K | -125K | -118K | -109K | -74K | -53K | -35K | -25K | -1K | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Imminent liquidity and dilution
As reported in financial statements, Tiziana Life Sciences has seen its total assets decline from $57.9M in 2021Q2 to $11.5M by 2025Q4, reflecting a consistent trajectory of capital consumption that signals a weakening balance sheet as the company exhausts its initial funding to support clinical development.
The steady contraction of the asset base suggests that the company is operating in a high-burn environment without the benefit of revenue-generating assets to replenish its coffers. This trend indicates that the firm's financial viability is increasingly tethered to the success of its clinical milestones and the ability to secure external financing.
Based on recent SEC filings, the company's cash position has dwindled to $4.0M as of 2025Q4, resulting in a current ratio of 0.76, which suggests that the firm may struggle to meet its short-term obligations without immediate access to additional capital or strategic funding.
A current ratio below 1.0 is a significant red flag for a pre-revenue entity, as it implies that current liabilities now exceed the liquid assets available to cover them. Investors should monitor this liquidity gap closely, as it likely necessitates dilutive equity raises to maintain ongoing clinical trial operations.
According to reported figures, equity has collapsed from $48.8M in 2021Q2 to a nominal $52.0K in 2025Q4, a trend that highlights the severe impact of accumulated losses and the potential for significant shareholder dilution as the company attempts to recapitalize its operations.
The near-total depletion of equity suggests that the company's book value provides almost no cushion for shareholders, effectively turning the stock into a pure option on future clinical success. The reliance on external financing to offset these losses indicates that existing shareholders face a high probability of further dilution.
As indicated by the balance sheet data, the debt-to-equity ratio has spiked to 8.77 in 2025Q4, which, while small in absolute dollar terms, suggests that the company's reliance on debt is increasing precisely as its equity base reaches a point of near-total exhaustion.
While the absolute debt level of $456K appears manageable, the extreme D/E ratio is a distortion caused by the erosion of equity rather than a strategic shift toward debt financing. This structure warrants investigation, as it may indicate that the company is utilizing all available levers, including debt, to bridge the gap between clinical milestones.
Quick answers to the most common questions about buying TLSA stock.
As of 2025, Tiziana Life Sciences Ltd (TLSA) had total assets of $11.5M including $8.6M in current assets.
Tiziana Life Sciences Ltd (TLSA) carries total debt of $0.5M, offset by $4.0M in cash and short-term investments. Comparing total debt to cash helps evaluate the company's debt burden and net leverage.
Tiziana Life Sciences Ltd (TLSA) has total shareholders' equity (book value) of $0.1M ($0.00 book value per share). Book value represents the net worth of the company belonging to common stock holders.
Tiziana Life Sciences Ltd (TLSA) reported a current ratio of 0.76x. A current ratio above 1.0x indicates that the company has more current assets than current liabilities, suggesting sufficient short-term liquidity.