Latest Ratios: P/E Ratio -26.0x · EV/EBITDA N/A · ROE -37.2%. (2019–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Market Cap | $3.5B | $1.0B | $338M | $936M | $637M | $679M | $1.0B | — |
| Enterprise Value | $3.4B | $951M | $304M | $909M | $618M | $538M | $980M | — |
| P/E Ratio → | -26.04 | — | — | — | — | — | — | — |
| P/S Ratio | 65.05 | 16.50 | 8.02 | 25.63 | 25.61 | 18.34 | 130.71 | — |
| P/B Ratio | 7.21 | 2.97 | 1.69 | 3.70 | 2.55 | 1.97 | 25.92 | — |
| P/FCF | — | — | — | — | — | — | 14.51 | — |
| P/OCF | — | — | — | — | — | — | 14.28 | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 15.24 | 7.24 | 24.88 | 24.85 | 14.53 | 128.03 | — |
| EV / EBITDA | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — |
| EV / FCF | — | — | — | — | — | — | 14.21 | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Gross Margin | 96.3% | 96.3% | 100.0% | 100.0% | 100.0% | 100.0% | 78.8% | -30.9% |
| Operating Margin | -178.4% | -178.4% | -346.1% | -312.6% | -446.8% | -157.1% | -681.8% | -61.5% |
| Net Profit Margin | -162.9% | -162.9% | -309.7% | -278.5% | -435.1% | -157.2% | -678.8% | -57.2% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| ROE | -37.2% | -37.2% | -57.6% | -40.5% | -36.4% | -30.4% | -223.5% | -178.3% |
| ROA | -28.4% | -28.4% | -36.2% | -24.3% | -23.1% | -16.5% | -39.5% | -25.3% |
| ROIC | -38.5% | -38.5% | -55.7% | -37.5% | -38.4% | -39.4% | -671.6% | — |
| ROCE | -34.0% | -34.0% | -45.9% | -31.0% | -26.4% | -18.6% | -53.2% | -50.7% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.10 | 0.10 | 0.18 | 0.15 | 0.16 | 0.00 | 0.20 | 1.08 |
| Debt / EBITDA | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.23 | -0.17 | -0.11 | -0.08 | -0.41 | -0.53 | -1.82 |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — |
| Debt / FCF | — | — | — | — | — | — | -0.30 | — |
| Interest Coverage | — | — | — | — | — | — | — | — |
Net cash position: cash ($112M) exceeds total debt ($34M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Current Ratio | 16.32 | 16.32 | 6.98 | 7.54 | 6.76 | 12.10 | 4.73 | 1.61 |
| Quick Ratio | 16.32 | 16.32 | 6.98 | 7.54 | 6.76 | 12.10 | 4.73 | 1.61 |
| Cash Ratio | 15.83 | 15.83 | 6.76 | 7.33 | 6.59 | 11.93 | 4.65 | 1.56 |
| Asset Turnover | — | 0.16 | 0.13 | 0.09 | 0.06 | 0.07 | 0.04 | 0.44 |
| Inventory Turnover | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | — | — | — | 29.36 | 19.71 | 95.35 | — |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | — |
| FCF Yield | — | — | — | — | — | — | 6.9% | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — |
| Shares Outstanding | — | $116M | $109M | $95M | $88M | $62M | $87M | $87M |
Includes 30+ ratios · 7 years · Updated daily
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10-year return with dividends reinvested.
Compare growth, multiples, and margins vs sector.
Quick answers to the most common questions about buying TNGX stock.
Tango Therapeutics, Inc.'s current P/E ratio is -26.0x. This places it at the 50th percentile of its historical range.
Tango Therapeutics, Inc.'s return on equity (ROE) is -37.2%. The historical average is -86.3%.
Based on historical data, Tango Therapeutics, Inc. is trading at a P/E of -26.0x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.
Tango Therapeutics, Inc. has 96.3% gross margin and -178.4% operating margin.
Key Metrics
Top Statement Risk
Persistent cash burn
Metrics are mathematically derived from official filings.
Liquidity Bolstered by Equity Infusion
Current ratio surged to 50.82 in 2026Q2 from 16.32 in 2025Q4, per recent SEC filings, reflecting a $700M equity raise that provides substantial short-term cushion despite accelerating burn.
The current ratio of 50.82 in 2026Q2, up from 16.32 in 2025Q4, indicates a fortress-like liquidity position on paper, but this is largely a function of the recent equity infusion rather than operational improvement. With quarterly cash burn widening to -$39.6M, the liquidity runway appears extended, yet the reliance on external funding highlights the pre-commercial stage's vulnerability. Investors should monitor whether the burn rate accelerates further, as the current ratio could deteriorate rapidly if operating losses persist without new capital.
Minimal Debt Masks Operating Leverage
D/E ratio stands at 0.03 in 2026Q2, with total debt of $32.0M, as reported in financial statements, indicating negligible financial leverage but significant operating leverage risk from fixed R&D costs.
The D/E ratio of 0.03 reflects a conservative capital structure with minimal debt, but this masks the high operating leverage inherent in a biotech with substantial fixed R&D expenses and sporadic revenue. Interest coverage is not meaningful given the lack of debt, yet the company's ability to service future debt would be strained by persistent operating losses. The low leverage provides flexibility, but the escalating SG&A and R&D costs suggest that any future borrowing could quickly become burdensome without a revenue inflection.
Asset-Light Model with Minimal Turnover
Asset turnover was 0.24 in 2025Q3 but fell to near zero in subsequent quarters, based on reported figures, reflecting the asset-light model and revenue volatility typical of early-stage biotech.
Asset turnover of 0.24 in 2025Q3, driven by the $53.8M milestone revenue, collapsed to near zero in 2026Q2 as revenue disappeared, illustrating the extreme inefficiency of the asset base when revenue is lumpy. The minimal PPE and zero goodwill underscore an asset-light model, but the lack of consistent revenue means asset turnover is not a meaningful efficiency metric here. The negative working capital drags, averaging -$10.9M per quarter, suggest that cash conversion is heavily influenced by milestone timing rather than operational efficiency.
Milestone-Driven Margins Obscure Core Losses
Gross margin was 100% in most quarters but operating margin swung from 26.2% in 2025Q3 to -12.9% in 2025Q2, per financial statements, highlighting the distortion from non-recurring milestone payments.
The 100% gross margin in quarters with revenue reflects the high-margin nature of milestone payments, but the operating margin of -12.9% in 2025Q2 and -148.7% in 2024Q2 reveals the underlying cost structure is unsustainable without such payments. Net margin of 29.5% in 2025Q3 was a one-time event, as subsequent quarters reverted to losses, indicating that profitability metrics are heavily skewed by non-recurring items. The true earning power is negative, with R&D and SG&A expenses outpacing revenue, and investors should focus on cash burn rather than reported margins.
Returns on Capital Remain Deeply Negative
ROIC was -9.2% in 2026Q2, improving from -22.3% in 2025Q2, as reported in financial statements, but still reflecting significant value destruction in the pre-commercial phase.
ROIC of -9.2% in 2026Q2, while an improvement from -22.3% in 2025Q2, remains deeply negative, indicating that the company is not generating returns on its invested capital. The improvement is largely due to the equity infusion increasing the capital base rather than operational gains, as net losses persist. ROE of -7.8% in 2026Q2 similarly reflects the drag of cumulative losses, and the trend suggests that returns will remain negative until the company achieves commercial viability. The drivers are primarily margin-related, as asset turnover is minimal, and the capital base is growing faster than any potential returns.
Misapplied Metric: P/S Ratio
The P/S ratio of 68.74, based on trailing revenue, is misleading for TNGX because revenue is sporadic and milestone-driven, as seen in the swing from $53.8M to zero in consecutive quarters.
The P/S ratio is commonly used to value biotech companies, but for TNGX it is particularly misleading because revenue is not recurring and is heavily dependent on milestone payments. A P/S of 68.74 based on trailing revenue fails to capture the underlying cash burn and the lack of a sustainable revenue stream. Instead, investors should focus on cash runway, R&D pipeline progress, and the potential for future milestone payments, as the P/S ratio overstates the company's ability to generate consistent sales. The ratio obscures the fact that the company's true value lies in its pipeline and capital position, not its current revenue.