Revenue growth of 183.2% in 2026Q1 is offset by extreme margin instability, evidenced by gross margins that fluctuated from -63.8% in 2025Q2 to 71.3% in 2025Q4.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 |
|---|
| Sales/Revenue | 17.56M | 13.11M | 10.09M | 7.77M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Revenue Growth % | 74.84% | 29.85% | 29.94% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Cost of Goods Sold | 8.32M | 8.56M | 7.76M | 4.74M | 0 | 0 | 27K | 0 | 26.32M | 21.29M | 38.97M | 48.16M | 27.66M | 10.89M | 6.66M | 3.38M | 0 | 17K | 7.11K |
| COGS % of Revenue | - | 65.35% | 76.93% | 61.03% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Gross Profit | 9.24M | 4.54M | 2.33M | 3.03M | 0 | 0 | -27K | 0 | -26.32M | -21.29M | -38.97M | -48.16M | -27.66M | -10.89M | -6.66M | -3.38M | 0 | -17K | -7.11K |
| Gross Margin % | 52.62% | 34.65% | 23.07% | 38.97% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Gross Profit Growth % | - | 95.02% | -23.06% | - | - | 100% | - | 100% | -23.63% | 45.36% | 19.09% | -74.15% | -154% | -63.45% | -97.17% | - | 100% | -139.07% | - |
| Operating Expenses | 160.42M | 130.25M | 139.03M | 121.41M | 112.09M | 92.31M | 50.48M | 28.83M | 26.32M | 21.29M | 38.97M | 48.16M | 27.66M | 10.89M | 6.66M | 3.38M | 17.72K | 13.87K | 14.02K |
| OpEx % of Revenue | - | 993.71% | 1377.35% | 1562.91% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Selling, General & Admin | 63.26M | 85.76M | 40.1M | 34.75M | 30.21M | 23.47M | 14.33M | 10.64M | 8.76M | 7.95M | 10.44M | 12.66M | 9.04M | 6.24M | 4.08M | 2.22M | 13.72K | 13.87K | 14.02K |
| SG&A % of Revenue | - | 654.3% | 397.28% | 447.37% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Research & Development | 55.26M | 44.49M | 40.45M | 86.66M | 81.88M | 68.84M | 36.16M | 18.19M | 17.56M | 13.34M | 28.53M | 35.5M | 18.62M | 4.65M | 2.58M | 1.16M | 0 | 0 | 0 |
| R&D % of Revenue | - | 339.41% | 400.71% | 1115.54% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Operating Expenses | 2M | 0 | 58.48M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.88K | 0 | 4K | 0 | 0 |
| Operating Income | -151.19M | -125.7M | -136.7M | -118.38M | -112.09M | -92.31M | -50.51M | -28.83M | -26.32M | -21.29M | -38.97M | -48.16M | -27.66M | -10.89M | -6.66M | -3.38M | -17.72K | -30.87K | -21.13K |
| Operating Margin % | -861.16% | -959.05% | -1354.28% | -1523.94% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Operating Income Growth % | - | 8.05% | -15.48% | -5.61% | -21.43% | -82.76% | -75.22% | -9.52% | -23.63% | 45.36% | 19.09% | -74.15% | -154% | -63.45% | -97.17% | -18961.88% | 42.58% | -46.05% | - |
| EBITDA | -149.2M | -123.78M | -133.28M | -114.09M | -110.84M | -92.26M | -50.48M | -28.8M | -26.27M | -21.23M | -38.76M | -48M | -27.62M | -10.87M | -6.65M | -3.37M | -17.72K | -30.87K | -21.13K |
| EBITDA Margin % | -849.85% | -944.37% | -1320.39% | -1468.7% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| EBITDA Growth % | -113.93% | 7.13% | -16.82% | -2.93% | -20.13% | -82.75% | -75.28% | -9.65% | -23.75% | 45.24% | 19.25% | -73.79% | -154.07% | -63.55% | -97.29% | -18909.41% | 42.58% | -46.05% | - |
| D&A (Non-Cash Add-back) | 1.99M | 1.93M | 3.42M | 4.29M | 1.25M | 50K | 27K | 26K | 54K | 64K | 206K | 161K | 36K | 17K | 14.33K | 9.3K | 0 | 0 | 0 |
| EBIT | -150.13M | -125.7M | -77.74M | -118.38M | -112.09M | -92.31M | -50.46M | -28.83M | -26.32M | -21.29M | -38.97M | -48.16M | -27.66M | -10.88M | -7.84M | -3.38M | -1.93M | -30.87K | -21.13K |
| Net Interest Income | 4.86M | 4.06M | 0 | 0 | 1.87M | 25K | 48K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interest Income | 4.86M | 4.15M | 0 | 0 | 1.87M | 25K | 48K | 0 | 233K | 168K | 127K | 108K | 40K | 4K | 0 | 0 | 0 | 0 | 0 |
| Interest Expense | 0 | 89K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4K | 1.61M | 0 | 0 | 0 | 0 |
| Other Income/Expense | 3.8M | 1.68M | 6.67M | 1.72M | 1.87M | 25K | 48K | 210K | 233K | 168K | 127K | 108K | 40K | 4K | -2.79M | -91.58K | -1.94M | 0 | 0 |
| Pretax Income | -147.39M | -124.02M | -130.04M | -116.66M | -110.22M | -92.29M | -50.46M | -28.62M | -26.09M | -21.12M | -38.84M | -48.05M | -27.62M | -10.88M | -9.45M | -3.47M | 0 | 0 | 0 |
| Pretax Margin % | -839.52% | -946.22% | -1288.25% | -1501.78% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Income Tax | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 233K | -70K | -206K | -161K | -36K | -17K | 1.61M | 0 | 17.72K | 30.87K | 21.13K |
| Effective Tax Rate % | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | -0.89% | 0.33% | 0.53% | 0.34% | 0.13% | 0.16% | -17.09% | 0% | - | - | - |
| Net Income | -147.39M | -124.02M | -130.04M | -116.66M | -110.22M | -92.29M | -50.46M | -28.62M | -29.36M | -21.12M | -38.84M | -48.05M | -27.62M | -10.88M | -9.45K | -3.47M | -17.72K | -30.87K | -21.13K |
| Net Margin % | -839.52% | -946.22% | -1288.25% | -1501.78% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Net Income Growth % | -11.72% | 4.63% | -11.47% | -5.84% | -19.43% | -82.88% | -76.33% | 2.51% | -38.97% | 45.62% | 19.17% | -74.01% | -153.73% | -115074.6% | 99.73% | -19478.61% | 42.58% | -46.05% | - |
| Net Income (Continuing) | -147.39M | -124.02M | -130.04M | -116.66M | -110.22M | -92.29M | -50.46M | -28.62M | -26.09M | -21.12M | -38.84M | -48.05M | -27.62M | -10.88M | -9.45K | -3.47M | -1.96M | -30.87K | -21.13K |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -10.75 | -14.57 | -176.60 | -6368.84 | -811.68 | -163968.00 | -5056.00 | -3866.00 | -18064.62 | -54023.02 | -199189.74 | -511212.77 | -511407.41 | -375310.34 | -945000.00 | -578352.17 | -999999.00 | -30867.00 | -21134.00 |
| EPS Growth % | 99.24% | 91.75% | 97.23% | -684.65% | 99.5% | -3143.04% | -30.78% | 78.6% | 66.56% | 72.88% | 61.04% | 0.04% | -36.26% | 60.28% | -63.4% | 70.56% | -6264.3% | -46.05% | - |
| EPS (Basic) | - | -14.57 | -176.60 | -6368.84 | -811.68 | -163968.00 | -5056.00 | -3866.00 | -18064.62 | -54023.02 | -199189.74 | -511212.77 | -511407.41 | -375310.34 | -945000.00 | -578352.17 | -999999.00 | -30867.00 | -21134.00 |
| Diluted Shares Outstanding | 13.71M | 8.51M | 2.26M | 1.83M | 3.07M | 563 | 2.56M | 804.2K | 162.5K | 39.1K | 19.5K | 9.4K | 5.4K | 2.9K | 1K | 600 | 100 | 100 | 100 |
| Basic Shares Outstanding | 13.71M | 8.51M | 2.26M | 1.83M | 3.07M | 563 | 2.56M | 804.2K | 162.5K | 39.1K | 19.5K | 9.4K | 5.4K | 2.9K | 1K | 600 | 100 | 100 | 100 |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Clinical trial failure risk
According to recent quarterly filings, Tonix reported a significant revenue acceleration to $6.9 million in 2026Q1, representing a 183.2% year-over-year increase, though this growth appears driven by volatile commercial product sales rather than a sustainable, high-margin expansion of the company's core clinical-stage pipeline assets.
The sharp uptick in top-line performance suggests a potential shift in commercial execution, yet the lack of consistent organic growth in previous periods warrants caution. Investors should monitor whether this revenue trajectory can be maintained without further dilutive financing, as the current scale remains insufficient to offset the company's massive R&D expenditure.
As reported in financial statements, Tonix's gross margin has exhibited extreme instability, fluctuating from a negative 63.8% in 2025Q2 to a peak of 71.3% in 2025Q4, highlighting the company's lack of pricing power and reliance on low-margin, acquired migraine assets that struggle to achieve consistent profitability.
The erratic nature of these margins suggests that the company's manufacturing and royalty obligations are not yet optimized for scale. This structural weakness implies that until the lead CNS pipeline assets reach commercialization, gross profitability will likely remain highly sensitive to product mix and third-party manufacturing cost fluctuations.
Based on the provided income statement data, Tonix continues to demonstrate a lack of operating leverage, with operating losses reaching $41.5 million in 2026Q1 as SG&A and R&D expenses consistently outpace the company's ability to generate meaningful gross profit from its current commercial portfolio.
The persistent gap between operating expenses and revenue indicates that the company is in a deep investment phase, prioritizing pipeline development over immediate operational efficiency. This trend suggests that the firm remains entirely dependent on external capital to fund its ongoing clinical operations, leaving little room for error in its R&D milestones.
Analysis of the company's cost structure reveals that R&D remains the primary driver of expenditure, with quarterly outlays frequently exceeding $15 million, which underscores the high-stakes nature of Tonix's diversified pipeline strategy and the significant capital required to maintain its various clinical-stage programs.
The company's expense discipline appears secondary to the necessity of funding multiple concurrent clinical trials, which may indicate a lack of strategic focus. Investors should consider that this high fixed-cost base creates a precarious financial position, where any delay in clinical progress could rapidly accelerate the depletion of existing cash reserves.
While recent clinical data for TNX-102 SL provides a potential path forward, the historical trend of massive share count expansion and persistent net losses suggests that the company's equity value may remain under pressure from ongoing dilution required to sustain its broad, capital-intensive R&D portfolio.
Short-term observers might focus on the disconnect between the company's clinical milestones and its deteriorating per-share metrics. The reliance on equity markets to bridge the gap between operating cash burn and revenue generation warrants further investigation into the long-term viability of the current capital allocation strategy.
Quick answers to the most common questions about buying TNXP stock.
For fiscal year 2025, Tonix Pharmaceuticals Holding Corp. (TNXP) reported total revenue of $13.1M.
Tonix Pharmaceuticals Holding Corp. (TNXP) reported a net loss of $124.0M for the fiscal year ending 2025.
Tonix Pharmaceuticals Holding Corp. (TNXP) reported an operating income of $-125.7M, resulting in an operating profit margin of -959.1%. This margin reflects the operational efficiency of the business before interest and taxes.
Tonix Pharmaceuticals Holding Corp. (TNXP) generated $4.5M in gross profit for the year, representing a gross profit margin of 34.7%. This demonstrates the company's core pricing power and production efficiency.