Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in TSHA held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 23.6M | $105.3M | 0.0% | 8.198% | 1.12% |
| 2 | GOLDMAN SACHS GROUP INC | 22.4M | $100.0M | +63.4% | 7.785% | 0.01% |
| 3 | Avoro Capital Advisors LLC | 21.7M | $97.0M | 0.0% | 7.552% | 0.99% |
| 4 | BlackRock, Inc. | 18.4M | $82.1M | -1.5% | 6.392% | 0.00% |
| 5 | Vestal Point Capital, LP | 18.0M | $80.5M | +30.9% | 6.264% | 2.25% |
| 6 | MORGAN STANLEY | 18.0M | $80.3M | -0.6% | 6.252% | 0.00% |
| 7 | FMR LLC | 14.3M | $64.0M | +5.9% | 4.984% | 0.00% |
| 8 | RTW INVESTMENTS, LP | 13.7M | $61.2M | -16.6% | 4.761% | 0.61% |
| 9 | STATE STREET CORP | 11.2M | $50.1M | +3.9% | 3.901% | 0.00% |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 10.2M | $45.7M | β | 3.561% | 0.00% |
| 11 | Octagon Capital Advisors LP | 8.9M | $39.6M | 0.0% | 3.083% | 4.38% |
| 12 | Siren, L.L.C. | 8.8M | $39.5M | -12.8% | 3.073% | 1.09% |
| 13 | Polar Capital Holdings Plc | 5.7M | $25.3M | -28.7% | 1.968% | 0.09% |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 5.5M | $24.7M | +2.7% | 1.925% | 0.00% |
| 15 | GordonMD Global Investments LP | 738K | $22.2M | -44.6% | 0.257% | 15.47% |
| 16 | D. E. Shaw & Co., Inc. | 4.4M | $19.8M | +10.3% | 1.541% | 0.02% |
| 17 | EverSource Wealth Advisors, LLC | 128K | $18.7M | +140287.9% | 0.044% | 0.57% |
| 18 | BAKER BROS. ADVISORS LP | 4.0M | $17.9M | 0.0% | 1.394% | 0.10% |
| 19 | MILLENNIUM MANAGEMENT LLC | 3.3M | $14.7M | +3.2% | 1.142% | 0.01% |
| 20 | Casdin Capital, LLC | 3.3M | $14.5M | +116.7% | 1.131% | 1.10% |
| 21 | ADAR1 Capital Management, LLC | 3.0M | $13.3M | +19.4% | 1.037% | 0.83% |
| 22 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 2.9M | $12.9M | -22.5% | 1.003% | 0.02% |
| 23 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 2.7M | $12.2M | 0.0% | 0.947% | 0.14% |
| 24 | BARCLAYS PLC | 2.8M | $11.4M | -49.2% | 0.979% | 0.00% |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | 2.0M | $9.0M | β | 0.704% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in TSHA β a direct measure of their conviction.
Filings activity in TSHA during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new TSHA position in Q1 2026
Institutions that fully closed their TSHA position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 188 | 1.6% | 73.59% | 16.20 pp | $1.21B | 18% |
| Q4 2025 | 191 | +28% | 89.79% | +37.06 pp | $1.47B | +70% |
| Q3 2025 | 149 | +0.7% | 52.73% | +16.62 pp | $865M | +46% |
| Q2 2025 | 148 | +18% | 36.11% | +21.90 pp | $592M | +154% |
| Q1 2025 | 125 | 1.6% | 14.21% | 3.27 pp | $233M | 19% |
| Q4 2024 | 127 | +7.6% | 17.48% | 1.48 pp | $287M | 7.8% |
| Q3 2024 | 118 | +12% | 18.96% | 2.40 pp | $311M | 11% |
| Q2 2024 | 105 | β | 21.36% | β | $351M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying TSHA stock.
Based on Q1 2026 13F filings, institutional ownership of Taysha Gene Therapies, Inc. stands at 73.6%, held across 188 reporting institutions.
RA CAPITAL MANAGEMENT, L.P. is the largest reported institutional holder of TSHA, with approximately 23,555,648 shares worth $0.11B as of Q1 2026.
Yes β 1 widely-followed marquee investor appear among the top 25 institutional holders of TSHA, including MILLENNIUM MANAGEMENT LLC.
Our composite Smart Money Score for TSHA is 34 out of 100 (Bearish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
37 institutions opened new positions in TSHA during Q1 2026, while 40 fully exited. 37 added to existing positions and 113 trimmed.
TSHA institutional ownership fell by 16.20 percentage points quarter-over-quarter, with a net change of -3 holders.
The top 10 institutions account for 63.5% of all reported 13F value in TSHA, and the top 25 account for 87.9%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Taysha Gene Therapies, Inc. (TSHA) Institutional Ownership