Xencor, Inc. (XNCR) P/E Ratio History
Deep ValueTrading at -10.2x · 0th percentile of 5-year range · Significant discount to historical valuation · Data 2016–2022
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P/E Ratio Analysis
As of June 22, 2026, Xencor, Inc. (XNCR) trades at a price-to-earnings ratio of -10.2x, with a stock price of $12.64 and trailing twelve-month earnings per share of $-2.29.
The current P/E is 119% below its 5-year average of 54.0x. Over the past five years, XNCR's P/E has ranged from a low of 15.0x to a high of 114.0x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 22.1x, XNCR trades at a 146% discount to its sector peers. The sector includes 234 companies with P/E ratios ranging from 0.0x to 197.0x.
Relative to the broader market, XNCR trades at a notable discount to the S&P 500 median P/E of 24.4x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our XNCR DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
XNCR Cross-Benchmark Valuation
How does the current P/E compare to sector peers and the broader market?
XNCR P/E vs Peers
Drug Discovery and Antibody Platforms peers sorted by market cap
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $7B | 31.5 | - | -34% | |
| $383B | 91.4 | - | -1% | |
| $63B | 14.7Lowest | 2.32Best | +8% | |
| $37B | 119.4 | - | +207% | |
| $20B | 15.3 | - | +4173%Best |
Lower P/E can signal a discount or weaker growth expectations; PEG adds growth context.
XNCR Historical P/E Data (2016–2022)
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Period End | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2022 Q3 | Sep 30 2022 | $25.98 | $0.38 | 68.4x | +27% |
| FY2022 Q2 | - | $27.37 | $0.24 | 114.0x | +111% |
| FY2022 Q1 | - | $26.68 | $1.78 | 15.0x | -72% |
| FY2021 Q4 | Dec 31 2021 | $40.12 | $1.35 | 29.8x | -45% |
| FY2021 Q2 | Jun 30 2021 | $34.49 | $0.37 | 94.0x | +74% |
| FY2019 Q4 | - | $34.39 | $0.45 | 76.4x | +41% |
| FY2019 Q3 | Sep 30 2019 | $33.73 | $0.60 | 56.2x | +4% |
| FY2019 Q2 | Jun 30 2019 | $40.93 | $0.83 | 49.3x | -9% |
| FY2019 Q1 | Mar 31 2019 | $31.06 | $0.65 | 47.8x | -12% |
| FY2017 Q1 | Mar 31 2017 | $23.92 | $0.41 | 58.3x | +8% |
| FY2016 Q4 | Dec 31 2016 | $26.32 | $0.56 | 47.0x | -13% |
| FY2016 Q3 | Sep 30 2016 | $24.49 | $0.96 | 25.5x | -53% |
| FY2016 Q2 | - | $18.99 | $0.91 | 20.9x | -61% |
Average P/E for displayed period: 54.0x
Intrinsic Valuation
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Historical Returns
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Peer Comparison
Compare growth, multiples, and margins vs sector.
XNCR — Frequently Asked Questions
Quick answers to the most common questions about buying XNCR stock.
What is XNCR's P/E ratio?
Xencor, Inc. (XNCR) trailing twelve-month P/E ratio is -10.2x, based on TTM diluted EPS of $-2.29. The 5-year average P/E is 54.0x and the historical range spans 15.0x to 114.0x.
Is XNCR stock overvalued or undervalued?
XNCR trades at -10.2x P/E, below its 5-year average of 54.0x. At the 0th percentile of its historical range (15.0x–114.0x), the stock is priced at a discount to its own history.
Is XNCR stock expensive?
No, XNCR is not expensive on a historical basis. The current P/E of -10.2x is below the 5-year average of 54.0x and sits at the 0th percentile of its valuation range.
What is XNCR's historical P/E range?
Over the past 5 years, XNCR's P/E ratio has ranged from 15.0x to 114.0x, with a median of 49.3x and an average of 54.0x. The current P/E of -10.2x places the stock at the 0th percentile of this range. Full historical data spans 2016–2022.
How does XNCR's P/E compare to the S&P 500?
XNCR trades at -10.2x P/E versus the S&P 500 median of 24.4x. The 142% discount to the market suggests lower growth expectations or perceived higher risk.
How does XNCR's valuation compare to Healthcare peers?
Xencor, Inc. P/E of -10.2x compares to the Healthcare sector median of 22.1x. The discount suggests lower growth expectations, weaker margins, or higher perceived risk relative to peers. See the peer comparison table on this page for ticker-by-ticker P/E and PEG.
What is XNCR's PEG ratio?
XNCR PEG ratio is N/A, based on a P/E of -10.2x and EPS growth of 65.4%. PEG normalises P/E by growth and helps compare stocks with different earnings trajectories.
What is XNCR's earnings yield?
XNCR earnings yield is N/A, the inverse of its -10.2x P/E ratio. Earnings yield represents the percentage of each dollar invested that the company earns. It can be compared directly to bond yields to assess relative attractiveness of stocks versus fixed income.