Alnylam Pharmaceuticals, Inc. (ALNY) P/E Ratio History
UndervaluedTrading at 105.8x vs 5Y avg 551.3x · 50th percentile · Below historical baseline · Data 2025–2026
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P/E Ratio Analysis
As of September 24, 2026, Alnylam Pharmaceuticals, Inc. (ALNY) trades at a price-to-earnings ratio of 105.8x, with a stock price of $246.51 and trailing twelve-month earnings per share of $5.84.
The current P/E is 81% below its 5-year average of 551.3x. Over the past five years, ALNY's P/E has ranged from a low of 50.8x to a high of 1900.0x, placing the current valuation at the 50th percentile of its historical range.
Compared to the Healthcare sector median P/E of 23.7x, ALNY trades at a 346% premium to its sector peers. The sector includes 225 companies with P/E ratios ranging from 0.0x to 167.0x.
Relative to the broader market, ALNY commands a significant premium over the S&P 500 median P/E of 25.3x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our ALNY DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
ALNY Cross-Benchmark Valuation
How does the current P/E compare to sector peers and the broader market?
ALNY P/E vs Peers
RNA and Genome Editing Developers peers sorted by market cap
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $83B | 19.3Lowest | 3.05Best | +8%Best | |
| $34B | 25.8 | - | -21% | |
| $12B | 34.6 | - | -19% |
Lower P/E can signal a discount or weaker growth expectations; PEG adds growth context.
ALNY Historical P/E Data (2025–2026)
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Period End | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2026 Q2 | - | $301.03 | $5.92 | 50.8x | -91% |
| FY2026 Q1 | - | $330.87 | $4.21 | 78.6x | -86% |
| FY2025 Q4 | Dec 31 2025 | $397.65 | $2.26 | 176.0x | -68% |
| FY2025 Q3 | - | $456.00 | $0.24 | 1900.0x | +245% |
Average P/E for displayed period: 551.3x
ALNY Chart Terminal
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Intrinsic Valuation
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Historical Returns
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Peer Comparison
Compare growth, multiples, and margins vs sector.
ALNY — Frequently Asked Questions
Quick answers to the most common questions about buying ALNY stock.
What is ALNY's P/E ratio?
Alnylam Pharmaceuticals, Inc. (ALNY) trailing twelve-month P/E ratio is 105.8x, based on TTM diluted EPS of $5.84. The 5-year average P/E is 551.3x and the historical range spans 50.8x to 1900.0x.
Is ALNY stock overvalued or undervalued?
ALNY trades at 105.8x P/E, below its 5-year average of 551.3x. At the 50th percentile of its historical range (50.8x–1900.0x), the stock is priced at a discount to its own history.
Is ALNY stock expensive?
No, ALNY is not expensive on a historical basis. The current P/E of 105.8x is below the 5-year average of 551.3x and sits at the 50th percentile of its valuation range.
What is ALNY's historical P/E range?
Over the past 5 years, ALNY's P/E ratio has ranged from 50.8x to 1900.0x, with a median of 176.0x and an average of 551.3x. The current P/E of 105.8x places the stock at the 50th percentile of this range. Full historical data spans 2025–2026.
How does ALNY's P/E compare to the S&P 500?
ALNY trades at 105.8x P/E versus the S&P 500 median of 25.3x. The 318% premium to the market typically reflects higher expected earnings growth or quality.
How does ALNY's valuation compare to Healthcare peers?
Alnylam Pharmaceuticals, Inc. P/E of 105.8x compares to the Healthcare sector median of 23.7x. The premium reflects expected growth above peers or stronger fundamentals. See the peer comparison table on this page for ticker-by-ticker P/E and PEG.
What is ALNY's PEG ratio?
ALNY PEG ratio is N/A, based on a P/E of 105.8x and EPS growth of 206.9%. PEG normalises P/E by growth and helps compare stocks with different earnings trajectories.
What is ALNY's earnings yield?
ALNY earnings yield is 0.95%, the inverse of its 105.8x P/E ratio. Earnings yield represents the percentage of each dollar invested that the company earns. It can be compared directly to bond yields to assess relative attractiveness of stocks versus fixed income.