Alnylam Pharmaceuticals, Inc. (ALNY) P/E Ratio History
Historical price-to-earnings valuation from 2025 to 2025
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Valuation Context
How does the current P/E compare to historical and market benchmarks?
P/E Ratio Analysis
As of February 28, 2026, Alnylam Pharmaceuticals, Inc. (ALNY) trades at a price-to-earnings ratio of 142.9x, with a stock price of $332.92 and trailing twelve-month earnings per share of $2.30.
The current P/E is 86% below its 5-year average of 1038.0x. Over the past five years, ALNY's P/E has ranged from a low of 176.0x to a high of 1900.0x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 23.7x, ALNY trades at a 503% premium to its sector peers. The sector includes 224 companies with P/E ratios ranging from 0.0x to 184.4x.
Relative to the broader market, ALNY commands a significant premium over the S&P 500 median P/E of 26.2x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our ALNY DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
Peer Comparison
P/E metrics vs. RNA and Genome Editing Developers peers
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
ALNYAlnylam Pharmaceuticals, Inc. | $44B | 142.9 | -Best | +207% |
SLXNWSilexion Therapeutics Ltd. | $64M | 0.0Lowest | -Best | +6436%Best |
DTILPrecision BioSciences, Inc. | $51M | 4.0 | -Best | +107% |
Peers sorted by market capitalization. P/E below peers may indicate undervaluation or lower growth expectations. Consider PEG ratio for growth-adjusted comparison.
Historical P/E Data
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Date | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2025 Q4 | Wed Dec 31 2025 00:00:00 GM | $397.65 | $2.26 | 176.0x | -83% |
| FY2025 Q3 | $456.00 | $0.24 | 1900.0x | +83% |
Average P/E for displayed period: 1038.0x
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Start ComparisonFrequently Asked Questions
Is ALNY stock overvalued or undervalued?
ALNY trades at 142.9x P/E, below its 5-year average of 1038.0x. At the N/A percentile of historical range, the stock is priced at a discount to its own history.
How does ALNY's valuation compare to peers?
Alnylam Pharmaceuticals, Inc. P/E of 142.9x compares to sector median of 23.7x. The premium reflects expected growth above peers.
What is ALNY's PEG ratio?
ALNY PEG ratio is N/A. Above 2.0 indicates premium valuation relative to growth rate. Historical P/E data spans 2025-2025.