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ZNTLZentalis Pharmaceuticals, Inc.$3.52$251M
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ZNTL logoZentalis Pharmaceuticals, Inc.(ZNTL)Earnings, Financials & Key Ratios

ZNTL•NASDAQ
Price updated Jun 11, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutZentalis Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics for the treatment of various cancers. Its lead product candidate includes the ZN-c3, an inhibitor of WEE1, a protein tyrosine kinase, which is in Phase 2 clinical trial for the treatment of advanced solid tumors; Phase 1/2 clinical trial for the treatment of advanced solid tumors as a monotherapy and in an ongoing Phase 1b clinical trial in combination with chemotherapy in patients with platinum resistant ovarian cancer; and Phase 2 monotherapy trial for a tumor agnostic, predictive biomarker. The company's other lead product candidate includes ZN-c5, an oral selective estrogen receptor degrader that is in a Phase 1/2 clinical trial for the treatment of advanced estrogen receptor-positive, human epidermal growth factor receptor 2-negative, or advanced or metastatic breast cancer. In addition, it is involved in developing ZN-d5, a selective inhibitor of B-cell lymphoma 2 that is in a Phase 1 clinical trial for the treatment of non-Hodgkin's lymphoma and acute myelogenous leukemia; and ZN-e4, an irreversible inhibitor of mutant epidermal growth factor receptor, which is in Phase 1/2 clinical trial for the treatment of advanced non-small cell lung cancer. Further, the company is developing BCL-xL heterobifunctional degraders based on E3 ligases not expressed in platelets, allowing for the avoidance of dose-limiting thrombocytopenia associated with BCL-xL inhibitors. Zentalis Pharmaceuticals, Inc. has licensing agreements and strategic collaborations with Recurium IP Holdings, LLC; Mayo Foundation for Medical Education and Research; SciClone Pharmaceuticals International (Cayman) Development Ltd.; Pfizer, Inc.; Eli Lilly and Company; GlaxoSmithKline, and Zentera Therapeutics (Cayman), Ltd. The company was incorporated in 2014 and is based in New York, New York.Show more
  • Revenue$0-100.0%
  • EBITDA-$152M+19.9%
  • Net Income-$137M+17.4%
  • EPS (Diluted)-1.91+18.0%
  • ROE-49.53%-15.7%
  • ROIC-40.52%-13.2%
  • Debt/Equity0.18+44.7%

ZNTL Key Insights

Zentalis Pharmaceuticals, Inc. (ZNTL) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Momentum leader: RS Rating 95 (top 5%)
  • ✓Trading at only 1.2x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 1/9
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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ZNTL Price & Volume

Zentalis Pharmaceuticals, Inc. (ZNTL) stock price & volume — 10-year historical chart

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ZNTL Growth Metrics

Zentalis Pharmaceuticals, Inc. (ZNTL) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-100%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM44.63%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM44.9%

Return on Capital

10 Years-58.96%
5 Years-51.75%
3 Years-51%
Last Year-48.51%

ZNTL Recent Earnings

Zentalis Pharmaceuticals, Inc. (ZNTL) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 1/12 qtrs (100%)
Q2 2026Latest
May 12, 2026
EPS
$0.50
Est $0.49
-2.0%
Revenue
—
Q2 2026
Mar 26, 2026
EPS
$0.49
Est $0.41
-19.5%
Revenue
—
Q4 2025
Nov 10, 2025
EPS
$0.37
Est $0.49
+24.5%
Revenue
—
Q3 2025
Aug 6, 2025
EPS
$0.37
Est $0.56
+33.9%
Revenue
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 12, 2026
$0.50vs $0.49-2.0%
—
Q2 2026Mar 26, 2026
$0.49vs $0.41-19.5%
—
Q4 2025Nov 10, 2025
$0.37vs $0.49+24.5%
—
Q3 2025Aug 6, 2025
$0.37vs $0.56+33.9%
—
Based on last 12 quarters of dataView full earnings history →

ZNTL Peer Comparison

Zentalis Pharmaceuticals, Inc. (ZNTL) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RVMD logoRVMDRevolution Medicines, Inc.Direct Competitor31.73B149.23-25.08-83.22%0.10
KYMR logoKYMRKymera Therapeutics, Inc.Direct Competitor6.77B82.96-22.48-16.72%-6.12%-25.02%0.05
AUPH logoAUPHAurinia Pharmaceuticals Inc.Direct Competitor2.04B15.857.6620.38%99.97%64.48%0.13
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor7.16B247.98-18.40-100%-43.02%0.00
TGTX logoTGTXTG Therapeutics, Inc.Direct Competitor7.36B48.0517.3587.32%65.95%87.36%0.40
IMVT logoIMVTImmunovant, Inc.Direct Competitor6.75B32.88-11.87-68.16%0.00
ARVN logoARVNArvinas, Inc.Product Competitor457.46M7.09-5.54-0.3%-247.54%-44.39%0.02
PTGX logoPTGXProtagonist Therapeutics, Inc.Product Competitor7.06B109.79-53.56-89.41%-6.48%-17.76%0.02

Compare ZNTL vs Peers

Zentalis Pharmaceuticals, Inc. (ZNTL) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RVMD

Most directly comparable listed peer for ZNTL.

Scale Benchmark

vs IQV

Larger-name benchmark to compare ZNTL against a more recognizable public peer.

Peer Set

Compare Top 5

vs RVMD, KYMR, AUPH, PRAX

ZNTL Income Statement

Zentalis Pharmaceuticals, Inc. (ZNTL) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
14K0000067.42M00
Revenue Growth %
--100%------100%-100%
Cost of Goods Sold
00000000151K
COGS % of Revenue
---------
Gross Profit
14K▲ 0%
0▼ 100.0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
67.42M▲ 0%
0▼ 100.0%
-151K▲ 0%
Gross Margin %
100%-----100%--
Gross Profit Growth %
--100%------100%-
Operating Expenses
23.8M46.84M118.79M216.54M227.29M299.51M258.62M152.81M144.89M
OpEx % of Revenue
169978.57%-----383.57%--
Selling, General & Admin
4.88M8.46M33.89M40.94M54.55M59.4M87.11M37.72M34.97M
SG&A % of Revenue
34828.57%-----129.2%--
Research & Development
18.92M38.39M84.9M175.6M172.73M235.16M167.77M107.3M108.76M
R&D % of Revenue
135150%-----248.82%--
Other Operating Expenses
000004.95M3.74M7.8M1000K
Operating Income
-23.78M▲ 0%
-46.84M▼ 97.0%
-118.79M▼ 153.6%
-216.54M▼ 82.3%
-227.29M▼ 5.0%
-299.51M▼ 31.8%
-191.19M▲ 36.2%
-152.81M▲ 20.1%
-145.04M▲ 0%
Operating Margin %
-169878.57%------283.57%--
Operating Income Growth %
--96.97%-153.57%-82.29%-4.96%-31.78%36.16%20.08%-
EBITDA
-23.73M-46.73M-118.63M-216M-225.86M-298.12M-189.91M-152.07M-144.41M
EBITDA Margin %
-169510.78%------281.65%--
EBITDA Growth %
--96.93%-153.83%-82.08%-4.57%-31.99%36.3%19.92%31.5%
D&A (Non-Cash Add-back)
51.49K111K160K544K1.43M1.39M1.29M739K628K
EBIT
-23.78M-46.84M-118.79M-207.74M-227.29M-248.99M-187.46M-145.01M-136.84M
Net Interest Income
355K498K00-2.57M0000
Interest Income
355K498K002.26K0000
Interest Expense
00002.58M0000
Other Income/Expense
355K482K683K50.15M-10.29M6.6M25.5M16.19M21.47M
Pretax Income
-23.43M▲ 0%
-46.36M▼ 97.9%
-118.1M▼ 154.7%
-166.39M▼ 40.9%
-237.58M▼ 42.8%
-292.91M▼ 23.3%
-165.69M▲ 43.4%
-136.62M▲ 17.5%
-123.57M▲ 0%
Pretax Margin %
-167342.86%------245.74%--
Income Tax
4K15K444K-297K-469K-601K177K442K562K
Effective Tax Rate %
-0.02%-0.03%-0.38%0.18%0.2%0.21%-0.11%-0.32%-0.45%
Net Income
-21.07M▲ 0%
-45.66M▼ 116.8%
-117.84M▼ 158.1%
-158.72M▼ 34.7%
-236.81M▼ 49.2%
-292.19M▼ 23.4%
-165.84M▲ 43.2%
-137.06M▲ 17.4%
-124.13M▲ 0%
Net Margin %
-150478.57%------245.96%--
Net Income Growth %
--116.75%-158.07%-34.69%-49.19%-23.39%43.24%17.35%44.63%
Net Income (Continuing)
-23.43M-46.38M-118.55M-166.09M-237.11M-292.31M-165.87M-137.06M-124.13M
Discontinued Operations
000000000
Minority Interest
7.54M6.82M24.8M528K221K107K000
EPS (Diluted)
-1.17▲ 0%
-1.29▼ 10.3%
-2.87▼ 122.5%
-3.72▼ 29.6%
-4.48▼ 20.4%
-4.47▲ 0.2%
-2.33▲ 47.9%
-1.91▲ 18.0%
-1.77▲ 0%
EPS Growth %
--10.26%-122.48%-29.62%-20.43%0.22%47.87%18.03%44.9%
EPS (Basic)
-1.17-1.29-2.87-3.72-4.48-4.47-2.33-1.91-
Diluted Shares Outstanding
18.06M35.88M41.04M42.69M52.86M65.41M71.08M71.87M70.26M
Basic Shares Outstanding
18.06M35.88M41.04M42.69M52.86M65.41M71.08M71.87M70.26M
Dividend Payout Ratio
---------

ZNTL Balance Sheet

Zentalis Pharmaceuticals, Inc. (ZNTL) balance sheet — assets, liabilities & shareholders' equity

MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
26.68M68.89M345.1M350.77M451.93M496.72M386.07M253.19M218.1M
Cash & Short-Term Investments
25.15M67.25M338.5M340.13M437.37M482.92M371.08M245.89M211.76M
Cash Only
25.15M67.25M54.95M59.96M43.07M28.04M33.9M35.99M31.93M
Short-Term Investments
00283.55M280.17M394.3M454.88M337.18M209.9M179.83M
Accounts Receivable
917K140K02.63M005M1.93M0
Days Sales Outstanding
23.91K-----27.07--
Inventory
000000000
Days Inventory Outstanding
---------
Other Current Assets
00417K014.56M13.8M05.37M6.34M
Total Non-Current Assets
14.32M19.34M20.45M121.25M101.52M65.31M44.27M35.78M34.97M
Property, Plant & Equipment
260K2.84M3.62M52.84M50.08M41.73M37.23M29.04M28.25M
Fixed Asset Turnover
0.05x-----1.81x-0.00x
Goodwill
3.74M3.74M3.74M3.74M3.74M3.74M000
Intangible Assets
8.8M8.8M8.8M000000
Long-Term Investments
-46.26K243K040.12M23.84M2.68M000
Other Non-Current Assets
1.52M2.97M4.3M7.04M9.72M6.82M7.04M6.74M6.72M
Total Assets
41M▲ 0%
88.23M▲ 115.2%
365.56M▲ 314.3%
472.02M▲ 29.1%
553.46M▲ 17.3%
562.03M▲ 1.5%
430.34M▼ 23.4%
288.97M▼ 32.9%
253.07M▲ 0%
Asset Turnover
0.00x-----0.16x-0.00x
Asset Growth %
-115.21%314.31%29.13%17.25%1.55%-23.43%-32.85%-122.8%
Total Current Liabilities
6.21M14.9M28.6M43.94M56.65M69.37M52.73M36.56M35.24M
Accounts Payable
3.43M4.29M8.66M11.59M11.25M14.93M7.44M7.21M7.38M
Days Payables Outstanding
--------15.31K
Short-Term Debt
0781K01.45M2.16M2.62M03.87M0
Deferred Revenue (Current)
223.42K0000281K000
Other Current Liabilities
223K6.85M410K20.68M43.24M-2.9M025.28M27.86M
Current Ratio
4.30x4.62x12.07x7.98x7.98x7.16x7.32x6.93x6.19x
Quick Ratio
4.30x4.62x12.07x7.98x7.98x7.16x7.32x6.93x6.19x
Cash Conversion Cycle
---------
Total Non-Current Liabilities
2.48M4.91M3.58M63.6M62.79M55.27M40.43M36.2M35.15M
Long-Term Debt
0000000034.65M
Capital Lease Obligations
01.7M1.1M44.46M45.17M43.15M39.58M35.7M110.1M
Deferred Tax Liabilities
2.46M3.21M019.14M15M10.34M000
Other Non-Current Liabilities
21K5K2.48M02.62M1.78M849K500K500K
Total Liabilities
8.69M19.81M32.18M107.54M119.43M124.64M93.15M72.76M70.39M
Total Debt
02.48M2M45.91M47.33M45.77M42.65M39.58M34.65M
Net Debt
-25.15M-64.77M-52.95M-14.04M4.26M17.73M8.75M3.58M2.72M
Debt / Equity
-0.04x0.01x0.13x0.11x0.10x0.13x0.18x0.19x
Debt / EBITDA
---------0.24x
Net Debt / EBITDA
---------0.02x
Interest Coverage
-----88.27x----
Total Equity
32.31M▲ 0%
68.42M▲ 111.8%
333.38M▲ 387.2%
364.48M▲ 9.3%
434.02M▲ 19.1%
437.39M▲ 0.8%
337.19M▼ 22.9%
216.2M▼ 35.9%
182.68M▲ 0%
Equity Growth %
-111.79%387.24%9.33%19.08%0.78%-22.91%-35.88%-130.92%
Book Value per Share
1.791.918.128.548.216.694.743.012.60
Total Shareholders' Equity
24.77M61.6M308.58M363.95M433.8M437.28M337.19M216.2M182.68M
Common Stock
2.27M2.89M41K45K59K70K71K69K71K
Retained Earnings
-37.33M-82.99M-200.83M-359.56M-596.37M-888.56M-1.05B-1.19B-1.23B
Treasury Stock
000000000
Accumulated OCI
-56K036K-125K-1.35M2.19M558K196K-50K
Minority Interest
7.54M6.82M24.8M528K221K107K000

ZNTL Cash Flow Statement

Zentalis Pharmaceuticals, Inc. (ZNTL) cash flow — operating, investing & free cash flow history

MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-24.25M-39.14M-86.83M-154.09M-163.75M-207.82M-170.86M-125.25M-125.57M
Operating CF Margin %
-173221.43%------253.41%--
Operating CF Growth %
--61.41%-121.81%-77.48%-6.27%-26.91%17.79%26.7%61.1%
Net Income
-23.43M-46.38M-118.55M-166.09M-237.11M-292.19M-165.87M-137.06M-124.13M
Depreciation & Amortization
51K111K160K544K1.43M1.39M1.29M739K628K
Stock-Based Compensation
308K617K23.15M35.74M46.84M54.82M67.27M20.72M14.24M
Deferred Taxes
2.37M017K-2.51M-769K-853K000
Other Non-Cash Items
-2.37M0556K-38.38M12.61M23.15M-57.01M-526K-4.69M
Working Capital Changes
-1.18M6.51M7.84M16.61M13.25M5.86M-16.54M-9.12M-11.6M
Change in Receivables
-254K777K-277K413K00-5M5M0
Change in Inventory
-1.86M0-5.52M000000
Change in Payables
977K7.12M14.31M13.96M15.53M10.92M-18.02M-17.32M-12.77M
Cash from Investing
-227K-352K-284.83M-18.11M-114.18M-44.46M176.56M131.62M121.16M
Capital Expenditures
-227K-352K-758K-6.11M-2.55M-583K-221K0-34K
CapEx % of Revenue
1621.43%-----0.33%--
Acquisitions
0018.42M-14.32M111.63K065K01.13M
Investments
---------
Other Investing
00-18.42M0-111.63K00698K-440K
Cash from Financing
9.47M81.83M360.44M178.52M261.04M237.3M108K-4.28M-5.59M
Debt Issued (Net)
000000000
Equity Issued (Net)
9.47M81.88M342.01M179.67M261.04M237.3M349K-4.28M-4.14M
Dividends Paid
000000000
Share Repurchases
000000000
Other Financing
0-46K18.42M-1.15M00-241K0-1.45M
Net Change in Cash
-15.01M▲ 0%
42.34M▲ 382.1%
-11.22M▼ 126.5%
6.31M▲ 156.3%
-16.89M▼ 367.5%
-14.98M▲ 11.3%
5.81M▲ 138.8%
2.09M▼ 64.0%
-10M▲ 0%
Free Cash Flow
-24.48M▲ 0%
-39.49M▼ 61.3%
-87.58M▼ 121.8%
-160.2M▼ 82.9%
-166.3M▼ 3.8%
-208.41M▼ 25.3%
-171.08M▲ 17.9%
-125.25M▲ 26.8%
-125.6M▲ 0%
FCF Margin %
-174842.86%------253.74%--
FCF Growth %
--61.35%-121.76%-82.91%-3.81%-25.32%17.91%26.79%17.21%
FCF per Share
-1.36-1.10-2.13-3.75-3.15-3.19-2.41-1.74-1.79
FCF Conversion (FCF/Net Income)
1.15x0.86x0.74x0.97x0.69x0.71x1.03x0.91x1.01x
Interest Paid
000000000
Taxes Paid
4K15K18K20K12K140K359K00

ZNTL Key Ratios

Zentalis Pharmaceuticals, Inc. (ZNTL) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2019202020212022202320242025TTM
Return on Equity (ROE)-90.67%-58.66%-45.49%-59.31%-67.06%-42.82%-49.53%-53.61%
Return on Invested Capital (ROIC)-650.44%-62.72%-51.49%-43.23%-50.29%-35.8%-40.52%-46.77%
Gross Margin-----100%--
Net Margin------245.96%--
Debt / Equity0.04x0.01x0.13x0.11x0.10x0.13x0.18x0.19x
Interest Coverage----88.27x----
FCF Conversion0.86x0.74x0.97x0.69x0.71x1.03x0.91x1.01x
Revenue Growth-100%------100%-100%
Related:ZNTL Dividend History·ZNTL Revenue History·ZNTL Price History·ZNTL P/E History·ZNTL Financial Ratios·ZNTL Institutional Holders

ZNTL SEC Filings & Documents

Zentalis Pharmaceuticals, Inc. (ZNTL) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 21, 2026·SEC

Material company update

May 12, 2026·SEC

Material company update

May 5, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 26, 2026·SEC

FY 2025

Mar 26, 2025·SEC

FY 2024

Feb 27, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 12, 2026·SEC

FY 2025

Nov 10, 2025·SEC

FY 2025

Aug 6, 2025·SEC

ZNTL Frequently Asked Questions

Zentalis Pharmaceuticals, Inc. (ZNTL) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Zentalis Pharmaceuticals, Inc. (ZNTL) saw revenue decline by 100.0% over the past year.

Zentalis Pharmaceuticals, Inc. (ZNTL) reported a net loss of $124.1M for fiscal year 2025.

Dividend & Returns

Zentalis Pharmaceuticals, Inc. (ZNTL) has a return on equity (ROE) of -49.5%. Negative ROE indicates the company is unprofitable.

Zentalis Pharmaceuticals, Inc. (ZNTL) had negative free cash flow of $125.6M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ZNTL back in 2018?

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