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ZNTLZentalis Pharmaceuticals, Inc.
$2.52$179M
Overview & Tools
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ZNTL logo

Zentalis Pharmaceuticals, Inc.

ZNTL
NASDAQ · Biotechnology
$2.52
At close - Oct 2, 4:00 PM EDT - USD
Market Cap$179M
P/E-1.3x
52W High$6.95
Volume1.45M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q1

Persistent Clinical Burn Challenges Zentalis Liquidity Position

Zentalis Pharmaceuticals faces a precarious outlook characterized by a lack of recurring revenue and a rapid depletion of capital reserves to fund its high-intensity R&D pipeline. The company's reliance on non-recurring milestone payments has resulted in extre...

GrowthContracting
ProfitabilityNegative
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

ZNTL price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

7/12 Beats

EPS beat 7 of last 12 quarters

02

Valuation risk

-104% Peers

P/E is 104% below peer median

03

Market leadership

RS 18 · Lag

Laggard (Underperforming 82% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystConfirmed earnings · Nov 10

Market performance

Price History →

Trailing total returns as of 10/3/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
ZNTL+83.94%
S&P 500 (^GSPC)+12.66%
1-Year Return
ZNTL+51.81%
S&P 500 (^GSPC)+15.01%
3-Year Return
ZNTL-87.31%
S&P 500 (^GSPC)+77.64%
5-Year Return
ZNTL-96.23%
S&P 500 (^GSPC)+77.07%

Growth & profitability

Annual revenue & EPS trend
Revenue
-
Net income
-$137M+17.4% YoY
Free cash flow
-$125M+26.8% YoY
Operating margin
-
ROIC (TTM)-40.5%
Avg ROIC 5Y-
ROE (TTM)-49.5%
Piotroski Score1 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate7/12 (58%)
Revenue Beat Rate1/12 (100%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 6, 2026
-$0.59-20.4%
vs -$0.49
—
vs —
Q2 2026
May 12, 2026
-$0.50-2.0%
vs -$0.49
—
vs —
Q2 2026
Mar 26, 2026
-$0.49-19.5%
vs -$0.41
—
vs —
Q4 2025
Nov 10, 2025
-$0.37+24.5%
vs -$0.49
—
vs —
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Benzinga·Sep 16, 2026
This Small Biotech's Cancer Drug Could Reach $1.3 Billion In Peak Sales

Zentalis Pharmaceuticals Inc. (NASDAQ:ZNTL) received a bullish initiation from William Blair on Tuesday, which sees a potential blockbuster opportunity for the biotech company's lead cancer drug, azenosertib.

Seeking Alpha·Sep 14, 2026
Zentalis Pharmaceuticals, Inc. (ZNTL) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript

Zentalis Pharmaceuticals, Inc. (ZNTL) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript

Defense World·Sep 4, 2026
BlackRock Inc. Invests $18.20 Million in Zentalis Pharmaceuticals, Inc. $ZNTL

BlackRock Inc. acquired a new position in Zentalis Pharmaceuticals, Inc. (NASDAQ: ZNTL) during the second quarter, according to the company in its most recent filing with the Securities and Exchange Commission. The firm acquired 3,753,525 shares of the company's stock, valued at approximately $18,205,000. BlackRock Inc. owned approximately 5.27% of Zentalis Pharmaceuticals as

GlobeNewsWire·Sep 2, 2026
Zentalis Pharmaceuticals to Participate in Upcoming Investor Conferences

SAN DIEGO, Sept. 02, 2026 (GLOBE NEWSWIRE) -- Zentalis® Pharmaceuticals, Inc. (Nasdaq: ZNTL), a clinical oncology innovator advancing late-stage development of investigational first-in-class WEE1 inhibitor azenosertib as a biomarker-driven treatment approach for ovarian cancer, today announced that members of the management team will participate in the following upcoming investor conferences:

Filtered for Zentalis Pharmaceuticals, Inc.More Headlines
04

Compare before deciding

Benchmark ZNTL against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Zentalis Pharmaceuticals, Inc. (ZNTL)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ZNTL logoZNTLZentalis Pharmaceuticals, Inc.Current
$2.52$179.39M-1.32-100%—-49.53%—
RVMD logoRVMDRevolution Medicines, Inc.
$206.64$43.93B-34.73——-96.44%—
KYMR logoKYMRKymera Therapeutics, Inc.
$107.39$8.83B-29.10-16.72%-285.41%-21.5%—
AUPH logoAUPHAurinia Pharmaceuticals Inc.
$15.83$2.04B7.6520.38%100.84%59%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$295.51$8.24B-21.92-100%—-34.15%—
TGTX logoTGTXTG Therapeutics, Inc.
$54.29$8.31B19.6087.32%55.22%72.3%—

Compare ZNTL vs Peers

Zentalis Pharmaceuticals, Inc. (ZNTL) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RVMD

Most directly comparable listed peer for ZNTL.

Scale Benchmark

vs IQV

Larger-name benchmark to compare ZNTL against a more recognizable public peer.

Peer Set

Compare Top 5

vs RVMD, KYMR, AUPH, PRAX

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

ZNTL SEC Filings & Documents

Zentalis Pharmaceuticals, Inc. (ZNTL) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

Jun 18, 2026·SEC

Material company update

May 27, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 26, 2026·SEC

FY 2025

Mar 26, 2025·SEC

FY 2024

Feb 27, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 12, 2026·SEC

FY 2025

Nov 10, 2025·SEC

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ZNTL Frequently Asked Questions

Zentalis Pharmaceuticals, Inc. (ZNTL) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
How fast is Zentalis Pharmaceuticals, Inc. growing?

Zentalis Pharmaceuticals, Inc. (ZNTL) saw revenue decline by 100.0% over the past year.

Is ZNTL profitable?

Zentalis Pharmaceuticals, Inc. (ZNTL) reported a net loss of $174.9M for fiscal year 2025.

Dividend & Returns
What is ZNTL's return on equity?

Zentalis Pharmaceuticals, Inc. (ZNTL) has a return on equity (ROE) of -49.5%. Negative ROE indicates the company is unprofitable.

What is Zentalis Pharmaceuticals, Inc.'s free cash flow?

Zentalis Pharmaceuticals, Inc. (ZNTL) had negative free cash flow of $161.1M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ZNTL back in 2018?

Total return calculator · dividends reinvested · 8+ years of data

See returns →