70% buyers of institutions opening or closing positions this quarter
15 more new buyers than exits, ownership rose 16.37 percentage points vs the prior quarter, and 3 well-known fund managers in the top 25.
70% buyers of institutions opening or closing positions this quarter
33.9% institutional ownership
Ishara Investments LP portfolio allocation
Institutional ownership vs Biotechnology peers
No Form 4 insider transactions on file
Latest positioning in ZNTL across 13F flow, ownership shift, marquee holders, and holder-count growth.
Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in ZNTL held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | 5AM Venture Management, LLC | 3.9M | $9.2M | 0.0% | 5.546% | 2.56% |
| 2 | TWO SIGMA INVESTMENTS, LP | 3.0M | $6.9M | +100.9% | 4.153% | 0.01% |
| 3 | VANGUARD CAPITAL MANAGEMENT LLC | 2.3M | $5.4M | — | 3.246% | 0.00% |
| 4 | RENAISSANCE TECHNOLOGIES LLC | 1.9M | $4.5M | -32.8% | 2.723% | 0.01% |
| 5 | CITADEL ADVISORS LLC | 1.8M | $4.1M | -10.6% | 2.467% | 0.00% |
| 6 | D. E. Shaw & Co., Inc. | 1.5M | $3.5M | -10.6% | 2.085% | 0.00% |
| 7 | Opaleye Management Inc. | 1.4M | $3.3M | +0.8% | 1.984% | 0.44% |
| 8 | Decheng Capital LLC | 1.3M | $3.1M | 0.0% | 1.859% | 0.47% |
| 9 | MILLENNIUM MANAGEMENT LLC | 1.3M | $3.0M | +91.6% | 1.812% | 0.00% |
| 10 | BlackRock, Inc. | 1.3M | $3.0M | +1.6% | 1.784% | 0.00% |
| 11 | Ishara Investments LP | 1.2M | $2.9M | -6.8% | 1.728% | 2.72% |
| 12 | BANK OF AMERICA CORP /DE/ | 1.1M | $2.6M | -17.2% | 1.591% | 0.00% |
| 13 | PRIMECAP MANAGEMENT CO/CA/ | 957K | $2.2M | 0.0% | 1.345% | 0.00% |
| 14 | PFIZER INC | 954K | $2.0M | 0.0% | 1.340% | 0.84% |
| 15 | Connor, Clark & Lunn Investment Management Ltd. | 792K | $1.9M | +0.6% | 1.113% | 0.00% |
| 16 | Qube Research & Technologies Ltd | 637K | $1.5M | +3546.7% | 0.895% | 0.00% |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 621K | $1.5M | +5.4% | 0.872% | 0.00% |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 617K | $1.4M | +5861.1% | 0.866% | 0.00% |
| 19 | Almitas Capital LLC | 610K | $1.4M | 0.0% | 0.857% | 0.32% |
| 20 | BARCLAYS PLC | 591K | $1.4M | +4.0% | 0.831% | 0.00% |
| 21 | JANE STREET GROUP, LLC | 490K | $1.1M | +3.6% | 0.689% | 0.00% |
| 22 | BNP PARIBAS ARBITRAGE, SA | 471K | $1.1M | +12.4% | 0.662% | 0.00% |
| 23 | GOLDMAN SACHS GROUP INC | 463K | $1.1M | +291.4% | 0.650% | 0.00% |
| 24 | MARSHALL WACE, LLP | 393K | $919K | +58.5% | 0.552% | 0.00% |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | 361K | $844K | — | 0.507% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in ZNTL — a direct measure of their conviction.
Filings activity in ZNTL during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 100 | +18% | 33.91% | +16.37 pp | $85M | +72% |
| Q4 2025 | 85 | 13% | 17.54% | 8.55 pp | $49M | 33% |
| Q3 2025 | 98 | 16% | 26.09% | +4.92 pp | $74M | +23% |
| Q2 2025 | 116 | 12% | 21.17% | 13.47 pp | $60M | 31% |
| Q1 2025 | 132 | 7.0% | 34.64% | 28.13 pp | $87M | 51% |
| Q4 2024 | 142 | +5.2% | 62.77% | 137.22 pp | $177M | 96% |
| Q3 2024 | 135 | 4.9% | 199.99% | +98.99 pp | $4.04B | +1318% |
| Q2 2024 | 142 | — | 101.00% | — | $285M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
No recent Form 4 insider transactions on file for ZNTL.
Quick answers to the most common questions about buying ZNTL stock.
Based on Q1 2026 13F filings, institutional ownership of Zentalis Pharmaceuticals, Inc. stands at 33.9%, held across 100 reporting institutions.
5AM Venture Management, LLC is the largest reported institutional holder of ZNTL, with approximately 3,947,913 shares worth $0.01B as of Q1 2026.
Yes — 3 widely-followed marquee investors appear among the top 25 institutional holders of ZNTL, including TWO SIGMA INVESTMENTS, LP, RENAISSANCE TECHNOLOGIES LLC, CITADEL ADVISORS LLC.
Our composite Smart Money Score for ZNTL is 77 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
26 institutions opened new positions in ZNTL during Q1 2026, while 11 fully exited. 63 added to existing positions and 10 trimmed.
ZNTL institutional ownership rose by 16.37 percentage points quarter-over-quarter, with a net change of +15 holders.
The top 10 institutions account for 54.2% of all reported 13F value in ZNTL, and the top 25 account for 82.4%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.