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Stock Comparison

ABSI vs RXRX vs SDGR vs ALIT vs TWST

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
ABSI
Absci Corporation

Biotechnology

HealthcareNASDAQ • US
Market Cap$917M
5Y Perf.-79.3%
RXRX
Recursion Pharmaceuticals, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.48B
5Y Perf.-89.1%
SDGR
Schrödinger, Inc.

Medical - Healthcare Information Services

HealthcareNASDAQ • US
Market Cap$981M
5Y Perf.-80.6%
ALIT
Alight, Inc.

Software - Application

TechnologyNYSE • US
Market Cap$490M
5Y Perf.-90.1%
TWST
Twist Bioscience Corporation

Medical - Diagnostics & Research

HealthcareNASDAQ • US
Market Cap$3.54B
5Y Perf.-53.8%

ABSI vs RXRX vs SDGR vs ALIT vs TWST — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
ABSI logoABSI
RXRX logoRXRX
SDGR logoSDGR
ALIT logoALIT
TWST logoTWST
IndustryBiotechnologyBiotechnologyMedical - Healthcare Information ServicesSoftware - ApplicationMedical - Diagnostics & Research
Market Cap$917M$1.48B$981M$490M$3.54B
Revenue (TTM)$2M$66M$255M$2.25B$409M
Net Income (TTM)$-118M$-560M$-103M$-3.09B$-81M
Gross Margin-13.4%-34.4%55.3%20.2%52.1%
Operating Margin-60.3%-8.8%-64.7%0.9%-33.9%
Forward P/E3.0x
Total Debt$5M$78M$109M$2.00B$137M
Cash & Equiv.$20M$743M$231M$273M$183M

ABSI vs RXRX vs SDGR vs ALIT vs TWSTLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

ABSI
RXRX
SDGR
ALIT
TWST
StockJul 21May 26Return
Absci Corporation (ABSI)10020.7-79.3%
Recursion Pharmaceu… (RXRX)10010.9-89.1%
Schrödinger, Inc. (SDGR)10019.4-80.6%
Alight, Inc. (ALIT)1009.9-90.1%
Twist Bioscience Co… (TWST)10046.2-53.8%

Price return only. Dividends and distributions are not included.

Quick Verdict: ABSI vs RXRX vs SDGR vs ALIT vs TWST

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: ALIT leads in 3 of 7 categories (5-stock set), making it the strongest pick for valuation and capital efficiency and capital preservation and lower volatility. Twist Bioscience Corporation is the stronger pick specifically for profitability and margin quality and operational efficiency and capital deployment. ABSI and RXRX also each lead in at least one category. This set spans 2 sectors — these stocks serve different portfolio roles, not just different price points.
ABSI
Absci Corporation
The Defensive Pick

ABSI ranks third and is worth considering specifically for sleep-well-at-night and defensive.

  • Lower volatility, beta 2.77, Low D/E 2.8%, current ratio 6.57x
  • Beta 2.77, current ratio 6.57x
  • +110.7% vs ALIT's -81.2%
Best for: sleep-well-at-night and defensive
RXRX
Recursion Pharmaceuticals, Inc.
The Growth Play

RXRX is the clearest fit if your priority is growth exposure.

  • Rev growth 26.9%, EPS growth 14.8%, 3Y rev CAGR 23.5%
  • 26.9% revenue growth vs ABSI's -38.2%
Best for: growth exposure
SDGR
Schrödinger, Inc.
The Growth Angle

Among these 5 stocks, SDGR doesn't own a clear edge in any measured category.

Best for: healthcare exposure
ALIT
Alight, Inc.
The Income Pick

ALIT carries the broadest edge in this set and is the clearest fit for income & stability.

  • Dividend streak 2 yrs, beta 1.40, yield 17.4%
  • Better valuation composite
  • Beta 1.40 vs RXRX's 2.99
  • 17.4% yield; 2-year raise streak; the other 4 pay no meaningful dividend
Best for: income & stability
TWST
Twist Bioscience Corporation
The Long-Run Compounder

TWST is the #2 pick in this set and the best alternative if long-term compounding is your priority.

  • 306.1% 10Y total return vs SDGR's -54.2%
  • -19.8% margin vs ABSI's -73.1%
  • -12.5% ROA vs ALIT's -58.3%, ROIC -26.9% vs 0.6%
Best for: long-term compounding
See the full category breakdown
CategoryWinnerWhy
GrowthRXRX logoRXRX26.9% revenue growth vs ABSI's -38.2%
ValueALIT logoALITBetter valuation composite
Quality / MarginsTWST logoTWST-19.8% margin vs ABSI's -73.1%
Stability / SafetyALIT logoALITBeta 1.40 vs RXRX's 2.99
DividendsALIT logoALIT17.4% yield; 2-year raise streak; the other 4 pay no meaningful dividend
Momentum (1Y)ABSI logoABSI+110.7% vs ALIT's -81.2%
Efficiency (ROA)TWST logoTWST-12.5% ROA vs ALIT's -58.3%, ROIC -26.9% vs 0.6%

ABSI vs RXRX vs SDGR vs ALIT vs TWST — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

ABSIAbsci Corporation

Segment breakdown not available.

RXRXRecursion Pharmaceuticals, Inc.
FY 2025
License and Service
99.4%$74M
Grant
0.6%$425,000
SDGRSchrödinger, Inc.
FY 2025
Software Products And Services
34.2%$200M
Revenue From Contract With Customer Before Software Contribution
31.5%$184M
On Premise Software
17.4%$101M
Hosted Software
7.7%$45M
Maintenance
4.7%$27M
Software Contribution
2.7%$16M
Professional Services
1.7%$10M
ALITAlight, Inc.
FY 2023
Other Segments
100.0%$26M
TWSTTwist Bioscience Corporation
FY 2025
Ngs Tools
55.3%$208M
Synthetic Genes
30.2%$114M
Antibody Discovery
6.2%$23M
Oligo Pools
5.4%$20M
Dna And Biopharma Libraries
3.0%$11M

ABSI vs RXRX vs SDGR vs ALIT vs TWST — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLALITLAGGINGSDGR

Income & Cash Flow (Last 12 Months)

Evenly matched — ALIT and TWST each lead in 2 of 6 comparable metrics.

ALIT is the larger business by revenue, generating $2.2B annually — 1386.8x ABSI's $2M. TWST is the more profitable business, keeping -19.8% of every revenue dollar as net income compared to ABSI's -73.1%. On growth, TWST holds the edge at +19.3% YoY revenue growth, suggesting stronger near-term business momentum.

MetricABSI logoABSIAbsci CorporationRXRX logoRXRXRecursion Pharmac…SDGR logoSDGRSchrödinger, Inc.ALIT logoALITAlight, Inc.TWST logoTWSTTwist Bioscience …
RevenueTrailing 12 months$2M$66M$255M$2.2B$409M
EBITDAEarnings before interest/tax-$116M-$501M-$159M$430M-$115M
Net IncomeAfter-tax profit-$118M-$560M-$103M-$3.1B-$81M
Free Cash FlowCash after capex-$99M-$326M-$148M$259M-$95M
Gross MarginGross profit ÷ Revenue-13.4%-34.4%+55.3%+20.2%+52.1%
Operating MarginEBIT ÷ Revenue-60.3%-8.8%-64.7%+0.9%-33.9%
Net MarginNet income ÷ Revenue-73.1%-8.4%-40.6%-137.5%-19.8%
FCF MarginFCF ÷ Revenue-60.8%-4.9%-58.2%+11.5%-23.2%
Rev. Growth (YoY)Latest quarter vs prior year-100.0%-56.1%-1.6%-2.6%+19.3%
EPS Growth (YoY)Latest quarter vs prior year+9.5%+56.0%+1.2%-25.4%-7.6%
Evenly matched — ALIT and TWST each lead in 2 of 6 comparable metrics.

Valuation Metrics

ALIT leads this category, winning 3 of 4 comparable metrics.
MetricABSI logoABSIAbsci CorporationRXRX logoRXRXRecursion Pharmac…SDGR logoSDGRSchrödinger, Inc.ALIT logoALITAlight, Inc.TWST logoTWSTTwist Bioscience …
Market CapShares × price$917M$1.5B$981M$490M$3.5B
Enterprise ValueMkt cap + debt − cash$902M$819M$860M$2.2B$3.5B
Trailing P/EPrice ÷ TTM EPS-7.02x-2.31x-9.31x-0.16x-43.73x
Forward P/EPrice ÷ next-FY EPS est.2.98x
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple5.04x
Price / SalesMarket cap ÷ Revenue327.55x19.88x3.83x0.22x9.40x
Price / BookPrice ÷ Book value/share4.26x1.31x2.65x0.47x7.19x
Price / FCFMarket cap ÷ FCF78.76x1.96x
ALIT leads this category, winning 3 of 4 comparable metrics.

Profitability & Efficiency

ALIT leads this category, winning 3 of 8 comparable metrics.

TWST delivers a -17.5% return on equity — every $100 of shareholder capital generates $-17 in annual profit, vs $-172 for ALIT. ABSI carries lower financial leverage with a 0.03x debt-to-equity ratio, signaling a more conservative balance sheet compared to ALIT's 1.92x.

MetricABSI logoABSIAbsci CorporationRXRX logoRXRXRecursion Pharmac…SDGR logoSDGRSchrödinger, Inc.ALIT logoALITAlight, Inc.TWST logoTWSTTwist Bioscience …
ROE (TTM)Return on equity-63.6%-54.3%-30.8%-171.7%-17.5%
ROA (TTM)Return on assets-54.7%-40.6%-15.3%-58.3%-12.5%
ROICReturn on invested capital-58.0%-95.8%-39.4%+0.6%-26.9%
ROCEReturn on capital employed-65.9%-50.1%-28.6%+0.6%-24.9%
Piotroski ScoreFundamental quality 0–944444
Debt / EquityFinancial leverage0.03x0.07x0.30x1.92x0.29x
Net DebtTotal debt minus cash-$15M-$665M-$121M$1.7B-$46M
Cash & Equiv.Liquid assets$20M$743M$231M$273M$183M
Total DebtShort + long-term debt$5M$78M$109M$2.0B$137M
Interest CoverageEBIT ÷ Interest expense-865.97x-342.92x-27.64x
ALIT leads this category, winning 3 of 8 comparable metrics.

Total Returns (Dividends Reinvested)

TWST leads this category, winning 5 of 6 comparable metrics.

A $10,000 investment in TWST five years ago would be worth $5,902 today (with dividends reinvested), compared to $1,132 for ALIT. Over the past 12 months, ABSI leads with a +110.7% total return vs ALIT's -81.2%. The 3-year compound annual growth rate (CAGR) favors TWST at 61.9% vs ALIT's -49.9% — a key indicator of consistent wealth creation.

MetricABSI logoABSIAbsci CorporationRXRX logoRXRXRecursion Pharmac…SDGR logoSDGRSchrödinger, Inc.ALIT logoALITAlight, Inc.TWST logoTWSTTwist Bioscience …
YTD ReturnYear-to-date+63.4%-21.0%-27.0%-50.2%+75.5%
1-Year ReturnPast 12 months+110.7%-24.4%-45.0%-81.2%+74.3%
3-Year ReturnCumulative with dividends+315.5%-40.7%-52.7%-87.4%+324.3%
5-Year ReturnCumulative with dividends-72.7%-85.6%-79.5%-88.7%-41.0%
10-Year ReturnCumulative with dividends-72.7%-81.6%-54.2%-89.1%+306.1%
CAGR (3Y)Annualised 3-year return+60.8%-16.0%-22.1%-49.9%+61.9%
TWST leads this category, winning 5 of 6 comparable metrics.

Risk & Volatility

Evenly matched — ABSI and ALIT each lead in 1 of 2 comparable metrics.

ALIT is the less volatile stock with a 1.40 beta — it tends to amplify market swings less than RXRX's 2.99 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ABSI currently trades 94.6% from its 52-week high vs ALIT's 15.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricABSI logoABSIAbsci CorporationRXRX logoRXRXRecursion Pharmac…SDGR logoSDGRSchrödinger, Inc.ALIT logoALITAlight, Inc.TWST logoTWSTTwist Bioscience …
Beta (5Y)Sensitivity to S&P 5002.77x2.99x1.65x1.40x2.41x
52-Week HighHighest price in past year$6.24$7.18$27.63$6.11$66.00
52-Week LowLowest price in past year$2.24$2.80$10.95$0.48$23.30
% of 52W HighCurrent price vs 52-week peak+94.6%+46.2%+47.5%+15.3%+86.1%
RSI (14)Momentum oscillator 0–10077.844.462.761.754.9
Avg Volume (50D)Average daily shares traded4.5M12.5M1.3M33.5M1.2M
Evenly matched — ABSI and ALIT each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: ABSI as "Buy", RXRX as "Hold", SDGR as "Buy", ALIT as "Buy", TWST as "Buy". Consensus price targets imply 300.9% upside for ALIT (target: $4) vs 4.4% for ABSI (target: $6). ALIT is the only dividend payer here at 17.43% yield — a key consideration for income-focused portfolios.

MetricABSI logoABSIAbsci CorporationRXRX logoRXRXRecursion Pharmac…SDGR logoSDGRSchrödinger, Inc.ALIT logoALITAlight, Inc.TWST logoTWSTTwist Bioscience …
Analyst RatingConsensus buy/hold/sellBuyHoldBuyBuyBuy
Price TargetConsensus 12-month target$6.16$11.00$18.00$3.75$60.50
# AnalystsCovering analysts1210121013
Dividend YieldAnnual dividend ÷ price+17.4%
Dividend StreakConsecutive years of raises2
Dividend / ShareAnnual DPS$0.16
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%+13.3%+0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

ALIT leads in 2 of 6 categories (Valuation Metrics, Profitability & Efficiency). TWST leads in 1 (Total Returns). 2 tied.

Best OverallAlight, Inc. (ALIT)Leads 2 of 6 categories
Loading custom metrics...

ABSI vs RXRX vs SDGR vs ALIT vs TWST: Key Questions Answered

9 questions · data-driven answers · updated daily

01

Is ABSI or RXRX or SDGR or ALIT or TWST a better buy right now?

For growth investors, Recursion Pharmaceuticals, Inc.

(RXRX) is the stronger pick with 26. 9% revenue growth year-over-year, versus -38. 2% for Absci Corporation (ABSI). Analysts rate Absci Corporation (ABSI) a "Buy" — based on 12 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — ABSI or RXRX or SDGR or ALIT or TWST?

Over the past 5 years, Twist Bioscience Corporation (TWST) delivered a total return of -41.

0%, compared to -88. 7% for Alight, Inc. (ALIT). Over 10 years, the gap is even starker: TWST returned +306. 1% versus ALIT's -89. 1%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — ABSI or RXRX or SDGR or ALIT or TWST?

By beta (market sensitivity over 5 years), Alight, Inc.

(ALIT) is the lower-risk stock at 1. 40β versus Recursion Pharmaceuticals, Inc. 's 2. 99β — meaning RXRX is approximately 114% more volatile than ALIT relative to the S&P 500. On balance sheet safety, Absci Corporation (ABSI) carries a lower debt/equity ratio of 3% versus 192% for Alight, Inc. — giving it more financial flexibility in a downturn.

04

Which is growing faster — ABSI or RXRX or SDGR or ALIT or TWST?

By revenue growth (latest reported year), Recursion Pharmaceuticals, Inc.

(RXRX) is pulling ahead at 26. 9% versus -38. 2% for Absci Corporation (ABSI). On earnings-per-share growth, the picture is similar: Twist Bioscience Corporation grew EPS 63. 9% year-over-year, compared to -1924. 1% for Alight, Inc.. Over a 3-year CAGR, RXRX leads at 23. 5% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — ABSI or RXRX or SDGR or ALIT or TWST?

Twist Bioscience Corporation (TWST) is the more profitable company, earning -20.

6% net margin versus -41. 1% for Absci Corporation — meaning it keeps -20. 6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ALIT leads at 1. 5% versus -44. 5% for ABSI. At the gross margin level — before operating expenses — SDGR leads at 55. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Is ABSI or RXRX or SDGR or ALIT or TWST more undervalued right now?

Analyst consensus price targets imply the most upside for ALIT: 300.

9% to $3. 75.

07

Which pays a better dividend — ABSI or RXRX or SDGR or ALIT or TWST?

In this comparison, ALIT (17.

4% yield) pays a dividend. ABSI, RXRX, SDGR, TWST do not pay a meaningful dividend and should not be held primarily for income.

08

Is ABSI or RXRX or SDGR or ALIT or TWST better for a retirement portfolio?

For long-horizon retirement investors, Alight, Inc.

(ALIT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (17. 4% yield). Recursion Pharmaceuticals, Inc. (RXRX) carries a higher beta of 2. 99 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (ALIT: -89. 1%, RXRX: -81. 6%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

09

What are the main differences between ABSI and RXRX and SDGR and ALIT and TWST?

These companies operate in different sectors (ABSI (Healthcare) and RXRX (Healthcare) and SDGR (Healthcare) and ALIT (Technology) and TWST (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.

In terms of investment character: ABSI is a small-cap quality compounder stock; RXRX is a small-cap high-growth stock; SDGR is a small-cap high-growth stock; ALIT is a small-cap income-oriented stock; TWST is a small-cap high-growth stock. ALIT pays a dividend while ABSI, RXRX, SDGR, TWST do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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