Biotechnology
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ABSI vs RXRX vs SDGR vs ALIT vs TWST
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Medical - Healthcare Information Services
Software - Application
Medical - Diagnostics & Research
ABSI vs RXRX vs SDGR vs ALIT vs TWST — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Medical - Healthcare Information Services | Software - Application | Medical - Diagnostics & Research |
| Market Cap | $917M | $1.48B | $981M | $490M | $3.54B |
| Revenue (TTM) | $2M | $66M | $255M | $2.25B | $409M |
| Net Income (TTM) | $-118M | $-560M | $-103M | $-3.09B | $-81M |
| Gross Margin | -13.4% | -34.4% | 55.3% | 20.2% | 52.1% |
| Operating Margin | -60.3% | -8.8% | -64.7% | 0.9% | -33.9% |
| Forward P/E | — | — | — | 3.0x | — |
| Total Debt | $5M | $78M | $109M | $2.00B | $137M |
| Cash & Equiv. | $20M | $743M | $231M | $273M | $183M |
ABSI vs RXRX vs SDGR vs ALIT vs TWST — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Jul 21 | May 26 | Return |
|---|---|---|---|
| Absci Corporation (ABSI) | 100 | 20.7 | -79.3% |
| Recursion Pharmaceu… (RXRX) | 100 | 10.9 | -89.1% |
| Schrödinger, Inc. (SDGR) | 100 | 19.4 | -80.6% |
| Alight, Inc. (ALIT) | 100 | 9.9 | -90.1% |
| Twist Bioscience Co… (TWST) | 100 | 46.2 | -53.8% |
Price return only. Dividends and distributions are not included.
Quick Verdict: ABSI vs RXRX vs SDGR vs ALIT vs TWST
Each card shows where this stock fits in a portfolio — not just who wins on paper.
ABSI ranks third and is worth considering specifically for sleep-well-at-night and defensive.
- Lower volatility, beta 2.77, Low D/E 2.8%, current ratio 6.57x
- Beta 2.77, current ratio 6.57x
- +110.7% vs ALIT's -81.2%
RXRX is the clearest fit if your priority is growth exposure.
- Rev growth 26.9%, EPS growth 14.8%, 3Y rev CAGR 23.5%
- 26.9% revenue growth vs ABSI's -38.2%
Among these 5 stocks, SDGR doesn't own a clear edge in any measured category.
ALIT carries the broadest edge in this set and is the clearest fit for income & stability.
- Dividend streak 2 yrs, beta 1.40, yield 17.4%
- Better valuation composite
- Beta 1.40 vs RXRX's 2.99
- 17.4% yield; 2-year raise streak; the other 4 pay no meaningful dividend
TWST is the #2 pick in this set and the best alternative if long-term compounding is your priority.
- 306.1% 10Y total return vs SDGR's -54.2%
- -19.8% margin vs ABSI's -73.1%
- -12.5% ROA vs ALIT's -58.3%, ROIC -26.9% vs 0.6%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 26.9% revenue growth vs ABSI's -38.2% | |
| Value | Better valuation composite | |
| Quality / Margins | -19.8% margin vs ABSI's -73.1% | |
| Stability / Safety | Beta 1.40 vs RXRX's 2.99 | |
| Dividends | 17.4% yield; 2-year raise streak; the other 4 pay no meaningful dividend | |
| Momentum (1Y) | +110.7% vs ALIT's -81.2% | |
| Efficiency (ROA) | -12.5% ROA vs ALIT's -58.3%, ROIC -26.9% vs 0.6% |
ABSI vs RXRX vs SDGR vs ALIT vs TWST — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
ABSI vs RXRX vs SDGR vs ALIT vs TWST — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
ALIT leads in 2 of 6 categories
TWST leads 1 • ABSI leads 0 • RXRX leads 0 • SDGR leads 0 • 2 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
Evenly matched — ALIT and TWST each lead in 2 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
ALIT is the larger business by revenue, generating $2.2B annually — 1386.8x ABSI's $2M. TWST is the more profitable business, keeping -19.8% of every revenue dollar as net income compared to ABSI's -73.1%. On growth, TWST holds the edge at +19.3% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $2M | $66M | $255M | $2.2B | $409M |
| EBITDAEarnings before interest/tax | -$116M | -$501M | -$159M | $430M | -$115M |
| Net IncomeAfter-tax profit | -$118M | -$560M | -$103M | -$3.1B | -$81M |
| Free Cash FlowCash after capex | -$99M | -$326M | -$148M | $259M | -$95M |
| Gross MarginGross profit ÷ Revenue | -13.4% | -34.4% | +55.3% | +20.2% | +52.1% |
| Operating MarginEBIT ÷ Revenue | -60.3% | -8.8% | -64.7% | +0.9% | -33.9% |
| Net MarginNet income ÷ Revenue | -73.1% | -8.4% | -40.6% | -137.5% | -19.8% |
| FCF MarginFCF ÷ Revenue | -60.8% | -4.9% | -58.2% | +11.5% | -23.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | -100.0% | -56.1% | -1.6% | -2.6% | +19.3% |
| EPS Growth (YoY)Latest quarter vs prior year | +9.5% | +56.0% | +1.2% | -25.4% | -7.6% |
Valuation Metrics
ALIT leads this category, winning 3 of 4 comparable metrics.
Valuation Metrics
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $917M | $1.5B | $981M | $490M | $3.5B |
| Enterprise ValueMkt cap + debt − cash | $902M | $819M | $860M | $2.2B | $3.5B |
| Trailing P/EPrice ÷ TTM EPS | -7.02x | -2.31x | -9.31x | -0.16x | -43.73x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | 2.98x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | — | 5.04x | — |
| Price / SalesMarket cap ÷ Revenue | 327.55x | 19.88x | 3.83x | 0.22x | 9.40x |
| Price / BookPrice ÷ Book value/share | 4.26x | 1.31x | 2.65x | 0.47x | 7.19x |
| Price / FCFMarket cap ÷ FCF | — | — | 78.76x | 1.96x | — |
Profitability & Efficiency
ALIT leads this category, winning 3 of 8 comparable metrics.
Profitability & Efficiency
TWST delivers a -17.5% return on equity — every $100 of shareholder capital generates $-17 in annual profit, vs $-172 for ALIT. ABSI carries lower financial leverage with a 0.03x debt-to-equity ratio, signaling a more conservative balance sheet compared to ALIT's 1.92x.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | -63.6% | -54.3% | -30.8% | -171.7% | -17.5% |
| ROA (TTM)Return on assets | -54.7% | -40.6% | -15.3% | -58.3% | -12.5% |
| ROICReturn on invested capital | -58.0% | -95.8% | -39.4% | +0.6% | -26.9% |
| ROCEReturn on capital employed | -65.9% | -50.1% | -28.6% | +0.6% | -24.9% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 4 | 4 | 4 | 4 |
| Debt / EquityFinancial leverage | 0.03x | 0.07x | 0.30x | 1.92x | 0.29x |
| Net DebtTotal debt minus cash | -$15M | -$665M | -$121M | $1.7B | -$46M |
| Cash & Equiv.Liquid assets | $20M | $743M | $231M | $273M | $183M |
| Total DebtShort + long-term debt | $5M | $78M | $109M | $2.0B | $137M |
| Interest CoverageEBIT ÷ Interest expense | -865.97x | -342.92x | — | -27.64x | — |
Total Returns (Dividends Reinvested)
TWST leads this category, winning 5 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in TWST five years ago would be worth $5,902 today (with dividends reinvested), compared to $1,132 for ALIT. Over the past 12 months, ABSI leads with a +110.7% total return vs ALIT's -81.2%. The 3-year compound annual growth rate (CAGR) favors TWST at 61.9% vs ALIT's -49.9% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | +63.4% | -21.0% | -27.0% | -50.2% | +75.5% |
| 1-Year ReturnPast 12 months | +110.7% | -24.4% | -45.0% | -81.2% | +74.3% |
| 3-Year ReturnCumulative with dividends | +315.5% | -40.7% | -52.7% | -87.4% | +324.3% |
| 5-Year ReturnCumulative with dividends | -72.7% | -85.6% | -79.5% | -88.7% | -41.0% |
| 10-Year ReturnCumulative with dividends | -72.7% | -81.6% | -54.2% | -89.1% | +306.1% |
| CAGR (3Y)Annualised 3-year return | +60.8% | -16.0% | -22.1% | -49.9% | +61.9% |
Risk & Volatility
Evenly matched — ABSI and ALIT each lead in 1 of 2 comparable metrics.
Risk & Volatility
ALIT is the less volatile stock with a 1.40 beta — it tends to amplify market swings less than RXRX's 2.99 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ABSI currently trades 94.6% from its 52-week high vs ALIT's 15.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 2.77x | 2.99x | 1.65x | 1.40x | 2.41x |
| 52-Week HighHighest price in past year | $6.24 | $7.18 | $27.63 | $6.11 | $66.00 |
| 52-Week LowLowest price in past year | $2.24 | $2.80 | $10.95 | $0.48 | $23.30 |
| % of 52W HighCurrent price vs 52-week peak | +94.6% | +46.2% | +47.5% | +15.3% | +86.1% |
| RSI (14)Momentum oscillator 0–100 | 77.8 | 44.4 | 62.7 | 61.7 | 54.9 |
| Avg Volume (50D)Average daily shares traded | 4.5M | 12.5M | 1.3M | 33.5M | 1.2M |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: ABSI as "Buy", RXRX as "Hold", SDGR as "Buy", ALIT as "Buy", TWST as "Buy". Consensus price targets imply 300.9% upside for ALIT (target: $4) vs 4.4% for ABSI (target: $6). ALIT is the only dividend payer here at 17.43% yield — a key consideration for income-focused portfolios.
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Hold | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | $6.16 | $11.00 | $18.00 | $3.75 | $60.50 |
| # AnalystsCovering analysts | 12 | 10 | 12 | 10 | 13 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | +17.4% | — |
| Dividend StreakConsecutive years of raises | — | — | — | 2 | — |
| Dividend / ShareAnnual DPS | — | — | — | $0.16 | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | +13.3% | +0.0% |
ALIT leads in 2 of 6 categories (Valuation Metrics, Profitability & Efficiency). TWST leads in 1 (Total Returns). 2 tied.
ABSI vs RXRX vs SDGR vs ALIT vs TWST: Key Questions Answered
9 questions · data-driven answers · updated daily
01Is ABSI or RXRX or SDGR or ALIT or TWST a better buy right now?
For growth investors, Recursion Pharmaceuticals, Inc.
(RXRX) is the stronger pick with 26. 9% revenue growth year-over-year, versus -38. 2% for Absci Corporation (ABSI). Analysts rate Absci Corporation (ABSI) a "Buy" — based on 12 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — ABSI or RXRX or SDGR or ALIT or TWST?
Over the past 5 years, Twist Bioscience Corporation (TWST) delivered a total return of -41.
0%, compared to -88. 7% for Alight, Inc. (ALIT). Over 10 years, the gap is even starker: TWST returned +306. 1% versus ALIT's -89. 1%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — ABSI or RXRX or SDGR or ALIT or TWST?
By beta (market sensitivity over 5 years), Alight, Inc.
(ALIT) is the lower-risk stock at 1. 40β versus Recursion Pharmaceuticals, Inc. 's 2. 99β — meaning RXRX is approximately 114% more volatile than ALIT relative to the S&P 500. On balance sheet safety, Absci Corporation (ABSI) carries a lower debt/equity ratio of 3% versus 192% for Alight, Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — ABSI or RXRX or SDGR or ALIT or TWST?
By revenue growth (latest reported year), Recursion Pharmaceuticals, Inc.
(RXRX) is pulling ahead at 26. 9% versus -38. 2% for Absci Corporation (ABSI). On earnings-per-share growth, the picture is similar: Twist Bioscience Corporation grew EPS 63. 9% year-over-year, compared to -1924. 1% for Alight, Inc.. Over a 3-year CAGR, RXRX leads at 23. 5% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — ABSI or RXRX or SDGR or ALIT or TWST?
Twist Bioscience Corporation (TWST) is the more profitable company, earning -20.
6% net margin versus -41. 1% for Absci Corporation — meaning it keeps -20. 6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ALIT leads at 1. 5% versus -44. 5% for ABSI. At the gross margin level — before operating expenses — SDGR leads at 55. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is ABSI or RXRX or SDGR or ALIT or TWST more undervalued right now?
Analyst consensus price targets imply the most upside for ALIT: 300.
9% to $3. 75.
07Which pays a better dividend — ABSI or RXRX or SDGR or ALIT or TWST?
In this comparison, ALIT (17.
4% yield) pays a dividend. ABSI, RXRX, SDGR, TWST do not pay a meaningful dividend and should not be held primarily for income.
08Is ABSI or RXRX or SDGR or ALIT or TWST better for a retirement portfolio?
For long-horizon retirement investors, Alight, Inc.
(ALIT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (17. 4% yield). Recursion Pharmaceuticals, Inc. (RXRX) carries a higher beta of 2. 99 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (ALIT: -89. 1%, RXRX: -81. 6%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between ABSI and RXRX and SDGR and ALIT and TWST?
These companies operate in different sectors (ABSI (Healthcare) and RXRX (Healthcare) and SDGR (Healthcare) and ALIT (Technology) and TWST (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.
In terms of investment character: ABSI is a small-cap quality compounder stock; RXRX is a small-cap high-growth stock; SDGR is a small-cap high-growth stock; ALIT is a small-cap income-oriented stock; TWST is a small-cap high-growth stock. ALIT pays a dividend while ABSI, RXRX, SDGR, TWST do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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