SEPN vs RXRX

For growth investors, Septerna, Inc.

(SEPN) is the stronger pick with 41. 7% revenue growth year-over-year, versus 26. 9% for Recursion Pharmaceuticals, Inc. (RXRX). Analysts rate Septerna, Inc. (SEPN) a "Buy" — based on 6 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

Over the past 5 years, Septerna, Inc.

(SEPN) delivered a total return of +11. 5%, compared to -85. 6% for Recursion Pharmaceuticals, Inc. (RXRX). Over 10 years, the gap is even starker: SEPN returned +11. 5% versus RXRX's -81. 6%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), Septerna, Inc.

(SEPN) is the lower-risk stock at 1. 24β versus Recursion Pharmaceuticals, Inc. 's 2. 99β — meaning RXRX is approximately 142% more volatile than SEPN relative to the S&P 500. On balance sheet safety, Septerna, Inc. (SEPN) carries a lower debt/equity ratio of 6% versus 7% for Recursion Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.

By revenue growth (latest reported year), Septerna, Inc.

(SEPN) is pulling ahead at 41. 7% versus 26. 9% for Recursion Pharmaceuticals, Inc. (RXRX). On earnings-per-share growth, the picture is similar: Septerna, Inc. grew EPS 84. 8% year-over-year, compared to 14. 8% for Recursion Pharmaceuticals, Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

Septerna, Inc.

(SEPN) is the more profitable company, earning -106. 4% net margin versus -863. 4% for Recursion Pharmaceuticals, Inc. — meaning it keeps -106. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: SEPN leads at -148. 6% versus -867. 9% for RXRX. At the gross margin level — before operating expenses — SEPN leads at 0. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

For long-horizon retirement investors, Septerna, Inc.

(SEPN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 24)). Recursion Pharmaceuticals, Inc. (RXRX) carries a higher beta of 2. 99 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (SEPN: +11. 5%, RXRX: -81. 6%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.