Last 45 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -2.77 | — | — | — | — | — | 18.90 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 55.30 | 234.96 | 76.26 | 39.10 | 47.42 | 59.88 | 3.74 | 144.54 | — | 7.11 | — | — | — |
| — | +292.4% | +1939.1% | -72.9% | — | +742.6% | — | — | — | -100.0% | — | — | — | |
| P/B Ratio | 4.35 | 7.07 | 4.59 | 2.73 | 1.98 | 2.43 | 2.93 | 3.22 | 2.03 | 2.62 | 1.91 | 1.79 | 1.29 |
| — | +191.5% | +56.6% | -15.1% | -2.6% | -7.4% | +53.5% | +80.0% | +57.9% | +159.5% | +37.3% | +26.7% | -13.1% | |
| P/FCF | — | — | — | — | — | 11.65 | — | 1.36 | 94.90 | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | 11.28 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | 15.89 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
AC Immune S.A.'s operating margin was -4124.0% in Q4 2025, down 2402.3 pp QoQ and down 2486.5 pp YoY. This marks the 3rd consecutive quarter of margin compression, signaling a persistent pressure on profitability that investors should monitor. The trailing four-quarter average of -2321.7% exceeds the current quarter, suggesting the latest result may reflect seasonal weakness or a one-off headwind.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | — | 100.0% | — | — | — |
| — | 0.0% | 0.0% | 0.0% | — | 0.0% | — | — | — | +100.0% | — | — | — | |
| Operating Margin | -1927.3% | -4124.0% | -1721.6% | -1484.5% | -1956.6% | -1637.5% | 28.5% | -3051.1% | — | -23.9% | — | — | — |
| — | -151.9% | -6136.0% | +51.3% | — | -6744.4% | — | — | — | +100.0% | — | — | — | |
| Net Margin | -1971.6% | -4220.1% | -1688.8% | -1622.4% | -1922.1% | -1389.4% | 21.6% | -3313.0% | — | -32.1% | — | — | — |
| — | -203.7% | -7921.1% | +51.0% | — | -4234.7% | — | — | — | +100.0% | — | — | — |
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -89.6% | -26.6% | -23.1% | -25.0% | -18.4% | -13.0% | 4.3% | -17.0% | -11.7% | -3.3% | -11.4% | -11.5% | -10.9% |
| — | -103.9% | -632.7% | -47.2% | -57.1% | -293.2% | +138.0% | -47.4% | -7.5% | +68.3% | -66.1% | -22.3% | -28.8% | |
| ROA | -36.6% | -8.7% | -8.8% | -10.6% | -8.6% | -6.6% | 2.3% | -11.2% | -10.2% | -2.9% | -10.1% | -10.3% | -9.9% |
| — | -31.6% | -483.7% | +6.1% | +15.6% | -128.3% | +122.6% | -8.7% | -3.4% | +69.6% | -58.1% | -19.1% | -30.0% | |
| ROIC | -99.2% | -33.7% | -26.0% | -21.7% | -18.0% | -15.3% | 6.2% | -18.9% | -17.0% | -2.9% | -11.7% | -12.8% | -11.1% |
| — | -120.0% | -519.3% | -14.7% | -5.6% | -424.4% | +152.9% | -48.1% | -54.1% | +70.0% | -68.5% | -29.3% | -22.0% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has weakened 40.1% YoY to 1.02x, tightening the short-term liquidity position. Debt/Equity has risen for 6 consecutive quarters, indicating increasing financial leverage that investors should watch closely.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.10 | 0.10 | 0.07 | 0.07 | 0.05 | 0.05 | 0.02 | 0.03 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 |
| — | +109.3% | +215.1% | +151.6% | +137.3% | +122.1% | +24.4% | +44.1% | +32.0% | +31.3% | +45.7% | +40.1% | +34.8% | |
| Debt / EBITDA | — | — | — | — | — | — | 0.40 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 1.02 | 1.02 | 1.16 | 1.33 | 1.53 | 1.71 | 1.86 | 1.80 | 7.78 | 9.22 | 7.36 | 8.89 | 10.38 |
| — | -40.1% | -37.7% | -25.8% | -80.3% | -81.5% | -74.8% | -79.8% | -25.1% | -17.4% | -32.2% | -33.1% | -30.1% | |
| Quick Ratio | 1.02 | 1.02 | 1.16 | 1.33 | 1.53 | 1.71 | 1.86 | 1.80 | 7.78 | 9.22 | 7.36 | 8.89 | 10.38 |
| — | -40.1% | -37.7% | -25.8% | -80.3% | -81.5% | -74.8% | -79.8% | -25.1% | -17.4% | -32.2% | -33.1% | -30.1% | |
| Interest Coverage | -367.83 | -344.75 | — | -422.78 | -351.39 | -525.47 | 167.76 | -668.41 | -495.17 | -181.42 | -581.31 | -622.33 | -179.52 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 45 years · Updated daily
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Quick answers to the most common questions about buying ACIU stock.
AC Immune S.A.'s current P/E is -2.8x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
AC Immune S.A.'s current operating margin is -1927.3%. Margins have been compressing over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking AC Immune S.A.'s business trajectory between earnings reports.