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ACIUAC Immune S.A.
$2.83$288M
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ACIU logo

AC Immune S.A.

ACIU
NASDAQ · Biotechnology
$2.83
At close - Sep 23, 4:00 PM EDT - USD
Market Cap$288M
P/E-3.3x
52W High$4.00
Volume491.47K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2025Q4

Milestone Dependency Drives Persistent Clinical Burn Risk

AC Immune remains a high-risk, clinical-stage biotechnology firm whose financial viability is tethered to the unpredictable timing of non-recurring milestone payments rather than sustainable commercial revenue. While the company maintains a pipeline focused on...

GrowthContracting
ProfitabilityNegative
ValuationReview
TechnicalsNeutral
Explore valuation models
MARKET ACTION

ACIU price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

9/12 Beats

EPS beat 9 of last 12 quarters

02

Valuation risk

-107% Peers

P/E is 107% below peer median

03

Market leadership

RS 50 · Avg

Average momentum (RS Rating: 50)

04

Trend Check

N/A

Trend data unavailable

Next CatalystEstimated earnings · Nov 5

Market performance

Price History →

Trailing total returns as of 9/24/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
ACIU-15.77%
S&P 500 (^GSPC)+12.39%
1-Year Return
ACIU+12.30%
S&P 500 (^GSPC)+15.77%
3-Year Return
ACIU-5.35%
S&P 500 (^GSPC)+81.87%
5-Year Return
ACIU-59.57%
S&P 500 (^GSPC)+72.05%

Growth & profitability

Annual revenue & EPS trend
Revenue
$4M-86.9% YoY
Net income
-$70M-38.4% YoY
Free cash flow
-$67M-202.7% YoY
Operating margin
-1927.3%-1735.5 pts YoY
ROIC (TTM)-99.2%
Avg ROIC 5Y-
ROE (TTM)-89.6%
Piotroski Score2 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate9/12 (75%)
Revenue Beat Rate9/12 (82%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 5, 2026
$0.03+128.7%
vs -$0.10
$15M+58.2%
vs $10M
Q2 2026
Apr 30, 2026
-$0.19+5.0%
vs -$0.20
$1M+325.0%
vs $329,435
Q2 2026
Apr 29, 2026
-$0.19+5.0%
vs -$0.20
$1M+325.0%
vs $329,435
Q2 2026
Mar 13, 2026
-$0.18+5.3%
vs -$0.19
$428,876-70.3%
vs $1M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
GlobeNewsWire·Aug 20, 2026
AC Immune Announces Positive Preliminary Phase 1 Data for NLRP3 Inhibitor ACI-19764

AC Immune announced positive interim Phase 1 results from a first-in-human clinical study evaluating ACI-19764, an NLRP3 inhibitor targeting inflammation.

Zacks Investment Research·Aug 5, 2026
AC Immune (ACIU) Beats Q2 Earnings and Revenue Estimates

AC Immune (ACIU) came out with quarterly earnings of $0.03 per share, beating the Zacks Consensus Estimate of a loss of $0.22 per share. This compares to a loss of $0.25 per share a year ago.

GlobeNewsWire·Aug 5, 2026
AC Immune First Half 2026 Financial and Corporate Update

AC Immune First Half 2026 Financial and Corporate Update Focused portfolio of wholly-owned programs approach near-term clinical catalysts as partnered programs generate milestone payments Key advances across pipeline, with further near-term clinical results anticipated for H2 2026 Phase 2 VacSYn trial of ACI-7104 in Parkinson's disease supported by a $4 million grant from The Vijay and Marie Goradia Charitable Foundation Morphomer small molecule program targeting intracellular Tau progresses with Lilly Initiation of Alzheimer's disease AD4 cohort in ABATE trial triggered $12 million milestone payment from Takeda Cash resources of CHF 75.4 million as of June 30, 2026, provide funding into Q4 2027 Lausanne, Switzerland, August 5, 2026 -- AC Immune SA (NASDAQ: ACIU), a clinical-stage biopharmaceutical company developing targeted therapeutics for neurodegenerative diseases, today provided a corporate and financial update for the half-year ended June 30, 2026. Martin Zügel, MD, interim CEO of AC Immune and Chair of the Board of Directors, commented: “AC Immune is moving towards key clinical milestones in two of our wholly-owned programs, a growing focus for AC Immune.

GlobeNewsWire·Jul 7, 2026
AC Immune to Showcase Neurodegenerative Disease Pipeline with Three Presentations at AAIC® 2026

AC Immune to Showcase Neurodegenerative Disease Pipeline with Three Presentations at AAIC ® 2026 Lausanne, Switzerland, July 7, 2026 -- AC Immune SA (NASDAQ: ACIU), a clinical-stage biopharmaceutical company pioneering precision therapeutics for neurodegenerative diseases, today announces three presentations at the Alzheimer's Association International Conference® 2026, taking place July 12-15 in London, UK. Across these AAIC presentations, we are showing how AC Immune's Morphomer®-based small molecule approach has generated differentiated therapeutic and imaging assets.

Filtered for AC Immune S.A.More Headlines
04

Compare before deciding

Benchmark ACIU against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for AC Immune S.A. (ACIU)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ACIU logoACIUAC Immune S.A.Current
$2.83$288.02M-3.34-86.92%-1971.65%-89.62%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$282.12$7.87B-20.93-100%—-34.15%—
SAVA logoSAVACassava Sciences, Inc.
$0.94$45.26M-1.80——-95.77%—
ANVS logoANVSAnnovis Bio, Inc.
$1.27$54.03M-0.91——-685.96%—
NRXP logoNRXPNRx Pharmaceuticals, Inc.
$3.16$54.62M-2.36—-691.81%——
BIIB logoBIIBBiogen Inc.
$227.53$33.62B25.771.39%8.39%4.52%—

Compare ACIU vs Peers

AC Immune S.A. (ACIU) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs PRAX

Most directly comparable listed peer for ACIU.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ACIU against a more recognizable public peer.

Peer Set

Compare Top 5

vs PRAX, SAVA, ANVS, NRXP

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ACIU Frequently Asked Questions

AC Immune S.A. (ACIU) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is AC Immune S.A.'s revenue?

AC Immune S.A. (ACIU) reported $17.5M in revenue for fiscal year 2025. This represents a 103% increase from $8.6M in 2013.

How fast is AC Immune S.A. growing?

AC Immune S.A. (ACIU) saw revenue decline by 86.9% over the past year.

Is ACIU profitable?

AC Immune S.A. (ACIU) reported a net loss of $43.2M for fiscal year 2025.

Dividend & Returns
What is ACIU's return on equity?

AC Immune S.A. (ACIU) has a return on equity (ROE) of -89.6%. Negative ROE indicates the company is unprofitable.

What is AC Immune S.A.'s free cash flow?

AC Immune S.A. (ACIU) had negative free cash flow of $35.0M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ACIU back in 2013?

Total return calculator · dividends reinvested · 13+ years of data

See returns →