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APLT logoApplied Therapeutics, Inc.(APLT)Earnings, Financials & Key Ratios

APLT•NASDAQ
$0.10
$15M mkt cap·Price updated Apr 24, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutApplied Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops novel products to target cardiovascular disease, galactosemia, and diabetic complications. Its lead product candidate is AT-007 that has completed phase 1/2 for the treatment of galactosemia in healthy volunteers and adults, as well as is in pediatric clinical study for the treatment of galactosemia in kids; for treating sorbitol dehydrogenase deficiency; and for the treatment of phosphomannomutase enzyme-CDG. The company also develops AT-001 that is in phase III clinical trials for treating diabetic cardiomyopathy, as well as for the treatment of diabetic peripheral neuropathy. Its preclinical stage products include AT-003 for the treatment diabetic retinopathy; AT-104, a PI3K inhibitor for treating orphan hematological oncology T Cell Acute Lymphoblastic Leukemia. Applied Therapeutics, Inc. was incorporated in 2016 and is headquartered in New York, New York.Show more
  • Revenue$455K-95.4%
  • EBITDA-$104M-61.6%
  • Net Income-$106M+11.8%
  • EPS (Diluted)-0.76+46.5%
  • Gross Margin-10612.97%-2315.2%
  • EBITDA Margin-22922.64%-3449.5%
  • Operating Margin-22922.86%-3449.5%
  • Net Margin-23214.07%-1837.0%
  • ROE-529.97%
  • Debt/Equity0.05
Technical→

APLT Key Insights

Applied Therapeutics, Inc. (APLT) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Trading at only 0.3x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 3/9
  • ✗Negative free cash flow
  • ✗Weak momentum: RS Rating 6 (bottom 6%)
  • ✗Shares diluted 65.6% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

APLT Price & Volume

Applied Therapeutics, Inc. (APLT) stock price & volume — 10-year historical chart

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APLT Growth Metrics

Applied Therapeutics, Inc. (APLT) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM573.93%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM90.32%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM93.64%

Return on Capital

10 Years-221.43%
5 Years-257.99%
3 Years-363.62%
Last Year-484.59%

APLT Peer Comparison

Applied Therapeutics, Inc. (APLT) competitors in Commercial Rare Disease Biopharma — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.55B25.93-4.4520.13%-91.03%-6.08%
FOLD logoFOLDAmicus Therapeutics, Inc.Direct Competitor4.47B14.49-80.5032.29%-2.35%-6.1%2.29
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.68B21.489.3811.87%36.49%41.9%0.04
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor5.52B66.618.56114.51%39.44%
KRYS logoKRYSKrystal Biotech, Inc.Direct Competitor8.52B288.9042.2433.94%53.92%19.25%0.01
RCKT logoRCKTRocket Pharmaceuticals, Inc.Direct Competitor418.11M3.86-1.92-80.49%0.09
MDGL logoMDGLMadrigal Pharmaceuticals, Inc.Product Competitor12.38B539.73-42.00432.05%-27.32%-50.15%0.59
BEAM logoBEAMBeam Therapeutics Inc.Product Competitor3.32B32.33-39.92120.01%-57.24%-7.31%0.24

Compare APLT vs Peers

Applied Therapeutics, Inc. (APLT) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RARE

Most directly comparable listed peer for APLT.

Scale Benchmark

vs ALNY

Larger-name benchmark to compare APLT against a more recognizable public peer.

Peer Set

Compare Top 5

vs RARE, FOLD, ACAD, PTCT

APLT Income Statement

Applied Therapeutics, Inc. (APLT) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Sales/Revenue0000009.99M455K1M
Revenue Growth %--------95.45%573.93%
Cost of Goods Sold0023K00441K53.91M48.74M29.45M
COGS % of Revenue------539.43%10712.97%-
Gross Profit
0▲ 0%
0▲ 0%
-23K▲ 0%
0▲ 100.0%
0▲ 0%
-441K▲ 0%
-43.91M▼ 9857.4%
-48.29M▼ 10.0%
-28.45M▲ 0%
Gross Margin %-------439.43%-10612.97%-2845.5%
Gross Profit Growth %---100%---9857.37%-9.97%-
Operating Expenses4.29M13.52M45.56M94.47M105.62M82.51M20.62M56.01M69.95M
OpEx % of Revenue------206.37%12309.89%-
Selling, General & Admin582K2.05M13.21M32.68M43.05M27.32M20.62M56.01M61.56M
SG&A % of Revenue------206.37%12309.89%-
Research & Development3.7M11.47M32.35M61.79M62.57M55.63M53.91M48.74M39.06M
R&D % of Revenue------539.43%10712.97%-
Other Operating Expenses00010-441K-53.91M-48.74M-4M
Operating Income
-4.29M▲ 0%
-13.52M▼ 215.5%
-45.58M▼ 237.2%
-94.47M▼ 107.2%
-105.62M▼ 11.8%
-82.95M▲ 21.5%
-64.53M▲ 22.2%
-104.3M▼ 61.6%
-98.4M▲ 0%
Operating Margin %-------645.8%-22922.86%-9840.3%
Operating Income Growth %--215.47%-237.19%-107.24%-11.81%21.46%22.2%-61.62%-
EBITDA00-45.56M-94.47M-105.62M-82.51M-64.53M-104.3M-98.29M
EBITDA Margin %-------645.79%-22922.64%-9829.13%
EBITDA Growth %----107.35%-11.8%21.88%21.79%-61.62%-6.78%
D&A (Non-Cash Add-back)4.29M13.52M23K01.33K441K1K1K111.75K
EBIT-4.28M-14.88M-45.51M-94.47M-105.62M-82.51M-64.53M-104.3M-100.64M
Net Interest Income00000685K1.37M3.53M2.09M
Interest Income0093K559K555K685K1.37M3.53M2.09M
Interest Expense0093K559K555K0000
Other Income/Expense3K-3M69K505K34K442K-55.23M-1.32M80.27M
Pretax Income
-4.28M▲ 0%
-16.52M▼ 285.8%
-45.51M▼ 175.5%
-93.96M▼ 106.4%
-105.58M▼ 12.4%
-82.51M▲ 21.9%
-119.76M▼ 45.2%
-105.62M▲ 11.8%
-18.14M▲ 0%
Pretax Margin %-------1198.47%-23214.07%-1813.8%
Income Tax000000000
Effective Tax Rate %0%0%0%0%0%0%0%0%0%
Net Income
-4.28M▲ 0%
-16.52M▼ 285.8%
-45.51M▼ 175.5%
-93.96M▼ 106.4%
-105.58M▼ 12.4%
-82.51M▲ 21.9%
-119.76M▼ 45.2%
-105.62M▲ 11.8%
-18.14M▲ 0%
Net Margin %-------1198.47%-23214.07%-1813.8%
Net Income Growth %--285.82%-175.49%-106.45%-12.37%21.86%-45.15%11.81%90.32%
Net Income (Continuing)-4.28M-16.52M-45.51M-93.96M-105.58M-82.51M-119.76M-105.62M-18.14M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-0.47▲ 0%
-1.80▼ 283.0%
-3.55▼ 97.2%
-4.28▼ 20.6%
-4.12▲ 3.7%
-2.18▲ 47.1%
-1.42▲ 34.9%
-0.76▲ 46.5%
-0.12▲ 0%
EPS Growth %--282.98%-97.22%-20.56%3.74%47.09%34.86%46.48%93.64%
EPS (Basic)-0.47-1.80-3.55-4.28-4.12-2.18-1.42-0.76-
Diluted Shares Outstanding9.16M9.16M12.83M21.97M25.6M37.83M84.24M139.53M145.56M
Basic Shares Outstanding9.16M9.16M12.83M21.97M25.6M37.83M84.24M139.53M145.56M
Dividend Payout Ratio---------

APLT Balance Sheet

Applied Therapeutics, Inc. (APLT) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Total Current Assets3.29M20.25M46.16M102.59M88.39M37.31M54.39M83.65M31.65M
Cash & Short-Term Investments3.28M18.75M38.85M96.83M80.82M30.58M49.9M79.4M11.95M
Cash Only3.28M18.75M18.85M57.47M53.89M16.66M49.9M79.4M11.95M
Short-Term Investments0020M39.36M26.93M13.92M000
Accounts Receivable000505K0275K285K016.65M
Days Sales Outstanding------10.41-1.52K
Inventory0000003.28M00
Days Inventory Outstanding------22.23--
Other Current Assets0388K5.87M1.74M5.01M1.8M-434K461K255K
Total Non-Current Assets002.23M1.91M1.5M1.05M447K3.04M2.72M
Property, Plant & Equipment002.04M1.91M1.3M1.05M447K2.79M2.47M
Fixed Asset Turnover------22.36x0.16x0.38x
Goodwill000000000
Intangible Assets000000000
Long-Term Investments000000000
Other Non-Current Assets00199K0200K00253K1.01M
Total Assets
3.29M▲ 0%
20.25M▲ 516.1%
48.39M▲ 139.0%
104.51M▲ 116.0%
89.89M▼ 14.0%
38.36M▼ 57.3%
54.83M▲ 42.9%
86.69M▲ 58.1%
34.37M▲ 0%
Asset Turnover------0.18x0.01x0.02x
Asset Growth %-516.13%139.01%115.97%-13.98%-57.32%42.93%58.1%-142.79%
Total Current Liabilities993K4.43M14.1M21.23M26.46M33.42M71.18M27.3M32.9M
Accounts Payable713K3.02M8.79M640K9.46M4.53M1.74M4.43M4.8M
Days Payables Outstanding--139.54K--3.75K11.833.1958.74
Short-Term Debt0001.07M789K622K310K00
Deferred Revenue (Current)000000667K212K848K
Other Current Liabilities0110K264K2.66M987K25.49M56.17M6.92M7.76M
Current Ratio3.31x4.57x3.27x4.83x3.34x1.12x0.76x3.06x3.06x
Quick Ratio3.31x4.57x3.27x4.83x3.34x1.12x0.72x3.06x3.06x
Cash Conversion Cycle------20.84-1.46K
Total Non-Current Liabilities6.25M01.68M1.33M891K878K797K2.39M2.03M
Long-Term Debt00000464K000
Capital Lease Obligations001.68M1.33M891K414K38K2.39M8.85M
Deferred Tax Liabilities000000000
Other Non-Current Liabilities6.25M00000759K00
Total Liabilities7.25M4.43M15.78M22.57M27.35M34.3M71.98M29.68M34.94M
Total Debt002.04M2.81M2.12M1.98M777K2.79M2.5M
Net Debt-3.28M-18.75M-16.81M-54.65M-51.77M-14.68M-49.12M-76.6M-9.45M
Debt / Equity--0.06x0.03x0.03x0.49x-0.05x0.05x
Debt / EBITDA---------0.03x
Net Debt / EBITDA--------0.10x
Interest Coverage---490.13x-168.99x-190.30x----
Total Equity
-3.96M▲ 0%
15.82M▲ 499.3%
32.61M▲ 106.1%
81.94M▲ 151.3%
62.54M▼ 23.7%
4.06M▼ 93.5%
-17.15M▼ 522.2%
57.01M▲ 432.5%
-561K▲ 0%
Equity Growth %-499.34%106.14%151.29%-23.68%-93.51%-522.21%432.47%201.53%
Book Value per Share-0.431.732.543.732.440.11-0.200.41-0.00
Total Shareholders' Equity-3.96M15.82M32.61M81.94M62.54M4.06M-17.15M57.01M-561K
Common Stock001K2K3K5K8K35K35K
Retained Earnings-4.74M-21.26M-66.77M-160.73M-266.31M-348.82M-468.59M-574.21M-636.36M
Treasury Stock000000000
Accumulated OCI00-2K-112K-107K51K000
Minority Interest000000000

APLT Cash Flow Statement

Applied Therapeutics, Inc. (APLT) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Cash from Operations-3.19M-11.18M-36.31M-78.21M-90.73M-78.09M-55.17M-84.31M-84.31M
Operating CF Margin %-------552.12%-18528.57%-
Operating CF Growth %--249.98%-224.69%-115.41%-16.01%13.93%29.35%-52.8%-34.81%
Net Income-4.28M-16.52M-45.51M-93.96M-105.58M-82.51M-119.76M-105.62M-18.14M
Depreciation & Amortization0023K380K415K443K354K425K405K
Stock-Based Compensation32K272K6.17M011.18M9.6M7.36M13.47M11.84M
Deferred Taxes000000000
Other Non-Cash Items486K3M-218K10.22M-404K3.21M58.32M4.91M-78.61M
Working Capital Changes569K2.06M3.23M5.15M3.67M-8.84M-1.44M2.52M-2.33M
Change in Receivables000000000
Change in Inventory000000000
Change in Payables499K2.3M5.75M-8.04M8.82M-4.93M-2.79M2.69M1.89M
Cash from Investing00-20.01M-19.47M12.43M13.17M13.87M00
Capital Expenditures000000000
CapEx % of Revenue---------
Acquisitions000000000
Investments---------
Other Investing000000000
Cash from Financing6.47M26.65M56.41M136.29M74.72M27.69M74.54M113.81M-75K
Debt Issued (Net)05.56M0-2.15M-4.72M-3.27M-1.86M-311K0
Equity Issued (Net)1000K1000K1000K1000K1000K1000K1000K1000K-1K
Dividends Paid000000000
Share Repurchases00-2.5M000000
Other Financing0-72K-2.27M2.73M5.01M3.15M11.89M9.37M-74K
Net Change in Cash
3.27M▲ 0%
15.47M▲ 372.4%
102K▼ 99.3%
38.62M▲ 37758.8%
-3.58M▼ 109.3%
-37.23M▼ 940.6%
33.24M▲ 189.3%
29.5M▼ 11.3%
-86.92M▲ 0%
Free Cash Flow
-3.19M▲ 0%
-11.18M▼ 250.0%
-36.31M▼ 224.7%
-78.21M▼ 115.4%
-90.73M▼ 16.0%
-78.09M▲ 13.9%
-55.17M▲ 29.3%
-84.31M▼ 52.8%
-86.85M▲ 0%
FCF Margin %-------552.12%-18528.57%-8684.7%
FCF Growth %--249.98%-224.69%-115.41%-16.01%13.93%29.35%-52.8%-6.12%
FCF per Share-0.35-1.22-2.83-3.56-3.54-2.06-0.65-0.60-0.60
FCF Conversion (FCF/Net Income)0.75x0.68x0.80x0.83x0.86x0.95x0.46x0.80x4.79x
Interest Paid000000000
Taxes Paid000000000

APLT Key Ratios

Applied Therapeutics, Inc. (APLT) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2018201920202021202220232024TTM
Return on Equity (ROE)-278.67%-187.97%-164.06%-146.16%-247.77%--529.97%-65.63%
Return on Invested Capital (ROIC)--531.42%-328.91%-416.28%-80795.45%--574.58%
Gross Margin------439.43%-10612.97%-2845.5%
Net Margin------1198.47%-23214.07%-1813.8%
Debt / Equity-0.06x0.03x0.03x0.49x-0.05x0.05x
Interest Coverage--490.13x-168.99x-190.30x----
FCF Conversion0.68x0.80x0.83x0.86x0.95x0.46x0.80x4.79x
Revenue Growth-------95.45%573.93%

APLT Frequently Asked Questions

Applied Therapeutics, Inc. (APLT) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Applied Therapeutics, Inc. (APLT) reported $1.0M in revenue for fiscal year 2024.

Applied Therapeutics, Inc. (APLT) saw revenue decline by 95.4% over the past year.

Applied Therapeutics, Inc. (APLT) reported a net loss of $18.1M for fiscal year 2024.

Dividend & Returns

Applied Therapeutics, Inc. (APLT) has a return on equity (ROE) of -530.0%. Negative ROE indicates the company is unprofitable.

Applied Therapeutics, Inc. (APLT) had negative free cash flow of $86.8M in fiscal year 2024, likely due to heavy capital investments.

Explore More APLT

Applied Therapeutics, Inc. (APLT) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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