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KRYSKrystal Biotech, Inc.
$348.06$10.3B
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KRYS logoKrystal Biotech, Inc.(KRYS)Earnings, Financials & Key Ratios

KRYS•NASDAQ
50.9× P/E·Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutKrystal Biotech, Inc., a clinical stage biotechnology company, engages in the field of redosable gene therapy to treat serious rare diseases in the United States. Its lead product candidate is beremagene geperpavec (B-VEC), which is in Phase III clinical study to treat dystrophic epidermolysis bullosa. The company is also involved in developing KB105 that is in Phase I/II clinical study for treating patients with deficient autosomal recessive congenital ichthyosis; KB301, which is in Phase I/II clinical stage for treating wrinkles and other presentations of aged or damaged skin; KB407 that is in preclinical stage for cystic fibrosis; and KB104, which is in preclinical stage for netherton syndrome. Its discovery stage product candidates include KB5xx for treating chronic skin diseases, KB3xx to treat aesthetic skin conditions, and KB3xx product. Krystal Biotech, Inc. was founded in 2015 and is headquartered in Pittsburgh, Pennsylvania.Show more
  • Revenue$389M+33.9%
  • EBITDA$168M+131.8%
  • Net Income$205M+129.7%
  • EPS (Diluted)6.84+128.0%
  • Gross Margin92.61%-0.5%
  • EBITDA Margin43.13%+73.1%
  • Operating Margin41.45%+83.3%
  • Net Margin52.64%+71.5%
  • ROE18.91%+83.0%

KRYS Key Insights

Krystal Biotech, Inc. (KRYS) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓FCF machine: 48.5% free cash flow margin
  • ✓Momentum leader: RS Rating 89 (top 11%)
  • ✓Healthy 5Y average net margin of 35.0%
  • ✓Trading near 52-week high

✗Weaknesses

  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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KRYS Price & Volume

Krystal Biotech, Inc. (KRYS) stock price & volume — 10-year historical chart

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KRYS Growth Metrics

Krystal Biotech, Inc. (KRYS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM25.15%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM81.53%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM79.81%

Return on Capital

10 Years-14.89%
5 Years-7.06%
3 Years1.88%
Last Year14.77%

KRYS Recent Earnings

Krystal Biotech, Inc. (KRYS) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 5/12 qtrs (45%)
Q2 2026Latest
May 4, 2026
Metric
Actual
Est
EPS
$1.83+26.2%
$1.45
Rev
$116M+3.8%
$112M
Q1 2026
Feb 17, 2026
Metric
Actual
Est
EPS
$1.70+4.9%
$1.62
Rev
$107M+1.7%
$105M
Q4 2025
Nov 3, 2025
Metric
Actual
Est
EPS
$2.66+137.5%
$1.12
Rev
$98M-7.1%
$105M
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$1.29+19.4%
$1.08
Rev
$96M+0.7%
$95M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 4, 2026
$1.83vs $1.45+26.2%
$116Mvs $112M+3.8%
Q1 2026Feb 17, 2026
$1.70vs $1.62+4.9%
$107Mvs $105M+1.7%
Q4 2025Nov 3, 2025
$2.66vs $1.12+137.5%
$98Mvs $105M-7.1%
Q3 2025Aug 4, 2025
$1.29vs $1.08+19.4%
$96Mvs $95M+0.7%
Based on last 12 quarters of dataView full earnings history →

KRYS Peer Comparison

Krystal Biotech, Inc. (KRYS) competitors in Cell and Gene Therapy Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RCKT logoRCKTRocket Pharmaceuticals, Inc.Direct Competitor365.8M3.35-1.67-70.79%0.09
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.7B27.44-4.7120.13%-91.03%-6.08%
FOLD logoFOLDAmicus Therapeutics, Inc.Direct Competitor4.55B14.49-164.8520.05%-4.27%-12.02%1.76
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor6.55B78.9810.15114.51%-22.58%
SRPT logoSRPTSarepta Therapeutics, Inc.Direct Competitor1.85B17.53-2.4615.58%2.98%4.89%0.91
CRSP logoCRSPCRISPR Therapeutics AGProduct Competitor5.22B54.09-8.36-89.97%-138.57%-30.88%0.21
EDIT logoEDITEditas Medicine, Inc.Product Competitor263.37M2.69-1.4925.39%-281.59%-6.77%2.81

Compare KRYS vs Peers

Krystal Biotech, Inc. (KRYS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RCKT

Most directly comparable listed peer for KRYS.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare KRYS against a more recognizable public peer.

Peer Set

Compare Top 5

vs RCKT, RARE, FOLD, ACAD

KRYS Income Statement

Krystal Biotech, Inc. (KRYS) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
01.03M000050.7M290.51M389.13M417.3M
Revenue Growth %
---100%----473.02%33.94%25.15%
Cost of Goods Sold
23K141K974K1.85M003.09M20.06M28.77M30.07M
COGS % of Revenue
-13.73%----6.1%6.91%7.39%-
Gross Profit
-23K▲ 0%
886K▲ 3952.2%
-974K▼ 209.9%
-1.85M▼ 90.0%
0▲ 100.0%
0▲ 0%
47.6M▲ 0%
270.45M▲ 468.1%
360.36M▲ 33.2%
387.24M▲ 0%
Gross Margin %
-86.27%----93.9%93.09%92.61%92.79%
Gross Profit Growth %
-1050%3952.17%-209.93%-90.04%100%--468.12%33.24%-
Operating Expenses
4.77M11.92M22.08M31.15M68.28M145.2M157.33M204.76M199.06M208.43M
OpEx % of Revenue
-1160.27%----310.33%70.48%51.16%-
Selling, General & Admin
1.56M4.16M6.46M13.21M40.39M77.73M98.4M113.69M146.74M155.03M
SG&A % of Revenue
-404.58%----194.09%39.13%37.71%-
Research & Development
3.21M7.76M15.62M17.94M27.88M42.46M46.43M53.57M58.05M59.12M
R&D % of Revenue
-755.7%----91.58%18.44%14.92%-
Other Operating Expenses
0000025M12.5M37.5M-5.72M-1000K
Operating Income
-4.77M▲ 0%
-11.92M▼ 149.7%
-22.08M▼ 85.3%
-33M▼ 49.4%
-68.28M▼ 106.9%
-145.2M▼ 112.7%
-109.73M▲ 24.4%
65.69M▲ 159.9%
161.29M▲ 145.5%
178.81M▲ 0%
Operating Margin %
--1160.27%-----216.43%22.61%41.45%42.85%
Operating Income Growth %
-317.5%-149.71%-85.31%-49.45%-106.9%-112.66%24.43%159.87%145.52%-
EBITDA
-4.75M-11.78M-21.11M-31.15M-66.43M-141.81M-103.82M72.41M167.85M185.45M
EBITDA Margin %
--1146.54%-----204.77%24.92%43.13%44.44%
EBITDA Growth %
-316.21%-147.95%-79.25%-47.57%-113.26%-113.49%26.79%169.75%131.8%60.85%
D&A (Non-Cash Add-back)
23K141K974K1.85M1.85M3.38M5.91M6.71M6.55M6.64M
EBIT
-4.66M-10.89M-19.09M-32.17M-68.08M-120.2M-97.23M103.19M161.29M178.81M
Net Interest Income
002.99M832K-1.29M5.22M22.62M29.66M28.18M0
Interest Income
002.99M832K197K5.22M22.62M29.66M28.18M0
Interest Expense
3.15M1.03M001.49M00000
Other Income/Expense
-3.15M1.03M2.99M832K-1.29M5.22M122.62M29.66M28.18M28.51M
Pretax Income
-7.92M▲ 0%
-10.89M▼ 37.5%
-19.09M▼ 75.3%
-32.17M▼ 68.5%
-69.57M▼ 116.3%
-139.97M▼ 101.2%
12.9M▲ 109.2%
95.36M▲ 639.4%
189.47M▲ 98.7%
207.32M▲ 0%
Pretax Margin %
--1060.27%----25.44%32.82%48.69%49.68%
Income Tax
0-20.14K00001.97M6.2M-15.36M-17.71M
Effective Tax Rate %
0%0.18%0%0%0%0%15.24%6.5%-8.11%-8.54%
Net Income
-7.92M▲ 0%
-10.89M▼ 37.5%
-19.09M▼ 75.3%
-32.17M▼ 68.5%
-69.57M▼ 116.3%
-139.97M▼ 101.2%
10.93M▲ 107.8%
89.16M▲ 715.6%
204.83M▲ 129.7%
225.03M▲ 0%
Net Margin %
--1060.27%----21.56%30.69%52.64%53.92%
Net Income Growth %
-588.7%-37.49%-75.3%-68.52%-116.28%-101.2%107.81%715.58%129.74%81.53%
Net Income (Continuing)
-7.92M-10.89M-19.09M-32.17M-69.57M-139.97M10.93M89.16M204.83M225.03M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-1.48▲ 0%
-0.97▲ 34.5%
-1.20▼ 23.7%
-1.71▼ 42.5%
-3.13▼ 83.0%
-5.49▼ 75.4%
0.39▲ 107.1%
3.00▲ 669.2%
6.84▲ 128.0%
7.38▲ 0%
EPS Growth %
-448.15%34.46%-23.71%-42.5%-83.04%-75.4%107.1%669.23%128%79.81%
EPS (Basic)
-1.48-0.97-1.20-1.71-3.13-5.490.403.127.08-
Diluted Shares Outstanding
5.36M11.2M15.9M18.79M22.2M25.49M27.75M29.74M29.95M30.51M
Basic Shares Outstanding
5.36M11.2M15.9M18.79M22.2M25.49M27.15M28.59M28.94M29.29M
Dividend Payout Ratio
----------

KRYS Balance Sheet

Krystal Biotech, Inc. (KRYS) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
49.91M112.65M195.88M275.06M442.27M383.78M587.91M742.04M1.02B1.02B
Cash & Short-Term Investments
49.59M111.76M193.69M271.26M438.1M379.17M532.18M597.52M827.79M823.4M
Cash Only
49.59M103.67M187.51M268.27M341.25M161.9M358.33M344.87M496.3M501.31M
Short-Term Investments
08.09M6.17M2.99M96.85M217.27M173.85M252.65M331.49M322.09M
Accounts Receivable
00000042.04M104.75M127.42M127.02M
Days Sales Outstanding
------302.66131.6119.52108.35
Inventory
0000006.99M26.51M40.48M42.65M
Days Inventory Outstanding
------824.02482.3513.45460.66
Other Current Assets
000004.61M6.71M13.27M28.91M26.67M
Total Non-Current Assets
200K3.47M13.14M35.79M184.03M174.67M230.45M313.79M309.19M377.23M
Property, Plant & Equipment
200K3.01M11.18M34.17M119.58M169.73M168.23M161.45M158.01M160.62M
Fixed Asset Turnover
-0.34x----0.30x1.80x2.46x2.64x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
00497K064.37M4.62M61.95M152.11M128.07M593.47M
Other Non-Current Assets
0452K1.46M1.61M74K324K263K231K287K300K
Total Assets
50.11M▲ 0%
116.12M▲ 131.7%
209.02M▲ 80.0%
310.84M▲ 48.7%
626.29M▲ 101.5%
558.45M▼ 10.8%
818.36M▲ 46.5%
1.06B▲ 29.0%
1.33B▲ 26.3%
1.4B▲ 0%
Asset Turnover
-0.01x----0.06x0.28x0.29x0.33x
Asset Growth %
2196.7%131.7%80.01%48.71%101.48%-10.83%46.54%29.02%26.33%106.64%
Total Current Liabilities
640K2.6M3.33M15.45M25.74M28.85M33.09M102M102.94M107.8M
Accounts Payable
193K888K1.02M2.1M8.4M3.98M1.85M4.99M3.24M4.09M
Days Payables Outstanding
3.06K2.3K382.61415.09--218.1390.741.0850.22
Short-Term Debt
0000000001.8M
Deferred Revenue (Current)
0000000000
Other Current Liabilities
437K1.36M12K26K87K267K16.75M2.4M97.93M101.91M
Current Ratio
77.99x43.39x58.88x17.80x17.18x13.30x17.76x7.28x9.95x9.46x
Quick Ratio
77.99x43.39x58.88x17.80x17.18x13.30x17.55x7.02x9.56x9.06x
Cash Conversion Cycle
------908.56523.2591.89518.8
Total Non-Current Liabilities
0294K2.78M3.31M6.98M7.37M6.62M7.46M11.29M12.44M
Long-Term Debt
0000000000
Capital Lease Obligations
002.78M3.31M6.98M7.37M6.62M6.04M7.57M23.45M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
0294K000001.42M3.72M12.44M
Total Liabilities
640K2.89M6.11M18.76M32.72M36.22M39.71M109.46M114.23M120.24M
Total Debt
003.26M11.55M8.02M8.93M8.09M7.26M9.34M1.8M
Net Debt
-49.59M-103.67M-184.25M-256.72M-333.22M-152.97M-350.23M-337.6M-486.96M-499.51M
Debt / Equity
--0.02x0.04x0.01x0.02x0.01x0.01x0.01x0.00x
Debt / EBITDA
-------0.10x0.06x0.01x
Net Debt / EBITDA
--------4.66x-2.90x-2.69x
Interest Coverage
-1.48x-10.60x---45.63x-----
Total Equity
49.47M▲ 0%
113.23M▲ 128.9%
202.91M▲ 79.2%
292.08M▲ 43.9%
593.58M▲ 103.2%
522.23M▼ 12.0%
778.64M▲ 49.1%
946.38M▲ 21.5%
1.22B▲ 28.9%
1.28B▲ 0%
Equity Growth %
17019.03%128.86%79.21%43.94%103.22%-12.02%49.1%21.54%28.87%111.03%
Book Value per Share
9.2310.1112.7615.5526.7420.4928.0631.8240.7241.85
Total Shareholders' Equity
49.47M113.23M202.91M292.08M593.58M522.23M778.64M946.38M1.22B1.28B
Common Stock
0000000000
Retained Earnings
-9.07M-19.96M-39.05M-71.21M-140.78M-280.76M-269.83M-180.67M24.16M80.09M
Treasury Stock
0000000000
Accumulated OCI
-25K2K10K6K-163K-728K638K-190K1.14M-1.62M
Minority Interest
0000000000

KRYS Cash Flow Statement

Krystal Biotech, Inc. (KRYS) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-3.89M-9.45M-18.71M-26.08M-47.94M-100.57M-88.8M123.42M200.87M250.28M
Operating CF Margin %
--919.67%-----175.16%42.48%51.62%-
Operating CF Growth %
-196.72%-142.8%-98.13%-39.38%-83.79%-109.79%11.7%238.98%62.75%1538.71%
Net Income
-7.92M-10.89M-19.09M-32.17M-69.57M-139.97M10.93M89.16M204.83M225.03M
Depreciation & Amortization
23K141K748K1.85M2.77M4.05M5.01M6.71M6.55M6.44M
Stock-Based Compensation
246K792K1.24M3.27M15.32M33.23M39.93M49.13M54.51M27.73M
Deferred Taxes
00000000-22.84M-22.84M
Other Non-Cash Items
3.26M962K67K33K1.49M-690K-106.79M-7.12M-5.77M17.8M
Working Capital Changes
498K511K-1.68M928K2.05M2.81M-37.88M-14.46M-36.42M-3.87M
Change in Receivables
000000-42.04M-62.71M-22.12M-23.55M
Change in Inventory
000000-4.47M-11.91M-6.29M-5.13M
Change in Payables
133K112K-199K783K712K-1.25M-101K1.01M826K942K
Cash from Investing
-210K-10.32M-4.97M-11.18M-226.77M-114.08M82.64M-163.44M-58.42M-67.23M
Capital Expenditures
-210K-2.23M-6.4M-14.84M-68.34M-52.98M-11.8M-4.24M-11.95M-12.89M
CapEx % of Revenue
-217.53%----23.27%1.46%3.07%3.09%
Acquisitions
00000000435K0
Investments
----------
Other Investing
000000100M000
Cash from Financing
51.77M73.85M107.53M118.02M347.69M35.35M202.75M27.01M8.71M10.71M
Debt Issued (Net)
2.3M000000000
Equity Issued (Net)
49.47M73.85M107.53M118.02M355.64M36M203.5M32.4M22.66M10.74M
Dividends Paid
0000000000
Share Repurchases
000000000-16.96M
Other Financing
0000-7.96M-649K-749K-5.39M-13.96M-28K
Net Change in Cash
47.67M▲ 0%
54.08M▲ 13.4%
83.84M▲ 55.0%
80.75M▼ 3.7%
72.98M▼ 9.6%
-179.35M▼ 345.8%
196.43M▲ 209.5%
-13.46M▼ 106.9%
151.44M▲ 1224.9%
192.54M▲ 0%
Free Cash Flow
-4.1M▲ 0%
-11.68M▼ 184.9%
-25.11M▼ 115.0%
-40.93M▼ 63.0%
-116.27M▼ 184.1%
-153.55M▼ 32.1%
-100.6M▲ 34.5%
119.18M▲ 218.5%
188.91M▲ 58.5%
237.38M▲ 0%
FCF Margin %
--1137.2%-----198.43%41.02%48.55%56.88%
FCF Growth %
-209.2%-184.85%-115.02%-62.97%-184.11%-32.06%34.48%218.47%58.51%83.56%
FCF per Share
-0.76-1.04-1.58-2.18-5.24-6.02-3.634.016.317.78
FCF Conversion (FCF/Net Income)
0.49x0.87x0.98x0.81x0.69x0.72x-8.12x1.38x0.98x1.05x
Interest Paid
0000000000
Taxes Paid
00000005.67M013.48M

KRYS Key Ratios

Krystal Biotech, Inc. (KRYS) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-31.83%-13.39%-12.08%-13%-15.71%-25.09%1.68%10.34%18.91%19.25%
Return on Invested Capital (ROIC)
-7780.43%-189.36%-117.38%-91.62%-34.63%-34.59%-20.63%9.5%18.04%18.12%
Gross Margin
-86.27%----93.9%93.09%92.61%92.79%
Net Margin
--1060.27%----21.56%30.69%52.64%53.92%
Debt / Equity
--0.02x0.04x0.01x0.02x0.01x0.01x0.01x0.00x
Interest Coverage
-1.48x-10.60x---45.63x-----
FCF Conversion
0.49x0.87x0.98x0.81x0.69x0.72x-8.12x1.38x0.98x1.05x
Revenue Growth
---100%----473.02%33.94%25.15%
Related:KRYS Dividend History·KRYS Revenue History·KRYS Price History·KRYS P/E History·KRYS Financial Ratios·KRYS Institutional Holders

KRYS SEC Filings & Documents

Krystal Biotech, Inc. (KRYS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 4, 2026·SEC

Material company update

Feb 17, 2026·SEC

Material company update

Jan 12, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 17, 2026·SEC

FY 2025

Feb 19, 2025·SEC

FY 2024

Feb 26, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 4, 2026·SEC

FY 2025

Nov 3, 2025·SEC

FY 2025

Aug 4, 2025·SEC

KRYS Frequently Asked Questions

Krystal Biotech, Inc. (KRYS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Krystal Biotech, Inc. (KRYS) reported $417.3M in revenue for fiscal year 2025.

Krystal Biotech, Inc. (KRYS) grew revenue by 33.9% over the past year. This is strong growth.

Yes, Krystal Biotech, Inc. (KRYS) is profitable, generating $225.0M in net income for fiscal year 2025 (52.6% net margin).

Dividend & Returns

Krystal Biotech, Inc. (KRYS) has a return on equity (ROE) of 18.9%. This is reasonable for most industries.

Krystal Biotech, Inc. (KRYS) generated $237.4M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in KRYS back in 2016?

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How much would $100/month in KRYS be worth today?

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