Revenue rose to $275.4M in 2026Q3 with gross margin of 66.2%, but operating margin compressed to 7.0% as SG&A climbed to $129.1M, leaving operating income of only $19.3M despite strong top-line expansion.
Caris Life Sciences, Inc. (CAI) annual income statement — 22-year revenue, gross profit & net income history
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 |
|---|
| Sales/Revenue | 1.05B | 812.03M | 412.26M | 306.13M | 258.49M | 294.01M | 416.54M | 432.1M | 348.39M | 294.35M | 249.67M | 227.59M | 212.41M | 173.93M | 125.71M | 77.9M | 65.26M | 83.14M | 64.87M | 18.61M | 61.59M | 66.69M | 48.08M |
| Revenue Growth % | 61.48% | 96.97% | 34.67% | 18.43% | -12.08% | -29.42% | -3.6% | 24.03% | 18.36% | 17.9% | 9.7% | 7.15% | 22.12% | 38.36% | 61.37% | 19.36% | -21.51% | 28.17% | 248.57% | -69.78% | -7.65% | 38.69% | - |
| Cost of Goods Sold | 323.99M | 272.87M | 233.48M | 216.82M | 178.46M | 109.86M | 216.03M | 218.47M | 179.11M | 156.86M | 123.76M | 77.98M | 67.11M | 48.35M | 5.51M | 6.17M | 8.72M | 4.87M | 4.04M | 1.17M | 0 | 0 | 0 |
| COGS % of Revenue | - | 33.6% | 56.63% | 70.83% | 69.04% | 37.36% | 51.86% | 50.56% | 51.41% | 53.29% | 49.57% | 34.26% | 31.59% | 27.8% | 4.39% | 7.92% | 13.36% | 5.86% | 6.22% | 6.31% | - | - | - |
| Gross Profit | 724.14M | 539.17M | 178.78M | 89.31M | 80.02M | 184.16M | 200.51M | 213.63M | 169.29M | 137.5M | 125.91M | 149.61M | 145.3M | 125.57M | 120.19M | 71.73M | 56.55M | 78.27M | 60.83M | 17.44M | 61.59M | 66.69M | 48.08M |
| Gross Margin % | 69.09% | 66.4% | 43.37% | 29.17% | 30.96% | 62.64% | 48.14% | 49.44% | 48.59% | 46.71% | 50.43% | 65.74% | 68.41% | 72.2% | 95.61% | 92.08% | 86.64% | 94.14% | 93.78% | 93.69% | 100% | 100% | 100% |
| Gross Profit Growth % | - | 201.58% | 100.18% | 11.61% | -56.55% | -8.16% | -6.14% | 26.19% | 23.12% | 9.21% | -15.85% | 2.97% | 15.71% | 4.48% | 67.57% | 26.85% | -27.75% | 28.66% | 248.88% | -71.69% | -7.65% | 38.69% | - |
| Operating Expenses | 584.21M | 494.06M | 435.9M | 408.86M | 395.78M | 45.07M | 70.23M | 64.85M | 63.62M | 71.54M | 57.81M | 52.58M | 43.88M | 34.96M | 55.9M | 34.76M | 33.71M | 33.98M | 20.9M | 5.39M | 37.45M | 43.69M | 44.4M |
| OpEx % of Revenue | - | 60.84% | 105.74% | 133.56% | 153.11% | 15.33% | 16.86% | 15.01% | 18.26% | 24.3% | 23.16% | 23.1% | 20.66% | 20.1% | 44.47% | 44.63% | 51.66% | 40.87% | 32.22% | 28.96% | 60.81% | 65.51% | 92.33% |
| Selling, General & Admin | 454.85M | 392.47M | 321.86M | 291.48M | 294.51M | 27.31M | 52.7M | 50.3M | 42.7M | 35.68M | 27.62M | 0 | 19.26M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SG&A % of Revenue | - | 48.33% | 78.07% | 95.21% | 113.94% | 9.29% | 12.65% | 11.64% | 12.26% | 12.12% | 11.06% | - | 9.07% | - | - | - | - | - | - | - | - | - | - |
| Research & Development | 103.42M | 45.31M | 113.92M | 116.88M | 101.27M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| R&D % of Revenue | - | 5.58% | 27.63% | 38.18% | 39.18% | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Operating Expenses | 1000K | 56.27M | 128K | 500K | 0 | 17.76M | 17.53M | 14.54M | 20.92M | 35.86M | 30.19M | 52.58M | 24.63M | 34.96M | 55.9M | 34.76M | 33.71M | 33.98M | 20.9M | 5.39M | 37.45M | 43.69M | 44.4M |
| Operating Income | 139.94M | 45.11M | -257.12M | -319.55M | -315.76M | 139.09M | 130.28M | 148.78M | 105.67M | 65.96M | 68.09M | 97.03M | 101.41M | 90.61M | 64.3M | 36.97M | 22.83M | 44.29M | 39.94M | 12.05M | 24.14M | 23M | 3.69M |
| Operating Margin % | 13.35% | 5.56% | -62.37% | -104.38% | -122.16% | 47.31% | 31.28% | 34.43% | 30.33% | 22.41% | 27.27% | 42.63% | 47.74% | 52.1% | 51.15% | 47.45% | 34.99% | 53.27% | 61.56% | 64.73% | 39.19% | 34.49% | 7.67% |
| Operating Income Growth % | - | 117.55% | 19.54% | -1.2% | -327.02% | 6.76% | -12.43% | 40.8% | 60.21% | -3.14% | -29.82% | -4.32% | 11.92% | 40.93% | 73.94% | 61.89% | -48.44% | 10.9% | 231.49% | -50.09% | 4.94% | 524.01% | - |
| EBITDA | 162.64M | 67.73M | -208.21M | -270.55M | -267.5M | 249.74M | 244.21M | 272.26M | 218.93M | 172.64M | 182.33M | 175.87M | 169.82M | 140.36M | 99.63M | 59.37M | 41.77M | 61.82M | 50.71M | 14.92M | 39M | 38.55M | 19.05M |
| EBITDA Margin % | 15.52% | 8.34% | -50.5% | -88.38% | -103.49% | 84.94% | 58.63% | 63.01% | 62.84% | 58.65% | 73.03% | 77.27% | 79.95% | 80.7% | 79.26% | 76.21% | 64% | 74.36% | 78.17% | 80.16% | 63.32% | 57.8% | 39.61% |
| EBITDA Growth % | 1057.98% | 132.53% | 23.04% | -1.14% | -207.11% | 2.26% | -10.3% | 24.36% | 26.82% | -5.32% | 3.67% | 3.56% | 20.99% | 40.88% | 67.82% | 42.14% | -32.44% | 21.92% | 239.9% | -61.74% | 1.17% | 102.39% | - |
| D&A (Non-Cash Add-back) | 15.89M | 22.61M | 48.91M | 49M | 48.25M | 110.65M | 113.93M | 123.48M | 113.26M | 106.68M | 114.23M | 78.83M | 68.41M | 49.75M | 35.33M | 22.4M | 18.93M | 17.54M | 10.77M | 2.87M | 14.86M | 15.54M | 15.36M |
| EBIT | 140.22M | -11.23M | -231.87M | -309.81M | -294.15M | 143.81M | 134.37M | 159.83M | 110.25M | 52.63M | 67.26M | 102.79M | 107.58M | 102.89M | 78.04M | 37.03M | 21.79M | -6.06M | 40.74M | 12.07M | 24.16M | 23.03M | 3.72M |
| Net Interest Income | -15.64M | -40.36M | -42.9M | -20.35M | -25.73M | -61.56M | -79.16M | -78.34M | -53.05M | -42.75M | -36.03M | -35.2M | -36M | -28.79M | -16.13M | -5.17M | -4.3M | -9.12M | -10.28M | -3.69M | -7.77M | 0 | 0 |
| Interest Income | 27M | 16.5M | 7.12M | 11.26M | 947K | 0 | 0 | 0 | 0 | 0 | 0 | 7K | 5K | 9K | 12K | 109K | 10K | 229K | 126K | 20K | 27K | 0 | 0 |
| Interest Expense | 42.64M | 56.85M | 50.02M | 31.61M | 26.68M | 61.56M | 79.16M | 78.34M | 53.05M | 42.75M | 36.03M | 35.21M | 36.01M | 28.8M | 16.14M | 5.28M | 4.31M | 9.35M | 10.41M | 3.71M | 7.8M | 7.65M | 7.39M |
| Other Income/Expense | -42.36M | -113.2M | -24.77M | -21.86M | -5.07M | -109.55M | 0 | -67.3M | -48.47M | -56.08M | -36.87M | -29.46M | -29.83M | -16.51M | -2.4M | -5.21M | -5.36M | -59.7M | -9.6M | -3.69M | -7.77M | -7.62M | -7.35M |
| Pretax Income | 97.57M | -68.09M | -281.89M | -341.42M | -320.83M | 29.53M | 55.21M | 81.48M | 57.2M | 9.88M | 31.22M | 67.58M | 71.58M | 74.1M | 61.9M | 31.76M | 17.48M | -15.41M | 30.34M | 8.35M | 16.37M | 15.38M | -3.66M |
| Pretax Margin % | 9.31% | -8.38% | -68.38% | -111.53% | -124.12% | 10.04% | 13.26% | 18.86% | 16.42% | 3.36% | 12.51% | 29.69% | 33.7% | 42.6% | 49.24% | 40.77% | 26.78% | -18.53% | 46.76% | 44.88% | 26.57% | 23.06% | -7.62% |
| Income Tax | 1.51M | 469.87M | 0 | 0 | 0 | 1.8M | 4.19M | 2.89M | -14.86M | 3.84M | 4.25M | 7.19M | 7.06M | 9.82M | 11.08M | 3.56M | 3.92M | 11.55M | 11.1M | 3.12M | 6.38M | 6.15M | -1.01M |
| Effective Tax Rate % | 1.55% | -690.09% | 0% | 0% | 0% | 6.09% | 7.59% | 3.54% | -25.98% | 38.91% | 13.62% | 10.64% | 9.86% | 13.25% | 17.91% | 11.19% | 22.43% | -74.95% | 36.6% | 37.34% | 38.96% | 39.99% | 27.7% |
| Net Income | 96.06M | -537.96M | -281.89M | -341.42M | -320.83M | 27.73M | 31.01M | 78.6M | 72.06M | 6M | 26.84M | 60.27M | 63.93M | 63.47M | 50.19M | 28.38M | 13.56M | -26.95M | 19.23M | 5.23M | 9.99M | 9.23M | -2.65M |
| Net Margin % | 9.16% | -66.25% | -68.38% | -111.53% | -124.12% | 9.43% | 7.44% | 18.19% | 20.68% | 2.04% | 10.75% | 26.48% | 30.1% | 36.49% | 39.93% | 36.44% | 20.77% | -32.42% | 29.65% | 28.12% | 16.22% | 13.84% | -5.51% |
| Net Income Growth % | 151.37% | -90.84% | 17.43% | -6.42% | -1256.84% | -10.57% | -60.54% | 9.07% | 1101.6% | -77.65% | -55.47% | -5.71% | 0.73% | 26.45% | 76.83% | 109.38% | 150.29% | -240.13% | 267.55% | -47.61% | 8.23% | 448.4% | - |
| Net Income (Continuing) | 96.06M | -537.96M | -281.89M | -341.42M | -320.83M | 27.73M | 31.01M | 78.6M | 72.06M | 6M | 26.84M | 60.27M | 63.93M | 63.47M | 50.19M | 28.38M | 13.56M | -26.95M | 19.23M | 5.23M | 9.99M | 9.23M | -2.65M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | 0.33 | -1.86 | -2.70 | -1.82 | -1.57 | 1.55 | 1.72 | 3.97 | 3.68 | 0.31 | 1.28 | 2.85 | 2.82 | 3.18 | 2.55 | 1.56 | 0.76 | -1.55 | 1.15 | 0.25 | 0.47 | 0.44 | -0.13 |
| EPS Growth % | 113.53% | 31.11% | -48.35% | -15.92% | -201.29% | -9.88% | -56.68% | 7.88% | 1087.1% | -75.78% | -55.09% | 1.06% | -11.32% | 24.71% | 63.46% | 105.26% | 149.03% | -234.78% | 360% | -46.81% | 6.82% | 438.46% | - |
| EPS (Basic) | - | -1.91 | -2.70 | -1.82 | -1.57 | 1.55 | 1.72 | 3.97 | 3.74 | 0.31 | 1.29 | 2.91 | 2.89 | 3.26 | 2.60 | 1.58 | 0.76 | -1.55 | 1.31 | 0.25 | 0.47 | 0.44 | -0.13 |
| Diluted Shares Outstanding | 295.14M | 289.89M | 254.66M | 254.66M | 254.79M | 17.95M | 18.01M | 19.82M | 19.61M | 19.39M | 20.99M | 21.16M | 22.67M | 19.95M | 19.69M | 18.2M | 17.9M | 17.41M | 16.68M | 21.17M | 21.17M | 21.17M | 21.17M |
| Basic Shares Outstanding | 283.89M | 282.33M | 254.66M | 254.66M | 254.79M | 17.95M | 18.01M | 19.82M | 19.25M | 19.32M | 20.77M | 20.73M | 22.16M | 19.5M | 19.3M | 17.97M | 17.9M | 17.41M | 14.71M | 21.17M | 21.17M | 21.17M | 21.17M |
| Dividend Payout Ratio | - | - | - | - | - | 63.84% | 28.47% | 4.15% | - | - | - | - | - | - | - | - | - | - | 4.18% | - | - | - | - |
Quick answers to the most common questions about buying CAI stock.
For fiscal year 2025, Caris Life Sciences, Inc. (CAI) reported total revenue of $812.0M. This represents a 1588.8% increase compared to $48.1M in 2003.
Caris Life Sciences, Inc. (CAI) reported a net loss of $538.0M for the fiscal year ending 2025.
Caris Life Sciences, Inc. (CAI) reported an operating income of $45.1M, resulting in an operating profit margin of 5.6%. This margin reflects the operational efficiency of the business before interest and taxes.
Caris Life Sciences, Inc. (CAI) generated $539.2M in gross profit for the year, representing a gross profit margin of 66.4%. This demonstrates the company's core pricing power and production efficiency.
Key Metrics
Top Statement Risk
Persistent GAAP losses despite growth
Metrics are mathematically derived from official filings.
Top-Line Growth Decelerating From Peak Surge
According to the reported quarterly figures, CAI's revenue climbed from $120.9M in 2025Q1 to $292.9M in 2025Q4 before moderating to $275.4M in 2026Q3, a 27.0% year-over-year rise that remains strong but well below the earlier triple-digit pace.
The steep sequential ramp through 2025 suggests a combination of rising clinical case volume and possibly lumpy biopharma milestone recognition, since the 2025Q4 peak was followed by sequential declines. The 27% year-over-year figure in the latest quarter indicates growth is durable but decelerating, which investors should monitor for whether volume gains are offsetting pricing or reimbursement pressure. Without a disclosed split between clinical and pharma revenue, the durability of the top-line trend cannot be fully verified from the provided data.
Gross Margin Holds While Operating Margin Stays Thin
As reported in the income statement, CAI sustained gross margins between 65% and 68% across most recent quarters, yet operating margin in 2026Q3 was only 7.0%, indicating that operating expenses absorb nearly all gross profit.
A gross margin in the mid-60s is respectable for a molecular profiling laboratory, suggesting reasonable unit economics on tests and data services. However, SG&A of $129.1M against $182.3M of gross profit in 2026Q3 leaves little room for error, and the thin operating spread implies that commercial and administrative scaling has not yet produced meaningful leverage. The margin structure is therefore highly sensitive to any reimbursement compression or cost inflation.
Operating Leverage Remains Largely Unrealized
Based on CAI's reported figures, SG&A rose from $104.8M in 2026Q1 to $129.1M in 2026Q3, growing in step with revenue and leaving operating income of $19.3M, far below what the top-line expansion would imply.
The fact that SG&A is scaling roughly in line with revenue suggests the business has not yet entered a phase where fixed commercial infrastructure is being spread across a larger base. Operating income swung from negative in 2025Q1 to positive in later periods, which is encouraging, but the magnitude remains modest relative to revenue. Investors should watch whether SG&A growth decouples from revenue growth in coming quarters, as this is the key test of whether the growth narrative converts into profit.
Net Income Volatility Obscures Underlying Earnings
Reported net income swung from a $102.6M loss in 2025Q1 to an $82.0M profit in 2025Q4, while the latest quarter's EPS of $0.05 fell short of the $0.11 consensus estimate, pointing to earnings that are difficult to read from headline figures.
The large gap between operating income and net income in several periods, along with a 2025Q4 profit that appears well above the operating result, suggests non-operating or one-time items may be driving reported earnings, though the provided data does not disclose their nature. Stock-based compensation of $18.5M in the latest quarter adds a non-cash drag that warrants separate review. The EPS miss against consensus implies that reported earnings quality is not yet stable enough to anchor valuation.
Persistent Losses Could Challenge the Growth Thesis
Based on the supplied financial snapshot, a reported net margin of -66.2% and ROE of -93.2% alongside a 42.2% widening of the 2025 net loss suggests growth may be funded by expenses that the top line has not yet justified.
The bear case would focus on whether revenue growth is being bought with unsustainable spending, given that net losses widened even as revenue nearly doubled. If the 2025Q4 profit proves to be non-recurring, the underlying run-rate may look considerably weaker than headline numbers imply. Investors should weigh whether the company's cash position provides enough runway to reach sustained profitability, while recognizing that these risks cannot be fully assessed without the balance sheet and cash flow detail.