Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in CCCC held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | MORGAN STANLEY | 9.1M | $23.9M | +1.0% | 10.953% | 0.00% |
| 2 | RA CAPITAL MANAGEMENT, L.P. | 8.0M | $21.0M | 0.0% | 9.659% | 0.22% |
| 3 | Bain Capital Life Sciences Investors, LLC | 7.2M | $18.9M | 0.0% | 8.659% | 1.70% |
| 4 | Lynx1 Capital Management LP | 7.0M | $18.4M | -1.4% | 8.450% | 2.91% |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 3.9M | $10.2M | β | 4.662% | 0.00% |
| 6 | Soleus Capital Management, L.P. | 3.8M | $10.0M | 0.0% | 4.593% | 0.41% |
| 7 | TWO SIGMA INVESTMENTS, LP | 3.0M | $8.0M | +101.1% | 3.665% | 0.01% |
| 8 | WASATCH ADVISORS INC | 3.0M | $7.8M | -31.8% | 3.576% | 0.05% |
| 9 | CITADEL ADVISORS LLC | 2.6M | $6.8M | +419.2% | 3.125% | 0.00% |
| 10 | RENAISSANCE TECHNOLOGIES LLC | 2.5M | $6.5M | +53.6% | 2.972% | 0.01% |
| 11 | GOLDMAN SACHS GROUP INC | 2.4M | $6.3M | +119.2% | 2.882% | 0.00% |
| 12 | BANK OF AMERICA CORP /DE/ | 2.4M | $6.2M | -1.2% | 2.848% | 0.00% |
| 13 | Squadron Capital Management LLC | 2.3M | $5.9M | β | 2.717% | 2.45% |
| 14 | BlackRock, Inc. | 2.0M | $5.4M | +4.0% | 2.473% | 0.00% |
| 15 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.9M | $5.0M | -4.1% | 2.308% | 0.59% |
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.4M | $3.7M | -25.9% | 1.684% | 0.00% |
| 17 | MILLENNIUM MANAGEMENT LLC | 1.4M | $3.7M | +17.2% | 1.682% | 0.00% |
| 18 | D. E. Shaw & Co., Inc. | 1.1M | $2.8M | +1905.2% | 1.280% | 0.00% |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 951K | $2.5M | -3.8% | 1.148% | 0.00% |
| 20 | WELLS FARGO & COMPANY/MN | 868K | $2.3M | +7.2% | 1.048% | 0.00% |
| 21 | ORBIMED ADVISORS LLC | 856K | $2.3M | -39.1% | 1.034% | 0.05% |
| 22 | CONGRESS ASSET MANAGEMENT CO /MA | 831K | $2.2M | β | 1.003% | 0.02% |
| 23 | Qube Research & Technologies Ltd | 752K | $2.0M | +159.1% | 0.908% | 0.00% |
| 24 | VANGUARD FIDUCIARY TRUST CO | 484K | $1.3M | β | 0.585% | 0.00% |
| 25 | STEMPOINT CAPITAL LP | 453K | $1.2M | β | 0.547% | 0.31% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in CCCC β a direct measure of their conviction.
Filings activity in CCCC during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 119 | +20% | 63.38% | +16.63 pp | $205M | +36% |
| Q4 2025 | 99 | +5.3% | 46.75% | +12.12 pp | $151M | +35% |
| Q3 2025 | 94 | 5.1% | 34.63% | +10.65 pp | $112M | +44% |
| Q2 2025 | 99 | 13% | 23.98% | 7.33 pp | $77M | 23% |
| Q1 2025 | 114 | +1.8% | 31.31% | 40.65 pp | $101M | 56% |
| Q4 2024 | 112 | 2.6% | 71.96% | 40.07 pp | $232M | 36% |
| Q3 2024 | 115 | +2.7% | 112.03% | 87.96 pp | $362M | 79% |
| Q2 2024 | 112 | β | 199.99% | β | $1.73B | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying CCCC stock.
Based on Q1 2026 13F filings, institutional ownership of C4 Therapeutics, Inc. stands at 63.4%, held across 119 reporting institutions.
MORGAN STANLEY is the largest reported institutional holder of CCCC, with approximately 9,072,400 shares worth $0.02B as of Q1 2026.
Yes β 5 widely-followed marquee investors appear among the top 25 institutional holders of CCCC, including TWO SIGMA INVESTMENTS, LP, CITADEL ADVISORS LLC, RENAISSANCE TECHNOLOGIES LLC, SUSQUEHANNA INTERNATIONAL GROUP, LLP, MILLENNIUM MANAGEMENT LLC.
Our composite Smart Money Score for CCCC is 83 out of 100 (Strong Smart Money). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
34 institutions opened new positions in CCCC during Q1 2026, while 14 fully exited. 70 added to existing positions and 14 trimmed.
CCCC institutional ownership rose by 16.63 percentage points quarter-over-quarter, with a net change of +20 holders.
The top 10 institutions account for 64.2% of all reported 13F value in CCCC, and the top 25 account for 89.9%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
C4 Therapeutics, Inc. (CCCC) Institutional Ownership