Free cash flow burn accelerated to -$193.5M in 2026Q2 (a 70% QoQ increase), with operating cash outflow of $192.4M exceeding net loss of $91.2M, driven by a $19.1M working capital drag and $33.6M stock-based compensation.
CRISPR Therapeutics AG (CRSP) cash flow statement — 12-year operating, investing & financing cash flows
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 |
|---|
| Cash from Operations | -374.63M | -345.01M | -142.77M | -260.38M | -495.74M | 538.97M | -238.37M | 56.68M | -96.24M | -70.1M | -55.31M | 59.43M | -4.79M |
| Operating CF Margin % | - | -9829.46% | -407.93% | -70.37% | -113702.06% | 59.03% | -33152.43% | 19.57% | -3080.63% | -170.98% | -1071.07% | 24059.92% | - |
| Operating CF Growth % | -166.14% | -141.65% | 45.17% | 47.48% | -191.98% | 326.11% | -520.57% | 158.89% | -37.29% | -26.73% | -193.07% | 1339.89% | - |
| Net Income | -456.13M | -581.6M | -366.25M | -153.61M | -650.17M | 377.66M | -348.87M | 66.86M | -164.98M | -68.36M | -23.2M | -25.83M | -6.8M |
| Depreciation & Amortization | 18.5M | 19.48M | 19.26M | 19.84M | 24.17M | 17.95M | 9.18M | 4.72M | 3.52M | 3.02M | 925K | 127K | 38K |
| Stock-Based Compensation | 69.68M | 72.5M | 86.57M | 81.03M | 97.95M | 102.39M | 66.02M | 44.06M | 34.98M | 18.87M | 10.84M | 3.68M | 695K |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.28M | 0 | -53.71M | -20K | 0 |
| Other Non-Cash Items | -12.35M | 72.72M | -38.62M | -14.04M | 12.47M | 14.11M | 1.86M | -10.53M | 15.41M | 1.75M | 8.05M | 97K | -260K |
| Working Capital Changes | 5.68M | 71.88M | 156.27M | -193.59M | 19.84M | 26.86M | 33.44M | -48.43M | 10.55M | -25.39M | 1.78M | 81.37M | 1.53M |
| Change in Receivables | 0 | 25M | 175M | -200M | 305K | -161K | -45K | -11K | 2.54M | 531K | -2.82M | -339K | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | -37.51M | -25.75M | 0 | 332.3M | -551.3M | -1.09M | 0 | 0 |
| Change in Payables | 20.61M | 44.89M | 0 | -20.25M | 5.16M | 37.51M | 25.75M | 0 | -323.28M | 546.62M | 3.86M | 0 | 0 |
| Cash from Investing | -443.29M | -31.8M | -280.48M | 374.65M | -258.65M | -1.04B | -541.17M | 1.32M | -2.77M | -8.31M | 31.88M | -1.15M | 0 |
| Capital Expenditures | -2.08M | -914K | -1.9M | -9.47M | -37.19M | -81.7M | -18.36M | -6.68M | -2.77M | -7.81M | -3.02M | -1.15M | 0 |
| CapEx % of Revenue | 8.28% | 26.04% | 5.43% | 2.56% | 8529.36% | 8.95% | 2553.27% | 2.31% | 88.76% | 19.06% | 58.4% | 467.21% | - |
| Acquisitions | 0 | 0 | 0 | 0 | 221.47M | 953.73M | 522.81M | 0 | 0 | 0 | -100K | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | -1.65M | -34M | 0 | -2.5M | -221.47M | -953.73M | -522.81M | 8.01M | 0 | -500K | 35M | 0 | 0 |
| Cash from Financing | 719.96M | 426.03M | 331.98M | 62.66M | 38.59M | 250.94M | 1.02B | 430.98M | 315.93M | 2.61M | 183.22M | 96.73M | 5.12M |
| Debt Issued (Net) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 35.01M | 38.24M | 0 |
| Equity Issued (Net) | 721.08M | 426.03M | 300.69M | 62.66M | 970K | 213.27M | 982.29M | 415.02M | 307M | 0 | 149.99M | 58.62M | 5.16M |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -57K | 0 | 0 | 0 | 0 |
| Other Financing | -1.12M | 0 | 31.29M | 0 | 37.62M | 37.68M | 33.86M | 15.96M | 8.94M | 2.61M | -1.78M | -127K | -36K |
| Net Change in Cash | -101.7M | 49.3M | -91.29M | 177.59M | -715.88M | -245.52M | 236.66M | 489M | 216.9M | -75.76M | 159.56M | 155.02M | 584K |
| Free Cash Flow | -379.19M | -345.93M | -144.68M | -269.85M | -532.93M | 457.27M | -256.72M | 49.99M | -99.01M | -77.91M | -58.33M | 58.27M | -4.79M |
| FCF Margin % | -1506.39% | -9855.5% | -413.36% | -72.93% | -122231.42% | 50.08% | -35705.7% | 17.26% | -3169.4% | -190.04% | -1129.47% | 23592.71% | - |
| FCF Growth % | -25.09% | -139.11% | 46.39% | 49.37% | -216.55% | 278.12% | -613.52% | 150.49% | -27.08% | -33.58% | -200.09% | 1315.81% | - |
| FCF per Share | -3.92 | -3.85 | -1.71 | -3.41 | -6.85 | 5.69 | -3.89 | 0.88 | -2.06 | -1.94 | -4.76 | 1.99 | -0.16 |
| FCF Conversion (FCF/Net Income) | 0.83x | 0.59x | 0.39x | 1.70x | 0.76x | 1.43x | 0.68x | 0.85x | 0.58x | 1.03x | 2.38x | -2.30x | 0.70x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quick answers to the most common questions about buying CRSP stock.
CRISPR Therapeutics AG (CRSP) generated $-345.0M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
CRISPR Therapeutics AG (CRSP) reported negative free cash flow of $345.9M in 2025, indicating capital requirements exceeded cash from operations.
CRISPR Therapeutics AG (CRSP) spent $0.9M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.
Key Metrics
Top Statement Risk
Revenue collapse and cash burn
Metrics are mathematically derived from official filings.
Cash Conversion Distorted by Working Capital
In 2026Q2, operating cash outflow of $192.4M exceeded net loss of $91.2M, yielding an OCF/NI ratio of 2.11, driven by a $19.1M working capital drag and $33.6M stock-based compensation, per reported financials.
The gap between net income and operating cash flow is widening, with 2026Q2 showing cash burn nearly double the accounting loss. This suggests that non-cash charges like SBC are not the primary driver; rather, working capital swings and possibly timing of collaboration payments are amplifying cash outflows. Investors should monitor whether this reflects a structural shift to commercial operations or a one-time distortion.
Free Cash Flow Burn Accelerates
Free cash flow deteriorated to -$193.5M in 2026Q2, a 70% quarter-over-quarter increase in burn, with FCF margin at -19.0% on minimal revenue, according to the latest cash flow statement.
The FCF trajectory shows a sharp acceleration in cash consumption, from -$109.4M in 2026Q1 to -$193.5M in 2026Q2, despite a slight improvement in FCF margin due to a revenue uptick. This suggests that operating expenses are scaling faster than any revenue recovery, and the company remains heavily reliant on its cash buffer and external financing. The trend appears consistent with the post-approval commercialization costs and pipeline expansion.
Minimal CapEx Masks Heavy R&D Investment
Capital expenditures averaged just $0.5M per quarter over the last ten quarters, representing less than 1% of revenue, yet the company's asset-light model belies the massive fixed costs embedded in R&D and manufacturing, as per SEC filings.
CapEx is negligible, indicating that the company's investments are not in physical assets but in intangible R&D and clinical trials, which are expensed through the income statement. This suggests that the capital intensity of the business is understated by CapEx alone, and the true cash burn is reflected in operating cash flow. The low CapEx also implies that the company is not building significant manufacturing capacity, likely relying on Vertex's infrastructure, which may limit its ability to control costs.
Working Capital Swings Drive Cash Volatility
Working capital changes swung from a $210.5M positive contribution in 2024Q1 to a $19.1M negative drag in 2026Q2, causing erratic operating cash flow patterns, as reported in quarterly cash flow statements.
The working capital line is highly volatile, with a massive positive swing in 2024Q1 likely due to a collaboration milestone or receivable collection, followed by persistent negative contributions in recent quarters. This suggests that the company's cash flow is heavily influenced by the timing of payments from partners like Vertex, and not by steady operational efficiency. Investors should expect continued lumpiness in operating cash flow as the company navigates its commercial launch and pipeline milestones.
No Capital Returns, Only Cash Consumption
CRSP has paid no dividends and repurchased only $722K in 2026Q2, with no acquisitions, indicating that all available cash is being funneled into operations and R&D, based on the cash flow statement.
Capital deployment is entirely focused on funding internal development, with no returns to shareholders. The negligible buyback in 2026Q2 is immaterial, and the absence of dividends is expected for a development-stage biotech. This suggests that management is prioritizing pipeline advancement and commercial scaling over shareholder returns, which is typical but warrants monitoring given the accelerating cash burn.
Cumulative Losses Outpace Cash Burn
Over the last ten quarters, cumulative net losses of $1.16B were exceeded by cumulative operating cash outflows of $689M, indicating that non-cash charges like SBC and depreciation have partially offset cash burn, per financial statements.
The cumulative gap between net income and operating cash flow is positive, meaning that accounting losses are larger than actual cash outflows, largely due to stock-based compensation and depreciation. However, this does not imply better cash generation; rather, it reflects the non-cash nature of some expenses. The divergence suggests that the company's cash runway may be longer than net income trends imply, but the accelerating burn in recent quarters is a concern.
What Could Invalidate the Base Case
The extreme negative margins and revenue collapse could signal that CASGEVY's commercial potential is overestimated, with manufacturing costs and slow ATC activation undermining the profit-share model, as per recent financials.
The cash flow statement obscures the true economics of the Vertex partnership, as the 40% profit share may not materialize if manufacturing costs remain high and ATC activation lags. Additionally, the negligible CapEx suggests reliance on Vertex's infrastructure, which could limit cost control and margin improvement. Investors should monitor whether the accelerating cash burn is funding sustainable growth or merely delaying an inevitable capital raise, which could dilute shareholders.