Last 38 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -7.85 | — | — | — | — | — | — | — | — | — | — | — | 5.67 |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | — | — | — | — | — | — | — | — | — | — | — | 560.30 | 3.53 |
| — | — | — | — | — | — | — | — | — | — | — | +110.5% | -79.5% | |
| P/B Ratio | 4.03 | 3.87 | 2.86 | 2.70 | 2.34 | 2.07 | 2.82 | 3.74 | 2.83 | 2.11 | 2.88 | 2.54 | 3.50 |
| — | +86.6% | +1.4% | -27.8% | -17.4% | -1.5% | -2.0% | +47.4% | -19.3% | -35.3% | -18.8% | -45.6% | -14.4% | |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | 5.91 |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — | — | 5.99 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | — | — | — | — | — | — | — | — | — | — | — | 100.0% | 100.0% |
| — | — | — | — | — | — | — | — | — | — | — | 0.0% | 0.0% | |
| Operating Margin | — | — | — | — | — | — | — | — | — | — | — | -8981.5% | 58.0% |
| — | — | — | — | — | — | — | — | — | — | — | -197.4% | +149.5% | |
| Net Margin | — | — | — | — | — | — | — | — | — | — | — | -7841.6% | 62.3% |
| — | — | — | — | — | — | — | — | — | — | — | -170.2% | +155.7% |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -45.7% | -13.2% | -13.3% | -13.0% | -11.5% | -11.3% | -9.0% | -7.9% | -7.0% | -8.2% | -11.1% | -8.6% | 17.0% |
| — | -17.1% | -47.1% | -64.0% | -65.7% | -38.1% | +19.0% | +8.1% | -140.9% | +25.1% | -4.4% | +29.2% | +361.0% | |
| ROA | -40.7% | -10.7% | -11.7% | -11.4% | -10.2% | -10.1% | -8.1% | -7.3% | -6.4% | -7.4% | -10.0% | -7.8% | 13.5% |
| — | -6.0% | -44.0% | -57.5% | -58.6% | -35.0% | +18.8% | +7.2% | -147.5% | +2.7% | -36.1% | +4.7% | +400.2% | |
| ROIC | -42.6% | -14.4% | -11.9% | -11.4% | -9.9% | -9.8% | -8.2% | -7.0% | -6.2% | -7.4% | -10.0% | -8.0% | 12.4% |
| — | -46.4% | -45.7% | -62.6% | -58.7% | -33.9% | +18.6% | +12.5% | -150.3% | +25.3% | -4.2% | +23.3% | +323.9% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.04 | 0.04 | 0.04 | 0.05 | 0.05 | 0.04 | 0.04 | 0.04 | 0.04 | 0.03 | 0.05 | 0.05 | 0.05 |
| — | -0.2% | +5.3% | +20.4% | +29.0% | +24.7% | -21.8% | -17.4% | -24.9% | -41.2% | -12.5% | -37.0% | -32.6% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | 0.32 |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 9.16 | 9.28 | 9.16 | 9.79 | 10.27 | 9.56 | 8.46 | 9.98 | 12.46 | 11.79 | 13.65 | 16.06 | 17.65 |
| — | -2.9% | +8.3% | -1.9% | -17.6% | -18.9% | -38.0% | -37.9% | -29.4% | +247.9% | +261.9% | +408.6% | +451.3% | |
| Quick Ratio | 9.16 | 9.28 | 9.16 | 9.79 | 10.27 | 9.56 | 8.46 | 9.98 | 12.46 | 11.79 | 13.65 | 16.06 | 17.65 |
| — | -2.9% | +8.3% | -1.9% | -17.6% | -18.9% | -38.0% | -37.9% | -29.4% | +247.9% | +261.9% | +408.6% | +451.3% | |
| Interest Coverage | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 38 years · Updated daily
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Quick answers to the most common questions about buying DNLI stock.
Denali Therapeutics Inc.'s current P/E is -7.8x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Denali Therapeutics Inc.'s business trajectory between earnings reports.