Denali Therapeutics Inc. (DNLI) P/E Ratio History
Deep ValueTrading at -8.1x · 0th percentile of 5-year range · Significant discount to historical valuation · Data 2020–2021
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P/E Ratio Analysis
As of June 22, 2026, Denali Therapeutics Inc. (DNLI) trades at a price-to-earnings ratio of -8.1x, with a stock price of $24.05 and trailing twelve-month earnings per share of $-2.72.
The current P/E is 103% below its 5-year average of 292.1x. Over the past five years, DNLI's P/E has ranged from a low of 248.3x to a high of 336.3x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 22.1x, DNLI trades at a 137% discount to its sector peers. The sector includes 233 companies with P/E ratios ranging from 0.0x to 194.5x.
Relative to the broader market, DNLI trades at a notable discount to the S&P 500 median P/E of 24.3x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our DNLI DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
DNLI Cross-Benchmark Valuation
How does the current P/E compare to sector peers and the broader market?
DNLI P/E vs Peers
Neuroscience and Psychiatry Therapies peers sorted by market cap
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $4B | 9.6 | - | +68% | |
| $29B | 22.6 | - | -21% | |
| $38B | 122.9 | - | +207% | |
| $2B | 6.9Lowest | 0.66Best | +817%Best |
Lower P/E can signal a discount or weaker growth expectations; PEG adds growth context.
DNLI Historical P/E Data (2020–2021)
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Period End | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2021 Q3 | - | $50.45 | $0.15 | 336.3x | +15% |
| FY2021 Q2 | Jun 30 2021 | $78.44 | $0.30 | 261.5x | -10% |
| FY2021 Q1 | Mar 31 2021 | $57.10 | $0.23 | 248.3x | -15% |
| FY2020 Q4 | - | $83.76 | $0.26 | 322.2x | +10% |
Average P/E for displayed period: 292.1x
Intrinsic Valuation
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Historical Returns
6+ years return with dividends reinvested.
DCA Calculator
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Peer Comparison
Compare growth, multiples, and margins vs sector.
DNLI — Frequently Asked Questions
Quick answers to the most common questions about buying DNLI stock.
What is DNLI's P/E ratio?
Denali Therapeutics Inc. (DNLI) trailing twelve-month P/E ratio is -8.1x, based on TTM diluted EPS of $-2.72. The 5-year average P/E is 292.1x and the historical range spans 248.3x to 336.3x.
Is DNLI stock overvalued or undervalued?
DNLI trades at -8.1x P/E, below its 5-year average of 292.1x. At the 0th percentile of its historical range (248.3x–336.3x), the stock is priced at a discount to its own history.
Is DNLI stock expensive?
No, DNLI is not expensive on a historical basis. The current P/E of -8.1x is below the 5-year average of 292.1x and sits at the 0th percentile of its valuation range.
What is DNLI's historical P/E range?
Over the past 5 years, DNLI's P/E ratio has ranged from 248.3x to 336.3x, with a median of 322.2x and an average of 292.1x. The current P/E of -8.1x places the stock at the 0th percentile of this range. Full historical data spans 2020–2021.
How does DNLI's P/E compare to the S&P 500?
DNLI trades at -8.1x P/E versus the S&P 500 median of 24.3x. The 133% discount to the market suggests lower growth expectations or perceived higher risk.
How does DNLI's valuation compare to Healthcare peers?
Denali Therapeutics Inc. P/E of -8.1x compares to the Healthcare sector median of 22.1x. The discount suggests lower growth expectations, weaker margins, or higher perceived risk relative to peers. See the peer comparison table on this page for ticker-by-ticker P/E and PEG.
What is DNLI's PEG ratio?
DNLI PEG ratio is N/A, based on a P/E of -8.1x and EPS growth of -15.6%. PEG normalises P/E by growth and helps compare stocks with different earnings trajectories.
What is DNLI's earnings yield?
DNLI earnings yield is N/A, the inverse of its -8.1x P/E ratio. Earnings yield represents the percentage of each dollar invested that the company earns. It can be compared directly to bond yields to assess relative attractiveness of stocks versus fixed income.