Ionis Pharmaceuticals, Inc. (IONS) Price Target Analysis
Updated Jun 18, 2026
Analyst Rating: Buy
Based on 32 analysts47.7% Below Target
IONS trades 47.7% below Wall Street's consensus target of $109.44.
Current Price$74.12
Average Target$109.44
Target
Current
Low$87.00
Median$110.00
High$130.00
Analyst Target Range
Forward P/E—
PEG Ratio—
Implied Growth-82.6%
(Declining)
Analyst Spread39.3%
(Moderate)
Price Forecast (1 Year)
Last 12 months price action with 12-month analyst target path
Consensus Scenario Assumptions
The base valuation assumes IONS achieves its forward estimates and maintains a stable P/E multiple of historical averagesx. This scenario reflects the blended consensus of 32 Wall Street analysts, balancing both positive catalysts and macroeconomic headwinds over the next 12 months.
IONS Price Target Analysis
Updated June 22, 2026As of June 22, 2026, Ionis Pharmaceuticals, Inc. (IONS) has a Wall Street consensus price target of $109.44, based on estimates from 32 covering analysts. With the stock currently trading at $74.12, this represents a potential upside of +47.7%. The company has a market capitalization of $12.25B.
Analyst price targets range from a low of $87.00 to a high of $130.00, representing a 39% spread in expectations. The median target of $110.00 aligns closely with the consensus average.
The current analyst consensus rating is Buy, with 20 analysts rating the stock as a Buy or Strong Buy,12 rating it Hold, and 0 rating it Sell or Strong Sell. The positive sentiment balance indicates moderate optimism about the stock prospects.
From a valuation perspective, IONS trades at a trailing P/E of -31.1x. Analysts expect EPS to grow -82.6% over the next year.
Investment Context: Price targets represent analyst expectations for the next 12 months and should be considered alongside your own research. Targets are based on analysts' assumptions about earnings growth, margins, and market conditions which may change. For sector-specific context, view other Healthcare stocks.
Analyst Sentiment Comparison
Industry Peer AnalysisAvg Peer Upside
+46.4%
Industry Consensus
Avg Forward P/E
17.7x
(Fair)
Peers with Coverage
10 / 10
Active Analyst Tracking
| Company | Market Cap | Price | Target | Upside Potential | Rating | Fwd P/E | Analysts |
|---|---|---|---|---|---|---|---|
 ALNYAlnylam Pharmaceuticals, Inc. | $37.1B | $278.09 | $454.27 | +63.4% | Buy | 37.1x | 52 |
 SRPTSarepta Therapeutics, Inc. | $1.9B | $17.53 | $25.14 | +43.4% | Buy | 5.0x | 54 |
 BMRNBioMarin Pharmaceutical Inc. | $10.5B | $54.69 | $89.93 | +64.4% | Buy | 11.1x | 41 |
 RAREUltragenyx Pharmaceutical Inc. | $2.7B | $27.44 | $48.36 | +76.2% | Buy | — | 33 |
 AKROAkero Therapeutics, Inc. | $4.5B | $54.65 | $48.40 | -11.4% | Buy | — | 14 |
 ARWRArrowhead Pharmaceuticals, Inc. | $11.5B | $81.82 | $84.00 | +2.7% | Buy | — | 21 |
 NTLAIntellia Therapeutics, Inc. | $1.8B | $15.67 | $26.13 | +66.8% | Buy | — | 39 |
 BEAMBeam Therapeutics Inc. | $3.5B | $34.14 | $48.00 | +40.6% | Buy | — | 27 |
 EDITEditas Medicine, Inc. | $263M | $2.69 | $5.00 | +85.9% | Buy | — | 25 |
 CRSPCRISPR Therapeutics AG | $5.2B | $54.09 | $71.67 | +32.5% | Buy | — | 38 |
IONS — Frequently Asked Questions
Quick answers to the most common questions about buying IONS stock.
What is the IONS stock price target for 2026?
The consensus Wall Street price target for IONS is $109.44, representing 47.7% upside from the current price of $74.12. With 32 analysts covering the stock, this strong upside suggests significant value not yet reflected in today's share price.
Is IONS a buy, sell, or hold?
IONS has a consensus rating of "Buy" based on 32 Wall Street analysts. The rating breakdown is predominantly bullish, with 20 Buy/Strong Buy ratings. The consensus 12-month price target of $109.44 implies 47.7% upside from current levels.
Is IONS stock overvalued or undervalued?
IONS's current price is $74.12 with a consensus target of $109.44 (47.7% implied move). Analyst estimates suggest the stock is undervalued at current levels.
How high can IONS stock go?
The most bullish Wall Street analyst has a price target of $130 for IONS, while the most conservative target is $87. The consensus of $109.44 represents the median expectation. These targets typically reflect 12-month expectations.
How many analysts cover IONS stock?
IONS is heavily covered by Wall Street, with 32 analysts providing price targets and ratings. Of these, 1 have Strong Buy ratings, 19 have Buy ratings, 12 recommend Hold, and 0 have Sell or Strong Sell ratings. Higher analyst coverage generally indicates greater institutional interest and more reliable consensus estimates.
What is the IONS stock forecast?
The 12-month IONS stock forecast based on 32 Wall Street analysts shows a consensus price target of $109.44, with estimates ranging from $87 (bear case) to $130 (bull case). The median consensus rating is "Buy".
Should I buy IONS stock?
Wall Street analysts are very optimistic on IONS, with a "Buy" consensus rating and $109.44 price target (47.7% upside). 20 of 32 analysts rate it Buy or Strong Buy. This information is for educational purposes only. Always conduct your own research, consider your financial situation, and consult a financial advisor before making investment decisions.
Why do IONS price targets vary so much?
IONS analyst price targets range from $87 to $130, a 39% moderate spread showing some variance in outlooks. Differences stem from varying assumptions about revenue growth, profit margins, competitive dynamics, and valuation multiples. The $109.44 consensus represents the middle ground.
Consensus-Based Analysis Tools
Full Stock Analysis
Deep dive into IONS consensus models and risk factors.
View Analysis
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Check Valuation
Historical Returns
10-year return with dividends reinvested.
Calculate
DCA Calculator
See how regular investing compounds over time.
Run Numbers
Peer Comparison
Compare growth, multiples, and margins vs sector.
Compare