Wall Street analyst price targets, ratings consensus & upside potential · Updated Feb 28, 2026
Last 12 months price action with 12-month analyst target path
As of March 1, 2026, Alnylam Pharmaceuticals, Inc. (ALNY) has a Wall Street consensus price target of $461.06, based on estimates from 51 covering analysts. With the stock currently trading at $332.92, this represents a potential upside of +38.5%. The company has a market capitalization of $44.07B.
Analyst price targets range from a low of $351.00 to a high of $549.00, representing a 43% spread in expectations. The median target of $465.00 aligns closely with the consensus average.
The current analyst consensus rating is Buy, with 39 analysts rating the stock as a Buy or Strong Buy,11 rating it Hold, and 1 rating it Sell or Strong Sell. This overwhelmingly bullish sentiment suggests analysts see significant catalysts for upside ahead.
From a valuation perspective, ALNY trades at a trailing P/E of 142.9x and forward P/E of 49.0x. Analysts expect EPS to grow +195.4% over the next year.
Our proprietary valuation model, which blends historical multiples with forward estimates, suggests a base-case price target of $332.92, with bear and bull scenarios of $-13700.71 and $317.53 respectively. Model confidence stands at 56/100, reflecting moderate uncertainty in projections.
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Start ComparisonThe consensus Wall Street price target for ALNY is $461.06, representing 38.5% upside from the current price of $332.92. With 51 analysts covering the stock, this strong upside suggests significant value not yet reflected in today's share price.
ALNY has a consensus rating of "Buy" based on 51 Wall Street analysts. The rating breakdown is predominantly bullish, with 39 Buy/Strong Buy ratings. The consensus 12-month price target of $461.06 implies 38.5% upside from current levels.
At a forward P/E of 48.9559x, ALNY trades at a premium valuation. The consensus price target of $461.06 (38.5% upside) suggests analysts still see growth justifying the multiple.
The most bullish Wall Street analyst has a price target of $549 for ALNY, while the most conservative target is $351. The consensus of $461.06 represents the median expectation. Our quantitative valuation model projects a bull case target of $318 based on optimistic growth and margin assumptions. These targets typically reflect 12-month expectations.
ALNY is heavily covered by Wall Street, with 51 analysts providing price targets and ratings. Of these, 0 have Strong Buy ratings, 39 have Buy ratings, 11 recommend Hold, and 1 have Sell or Strong Sell ratings. Higher analyst coverage generally indicates greater institutional interest and more reliable consensus estimates.
The 12-month ALNY stock forecast based on 51 Wall Street analysts shows a consensus price target of $461.06, with estimates ranging from $351 (bear case) to $549 (bull case). The median consensus rating is "Buy". Our proprietary valuation model produces a base case fair value of $333, with bear/bull scenarios of $-13701/$318.
Our quantitative valuation model calculates ALNY's fair value at $333 (base case), with a bear case of $-13701 and bull case of $318. The model uses discounted cash flow analysis, historical growth rates, and margin mean-reversion to project FY+2 earnings, then applies an appropriate P/E multiple. The model confidence score is 56/100.
ALNY trades at a forward P/E ratio of 49.0x based on next-twelve-months earnings estimates compared to a trailing P/E of 142.9x. The lower forward P/E indicates analysts expect earnings growth. A forward P/E is useful for comparing valuations when earnings are expected to change significantly.
Wall Street analysts are very optimistic on ALNY, with a "Buy" consensus rating and $461.06 price target (38.5% upside). 39 of 51 analysts rate it Buy or Strong Buy. This information is for educational purposes only. Always conduct your own research, consider your financial situation, and consult a financial advisor before making investment decisions.
ALNY analyst price targets range from $351 to $549, a 43% moderate spread showing some variance in outlooks. Differences stem from varying assumptions about revenue growth, profit margins, competitive dynamics, and valuation multiples. The $461.06 consensus represents the middle ground. Our model's $-13701-$318 range provides an independent fundamental perspective.