Karyopharm Therapeutics Inc. (KPTI) Earnings History
Net Loss15 years of earnings data (2011–2025) · Currently unprofitable on a TTM basis
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Karyopharm Therapeutics Inc. (KPTI) Earnings Overview
As of June 22, 2026, Karyopharm Therapeutics Inc. (KPTI) reported trailing twelve-month net income of -$195M, reflecting -90.5% year-over-year growth. The company earned $-7.89 per diluted share over the past four quarters, with a net profit margin of -134.2%.
Looking at the long-term picture, KPTI's historical earnings data spans multiple years. The company achieved its highest annual net income of -$10M in fiscal 2011.
Karyopharm Therapeutics Inc. is currently reporting a net loss, though operating performance should be evaluated in the context of growth investments and industry dynamics View revenue history →
Compared to peers including PTCT (-$187M net income, 39.4% margin), FOLD (-$27M net income, -4.3% margin), MGNX (-$70M net income, -49.9% margin), KPTI has room to improve margins relative to the peer group. Compare KPTI vs PTCT →
KPTI Earnings vs Peers
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KPTI Historical Earnings Data (2011–2025)
15 years| Fiscal Year | Net Income | YoY % | Operating Income | EPS (Diluted) | Net Margin | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | -$196M | -156.5% | -$91M | $-17.93 | -134.2% | -62.1% |
| 2024 | -$76M | +46.6% | -$119M | $-9.41 | -52.6% | -82.2% |
| 2023 | -$143M | +13.4% | -$130M | $-18.79 | -98.0% | -88.7% |
| 2022 | -$165M | -33.2% | -$142M | $-30.28 | -105.2% | -90.5% |
| 2021 | -$124M | +36.8% | -$98M | $-24.75 | -59.1% | -46.8% |
| 2020 | -$196M | +1.7% | -$172M | $-40.87 | -181.6% | -159.0% |
| 2019 | -$200M | -11.9% | -$189M | $-48.32 | -488.1% | -462.9% |
| 2018 | -$178M | -38.3% | -$180M | $-47.11 | -588.1% | -593.0% |
| 2017 | -$129M | -17.7% | -$131M | $-42.15 | -8036.4% | -8133.2% |
| 2016 | -$110M | +7.3% | -$111M | $-43.80 | -71153.9% | -71903.9% |
| 2015 | -$118M | -56.0% | -$119M | $-49.80 | -47272.4% | -47630.4% |
| 2014 | -$76M | -123.2% | -$76M | $-36.45 | -33090.4% | -33120.5% |
| 2013 | -$34M | -113.7% | -$34M | $-83.85 | -8771.8% | -8772.6% |
| 2012 | -$16M | -54.1% | -$16M | $-8.01 | -2506.0% | -2506.3% |
| 2011 | -$10M | - | -$10M | $-5.20 | -6783.6% | -6783.6% |
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KPTI — Frequently Asked Questions
Quick answers to the most common questions about buying KPTI stock.
What is KPTI earnings per share (EPS)?
KPTI trailing twelve-month (TTM) diluted EPS is $-7.89, reflecting -90.5% year-over-year growth. The 5-year EPS CAGR is N/A. Complete EPS history from 2011 to 2025 is available in the table on this page.
What is Karyopharm Therapeutics Inc.'s net income?
Karyopharm Therapeutics Inc. (KPTI) trailing twelve-month net income is $-195M as of 2025. Earnings declined -90.5% year-over-year.
Is KPTI profitable?
KPTI is not currently profitable on a TTM basis, reporting a net loss of $-195M. Net margin is -134.2%. Investors should monitor for a return to profitability.
What is KPTI's earnings growth rate?
KPTI compound annual EPS growth rates (CAGR): 1-Year: N/A, 3-Year: N/A, 5-Year: N/A, 10-Year: N/A. These figures measure the annualised rate of diluted EPS growth over each period, based on data from 2011 to 2025.
What are KPTI's profit margins?
Karyopharm Therapeutics Inc. net profit margin is -134.2%, operating margin is -62.1%, and gross margin is +95.9%. Below-average margins reflect competitive or cost pressures. Return on Equity is N/A.
Is KPTI growing earnings?
KPTI earnings are declining — EPS fell -90.5% year-over-year. TTM net income dropped to $-195M. This contrasts with the 5-year CAGR of N/A.
What was KPTI's best earnings year?
Karyopharm Therapeutics Inc.'s highest annual net income on record is $-10M, achieved in fiscal year 2011. Earnings history on this page spans 2011 to 2025 and includes all annual and quarterly figures.
What were KPTI's earnings last quarter?
KPTI's most recent reported quarter was Q1 2026. Net income was $-22M with diluted EPS of $-1.24. For a full breakdown of all quarters, see the quarterly earnings table on this page.