Karyopharm Therapeutics Inc. (KPTI) P/E Ratio History
Historical price-to-earnings valuation from 2026 to 2026
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KPTI Valuation Context
How does the current P/E compare to historical and market benchmarks?
P/E Ratio Analysis
As of May 8, 2026, Karyopharm Therapeutics Inc. (KPTI) trades at a price-to-earnings ratio of -0.5x, with a stock price of $8.85 and trailing twelve-month earnings per share of $-14.38.
Compared to the Healthcare sector median P/E of 22.3x, KPTI trades at a 102% discount to its sector peers. The sector includes 241 companies with P/E ratios ranging from 0.0x to 177.5x.
Relative to the broader market, KPTI trades at a notable discount to the S&P 500 median P/E of 25.1x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our KPTI DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
KPTI P/E vs Peers
P/E ratio compared to closely matched public peers
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $5B | 8.3Lowest | - | +264% | |
| $2B | 14.1 | - | -26% | |
| $7B | 15.5 | - | +1747%Best | |
| $8B | 25.5 | 1.11Best | -25% | |
| $4B | 9.9 | - | +68% |
Peers sorted by market capitalization. P/E below peers may indicate undervaluation or lower growth expectations. Consider PEG ratio for growth-adjusted comparison.
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Start ComparisonKPTI — Frequently Asked Questions
Quick answers to the most common questions about buying KPTI stock.
Is KPTI stock overvalued or undervalued?
KPTI current P/E: -0.5x. 5-year average P/E: N/A. Percentile: N/A.
How does KPTI's valuation compare to peers?
Karyopharm Therapeutics Inc. P/E of -0.5x compares to sector median of 22.3x. The discount suggests lower growth expectations or higher risk.
What is KPTI's PEG ratio?
KPTI PEG ratio is N/A. Above 2.0 indicates premium valuation relative to growth rate. Historical P/E data spans 2026-2026.