Karyopharm Therapeutics Inc. (KPTI) Stock Price History
Historical prices from 2013 to 2026
- 1M
- -91.6%
- 3M
- -97.2%
- YTD
- -99.2%
- 1Y
- -98.9%
- 3Y
- -83.9%
- 5Y
- -78.6%
Loading 10-year price history...
KPTI Historical Performance
KPTI Annual Returns
Year-by-year price performance · 2013–2026
- 2013 annual price return
- +42.9%
- 2014 annual price return
- +62.6%
- 2015 annual price return
- -65.1%
- 2016 annual price return
- -30.2%
- 2017 annual price return
- -0.4%
- 2018 annual price return
- -5.5%
- 2019 annual price return
- +100.5%
- 2020 annual price return
- -17.3%
- 2021 annual price return
- -62.0%
- 2022 annual price return
- -52.0%
- 2023 annual price return
- -73.5%
- 2024 annual price return
- -25.0%
- 2025 annual price return
- -39.5%
- 2026 annual price return
- -91.6%
KPTI Stock Price Trajectory (2013–2026)
As of November 8, 2026, Karyopharm Therapeutics Inc. (KPTI) trades at $0.05, representing a -98.9% return over the past year. The stock has delivered a -100.0% total return over five years (-78.6% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $734.40 on December 8, 2014. From this peak, KPTI has corrected -100.0%, currently trading 99% below its 200-day moving average, suggesting potential weakness.
When compared to Healthcare sector peers PTCT (-9.8% 1Y), MGNX (+71.3% 1Y), and ADMA (-9.3% 1Y), KPTI has underperformed the peer group average. Compare KPTI vs PTCT →
KPTI Historical Price Data · from 2013
Rows 1–50 of 3,270| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-11-06 | 0.05 | 0.06 | 0.04 | 0.05 | 103.55M | -8.65% |
| 2026-11-05 | 0.05 | 0.06 | 0.05 | 0.06 | 18.85M | -17.56% |
| 2026-11-04 | 0.08 | 0.13 | 0.07 | 0.07 | 40.92M | -17.44% |
| 2026-11-03 | 0.11 | 0.11 | 0.08 | 0.09 | 16.87M | -21.16% |
| 2026-11-02 | 0.15 | 0.16 | 0.09 | 0.11 | 47.45M | -83.08% |
| 2026-10-30 | 0.90 | 0.90 | 0.58 | 0.66 | 3.52M | -24.76% |
| 2026-10-29 | 0.81 | 0.99 | 0.78 | 0.88 | 6.85M | +5.73% |
| 2026-10-28 | 0.46 | 0.91 | 0.46 | 0.83 | 55.29M | +73.35% |
| 2026-10-27 | 0.46 | 0.48 | 0.43 | 0.48 | 997K | -0.44% |
| 2026-10-26 | 0.51 | 0.52 | 0.42 | 0.48 | 1.37M | -6.84% |
| 2026-10-23 | 0.54 | 0.56 | 0.44 | 0.52 | 1.96M | -5.24% |
| 2026-10-22 | 0.44 | 0.55 | 0.42 | 0.55 | 7.49M | +28.68% |
| 2026-10-21 | 0.36 | 0.44 | 0.36 | 0.42 | 1.62M | +18.35% |
| 2026-10-20 | 0.34 | 0.39 | 0.34 | 0.36 | 767K | +3.64% |
| 2026-10-19 | 0.40 | 0.40 | 0.33 | 0.35 | 1.26M | -11.30% |
| 2026-10-16 | 0.35 | 0.40 | 0.33 | 0.39 | 2.71M | +11.20% |
| 2026-10-15 | 0.31 | 0.35 | 0.31 | 0.35 | 1.40M | +11.37% |
| 2026-10-14 | 0.43 | 0.43 | 0.32 | 0.32 | 2.08M | -26.30% |
| 2026-10-13 | 0.49 | 0.50 | 0.40 | 0.43 | 1.75M | -15.38% |
| 2026-10-12 | 0.59 | 0.60 | 0.50 | 0.51 | 899K | -16.51% |
| 2026-10-09 | 0.60 | 0.63 | 0.56 | 0.60 | 963K | +0.83% |
| 2026-10-08 | 0.63 | 0.64 | 0.60 | 0.60 | 871K | -6.98% |
| 2026-10-07 | 0.65 | 0.69 | 0.62 | 0.65 | 759K | -0.75% |
| 2026-10-06 | 0.69 | 0.71 | 0.64 | 0.65 | 1.18M | -3.07% |
| 2026-10-05 | 0.80 | 0.80 | 0.63 | 0.67 | 1.98M | -16.42% |
| 2026-10-02 | 0.86 | 0.89 | 0.75 | 0.80 | 2.34M | -7.45% |
| 2026-10-01 | 1.19 | 1.20 | 0.85 | 0.87 | 2.66M | -28.95% |
| 2026-09-30 | 1.26 | 1.27 | 1.18 | 1.22 | 1.75M | +0.83% |
| 2026-09-29 | 1.62 | 1.63 | 1.20 | 1.21 | 1.87M | -25.31% |
| 2026-09-28 | 1.59 | 1.66 | 1.54 | 1.62 | 331K | 0.00% |
| 2026-09-25 | 1.73 | 1.77 | 1.57 | 1.62 | 1.47M | -6.36% |
| 2026-09-24 | 1.73 | 1.77 | 1.71 | 1.73 | 677K | -1.14% |
| 2026-09-23 | 1.81 | 1.84 | 1.66 | 1.75 | 958K | -3.85% |
| 2026-09-22 | 1.87 | 1.92 | 1.78 | 1.82 | 987K | -2.15% |
| 2026-09-21 | 1.85 | 1.93 | 1.78 | 1.86 | 1.62M | -1.06% |
| 2026-09-18 | 1.77 | 1.89 | 1.67 | 1.88 | 1.90M | +5.03% |
| 2026-09-17 | 1.75 | 1.85 | 1.66 | 1.79 | 1.09M | +5.29% |
| 2026-09-16 | 1.54 | 1.72 | 1.54 | 1.70 | 1.35M | +10.39% |
| 2026-09-15 | 1.59 | 1.70 | 1.53 | 1.54 | 1.33M | -3.75% |
| 2026-09-14 | 1.55 | 1.62 | 1.55 | 1.60 | 992K | -0.62% |
| 2026-09-11 | 1.50 | 1.61 | 1.24 | 1.61 | 6.74M | -0.62% |
| 2026-09-10 | 1.68 | 1.68 | 1.60 | 1.62 | 801K | -4.14% |
| 2026-09-09 | 1.72 | 1.75 | 1.65 | 1.69 | 773K | -1.74% |
| 2026-09-08 | 1.77 | 1.79 | 1.70 | 1.72 | 1.01M | -3.91% |
| 2026-09-04 | 1.77 | 1.84 | 1.76 | 1.79 | 578K | +1.13% |
| 2026-09-03 | 1.79 | 1.81 | 1.72 | 1.77 | 820K | -1.12% |
| 2026-09-02 | 1.90 | 1.94 | 1.73 | 1.79 | 1.30M | -3.24% |
| 2026-09-01 | 2.02 | 2.07 | 1.84 | 1.85 | 1.60M | -10.19% |
| 2026-08-31 | 1.91 | 2.14 | 1.79 | 2.06 | 2.03M | +10.16% |
| 2026-08-28 | 1.98 | 1.99 | 1.86 | 1.87 | 827K | -3.61% |
KPTI Chart Terminal
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Live Breakouts Feed
High-probability breakout stocks crossing their pivot across 5 pattern engines.
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
Peer Comparison
Compare growth, multiples, and margins vs sector.
KPTI — Frequently Asked Questions
Quick answers to the most common questions about buying KPTI stock.
How has KPTI stock performed recently?
KPTI declined -98.9% over the past year, below its 5-year annualized CAGR of -78.6%. The stock trades below its 200-day moving average, reflecting the downtrend.
What is KPTI's all-time high price?
Karyopharm Therapeutics Inc. reached $734.40 on 2014-12-08. The 52-week high is $10.99. Current 1-year return of -98.9% places the stock further from historical peaks.
Where can I download KPTI historical price data?
This page provides KPTI daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2013-2026, downloadable in CSV format.