Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in OMER held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BlackRock, Inc. | 5.3M | $56.1M | +4.9% | 7.336% | 0.00% |
| 2 | VANGUARD CAPITAL MANAGEMENT LLC | 3.0M | $31.5M | — | 4.122% | 0.00% |
| 3 | UBS Group AG | 2.3M | $24.7M | +5.3% | 3.234% | 0.00% |
| 4 | STATE STREET CORP | 1.9M | $20.3M | +22.0% | 2.652% | 0.00% |
| 5 | STIFEL FINANCIAL CORP | 1.8M | $19.3M | +1.2% | 2.531% | 0.02% |
| 6 | GEODE CAPITAL MANAGEMENT, LLC | 1.8M | $18.5M | +7.4% | 2.421% | 0.00% |
| 7 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.4M | $14.8M | -43.7% | 1.940% | 0.00% |
| 8 | Corient Private Wealth LLC | 801K | $8.5M | +16.6% | 1.107% | 0.01% |
| 9 | VANGUARD PORTFOLIO MANAGEMENT LLC | 719K | $7.6M | — | 0.993% | 0.00% |
| 10 | CITADEL ADVISORS LLC | 714K | $7.5M | — | 0.987% | 0.00% |
| 11 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 583K | $6.2M | -1.8% | 0.805% | 0.00% |
| 12 | BANK OF MONTREAL /CAN/ | 568K | $6.0M | -62.6% | 0.785% | 0.00% |
| 13 | NORTHERN TRUST CORP | 564K | $6.0M | +7.0% | 0.779% | 0.00% |
| 14 | VANGUARD FIDUCIARY TRUST CO | 492K | $5.2M | — | 0.680% | 0.00% |
| 15 | MILLENNIUM MANAGEMENT LLC | 411K | $4.3M | -7.1% | 0.567% | 0.00% |
| 16 | MORGAN STANLEY | 318K | $3.4M | -17.7% | 0.439% | 0.00% |
| 17 | Clutterbuck Capital Management LLC | 300K | $3.2M | +100.0% | 0.415% | 1.93% |
| 18 | Itau Unibanco Holding S.A. | 180K | $3.1M | 0.0% | 0.249% | 0.07% |
| 19 | TWO SIGMA INVESTMENTS, LP | 286K | $3.0M | -45.4% | 0.396% | 0.00% |
| 20 | Badgley Phelps Wealth Managers, LLC | 264K | $2.8M | 0.0% | 0.364% | 0.06% |
| 21 | BANK OF AMERICA CORP /DE/ | 205K | $2.2M | +78.4% | 0.283% | 0.00% |
| 22 | GOLDMAN SACHS GROUP INC | 203K | $2.1M | -10.7% | 0.280% | 0.00% |
| 23 | Polar Asset Management Partners Inc. | 200K | $2.1M | -25.6% | 0.276% | 0.05% |
| 24 | Jump Financial, LLC | 196K | $2.1M | -14.1% | 0.271% | 0.03% |
| 25 | WELLINGTON MANAGEMENT GROUP LLP | 187K | $2.0M | -7.6% | 0.259% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in OMER — a direct measure of their conviction.
Filings activity in OMER during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new OMER position in Q1 2026
Institutions that fully closed their OMER position in Q1 2026
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 159 | +8.2% | 47.93% | 36.64 pp | $303M | 43% |
| Q4 2025 | 147 | +17% | 84.57% | +64.81 pp | $535M | +328% |
| Q3 2025 | 126 | +0.0% | 19.76% | +7.72 pp | $125M | +64% |
| Q2 2025 | 126 | 5.3% | 12.04% | 18.25 pp | $76M | 60% |
| Q1 2025 | 133 | +3.9% | 30.29% | 5.44 pp | $191M | 15% |
| Q4 2024 | 128 | +21% | 35.73% | +22.89 pp | $226M | +178% |
| Q3 2024 | 106 | +2.9% | 12.84% | 0.60 pp | $81M | 4.4% |
| Q2 2024 | 103 | — | 13.44% | — | $85M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying OMER stock.
Based on Q1 2026 13F filings, institutional ownership of Omeros Corporation stands at 47.9%, held across 159 reporting institutions.
BlackRock, Inc. is the largest reported institutional holder of OMER, with approximately 5,309,626 shares worth $0.06B as of Q1 2026.
Yes — 4 widely-followed marquee investors appear among the top 25 institutional holders of OMER, including SUSQUEHANNA INTERNATIONAL GROUP, LLP, CITADEL ADVISORS LLC, MILLENNIUM MANAGEMENT LLC, TWO SIGMA INVESTMENTS, LP.
Our composite Smart Money Score for OMER is 54 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
38 institutions opened new positions in OMER during Q1 2026, while 26 fully exited. 17 added to existing positions and 103 trimmed.
OMER institutional ownership fell by 36.64 percentage points quarter-over-quarter, with a net change of +12 holders.
The top 10 institutions account for 68.9% of all reported 13F value in OMER, and the top 25 account for 86.6%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Omeros Corporation (OMER) Institutional Ownership