Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in OPK held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Rubric Capital Management LP | 47.8M | $54.5M | 0.0% | 6.329% | 0.67% |
| 2 | BlackRock, Inc. | 36.2M | $41.3M | +4.0% | 4.798% | 0.00% |
| 3 | VANGUARD PORTFOLIO MANAGEMENT LLC | 14.8M | $16.8M | β | 1.956% | 0.00% |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 14.5M | $16.5M | β | 1.920% | 0.00% |
| 5 | GEODE CAPITAL MANAGEMENT, LLC | 11.3M | $12.9M | +2.2% | 1.497% | 0.00% |
| 6 | STATE STREET CORP | 9.5M | $10.8M | +6.1% | 1.258% | 0.00% |
| 7 | GOLDMAN SACHS GROUP INC | 7.7M | $8.7M | +28.2% | 1.016% | 0.00% |
| 8 | UBS Group AG | 6.1M | $6.9M | +13.4% | 0.804% | 0.00% |
| 9 | Whitefort Capital Management, LP | 4.3M | $4.8M | 0.0% | 0.563% | 1.48% |
| 10 | NORTHERN TRUST CORP | 3.6M | $4.1M | +5.3% | 0.479% | 0.00% |
| 11 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3.6M | $4.1M | -3.2% | 0.473% | 0.00% |
| 12 | VANGUARD FIDUCIARY TRUST CO | 2.7M | $3.1M | β | 0.363% | 0.00% |
| 13 | CITADEL ADVISORS LLC | 2.2M | $2.5M | -25.5% | 0.296% | 0.00% |
| 14 | AWM Investment Company, Inc. | 2.1M | $2.4M | 0.0% | 0.278% | 0.27% |
| 15 | DIMENSIONAL FUND ADVISORS LP | 1.6M | $1.8M | -3.2% | 0.207% | 0.00% |
| 16 | WASHINGTON GROWTH STRATEGIES LLC | 1.4M | $1.5M | 0.0% | 0.180% | 1.01% |
| 17 | Y.D. More Investments Ltd | 1.3M | $1.5M | -0.5% | 0.172% | 0.06% |
| 18 | Bank of New York Mellon Corp | 1.3M | $1.5M | -2.3% | 0.169% | 0.00% |
| 19 | OP Asset Management Ltd | 1.1M | $1.5M | β | 0.146% | 0.00% |
| 20 | MORGAN STANLEY | 1.2M | $1.4M | +30.4% | 0.158% | 0.00% |
| 21 | VOYA INVESTMENT MANAGEMENT LLC | 1.2M | $1.3M | +5.3% | 0.154% | 0.00% |
| 22 | BANK OF AMERICA CORP /DE/ | 1.1M | $1.3M | +84.7% | 0.151% | 0.00% |
| 23 | PFG Investments, LLC | 1.1M | $1.3M | -15.7% | 0.147% | 0.06% |
| 24 | Clearstead Advisors, LLC | 884K | $1.0M | β | 0.117% | 0.01% |
| 25 | Tejara Capital Ltd | 878K | $1.0M | 0.0% | 0.116% | 0.33% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in OPK β a direct measure of their conviction.
Filings activity in OPK during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new OPK position in Q1 2026
Institutions that fully closed their OPK position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 227 | +5.6% | 21.03% | 2.02 pp | $226M | 8.8% |
| Q4 2025 | 215 | 3.2% | 23.05% | 5.01 pp | $247M | 18% |
| Q3 2025 | 222 | +2.8% | 28.06% | +3.18 pp | $301M | +13% |
| Q2 2025 | 216 | 12% | 24.88% | 10.83 pp | $267M | 30% |
| Q1 2025 | 246 | +7.0% | 35.71% | +9.56 pp | $383M | +37% |
| Q4 2024 | 230 | +0.0% | 26.15% | 48.80 pp | $280M | 65% |
| Q3 2024 | 230 | +0.9% | 74.95% | +32.49 pp | $804M | +77% |
| Q2 2024 | 228 | β | 42.46% | β | $455M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying OPK stock.
Based on Q1 2026 13F filings, institutional ownership of OPKO Health, Inc. stands at 21.0%, held across 227 reporting institutions.
Rubric Capital Management LP is the largest reported institutional holder of OPK, with approximately 47,791,243 shares worth $0.05B as of Q1 2026.
Yes β 1 widely-followed marquee investor appear among the top 25 institutional holders of OPK, including CITADEL ADVISORS LLC.
Our composite Smart Money Score for OPK is 41 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
44 institutions opened new positions in OPK during Q1 2026, while 32 fully exited. 36 added to existing positions and 143 trimmed.
OPK institutional ownership fell by 2.02 percentage points quarter-over-quarter, with a net change of +12 holders.
The top 10 institutions account for 78.7% of all reported 13F value in OPK, and the top 25 account for 90.7%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
OPKO Health, Inc. (OPK) Institutional Ownership