OPKO Health, Inc. (OPK) P/E Ratio History
Deep ValueTrading at -5.1x · 0th percentile of 5-year range · Significant discount to historical valuation · Data 2006–2021
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P/E Ratio Analysis
As of June 28, 2026, OPKO Health, Inc. (OPK) trades at a price-to-earnings ratio of -5.1x, with a stock price of $1.53 and trailing twelve-month earnings per share of $-0.28.
The current P/E is 108% below its 5-year average of 64.3x. Over the past five years, OPK's P/E has ranged from a low of 22.6x to a high of 151.7x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 23.0x, OPK trades at a 122% discount to its sector peers. The sector includes 231 companies with P/E ratios ranging from 0.0x to 191.4x.
Relative to the broader market, OPK trades at a notable discount to the S&P 500 median P/E of 25.3x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our OPK DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
OPK Cross-Benchmark Valuation
How does the current P/E compare to sector peers and the broader market?
OPK P/E vs Peers
Clinical and Specialty Lab Testing peers sorted by market cap
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $1B | 26.6 | 3.56Best | +1883%Best | |
| $22B | 26.0 | - | +18% | |
| $23B | 24.0 | - | +14% | |
| $8B | 10.8Lowest | - | +143% | |
| $191B | 28.9 | 13.69 | +7% | |
| $138B | 38.8 | - | -5% |
Lower P/E can signal a discount or weaker growth expectations; PEG adds growth context.
OPK Historical P/E Data (2006–2021)
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Period End | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2021 Q3 | - | $3.65 | $0.12 | 31.7x | -51% |
| FY2021 Q2 | Jun 30 2021 | $4.05 | $0.12 | 35.2x | -45% |
| FY2021 Q1 | Mar 31 2021 | $4.29 | $0.19 | 22.6x | -65% |
| FY2020 Q4 | - | $3.95 | $0.05 | 79.0x | +23% |
| FY2016 Q2 | - | $9.34 | $0.18 | 51.6x | -20% |
| FY2016 Q1 | - | $10.39 | $0.07 | 151.7x | +136% |
| FY2006 Q2 | Jun 30 2006 | $0.43 | $0.01 | 78.2x | +22% |
Average P/E for displayed period: 64.3x
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
20+ years return with dividends reinvested.
DCA Calculator
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Peer Comparison
Compare growth, multiples, and margins vs sector.
OPK — Frequently Asked Questions
Quick answers to the most common questions about buying OPK stock.
What is OPK's P/E ratio?
OPKO Health, Inc. (OPK) trailing twelve-month P/E ratio is -5.1x, based on TTM diluted EPS of $-0.28. The 5-year average P/E is 64.3x and the historical range spans 22.6x to 151.7x.
Is OPK stock overvalued or undervalued?
OPK trades at -5.1x P/E, below its 5-year average of 64.3x. At the 0th percentile of its historical range (22.6x–151.7x), the stock is priced at a discount to its own history.
Is OPK stock expensive?
No, OPK is not expensive on a historical basis. The current P/E of -5.1x is below the 5-year average of 64.3x and sits at the 0th percentile of its valuation range.
What is OPK's historical P/E range?
Over the past 5 years, OPK's P/E ratio has ranged from 22.6x to 151.7x, with a median of 51.6x and an average of 64.3x. The current P/E of -5.1x places the stock at the 0th percentile of this range. Full historical data spans 2006–2021.
How does OPK's P/E compare to the S&P 500?
OPK trades at -5.1x P/E versus the S&P 500 median of 25.3x. The 120% discount to the market suggests lower growth expectations or perceived higher risk.
How does OPK's valuation compare to Healthcare peers?
OPKO Health, Inc. P/E of -5.1x compares to the Healthcare sector median of 23.0x. The discount suggests lower growth expectations, weaker margins, or higher perceived risk relative to peers. See the peer comparison table on this page for ticker-by-ticker P/E and PEG.
What is OPK's PEG ratio?
OPK PEG ratio is N/A, based on a P/E of -5.1x and EPS growth of -291.1%. PEG normalises P/E by growth and helps compare stocks with different earnings trajectories.
What is OPK's earnings yield?
OPK earnings yield is N/A, the inverse of its -5.1x P/E ratio. Earnings yield represents the percentage of each dollar invested that the company earns. It can be compared directly to bond yields to assess relative attractiveness of stocks versus fixed income.