Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in PRAX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Orbis Allan Gray Ltd | 2.5M | $796.6M | +97.0% | 8.560% | 3.36% |
| 2 | BlackRock, Inc. | 2.3M | $749.1M | +11.9% | 8.049% | 0.01% |
| 3 | FMR LLC | 2.2M | $696.2M | +59.1% | 7.482% | 0.04% |
| 4 | PERCEPTIVE ADVISORS LLC | 2.0M | $656.0M | +2.0% | 7.049% | 12.97% |
| 5 | BAKER BROS. ADVISORS LP | 1.8M | $564.9M | +55.6% | 6.070% | 3.24% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | $393.7M | — | 4.231% | 0.01% |
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 963K | $310.4M | +6.6% | 3.335% | 3.66% |
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 949K | $305.8M | +1.7% | 3.286% | 2.25% |
| 9 | Cormorant Asset Management, LP | 886K | $285.3M | -6.8% | 3.066% | 14.33% |
| 10 | STATE STREET CORP | 884K | $284.9M | +0.2% | 3.061% | 0.01% |
| 11 | MORGAN STANLEY | 833K | $268.5M | -6.3% | 2.886% | 0.02% |
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 816K | $262.8M | -15.5% | 2.824% | 0.41% |
| 13 | VANGUARD PORTFOLIO MANAGEMENT LLC | 757K | $243.8M | — | 2.620% | 0.01% |
| 14 | GOLDMAN SACHS GROUP INC | 711K | $229.0M | -0.8% | 2.461% | 0.03% |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 651K | $209.8M | +15.7% | 2.253% | 0.01% |
| 16 | BANK OF AMERICA CORP /DE/ | 535K | $172.2M | +2.3% | 1.851% | 0.01% |
| 17 | RA CAPITAL MANAGEMENT, L.P. | 374K | $120.4M | 0.0% | 1.294% | 1.28% |
| 18 | Hood River Capital Management LLC | 359K | $115.5M | +23.9% | 1.242% | 1.16% |
| 19 | Vivo Capital, LLC | 339K | $109.2M | +3.0% | 1.173% | 9.11% |
| 20 | Soleus Capital Management, L.P. | 331K | $106.5M | -8.9% | 1.144% | 4.31% |
| 21 | Logos Global Management LP | 285K | $91.8M | -24.0% | 0.987% | 4.58% |
| 22 | Pictet Asset Management Holding SA | 287K | $91.4M | +19.1% | 0.992% | 0.10% |
| 23 | FRANKLIN RESOURCES INC | 276K | $89.0M | -22.4% | 0.956% | 0.02% |
| 24 | NORTHERN TRUST CORP | 228K | $73.4M | +18.5% | 0.789% | 0.01% |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 215K | $69.4M | +8.6% | 0.746% | 0.01% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in PRAX — a direct measure of their conviction.
Filings activity in PRAX during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 282 | +14% | 115.70% | +4.26 pp | $8.91B | +3.8% |
| Q4 2025 | 248 | +69% | 111.44% | +94.98 pp | $8.58B | +577% |
| Q3 2025 | 147 | +2.8% | 16.46% | +3.84 pp | $1.27B | +30% |
| Q2 2025 | 143 | 4.7% | 12.62% | +1.54 pp | $971M | +14% |
| Q1 2025 | 150 | 7.4% | 11.08% | 10.29 pp | $853M | 48% |
| Q4 2024 | 162 | +24% | 21.37% | +7.78 pp | $1.64B | +57% |
| Q3 2024 | 131 | +17% | 13.59% | +4.18 pp | $1.05B | +44% |
| Q2 2024 | 112 | — | 9.41% | — | $724M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying PRAX stock.
Based on Q1 2026 13F filings, institutional ownership of Praxis Precision Medicines, Inc. stands at 115.7%, held across 282 reporting institutions.
Orbis Allan Gray Ltd is the largest reported institutional holder of PRAX, with approximately 2,472,480 shares worth $0.80B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of PRAX.
Our composite Smart Money Score for PRAX is 55 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
75 institutions opened new positions in PRAX during Q1 2026, while 41 fully exited. 148 added to existing positions and 57 trimmed.
PRAX institutional ownership rose by 4.26 percentage points quarter-over-quarter, with a net change of +34 holders.
The top 10 institutions account for 56.6% of all reported 13F value in PRAX, and the top 25 account for 81.9%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Praxis Precision Medicines, Inc. (PRAX) Institutional Ownership