59% buyers of institutions opening or closing positions this quarter
3 more new buyers than exits, ownership fell 8.07 percentage points vs the prior quarter, and 3 well-known fund managers in the top 25.
59% buyers of institutions opening or closing positions this quarter
37.2% institutional ownership
Privium Fund Management portfolio allocation
Institutional ownership vs Biotechnology peers
No Form 4 insider transactions on file
Latest positioning in PRQR across 13F flow, ownership shift, marquee holders, and holder-count growth.
Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in PRQR held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 6.3M | $10.1M | 0.0% | 5.935% | 0.02% |
| 2 | Privium Fund Management B.V. | 5.5M | $8.9M | +2.0% | 5.189% | 1.84% |
| 3 | abrdn plc | 3.3M | $5.4M | +12.4% | 3.148% | 0.01% |
| 4 | Affinity Asset Advisors, LLC | 2.5M | $4.0M | 0.0% | 2.329% | 0.21% |
| 5 | Sio Capital Management, LLC | 2.0M | $3.2M | -9.7% | 1.855% | 0.45% |
| 6 | DAFNA Capital Management LLC | 1.6M | $2.5M | 0.0% | 1.488% | 0.58% |
| 7 | Kynam Capital Management, LP | 1.6M | $2.5M | 0.0% | 1.487% | 0.16% |
| 8 | Ikarian Capital, LLC | 1.5M | $2.4M | 0.0% | 1.416% | 0.20% |
| 9 | MORGAN STANLEY | 1.3M | $2.1M | -4.9% | 1.234% | 0.00% |
| 10 | PLATINUM INVESTMENT MANAGEMENT LTD | 1.2M | $2.0M | 0.0% | 1.173% | 0.50% |
| 11 | TWO SIGMA INVESTMENTS, LP | 919K | $1.5M | +9.5% | 0.872% | 0.00% |
| 12 | Point72 Asset Management, L.P. | 756K | $1.2M | -7.1% | 0.717% | 0.00% |
| 13 | CITADEL ADVISORS LLC | 703K | $1.1M | +13.9% | 0.667% | 0.00% |
| 14 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 620K | $1.0M | 0.0% | 0.588% | 0.00% |
| 15 | Walleye Capital LLC | 608K | $984K | +2.7% | 0.577% | 0.00% |
| 16 | M28 Capital Management LP | 600K | $972K | -41.2% | 0.569% | 1.81% |
| 17 | RAYMOND JAMES FINANCIAL INC | 546K | $885K | +59.3% | 0.518% | 0.00% |
| 18 | Monaco Asset Management SAM | 419K | $678K | -2.3% | 0.398% | 0.13% |
| 19 | BOOTHBAY FUND MANAGEMENT, LLC | 355K | $576K | 0.0% | 0.337% | 0.01% |
| 20 | UBS Group AG | 305K | $495K | -61.7% | 0.290% | 0.00% |
| 21 | NORTHERN TRUST CORP | 291K | $472K | -1.2% | 0.277% | 0.00% |
| 22 | MILLENNIUM MANAGEMENT LLC | 194K | $315K | -55.3% | 0.184% | 0.00% |
| 23 | Palo Alto Investors LP | 189K | $306K | 0.0% | 0.179% | 0.05% |
| 24 | BANK OF AMERICA CORP /DE/ | 185K | $300K | +6.4% | 0.176% | 0.00% |
| 25 | DIADEMA PARTNERS LP | 180K | $292K | +7.5% | 0.171% | 0.05% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in PRQR — a direct measure of their conviction.
Filings activity in PRQR during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 66 | +4.8% | 37.16% | 8.07 pp | $56M | 25% |
| Q4 2025 | 63 | +1.6% | 45.23% | 2.92 pp | $75M | 6.1% |
| Q3 2025 | 62 | +0.0% | 48.15% | 1.45 pp | $80M | 2.9% |
| Q2 2025 | 62 | 1.6% | 49.60% | +14.27 pp | $82M | +53% |
| Q1 2025 | 63 | 16% | 35.33% | 34.89 pp | $54M | 54% |
| Q4 2024 | 75 | +63% | 70.22% | +51.33 pp | $116M | +272% |
| Q3 2024 | 46 | 2.1% | 18.89% | +1.72 pp | $31M | +10% |
| Q2 2024 | 47 | — | 17.17% | — | $28M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
No recent Form 4 insider transactions on file for PRQR.
Quick answers to the most common questions about buying PRQR stock.
Based on Q1 2026 13F filings, institutional ownership of ProQR Therapeutics N.V. stands at 37.2%, held across 66 reporting institutions.
ADAGE CAPITAL PARTNERS GP, L.L.C. is the largest reported institutional holder of PRQR, with approximately 6,253,467 shares worth $0.01B as of Q1 2026.
Yes — 3 widely-followed marquee investors appear among the top 25 institutional holders of PRQR, including TWO SIGMA INVESTMENTS, LP, Point72 Asset Management, L.P., CITADEL ADVISORS LLC.
Our composite Smart Money Score for PRQR is 54 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
10 institutions opened new positions in PRQR during Q1 2026, while 7 fully exited. 3 added to existing positions and 52 trimmed.
PRQR institutional ownership fell by 8.07 percentage points quarter-over-quarter, with a net change of +3 holders.
The top 10 institutions account for 76.5% of all reported 13F value in PRQR, and the top 25 account for 96.2%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.