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PRTAProthena Corporation plc
$8.68$454M
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
PRTA logo

Prothena Corporation plc

PRTA
NASDAQ · Biotechnology
$8.68
At close - Sep 23, 4:00 PM EDT - USD
Market Cap$454M
P/E-1.9x
52W High$11.80
Volume357.77K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Milestone-Driven Revenue Masks Persistent Cash Burn

Prothena's financial profile is defined by extreme revenue lumpiness, with quarterly swings from $51.1M in 2026Q1 to $1.0M in 2026Q2, suggesting a model reliant on non-recurring licensing milestones rather than sustainable product sales. The company's cost str...

GrowthMixed
ProfitabilityStrained
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

PRTA price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

6/12 Beats

EPS beat 6 of last 12 quarters

02

Valuation risk

-107% Peers

P/E is 107% below peer median

03

Market leadership

RS 41 · Lag

Laggard (Underperforming 59% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystEstimated earnings · Nov 6

Market performance

Price History →

Trailing total returns as of 9/24/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
PRTA-5.65%
S&P 500 (^GSPC)+12.39%
1-Year Return
PRTA+4.45%
S&P 500 (^GSPC)+15.77%
3-Year Return
PRTA-81.65%
S&P 500 (^GSPC)+80.99%
5-Year Return
PRTA-89.00%
S&P 500 (^GSPC)+66.17%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/E5Y Low
-1.9x
Forward P/E
78.9x
EV/EBITDA
N/A
FCF YieldCash Flow
N/A

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
-1.9x
35.8x
0th· Low
EV/EBITDA
N/A
25.0x
N/A
Price/FCF
N/A
26.0x
N/A
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
No DCF Model AvailableIntrinsic value modeling is not supported for this equity.

Growth & profitability

Annual revenue & EPS trend
Revenue
$10M-92.8% YoY
Net income
-$244M-99.6% YoY
Free cash flow
-$164M-8.9% YoY
Operating margin
-1905.8%-1791.5 pts YoY
ROIC (TTM)-2099.8%
Avg ROIC 5Y-
ROE (TTM)-63.6%
Piotroski Score1 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate6/12 (50%)
Revenue Beat Rate5/12 (42%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 6, 2026
-$0.32+17.9%
vs -$0.39
$1M+139.5%
vs $421,667
Q2 2026
May 7, 2026
$0.60+293.5%
vs -$0.31
$51M+6215.2%
vs $808,909
Q1 2026
Feb 19, 2026
-$0.44+2.2%
vs -$0.45
$21,000-98.4%
vs $1M
Q4 2025
Nov 6, 2025
-$0.67-11.7%
vs -$0.60
$2M+262.2%
vs $666,670
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Zacks Investment Research·2d ago
4 Alzheimer's Drug Stocks to Watch on World Alzheimer's Day

Four biotech stocks advance Alzheimer's therapies, from marketed treatments to experimental programs targeting amyloid and tau.

Defense World·2d ago
Prothena Corporation plc (NASDAQ:PRTA) Receives $24.57 Consensus PT from Analysts

Shares of Prothena Corporation plc (NASDAQ: PRTA - Get Free Report) have been assigned an average rating of "Moderate Buy" from the eight research firms that are currently covering the firm, MarketBeat.com reports. One equities research analyst has rated the stock with a sell recommendation, one has issued a hold recommendation, five have assigned a buy

Business Wire·Sep 9, 2026
Prothena to Participate in the H.C. Wainwright 28th Annual Global Investment Conference

DUBLIN, Ireland--(BUSINESS WIRE)---- $PRTA #Prothena--Prothena to Participate in the H.C. Wainwright 28th Annual Global Investment Conference.

Zacks Investment Research·Aug 14, 2026
KMDA or PRTA: Which Is the Better Value Stock Right Now?

Investors interested in Medical - Biomedical and Genetics stocks are likely familiar with Kamada (KMDA) and Prothena (PRTA). But which of these two companies is the best option for those looking for undervalued stocks?

Filtered for Prothena Corporation plcMore Headlines
04

Compare before deciding

Benchmark PRTA against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Prothena Corporation plc (PRTA)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
PRTA logoPRTAProthena Corporation plcCurrent
$8.68$454.43M-1.92-92.84%-2520.57%-63.62%—
FOLD logoFOLDAmicus Therapeutics, Inc.
$14.49$4.55B-164.8520.05%-4.27%-12.02%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$14.88$1.47B-2.5520.13%-81.79%——
IONS logoIONSIonis Pharmaceuticals, Inc.
$43.93$7.3B-18.4633.87%-64.64%-110.84%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$246.51$32.91B105.8065.19%16.82%93.61%—
RCUS logoRCUSArcus Biosciences, Inc.
$26.39$3.32B-8.02-4.26%-386.32%-87.98%—

Compare PRTA vs Peers

Prothena Corporation plc (PRTA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs FOLD

Most directly comparable listed peer for PRTA.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare PRTA against a more recognizable public peer.

Peer Set

Compare Top 5

vs FOLD, RARE, IONS, ALNY

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

PRTA SEC Filings & Documents

Prothena Corporation plc (PRTA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

May 15, 2026·SEC

Material company update

May 7, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 27, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 22, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

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PRTA Frequently Asked Questions

Prothena Corporation plc (PRTA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Prothena Corporation plc's revenue?

Prothena Corporation plc (PRTA) reported $54.5M in revenue for fiscal year 2025. This represents a 4287% increase from $1.2M in 2010.

How fast is Prothena Corporation plc growing?

Prothena Corporation plc (PRTA) saw revenue decline by 92.8% over the past year.

Is PRTA profitable?

Prothena Corporation plc (PRTA) reported a net loss of $44.0M for fiscal year 2025.

Dividend & Returns
What is PRTA's return on equity?

Prothena Corporation plc (PRTA) has a return on equity (ROE) of -63.6%. Negative ROE indicates the company is unprofitable.

What is Prothena Corporation plc's free cash flow?

Prothena Corporation plc (PRTA) had negative free cash flow of $60.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PRTA back in 2010?

Total return calculator · dividends reinvested · 16+ years of data

See returns →