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PRTAProthena Corporation plc
$7.97$417M
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
PRTA logo

Prothena Corporation plc

PRTA
NASDAQ · Neuroscience Biotech
$7.97
At close - Nov 6, 4:00 PM EST - USD
Market Cap$417M
P/E-17.1x
52W High$11.80
Volume421.78K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Milestone-Driven Revenue Masks Persistent Cash Burn

Prothena's financial profile is defined by extreme revenue lumpiness, with quarterly swings from $51.1M in 2026Q1 to $1.0M in 2026Q2, suggesting a model reliant on non-recurring licensing milestones rather than sustainable product sales.

GrowthMixed
ProfitabilityStrained
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

PRTA price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

5/12 Beats

EPS beat 5 of last 12 quarters

02

Valuation risk

-144% Peers

P/E is 144% below peer median

03

Market leadership

RS 35 · Lag

Laggard (Underperforming 65% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystEstimated earnings · Feb 5

Market performance

Price History →

Trailing total returns as of 11/8/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
PRTA-13.37%
S&P 500 (^GSPC)+7.63%
1-Year Return
PRTA-20.93%
S&P 500 (^GSPC)+9.69%
3-Year Return
PRTA-77.69%
S&P 500 (^GSPC)+69.63%
5-Year Return
PRTA-86.38%
S&P 500 (^GSPC)+57.77%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/E5Y Low
-17.1x
Forward P/E
67.2x
EV/EBITDA
N/A
FCF YieldCash Flow
N/A

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
-17.1x
35.8x
0th· Low
EV/EBITDA
N/A
25.0x
N/A
Price/FCF
N/A
26.0x
N/A
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
No DCF Model AvailableIntrinsic value modeling is not supported for this equity.

Growth & profitability

Annual revenue & EPS trend
Revenue FY25
$10M-92.8% YoY
Net income FY25
-$244M-99.6% YoY
Free cash flow FY25
-$164M-8.9% YoY
Operating margin FY25
-1905.8%-1791.5 pts YoY
ROIC (FY25)-2099.8%
Avg ROIC 5Y-1269.6%
ROE (TTM)-8.3%
Piotroski Score1 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate5/12 (42%)
Revenue Beat Rate4/12 (33%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q4 2026Latest
Nov 5, 2026
-$0.32-40.9%
vs -$0.23
$620,000-93.5%
vs $10M
Q3 2026
Aug 6, 2026
-$0.32+17.9%
vs -$0.39
$1M+139.5%
vs $421,667
Q2 2026
May 7, 2026
$0.60+293.5%
vs -$0.31
$51M+6215.2%
vs $808,909
Q1 2026
Feb 19, 2026
-$0.44+2.2%
vs -$0.45
$21,000-98.4%
vs $1M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

4 Stories
Defense World·18h ago
Prothena Corporation plc (NASDAQ:PRTA) Stock Has Average Target Price of $20.00

Shares of Prothena Corporation plc (NASDAQ: PRTA - Get Free Report) have been assigned a consensus rating of "Moderate Buy" from the seven analysts that are covering the stock, Marketbeat.com reports. One equities research analyst has rated the stock with a sell rating, one has given a hold rating, four have issued a buy rating and

Business Wire·2d ago
Prothena Reports Third Quarter 2026 Financial Results and Business Highlights

DUBLIN--(BUSINESS WIRE)---- $PRTA #Prothena--Prothena today reported financial results for the third quarter and first nine months of 2026 and provided business highlights.

Defense World·Oct 27, 2026
Prothena (NASDAQ:PRTA) Major Shareholder William Scully Purchases 50,000 Shares of Company Stock

Prothena Corporation plc (NASDAQ: PRTA - Get Free Report) major shareholder William Scully acquired 50,000 shares of the company's stock in a transaction on Friday, October 23rd. The shares were acquired at an average price of $8.07 per share, for a total transaction of $403,500.00. Following the completion of the acquisition, the insider directly owned 1,187,000

Defense World·Oct 27, 2026
Prothena (NASDAQ:PRTA) Major Shareholder William Scully Buys 100,000 Shares of Stock

Prothena Corporation plc (NASDAQ: PRTA - Get Free Report) major shareholder William Scully purchased 100,000 shares of the business's stock in a transaction that occurred on Thursday, October 22nd. The stock was bought at an average cost of $8.19 per share, with a total value of $819,000.00. Following the acquisition, the insider owned 1,137,000 shares in

Filtered for Prothena Corporation plcMore Headlines
04

Compare before deciding

Benchmark PRTA against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Prothena Corporation plc (PRTA)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
PRTA logoPRTAProthena Corporation plcCurrent
$7.97$417.26M-17.11-92.84%-45.43%-8.34%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$15.43$1.52B-3.0120.13%-71.78%——
IONS logoIONSIonis Pharmaceuticals, Inc.
$39.42$6.55B-11.5533.87%-64.64%-110.84%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$155.94$20.82B7.9065.19%54.34%159.72%—
RCUS logoRCUSArcus Biosciences, Inc.
$18.28$2.3B-5.23-4.26%-445%-90.04%—
BIIB logoBIIBBiogen Inc.
$248.35$36.69B105.481.39%3.38%1.86%—

Compare PRTA vs Peers

Prothena Corporation plc (PRTA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RARE

Most directly comparable listed peer for PRTA.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare PRTA against a more recognizable public peer.

Peer Set

Compare Top 5

vs RARE, IONS, ALNY, RCUS

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

PRTA SEC Filings & Documents

Prothena Corporation plc (PRTA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

May 15, 2026·SEC

Material company update

May 7, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 27, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 22, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

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PRTA Frequently Asked Questions

Prothena Corporation plc (PRTA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Prothena Corporation plc's revenue?

Prothena Corporation plc (PRTA) reported $52.7M in revenue over the trailing twelve months. Revenue was $9.7M in fiscal year 2025. That is 679% more than the $1.2M of fiscal year 2010.

How fast is Prothena Corporation plc growing?

Prothena Corporation plc (PRTA) grew revenue by 347.4% over the trailing twelve months, compared with the twelve months before.

Is PRTA profitable?

No. Prothena Corporation plc (PRTA) reported a net loss of $24.0M over the trailing twelve months.

Dividend & Returns
What is PRTA's return on equity?

Prothena Corporation plc (PRTA) had a return on equity (ROE) of -8.3% over the trailing twelve months. A negative ROE means the company lost money over the period.

What is Prothena Corporation plc's free cash flow?

Prothena Corporation plc (PRTA) had negative free cash flow of $32.2M over the trailing twelve months.

What if you invested $1,000 in PRTA back in 2010?

Total return calculator · dividends reinvested · 16+ years of data

See returns →