47% buyers of institutions opening or closing positions this quarter
2 more exits than new buyers, ownership rose 5.14 percentage points vs the prior quarter, and 2 well-known fund managers in the top 25.
47% buyers of institutions opening or closing positions this quarter
38.7% institutional ownership
GordonMD Global Investments portfolio allocation
Institutional ownership vs Biotechnology peers
No Form 4 insider transactions on file
Latest positioning in PYXS across 13F flow, ownership shift, marquee holders, and holder-count growth.
Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in PYXS held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | PFIZER INC | 7.0M | $9.2M | 0.0% | 11.101% | 3.86% |
| 2 | Laurion Capital Management LP | 5.0M | $7.3M | +4.2% | 7.888% | 0.32% |
| 3 | GordonMD Global Investments LP | 4.1M | $6.0M | 0.0% | 6.506% | 4.19% |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 2.0M | $3.0M | β | 3.210% | 0.00% |
| 5 | HealthInvest Partners AB | 197K | $1.6M | -68.1% | 0.311% | 0.52% |
| 6 | Palo Alto Investors LP | 1.0M | $1.5M | -2.6% | 1.595% | 0.23% |
| 7 | 683 Capital Management, LLC | 896K | $1.3M | +0.5% | 1.415% | 0.07% |
| 8 | RENAISSANCE TECHNOLOGIES LLC | 889K | $1.3M | +22.0% | 1.403% | 0.00% |
| 9 | BlackRock, Inc. | 789K | $1.2M | +0.6% | 1.245% | 0.00% |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 598K | $874K | +3.6% | 0.944% | 0.00% |
| 11 | Longaeva Partners L.P. | 503K | $735K | 0.0% | 0.794% | 0.03% |
| 12 | JACOBS LEVY EQUITY MANAGEMENT, INC | 461K | $673K | β | 0.728% | 0.00% |
| 13 | MILLENNIUM MANAGEMENT LLC | 398K | $581K | -46.5% | 0.628% | 0.00% |
| 14 | MARSHALL WACE, LLP | 354K | $517K | -9.1% | 0.559% | 0.00% |
| 15 | Decheng Capital LLC | 327K | $477K | 0.0% | 0.516% | 0.07% |
| 16 | VANGUARD FIDUCIARY TRUST CO | 301K | $439K | β | 0.475% | 0.00% |
| 17 | UBS Group AG | 254K | $371K | -35.3% | 0.401% | 0.00% |
| 18 | STATE STREET CORP | 249K | $363K | +3.0% | 0.393% | 0.00% |
| 19 | XTX Topco Ltd | 200K | $292K | -30.8% | 0.316% | 0.01% |
| 20 | Bank of New York Mellon Corp | 134K | $196K | -18.8% | 0.212% | 0.00% |
| 21 | CITADEL ADVISORS LLC | 128K | $187K | β | 0.203% | 0.00% |
| 22 | NewEdge Wealth, LLC | 116K | $169K | 0.0% | 0.183% | 0.00% |
| 23 | NORTHERN TRUST CORP | 102K | $149K | 0.0% | 0.161% | 0.00% |
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84K | $122K | -71.1% | 0.132% | 0.00% |
| 25 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 81K | $119K | +11.8% | 0.128% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in PYXS β a direct measure of their conviction.
Filings activity in PYXS during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 75 | 2.6% | 38.73% | +5.14 pp | $40M | +15% |
| Q4 2025 | 77 | +5.5% | 33.59% | 24.02 pp | $35M | 42% |
| Q3 2025 | 73 | 2.7% | 57.61% | +28.54 pp | $59M | +98% |
| Q2 2025 | 75 | 16% | 29.07% | +0.48 pp | $30M | +1.7% |
| Q1 2025 | 89 | 11% | 28.59% | 20.12 pp | $30M | 41% |
| Q4 2024 | 100 | +11% | 48.71% | 39.19 pp | $50M | 45% |
| Q3 2024 | 90 | +13% | 87.90% | +3.47 pp | $91M | +4.1% |
| Q2 2024 | 80 | β | 84.43% | β | $87M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
No recent Form 4 insider transactions on file for PYXS.
Quick answers to the most common questions about buying PYXS stock.
Based on Q1 2026 13F filings, institutional ownership of Pyxis Oncology, Inc. stands at 38.7%, held across 75 reporting institutions.
PFIZER INC is the largest reported institutional holder of PYXS, with approximately 7,032,770 shares worth $0.01B as of Q1 2026.
Yes β 2 widely-followed marquee investors appear among the top 25 institutional holders of PYXS, including RENAISSANCE TECHNOLOGIES LLC, CITADEL ADVISORS LLC.
Our composite Smart Money Score for PYXS is 62 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
16 institutions opened new positions in PYXS during Q1 2026, while 18 fully exited. 38 added to existing positions and 19 trimmed.
PYXS institutional ownership rose by 5.14 percentage points quarter-over-quarter, with a net change of β holders.
The top 10 institutions account for 83.1% of all reported 13F value in PYXS, and the top 25 account for 96.5%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.