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RYTMRhythm Pharmaceuticals, Inc.
$96.79$6.6B
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RYTM logoRhythm Pharmaceuticals, Inc.(RYTM)Earnings, Financials & Key Ratios

RYTM•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryMetabolic and Obesity Therapies
AboutRhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the treatment of rare genetic diseases of obesity. The company's lead product candidate is IMCIVREE, a potent melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is also developing setmelanotide, which is in Phase II clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, Smith-Magenis syndrome obesity, POMC epigenetic disorders, and other MC4R disorders. Rhythm Pharmaceuticals, Inc. has a collaborative research agreement with the Clinical Registry Investigating Bardet-Biedl Syndrome. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.Show more
  • Revenue$190M+45.8%
  • EBITDA-$191M+27.8%
  • Net Income-$197M+24.6%
  • EPS (Diluted)-3.11+28.3%
  • Gross Margin89.73%
  • EBITDA Margin-100.49%+50.5%
  • Operating Margin-101.19%+50.4%
  • Net Margin-103.57%+48.3%
  • ROE-129.46%+17.0%

RYTM Key Insights

Rhythm Pharmaceuticals, Inc. (RYTM) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

No significant strengths identified

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Expensive at 45.2x book value

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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RYTM Price & Volume

Rhythm Pharmaceuticals, Inc. (RYTM) stock price & volume — 10-year historical chart

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RYTM Growth Metrics

Rhythm Pharmaceuticals, Inc. (RYTM) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years100.23%
TTM58.67%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-20.8%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-13%

Return on Capital

10 Years-67.45%
5 Years-69.17%
3 Years-71.38%
Last Year-58.9%

RYTM Recent Earnings

Rhythm Pharmaceuticals, Inc. (RYTM) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 4/12 qtrs (33%)●Beat Revenue 4/12 qtrs (33%)
Q2 2026Latest
May 5, 2026
Metric
Actual
Est
EPS
$0.83+3.5%
$0.86
Rev
$60M+7.8%
$56M
Q1 2026
Feb 26, 2026
Metric
Actual
Est
EPS
$0.73+7.6%
$0.79
Rev
$57M+1.9%
$56M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.82-13.9%
$0.72
Rev
$51M-8.4%
$56M
Q3 2025
Aug 5, 2025
Metric
Actual
Est
EPS
$0.75-13.6%
$0.66
Rev
$49M-5.5%
$51M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 5, 2026
$0.83vs $0.86+3.5%
$60Mvs $56M+7.8%
Q1 2026Feb 26, 2026
$0.73vs $0.79+7.6%
$57Mvs $56M+1.9%
Q4 2025Nov 4, 2025
$0.82vs $0.72-13.9%
$51Mvs $56M-8.4%
Q3 2025Aug 5, 2025
$0.75vs $0.66-13.6%
$49Mvs $51M-5.5%
Based on last 12 quarters of dataView full earnings history →

RYTM Peer Comparison

Rhythm Pharmaceuticals, Inc. (RYTM) competitors in Metabolic and Obesity Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
HALO logoHALOHalozyme Therapeutics, Inc.Direct Competitor8.13B68.5526.7837.55%23.13%126.27%43.89
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.7B27.44-4.7120.13%-91.03%-6.08%
FOLD logoFOLDAmicus Therapeutics, Inc.Direct Competitor4.55B14.49-164.8520.05%-4.27%-12.02%1.76
ACMR logoACMRACM Research, Inc.Direct Competitor7.28B109.8780.2015.24%9.48%5.13%0.16
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor6.55B78.9810.15114.51%-22.58%
KRYS logoKRYSKrystal Biotech, Inc.Direct Competitor10.26B348.0650.8933.94%53.92%19.25%0.01
VNDA logoVNDAVanda Pharmaceuticals Inc.Product Competitor342.83M5.80-1.558.72%-109.99%-61.41%0.04
MDGL logoMDGLMadrigal Pharmaceuticals, Inc.Product Competitor11.66B505.75-39.36432.05%-27.32%-50.15%0.59

Compare RYTM vs Peers

Rhythm Pharmaceuticals, Inc. (RYTM) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs HALO

Most directly comparable listed peer for RYTM.

Scale Benchmark

vs LLY

Larger-name benchmark to compare RYTM against a more recognizable public peer.

Peer Set

Compare Top 5

vs HALO, RARE, FOLD, ACMR

RYTM Income Statement

Rhythm Pharmaceuticals, Inc. (RYTM) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
00003.15M23.64M77.43M130.13M189.76M217.16M
Revenue Growth %
-----649.46%227.56%68.06%45.83%58.67%
Cost of Goods Sold
223K442K834K690K599K2.13M9.3M13.37M19.49M23M
COGS % of Revenue
----18.99%9.02%12.01%10.27%10.27%-
Gross Profit
-223K▲ 0%
-442K▼ 98.2%
-834K▼ 88.7%
-690K▲ 17.3%
2.56M▲ 470.3%
21.5M▲ 741.7%
68.13M▲ 216.8%
116.76M▲ 71.4%
170.26M▲ 45.8%
194.16M▲ 0%
Gross Margin %
----81.01%90.98%87.99%89.73%89.73%89.41%
Gross Profit Growth %
-54.86%-98.21%-88.69%17.27%470.29%741.68%216.79%71.39%45.83%-
Operating Expenses
32.41M78.42M145.17M135.88M172.61M200.66M252.48M382.26M362.28M391.54M
OpEx % of Revenue
----5472.86%848.9%326.09%293.76%190.92%-
Selling, General & Admin
9.52M28.08M36.55M46.13M68.49M92.03M117.53M144.3M194.94M219.44M
SG&A % of Revenue
----2171.4%389.34%151.8%110.9%102.73%-
Research & Development
22.89M50.34M109.45M90.45M104.13M108.63M134.95M237.96M167.34M172.09M
R&D % of Revenue
----3301.46%459.56%174.29%182.87%88.19%-
Other Operating Expenses
00-834K-690K000000
Operating Income
-32.41M▲ 0%
-78.42M▼ 141.9%
-146M▼ 86.2%
-136.57M▲ 6.5%
-170.06M▼ 24.5%
-179.16M▼ 5.3%
-184.36M▼ 2.9%
-265.5M▼ 44.0%
-192.02M▲ 27.7%
-197.37M▲ 0%
Operating Margin %
-----5391.85%-757.92%-238.1%-204.04%-101.19%-90.89%
Operating Income Growth %
-25.12%-141.94%-86.18%6.46%-24.52%-5.35%-2.9%-44.02%27.68%-
EBITDA
-32.19M-77.97M-145.17M-135.88M-168.9M-177.49M-182.6M-263.94M-190.68M-196.42M
EBITDA Margin %
-----5355.14%-750.85%-235.83%-202.83%-100.49%-90.45%
EBITDA Growth %
-24.95%-142.24%-86.17%6.39%-24.3%-5.08%-2.88%-44.55%27.76%-14.81%
D&A (Non-Cash Add-back)
223K442K834K690K1.16M1.67M1.76M1.56M1.34M955K
EBIT
-32.41M-78.42M-146M-136.57M-69.61M-175.92M-170.22M-239.65M-175.46M-131.45M
Net Interest Income
005.27M2.58M447K-1.17M53K-5.89M-5.29M-3.52M
Interest Income
566K4.35M5.27M2.58M447K4.03M13.95M14.71M15.29M15.21M
Interest Expense
000005.2M13.89M20.6M20.58M10.59M
Other Income/Expense
-1.3M4.35M5.27M2.58M100.45M-1.96M243K5.25M-4.03M-4.34M
Pretax Income
-33.71M▲ 0%
-74.06M▼ 119.7%
-140.73M▼ 90.0%
-134M▲ 4.8%
-69.61M▲ 48.0%
-181.12M▼ 160.2%
-184.11M▼ 1.7%
-260.26M▼ 41.4%
-196.04M▲ 24.7%
-201.72M▲ 0%
Pretax Margin %
-----2207.1%-766.22%-237.79%-200%-103.31%-92.89%
Income Tax
000000564K346K497K962K
Effective Tax Rate %
0%0%0%0%0%0%-0.31%-0.13%-0.25%-0.48%
Net Income
-33.71M▲ 0%
-74.06M▼ 119.7%
-134.62M▼ 81.8%
-130.73M▲ 2.9%
-69.61M▲ 46.8%
-181.12M▼ 160.2%
-184.68M▼ 2.0%
-260.6M▼ 41.1%
-196.54M▲ 24.6%
-203.78M▲ 0%
Net Margin %
-----2207.1%-766.22%-238.52%-200.27%-103.57%-93.84%
Net Income Growth %
-30.29%-119.72%-81.77%2.89%46.75%-160.18%-1.97%-41.11%24.58%-20.8%
Net Income (Continuing)
-33.71M-74.06M-140.73M-134M-69.61M-181.12M-184.68M-260.6M-196.54M-203.78M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-1.26▲ 0%
-2.39▼ 89.7%
-3.70▼ 54.8%
-2.96▲ 20.0%
-1.37▲ 53.7%
-3.51▼ 156.2%
-3.20▲ 8.8%
-4.34▼ 35.6%
-3.11▲ 28.3%
-3.00▲ 0%
EPS Growth %
18.71%-89.68%-54.81%20%53.72%-156.2%8.83%-35.63%28.34%-13%
EPS (Basic)
-1.26-2.39-3.70-2.96-1.37-3.51-3.20-4.34-3.11-
Diluted Shares Outstanding
26.73M31M36.42M44.13M49.6M52.12M57.67M60.99M64.98M67.97M
Basic Shares Outstanding
26.73M31M36.42M44.13M49.6M52.12M57.67M60.99M64.98M67.97M
Dividend Payout Ratio
----------

RYTM Balance Sheet

Rhythm Pharmaceuticals, Inc. (RYTM) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
150.67M258.69M302.4M181.67M308.39M354.24M308.27M374.2M466.92M430.09M
Cash & Short-Term Investments
148.08M252.06M292.46M172.79M294.86M333.29M275.85M320.56M388.95M340.63M
Cash Only
34.24M49.54M62.29M100.85M59.25M127.68M60.08M89.14M54.3M62.14M
Short-Term Investments
113.85M202.52M230.16M71.94M235.61M205.61M215.76M231.43M334.65M278.49M
Accounts Receivable
00001.02M6.22M14.87M18.51M26.08M34.19M
Days Sales Outstanding
----118.6296.1170.0851.9350.1750.18
Inventory
0000111K2.92M8.62M18.74M25.75M28.65M
Days Inventory Outstanding
----67.64499.16338.4511.7482.24290.7
Other Current Assets
1.06M1.34M3.51M3.05M3.99M7.42M6.67M8.8M9.97M26.62M
Total Non-Current Assets
1.06M1.52M6.12M5.41M21.14M28.25M24.48M18.07M14.28M12.23M
Property, Plant & Equipment
840K1.12M5.72M5M4.33M3.38M2.12M4.11M4.15M4M
Fixed Asset Turnover
----0.73x7.00x36.49x31.67x45.69x74.16x
Goodwill
0000000000
Intangible Assets
00004.66M7.88M7.03M6.17M5.32M5.11M
Long-Term Investments
00000000522K1.79M
Other Non-Current Assets
225K401K403K403K12.14M16.98M15.33M7.79M3.29M2.52M
Total Assets
151.74M▲ 0%
260.21M▲ 71.5%
308.52M▲ 18.6%
187.07M▼ 39.4%
329.52M▲ 76.1%
382.48M▲ 16.1%
332.75M▼ 13.0%
392.27M▲ 17.9%
481.19M▲ 22.7%
442.32M▲ 0%
Asset Turnover
----0.01x0.06x0.23x0.33x0.39x0.48x
Asset Growth %
1129.73%71.49%18.57%-39.37%76.15%16.07%-13%17.89%22.67%74.08%
Total Current Liabilities
6.72M13.58M24.42M17.99M43.43M39.81M55.2M115.52M105.94M103.2M
Accounts Payable
2.43M7.64M10.41M4.9M5.74M4.8M4.88M12.33M13.95M12.3M
Days Payables Outstanding
3.97K6.31K4.56K2.59K3.5K820.87191.68336.6261.17221.6
Short-Term Debt
000000007.95M10.81M
Deferred Revenue (Current)
00007M1.43M1.29M1.29M194K242K
Other Current Liabilities
101K60K377K180K800K2.42M5.41M43.59M61.42M65.65M
Current Ratio
22.42x19.05x12.38x10.10x7.10x8.90x5.58x3.24x4.41x4.17x
Quick Ratio
22.42x19.05x12.38x10.10x7.10x8.83x5.43x3.08x4.16x3.89x
Cash Conversion Cycle
-----3.31K-225.6216.8227.03271.24119.28
Total Non-Current Liabilities
228K372K3.09M2.55M1.95M78.41M107.78M112.21M236.18M216.21M
Long-Term Debt
00000000235.19M213.05M
Capital Lease Obligations
003.09M2.55M1.95M1.26M490K3.94M3.34M13.7M
Deferred Tax Liabilities
00000000998K998K
Other Non-Current Liabilities
228K372K00077.15M107.29M108.27M-3.34M0
Total Liabilities
6.95M13.95M27.5M20.55M45.37M118.22M162.99M227.72M342.13M319.41M
Total Debt
003.56M3.09M2.55M1.94M1.26M3.94M246.47M227.02M
Net Debt
-34.24M-49.54M-58.74M-97.77M-56.7M-125.73M-58.82M-85.2M192.17M164.88M
Debt / Equity
--0.01x0.02x0.01x0.01x0.01x0.02x1.77x1.85x
Debt / EBITDA
----------1.16x
Net Debt / EBITDA
----------0.84x
Interest Coverage
------33.82x-12.25x-11.63x-8.52x-12.41x
Total Equity
144.79M▲ 0%
246.26M▲ 70.1%
281.02M▲ 14.1%
166.53M▼ 40.7%
284.15M▲ 70.6%
264.26M▼ 7.0%
169.76M▼ 35.8%
164.55M▼ 3.1%
139.07M▼ 15.5%
122.91M▲ 0%
Equity Growth %
1884.21%70.08%14.12%-40.74%70.63%-7%-35.76%-3.07%-15.48%-149.3%
Book Value per Share
5.427.947.723.775.735.072.942.702.141.81
Total Shareholders' Equity
144.79M246.26M281.02M166.53M284.15M264.26M169.76M164.55M139.07M122.91M
Common Stock
27K34K44K44K50K56K59K61K67K69K
Retained Earnings
-110.25M-184.6M-325.33M-459.33M-528.94M-710.06M-894.74M-1.16B-1.35B-1.41B
Treasury Stock
0000000000
Accumulated OCI
00049K-1K-92K134K-39K-796K444K
Minority Interest
0000000000

RYTM Cash Flow Statement

Rhythm Pharmaceuticals, Inc. (RYTM) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-29.46M-62.06M-122.75M-121.98M-146M-173.43M-136.16M-113.88M-115.67M-75.32M
Operating CF Margin %
-----4629.14%-733.68%-175.85%-87.51%-60.96%-
Operating CF Growth %
-26.88%-110.64%-97.81%0.63%-19.69%-18.78%21.49%16.36%-1.58%79.52%
Net Income
-33.71M-74.06M-140.73M-134M-69.61M-181.12M-184.68M-260.6M-196.54M-203.78M
Depreciation & Amortization
223K442K834K690K1.16M1.67M1.76M1.56M1.34M955K
Stock-Based Compensation
2.28M6.39M11.88M17.45M20.8M19.83M32.55M39.68M66.82M34.69M
Deferred Taxes
1.86M000-100M00000
Other Non-Cash Items
-76K4.51M203K-234K-250K5.91M9.4M94.9M13.68M29.13M
Working Capital Changes
-39K667K5.07M-5.89M1.9M-19.72M4.81M10.57M-968K6.94M
Change in Receivables
0000-1.25M-5.2M-8.64M-3.65M-7.57M-8.26M
Change in Inventory
0000-11K-2.81M-5.71M-10.12M-7.47M-6.9M
Change in Payables
1.95M6.95M10.51M-6.45M18.31M1.54M14.77M21.92M21.89M25.52M
Cash from Investing
-110.04M-87.15M-27.97M158.53M-62.16M28.03M-5.67M-48.17M-137.15M-161.97M
Capital Expenditures
-133K-722K-3.38M-214K-5.43M-4.28M-47K0-953K-953K
CapEx % of Revenue
----172.29%18.11%0.06%-0.5%0.44%
Acquisitions
0024.59M0100M4M0000
Investments
----------
Other Investing
-109.91M-86.43M-24.59M07M-4M-5.67M-40.5M-40M-40M
Cash from Financing
167.2M164.69M163.47M2.01M166.48M213.83M74.37M191.24M217.96M185.46M
Debt Issued (Net)
0000000-12.9M0-5.4M
Equity Issued (Net)
166.5M162.88M161.35M0161.73M131.11M48.88M195.24M237.88M191.11M
Dividends Paid
0000000-3.97M00
Share Repurchases
0000000000
Other Financing
700K1.81M2.12M2.01M4.75M82.72M25.49M12.87M-19.92M-244K
Net Change in Cash
27.7M▲ 0%
15.48M▼ 44.1%
12.75M▼ 17.6%
38.56M▲ 202.3%
-41.68M▼ 208.1%
68.43M▲ 264.2%
-67.6M▼ 198.8%
29.19M▲ 143.2%
-34.78M▼ 219.1%
-43.75M▲ 0%
Free Cash Flow
-29.59M▲ 0%
-62.78M▼ 112.1%
-126.14M▼ 100.9%
-122.19M▲ 3.1%
-151.44M▼ 23.9%
-177.71M▼ 17.3%
-136.2M▲ 23.4%
-113.88M▲ 16.4%
-116.63M▼ 2.4%
-76.28M▲ 0%
FCF Margin %
-----4801.43%-751.79%-175.91%-87.51%-61.46%-35.12%
FCF Growth %
-21.9%-112.14%-100.92%3.12%-23.93%-17.35%23.36%16.39%-2.41%32.79%
FCF per Share
-1.11-2.02-3.46-2.77-3.05-3.41-2.36-1.87-1.79-1.12
FCF Conversion (FCF/Net Income)
0.87x0.84x0.91x0.93x2.10x0.96x0.74x0.44x0.59x0.37x
Interest Paid
0000000000
Taxes Paid
0000000000

RYTM Key Ratios

Rhythm Pharmaceuticals, Inc. (RYTM) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-44.33%-37.88%-51.06%-58.42%-30.89%-66.05%-85.1%-155.91%-129.46%-204.35%
Return on Invested Capital (ROIC)
-43.68%-38.28%-52.27%-70.39%-86.12%-73.43%-110.85%-209.29%-70.15%-60.5%
Gross Margin
----81.01%90.98%87.99%89.73%89.73%89.41%
Net Margin
-----2207.1%-766.22%-238.52%-200.27%-103.57%-93.84%
Debt / Equity
--0.01x0.02x0.01x0.01x0.01x0.02x1.77x1.85x
Interest Coverage
------33.82x-12.25x-11.63x-8.52x-12.41x
FCF Conversion
0.87x0.84x0.91x0.93x2.10x0.96x0.74x0.44x0.59x0.37x
Revenue Growth
-----649.46%227.56%68.06%45.83%58.67%
Related:RYTM Dividend History·RYTM Revenue History·RYTM Price History·RYTM P/E History·RYTM Financial Ratios·RYTM Institutional Holders

RYTM SEC Filings & Documents

Rhythm Pharmaceuticals, Inc. (RYTM) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 5, 2026·SEC

Material company update

Apr 3, 2026·SEC

Material company update

Mar 26, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 28, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 5, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 5, 2025·SEC

RYTM Frequently Asked Questions

Rhythm Pharmaceuticals, Inc. (RYTM) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Rhythm Pharmaceuticals, Inc. (RYTM) reported $217.2M in revenue for fiscal year 2025.

Rhythm Pharmaceuticals, Inc. (RYTM) grew revenue by 45.8% over the past year. This is strong growth.

Rhythm Pharmaceuticals, Inc. (RYTM) reported a net loss of $203.8M for fiscal year 2025.

Dividend & Returns

Rhythm Pharmaceuticals, Inc. (RYTM) has a return on equity (ROE) of -129.5%. Negative ROE indicates the company is unprofitable.

Rhythm Pharmaceuticals, Inc. (RYTM) had negative free cash flow of $76.3M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in RYTM back in 2012?

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How much would $100/month in RYTM be worth today?

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