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RYTM logoRhythm Pharmaceuticals, Inc.(RYTM)Earnings, Financials & Key Ratios

RYTM•NASDAQ
$92.31
$6.3B mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryMetabolic and Obesity Therapies
AboutRhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the treatment of rare genetic diseases of obesity. The company's lead product candidate is IMCIVREE, a potent melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is also developing setmelanotide, which is in Phase II clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, Smith-Magenis syndrome obesity, POMC epigenetic disorders, and other MC4R disorders. Rhythm Pharmaceuticals, Inc. has a collaborative research agreement with the Clinical Registry Investigating Bardet-Biedl Syndrome. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.Show more
  • Revenue$190M+45.8%
  • EBITDA-$191M+27.8%
  • Net Income-$197M+24.6%
  • EPS (Diluted)-3.11+28.3%
  • Gross Margin89.73%
  • EBITDA Margin-100.49%+50.5%
  • Operating Margin-101.19%+50.4%
  • Net Margin-103.57%+48.3%
  • ROE-129.46%+17.0%
  • ROIC-70.15%+66.5%
  • Debt/Equity1.77+7305.6%
  • Interest Coverage-8.52+26.7%
Technical→

RYTM Key Insights

Rhythm Pharmaceuticals, Inc. (RYTM) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

No significant strengths identified

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Expensive at 43.1x book value

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

RYTM Price & Volume

Rhythm Pharmaceuticals, Inc. (RYTM) stock price & volume — 10-year historical chart

Loading chart...

RYTM Growth Metrics

Rhythm Pharmaceuticals, Inc. (RYTM) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years100.23%
TTM58.67%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-20.8%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-13%

Return on Capital

10 Years-67.45%
5 Years-69.17%
3 Years-71.38%
Last Year-58.9%

RYTM Recent Earnings

Rhythm Pharmaceuticals, Inc. (RYTM) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 4/12 qtrs (33%)●Beat Revenue 4/12 qtrs (33%)
Q2 2026Latest
May 5, 2026
EPS
$0.83
Est $0.86
+3.5%
Revenue
$60M
Est $56M
+7.8%
Q1 2026
Feb 26, 2026
EPS
$0.73
Est $0.79
+7.6%
Revenue
$57M
Est $56M
+1.9%
Q4 2025
Nov 4, 2025
EPS
$0.82
Est $0.72
-13.9%
Revenue
$51M
Est $56M
-8.4%
Q3 2025
Aug 5, 2025
EPS
$0.75
Est $0.66
-13.6%
Revenue
$49M
Est $51M
-5.5%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 5, 2026
$0.83vs $0.86+3.5%
$60Mvs $56M+7.8%
Q1 2026Feb 26, 2026
$0.73vs $0.79+7.6%
$57Mvs $56M+1.9%
Q4 2025Nov 4, 2025
$0.82vs $0.72-13.9%
$51Mvs $56M-8.4%
Q3 2025Aug 5, 2025
$0.75vs $0.66-13.6%
$49Mvs $51M-5.5%
Based on last 12 quarters of dataView full earnings history →

RYTM Peer Comparison

Rhythm Pharmaceuticals, Inc. (RYTM) competitors in Metabolic and Obesity Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
HALO logoHALOHalozyme Therapeutics, Inc.Direct Competitor7.76B65.8725.7337.55%22.69%6.49%8.31%
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.46B25.01-4.2920.13%-85.54%-9.11%
FOLD logoFOLDAmicus Therapeutics, Inc.Direct Competitor4.47B14.49-80.5032.29%-2.35%-6.1%2.29
ACMR logoACMRACM Research, Inc.Direct Competitor3.5B52.8038.5415.24%10.44%6.11%0.16
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor5.39B65.048.36114.51%39.44%13.02%
KRYS logoKRYSKrystal Biotech, Inc.Direct Competitor8.38B284.5741.6033.94%53.92%19.25%2.26%0.01
VNDA logoVNDAVanda Pharmaceuticals Inc.Product Competitor436.72M7.39-1.988.72%-39.7%-18.07%0.02
MDGL logoMDGLMadrigal Pharmaceuticals, Inc.Product Competitor11.41B502.47-39.10432.05%-39.04%-46.21%0.00

Compare RYTM vs Peers

Rhythm Pharmaceuticals, Inc. (RYTM) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs HALO

Most directly comparable listed peer for RYTM.

Scale Benchmark

vs LLY

Larger-name benchmark to compare RYTM against a more recognizable public peer.

Peer Set

Compare Top 5

vs HALO, RARE, FOLD, ACMR

RYTM Income Statement

Rhythm Pharmaceuticals, Inc. (RYTM) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue00003.15M23.64M77.43M130.13M189.76M217.16M
Revenue Growth %-----649.46%227.56%68.06%45.83%58.67%
Cost of Goods Sold223K442K834K690K599K2.13M9.3M13.37M19.49M23M
COGS % of Revenue----18.99%9.02%12.01%10.27%10.27%-
Gross Profit
-223K▲ 0%
-442K▼ 98.2%
-834K▼ 88.7%
-690K▲ 17.3%
2.56M▲ 470.3%
21.5M▲ 741.7%
68.13M▲ 216.8%
116.76M▲ 71.4%
170.26M▲ 45.8%
194.16M▲ 0%
Gross Margin %----81.01%90.98%87.99%89.73%89.73%89.41%
Gross Profit Growth %-54.86%-98.21%-88.69%17.27%470.29%741.68%216.79%71.39%45.83%-
Operating Expenses32.41M78.42M145.17M135.88M172.61M200.66M252.48M382.26M362.28M391.54M
OpEx % of Revenue----5472.86%848.9%326.09%293.76%190.92%-
Selling, General & Admin9.52M28.08M36.55M46.13M68.49M92.03M117.53M144.3M194.94M219.44M
SG&A % of Revenue----2171.4%389.34%151.8%110.9%102.73%-
Research & Development22.89M50.34M109.45M90.45M104.13M108.63M134.95M237.96M167.34M172.09M
R&D % of Revenue----3301.46%459.56%174.29%182.87%88.19%-
Other Operating Expenses00-834K-690K000000
Operating Income
-32.41M▲ 0%
-78.42M▼ 141.9%
-146M▼ 86.2%
-136.57M▲ 6.5%
-170.06M▼ 24.5%
-179.16M▼ 5.3%
-184.36M▼ 2.9%
-265.5M▼ 44.0%
-192.02M▲ 27.7%
-197.37M▲ 0%
Operating Margin %-----5391.85%-757.92%-238.1%-204.04%-101.19%-90.89%
Operating Income Growth %-25.12%-141.94%-86.18%6.46%-24.52%-5.35%-2.9%-44.02%27.68%-
EBITDA-32.19M-77.97M-145.17M-135.88M-168.9M-177.49M-182.6M-263.94M-190.68M-196.42M
EBITDA Margin %-----5355.14%-750.85%-235.83%-202.83%-100.49%-90.45%
EBITDA Growth %-24.95%-142.24%-86.17%6.39%-24.3%-5.08%-2.88%-44.55%27.76%-14.81%
D&A (Non-Cash Add-back)223K442K834K690K1.16M1.67M1.76M1.56M1.34M955K
EBIT-32.41M-78.42M-146M-136.57M-69.61M-175.92M-170.22M-239.65M-175.46M-131.45M
Net Interest Income005.27M2.58M447K-1.17M53K-5.89M-5.29M-3.52M
Interest Income566K4.35M5.27M2.58M447K4.03M13.95M14.71M15.29M15.21M
Interest Expense000005.2M13.89M20.6M20.58M10.59M
Other Income/Expense-1.3M4.35M5.27M2.58M100.45M-1.96M243K5.25M-4.03M-4.34M
Pretax Income
-33.71M▲ 0%
-74.06M▼ 119.7%
-140.73M▼ 90.0%
-134M▲ 4.8%
-69.61M▲ 48.0%
-181.12M▼ 160.2%
-184.11M▼ 1.7%
-260.26M▼ 41.4%
-196.04M▲ 24.7%
-201.72M▲ 0%
Pretax Margin %-----2207.1%-766.22%-237.79%-200%-103.31%-92.89%
Income Tax000000564K346K497K962K
Effective Tax Rate %0%0%0%0%0%0%-0.31%-0.13%-0.25%-0.48%
Net Income
-33.71M▲ 0%
-74.06M▼ 119.7%
-134.62M▼ 81.8%
-130.73M▲ 2.9%
-69.61M▲ 46.8%
-181.12M▼ 160.2%
-184.68M▼ 2.0%
-260.6M▼ 41.1%
-196.54M▲ 24.6%
-203.78M▲ 0%
Net Margin %-----2207.1%-766.22%-238.52%-200.27%-103.57%-93.84%
Net Income Growth %-30.29%-119.72%-81.77%2.89%46.75%-160.18%-1.97%-41.11%24.58%-20.8%
Net Income (Continuing)-33.71M-74.06M-140.73M-134M-69.61M-181.12M-184.68M-260.6M-196.54M-203.78M
Discontinued Operations0000000000
Minority Interest0000000000
EPS (Diluted)
-1.26▲ 0%
-2.39▼ 89.7%
-3.70▼ 54.8%
-2.96▲ 20.0%
-1.37▲ 53.7%
-3.51▼ 156.2%
-3.20▲ 8.8%
-4.34▼ 35.6%
-3.11▲ 28.3%
-3.00▲ 0%
EPS Growth %18.71%-89.68%-54.81%20%53.72%-156.2%8.83%-35.63%28.34%-13%
EPS (Basic)-1.26-2.39-3.70-2.96-1.37-3.51-3.20-4.34-3.11-
Diluted Shares Outstanding26.73M31M36.42M44.13M49.6M52.12M57.67M60.99M64.98M67.97M
Basic Shares Outstanding26.73M31M36.42M44.13M49.6M52.12M57.67M60.99M64.98M67.97M
Dividend Payout Ratio----------

RYTM Balance Sheet

Rhythm Pharmaceuticals, Inc. (RYTM) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets150.67M258.69M302.4M181.67M308.39M354.24M308.27M374.2M466.92M430.09M
Cash & Short-Term Investments148.08M252.06M292.46M172.79M294.86M333.29M275.85M320.56M388.95M340.63M
Cash Only34.24M49.54M62.29M100.85M59.25M127.68M60.08M89.14M54.3M62.14M
Short-Term Investments113.85M202.52M230.16M71.94M235.61M205.61M215.76M231.43M334.65M278.49M
Accounts Receivable00001.02M6.22M14.87M18.51M26.08M34.19M
Days Sales Outstanding----118.6296.1170.0851.9350.1750.18
Inventory0000111K2.92M8.62M18.74M25.75M28.65M
Days Inventory Outstanding----67.64499.16338.4511.7482.24290.7
Other Current Assets1.06M1.34M3.51M3.05M3.99M7.42M6.67M8.8M9.97M26.62M
Total Non-Current Assets1.06M1.52M6.12M5.41M21.14M28.25M24.48M18.07M14.28M12.23M
Property, Plant & Equipment840K1.12M5.72M5M4.33M3.38M2.12M4.11M4.15M4M
Fixed Asset Turnover----0.73x7.00x36.49x31.67x45.69x74.16x
Goodwill0000000000
Intangible Assets00004.66M7.88M7.03M6.17M5.32M5.11M
Long-Term Investments00000000522K1.19M
Other Non-Current Assets225K401K403K403K12.14M16.98M15.33M7.79M3.29M15.02M
Total Assets
151.74M▲ 0%
260.21M▲ 71.5%
308.52M▲ 18.6%
187.07M▼ 39.4%
329.52M▲ 76.1%
382.48M▲ 16.1%
332.75M▼ 13.0%
392.27M▲ 17.9%
481.19M▲ 22.7%
442.32M▲ 0%
Asset Turnover----0.01x0.06x0.23x0.33x0.39x0.48x
Asset Growth %1129.73%71.49%18.57%-39.37%76.15%16.07%-13%17.89%22.67%74.08%
Total Current Liabilities6.72M13.58M24.42M17.99M43.43M39.81M55.2M115.52M105.94M103.2M
Accounts Payable2.43M7.64M10.41M4.9M5.74M4.8M4.88M12.33M13.95M12.3M
Days Payables Outstanding3.97K6.31K4.56K2.59K3.5K820.87191.68336.6261.17221.6
Short-Term Debt000000007.95M676K
Deferred Revenue (Current)00007M1.43M1.29M1.29M194K242K
Other Current Liabilities101K60K377K180K800K2.42M5.41M43.59M61.42M102.47M
Current Ratio22.42x19.05x12.38x10.10x7.10x8.90x5.58x3.24x4.41x4.41x
Quick Ratio22.42x19.05x12.38x10.10x7.10x8.83x5.43x3.08x4.16x4.16x
Cash Conversion Cycle-----3.31K-225.6216.8227.03271.24119.28
Total Non-Current Liabilities228K372K3.09M2.55M1.95M78.41M107.78M112.21M236.18M101.5M
Long-Term Debt00000000235.19M3.16M
Capital Lease Obligations003.09M2.55M1.95M1.26M490K3.94M3.34M10.54M
Deferred Tax Liabilities00000000998K998K
Other Non-Current Liabilities228K372K00077.15M107.29M108.27M-3.34M198.41M
Total Liabilities6.95M13.95M27.5M20.55M45.37M118.22M162.99M227.72M342.13M204.7M
Total Debt003.56M3.09M2.55M1.94M1.26M3.94M246.47M3.84M
Net Debt-34.24M-49.54M-58.74M-97.77M-56.7M-125.73M-58.82M-85.2M192.17M-58.3M
Debt / Equity--0.01x0.02x0.01x0.01x0.01x0.02x1.77x1.77x
Debt / EBITDA----------0.02x
Net Debt / EBITDA---------0.30x
Interest Coverage------33.82x-12.25x-11.63x-8.52x-12.41x
Total Equity
144.79M▲ 0%
246.26M▲ 70.1%
281.02M▲ 14.1%
166.53M▼ 40.7%
284.15M▲ 70.6%
264.26M▼ 7.0%
169.76M▼ 35.8%
164.55M▼ 3.1%
139.07M▼ 15.5%
122.91M▲ 0%
Equity Growth %1884.21%70.08%14.12%-40.74%70.63%-7%-35.76%-3.07%-15.48%-149.3%
Book Value per Share5.427.947.723.775.735.072.942.702.141.81
Total Shareholders' Equity144.79M246.26M281.02M166.53M284.15M264.26M169.76M164.55M139.07M122.91M
Common Stock27K34K44K44K50K56K59K61K67K69K
Retained Earnings-110.25M-184.6M-325.33M-459.33M-528.94M-710.06M-894.74M-1.16B-1.35B-1.41B
Treasury Stock0000000000
Accumulated OCI00049K-1K-92K134K-39K-796K444K
Minority Interest0000000000

RYTM Cash Flow Statement

Rhythm Pharmaceuticals, Inc. (RYTM) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations-29.46M-62.06M-122.75M-121.98M-146M-173.43M-136.16M-113.88M-115.67M-115.67M
Operating CF Margin %-----4629.14%-733.68%-175.85%-87.51%-60.96%-
Operating CF Growth %-26.88%-110.64%-97.81%0.63%-19.69%-18.78%21.49%16.36%-1.58%-29.99%
Net Income-33.71M-74.06M-140.73M-134M-69.61M-181.12M-184.68M-260.6M-196.54M-203.78M
Depreciation & Amortization223K442K834K690K1.16M1.67M1.76M1.56M1.34M1.21M
Stock-Based Compensation2.28M6.39M11.88M17.45M20.8M19.83M32.55M39.68M66.82M77.06M
Deferred Taxes1.86M000-100M00000
Other Non-Cash Items-76K4.51M203K-234K-250K5.91M9.4M94.9M13.68M-928K
Working Capital Changes-39K667K5.07M-5.89M1.9M-19.72M4.81M10.57M-968K6.94M
Change in Receivables0000-1.25M-5.2M-8.64M-3.65M-7.57M-16.37M
Change in Inventory0000-11K-2.81M-5.71M-10.12M-7.47M-9.98M
Change in Payables1.95M6.95M10.51M-6.45M18.31M1.54M14.77M21.92M21.89M19.91M
Cash from Investing-110.04M-87.15M-27.97M158.53M-62.16M28.03M-5.67M-48.17M-137.15M-104.91M
Capital Expenditures-133K-722K-3.38M-214K-5.43M-4.28M-47K0-953K-953K
CapEx % of Revenue----172.29%18.11%0.06%-0.5%-
Acquisitions0024.59M0100M4M0000
Investments----------
Other Investing-109.91M-86.43M-24.59M07M-4M-5.67M-40.5M-40M-40M
Cash from Financing167.2M164.69M163.47M2.01M166.48M213.83M74.37M191.24M217.96M180.06M
Debt Issued (Net)0000000-12.9M-19.92M-5.4M
Equity Issued (Net)166.5M162.88M161.35M0161.73M131.11M48.88M195.24M237.88M191.11M
Dividends Paid0000000-3.97M-5.38M-1.11M
Share Repurchases0000000000
Other Financing700K1.81M2.12M2.01M4.75M82.72M25.49M12.87M5.38M-4.53M
Net Change in Cash
27.7M▲ 0%
15.48M▼ 44.1%
12.75M▼ 17.6%
38.56M▲ 202.3%
-41.68M▼ 208.1%
68.43M▲ 264.2%
-67.6M▼ 198.8%
29.19M▲ 143.2%
-34.78M▼ 219.1%
-43.82M▲ 0%
Free Cash Flow
-29.59M▲ 0%
-62.78M▼ 112.1%
-126.14M▼ 100.9%
-122.19M▲ 3.1%
-151.44M▼ 23.9%
-177.71M▼ 17.3%
-136.2M▲ 23.4%
-113.88M▲ 16.4%
-116.63M▼ 2.4%
-120.46M▲ 0%
FCF Margin %-----4801.43%-751.79%-175.91%-87.51%-61.46%-55.47%
FCF Growth %-21.9%-112.14%-100.92%3.12%-23.93%-17.35%23.36%16.39%-2.41%-6.15%
FCF per Share-1.11-2.02-3.46-2.77-3.05-3.41-2.36-1.87-1.79-1.79
FCF Conversion (FCF/Net Income)0.87x0.84x0.91x0.93x2.10x0.96x0.74x0.44x0.59x0.59x
Interest Paid0000000000
Taxes Paid0000000000

RYTM Key Ratios

Rhythm Pharmaceuticals, Inc. (RYTM) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)-44.33%-37.88%-51.06%-58.42%-30.89%-66.05%-85.1%-155.91%-129.46%-204.35%
Return on Invested Capital (ROIC)-43.68%-38.28%-52.27%-70.39%-86.12%-73.43%-110.85%-209.29%-70.15%-70.15%
Gross Margin----81.01%90.98%87.99%89.73%89.73%89.41%
Net Margin-----2207.1%-766.22%-238.52%-200.27%-103.57%-93.84%
Debt / Equity--0.01x0.02x0.01x0.01x0.01x0.02x1.77x1.77x
Interest Coverage------33.82x-12.25x-11.63x-8.52x-12.41x
FCF Conversion0.87x0.84x0.91x0.93x2.10x0.96x0.74x0.44x0.59x0.59x
Revenue Growth-----649.46%227.56%68.06%45.83%58.67%

RYTM SEC Filings & Documents

Rhythm Pharmaceuticals, Inc. (RYTM) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 5, 2026·SEC

Material company update

Apr 3, 2026·SEC

Material company update

Mar 26, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 28, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 5, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 5, 2025·SEC

RYTM Frequently Asked Questions

Rhythm Pharmaceuticals, Inc. (RYTM) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Rhythm Pharmaceuticals, Inc. (RYTM) reported $217.2M in revenue for fiscal year 2025.

Rhythm Pharmaceuticals, Inc. (RYTM) grew revenue by 45.8% over the past year. This is strong growth.

Rhythm Pharmaceuticals, Inc. (RYTM) reported a net loss of $203.8M for fiscal year 2025.

Dividend & Returns

Rhythm Pharmaceuticals, Inc. (RYTM) does not currently pay a meaningful dividend. The company may be reinvesting profits for growth.

Rhythm Pharmaceuticals, Inc. (RYTM) has a return on equity (ROE) of -129.5%. Negative ROE indicates the company is unprofitable.

Rhythm Pharmaceuticals, Inc. (RYTM) had negative free cash flow of $120.5M in fiscal year 2025, likely due to heavy capital investments.

Explore More RYTM

Rhythm Pharmaceuticals, Inc. (RYTM) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

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