The company's financial stability appears increasingly fragile, as total debt escalated to $246.5 million in 2025Q4 from a nominal $1.3 million in 2023Q4, significantly increasing the firm's leverage profile.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|
| Total Current Assets | 430.09M | 466.92M | 374.2M | 308.27M | 354.24M | 308.39M | 181.67M | 302.4M | 258.69M | 150.67M | 11.18M | 35.49M | 194K | 18.14M | 18.86M |
| Cash & Short-Term Investments | 340.63M | 388.95M | 320.56M | 275.85M | 333.29M | 294.86M | 172.79M | 292.46M | 252.06M | 148.08M | 10.54M | 34.87M | 152K | 17.76M | 17.04M |
| Cash Only | 62.14M | 54.3M | 89.14M | 60.08M | 127.68M | 59.25M | 100.85M | 62.29M | 49.54M | 34.24M | 6.54M | 34.87M | 152K | 7.36M | 11.77M |
| Short-Term Investments | 278.49M | 334.65M | 231.43M | 215.76M | 205.61M | 235.61M | 71.94M | 230.16M | 202.52M | 113.85M | 4M | 0 | 0 | 10.4M | 5.27M |
| Accounts Receivable | 34.19M | 26.08M | 18.51M | 14.87M | 6.22M | 1.02M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Sales Outstanding | 50.18 | 50.17 | 51.93 | 70.08 | 96.11 | 118.62 | - | - | - | - | - | - | - | - | - |
| Inventory | 28.65M | 25.75M | 18.74M | 8.62M | 2.92M | 111K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Inventory Outstanding | 290.7 | 482.24 | 511.7 | 338.4 | 499.16 | 67.64 | - | - | - | - | - | - | - | - | - |
| Other Current Assets | 26.62M | 9.97M | 8.8M | 6.67M | 7.42M | 3.99M | 3.05M | 3.51M | 1.34M | 1.06M | 216K | 623K | 42K | 0 | 0 |
| Total Non-Current Assets | 12.23M | 14.28M | 18.07M | 24.48M | 28.25M | 21.14M | 5.41M | 6.12M | 1.52M | 1.06M | 1.16M | 1.78M | 0 | 47K | 67K |
| Property, Plant & Equipment | 4M | 4.15M | 4.11M | 2.12M | 3.38M | 4.33M | 5M | 5.72M | 1.12M | 840K | 930K | 17K | 0 | 24K | 44K |
| Fixed Asset Turnover | 74.16x | 45.69x | 31.67x | 36.49x | 7.00x | 0.73x | - | - | - | - | - | - | - | - | - |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 5.11M | 5.32M | 6.17M | 7.03M | 7.88M | 4.66M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Long-Term Investments | 1.79M | 522K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Assets | 2.52M | 3.29M | 7.79M | 15.33M | 16.98M | 12.14M | 403K | 403K | 401K | 225K | 234K | 1.77M | 0 | 23K | 23K |
| Total Assets | 442.32M | 481.19M | 392.27M | 332.75M | 382.48M | 329.52M | 187.07M | 308.52M | 260.21M | 151.74M | 12.34M | 37.27M | 194K | 18.19M | 18.92M |
| Asset Turnover | 0.48x | 0.39x | 0.33x | 0.23x | 0.06x | 0.01x | - | - | - | - | - | - | - | - | - |
| Asset Growth % | 74.08% | 22.67% | 17.89% | -13% | 16.07% | 76.15% | -39.37% | 18.57% | 71.49% | 1129.73% | -66.9% | 19113.92% | -98.93% | -3.89% | - |
| Total Current Liabilities | 103.2M | 105.94M | 115.52M | 55.2M | 39.81M | 43.43M | 17.99M | 24.42M | 13.58M | 6.72M | 4.73M | 5.27M | 552K | 3.06M | 2.5M |
| Accounts Payable | 12.3M | 13.95M | 12.33M | 4.88M | 4.8M | 5.74M | 4.9M | 10.41M | 7.64M | 2.43M | 1.9M | 1.43M | 535K | 1.47M | 2.25M |
| Days Payables Outstanding | 221.6 | 261.17 | 336.6 | 191.68 | 820.87 | 3.5K | 2.59K | 4.56K | 6.31K | 3.97K | 4.8K | - | - | - | - |
| Short-Term Debt | 10.81M | 7.95M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Revenue (Current) | 242K | 194K | 1.29M | 1.29M | 1.43M | 7M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Current Liabilities | 65.65M | 61.42M | 43.59M | 5.41M | 2.42M | 800K | 180K | 377K | 60K | 101K | 156K | 249K | 0 | 12K | 23K |
| Current Ratio | 4.17x | 4.41x | 3.24x | 5.58x | 8.90x | 7.10x | 10.10x | 12.38x | 19.05x | 22.42x | 2.36x | 6.73x | 0.35x | 5.93x | 7.54x |
| Quick Ratio | 3.89x | 4.16x | 3.08x | 5.43x | 8.83x | 7.10x | 10.10x | 12.38x | 19.05x | 22.42x | 2.36x | 6.73x | 0.35x | 5.93x | 7.54x |
| Cash Conversion Cycle | 119.28 | 271.24 | 227.03 | 216.8 | -225.6 | -3.31K | - | - | - | - | - | - | - | - | - |
| Total Non-Current Liabilities | 216.21M | 236.18M | 112.21M | 107.78M | 78.41M | 1.95M | 2.55M | 3.09M | 372K | 228K | 311K | 0 | 0 | 72.59M | 52.7M |
| Long-Term Debt | 213.05M | 235.19M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Capital Lease Obligations | 13.7M | 3.34M | 3.94M | 490K | 1.26M | 1.95M | 2.55M | 3.09M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Tax Liabilities | 998K | 998K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 0 | -3.34M | 108.27M | 107.29M | 77.15M | 0 | 0 | 0 | 372K | 228K | 311K | 0 | 0 | 72.59M | 52.7M |
| Total Liabilities | 319.41M | 342.13M | 227.72M | 162.99M | 118.22M | 45.37M | 20.55M | 27.5M | 13.95M | 6.95M | 5.04M | 5.27M | 552K | 75.65M | 55.21M |
| Total Debt | 227.02M | 246.47M | 3.94M | 1.26M | 1.94M | 2.55M | 3.09M | 3.56M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Net Debt | 164.88M | 192.17M | -85.2M | -58.82M | -125.73M | -56.7M | -97.77M | -58.74M | -49.54M | -34.24M | -6.54M | -34.87M | -152K | -7.36M | -11.77M |
| Debt / Equity | 1.85x | 1.77x | 0.02x | 0.01x | 0.01x | 0.01x | 0.02x | 0.01x | - | - | - | - | - | - | - |
| Debt / EBITDA | -1.16x | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Net Debt / EBITDA | -0.84x | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Interest Coverage | -12.41x | -8.52x | -11.63x | -12.25x | -33.82x | - | - | - | - | - | - | - | - | - | - |
| Total Equity | 122.91M | 139.07M | 164.55M | 169.76M | 264.26M | 284.15M | 166.53M | 281.02M | 246.26M | 144.79M | 7.3M | 32M | -358K | -57.46M | -36.28M |
| Equity Growth % | -149.3% | -15.48% | -3.07% | -35.76% | -7% | 70.63% | -40.74% | 14.12% | 70.08% | 1884.21% | -77.2% | 9038.83% | 99.38% | -58.36% | - |
| Book Value per Share | 1.81 | 2.14 | 2.70 | 2.94 | 5.07 | 5.73 | 3.77 | 7.72 | 7.94 | 5.42 | 0.44 | 3.14 | -0.04 | -1.14 | -0.72 |
| Total Shareholders' Equity | 122.91M | 139.07M | 164.55M | 169.76M | 264.26M | 284.15M | 166.53M | 281.02M | 246.26M | 144.79M | 7.3M | 32M | -358K | -57.46M | -36.28M |
| Common Stock | 69K | 67K | 61K | 59K | 56K | 50K | 44K | 44K | 34K | 27K | 10K | 93K | 93K | 53K | 3K |
| Retained Earnings | -1.41B | -1.35B | -1.16B | -894.74M | -710.06M | -528.94M | -459.33M | -325.33M | -184.6M | -110.25M | -76.54M | -50.67M | -39.6M | -58.44M | -37.01M |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accumulated OCI | 444K | -796K | -39K | 134K | -92K | -1K | 49K | 0 | 0 | 0 | -144K | 0 | 0 | 8K | -26K |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Liquidity and financing risk
As reported in recent financial statements, RYTM's equity position has contracted significantly from $169.8 million in 2023Q4 to $139.1 million by 2025Q4, reflecting a persistent erosion of book value driven by ongoing net losses that continue to outpace the company's commercial revenue expansion.
The downward trend in equity suggests that the company is consuming its capital base to fund commercialization efforts rather than building a self-sustaining asset foundation. Investors should monitor whether this trajectory forces a shift in capital allocation strategy to prioritize preservation over aggressive market expansion.
Based on the latest quarterly filings, RYTM's total debt has surged to $246.5 million in 2025Q4 from just $1.3 million in 2023Q4, indicating a rapid transition toward debt-based financing to support operations as the company navigates its high-burn commercial launch phase.
This sharp increase in leverage, coupled with a debt-to-equity ratio of 1.77, suggests that the company is increasingly reliant on external credit to bridge its operational funding gap. Such a reliance on debt in a pre-profit state warrants further investigation into the company's long-term debt service capacity and potential refinancing risks.
According to the most recent balance sheet data, RYTM's cash and equivalents have dwindled to $54.3 million as of 2025Q4, a level that appears insufficient given the company's historical quarterly burn rates and the ongoing capital requirements of its rare disease commercial infrastructure.
While the current ratio remains above 4.0, this metric may provide a false sense of security as it includes assets that are not immediately liquid for operational needs. The narrowing cash buffer suggests that the company may face a liquidity crunch in the near term, potentially necessitating dilutive equity raises.
As indicated by the company's financial statements, retained earnings have plummeted to -$1.4 billion, a trend that underscores the cumulative impact of years of heavy R&D and commercial investment without achieving a corresponding inflection in bottom-line profitability.
The persistent negative retained earnings highlight the significant capital intensity required to bring setmelanotide to market. This erosion of equity quality suggests that shareholders are bearing the brunt of the company's high-risk, high-reward strategy, with little evidence of a near-term reversal in value creation.
Based on reported figures, the company's asset base is heavily weighted toward intangible assets and goodwill, which, while typical for biotech, may be subject to impairment risk if the commercial adoption of IMCIVREE fails to meet the aggressive growth targets currently priced into the valuation.
The reliance on intangible assets rather than tangible, revenue-generating infrastructure makes the balance sheet particularly sensitive to changes in clinical trial outcomes or regulatory approvals. Investors should be wary that these book values may not reflect the true economic reality if the competitive landscape for obesity treatments shifts.
Quick answers to the most common questions about buying RYTM stock.
As of 2025, Rhythm Pharmaceuticals, Inc. (RYTM) had total assets of $481.2M including $466.9M in current assets.
Rhythm Pharmaceuticals, Inc. (RYTM) carries total debt of $246.5M, offset by $388.9M in cash and short-term investments. Comparing total debt to cash helps evaluate the company's debt burden and net leverage.
Rhythm Pharmaceuticals, Inc. (RYTM) has total shareholders' equity (book value) of $139.1M ($2.14 book value per share). Book value represents the net worth of the company belonging to common stock holders.
Rhythm Pharmaceuticals, Inc. (RYTM) reported a current ratio of 4.41x. A current ratio above 1.0x indicates that the company has more current assets than current liabilities, suggesting sufficient short-term liquidity.