Free cash flow burn widened to -$53.3M in Q2 2026 (FCF margin -74.9%) from -$23.3M a year earlier, with SBC of $49.2M masking true cash consumption and no capital returns.
Rhythm Pharmaceuticals, Inc. (RYTM) cash flow statement — 14-year operating, investing & financing cash flows
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|
| Cash from Operations | -149.53M | -115.67M | -113.88M | -136.16M | -173.43M | -146M | -121.98M | -122.75M | -62.06M | -29.46M | -23.22M | -6.98M | -7.51M | -19.16M | -17.83M |
| Operating CF Margin % | - | -60.96% | -87.51% | -175.85% | -733.68% | -4629.14% | - | - | - | - | - | - | - | - | - |
| Operating CF Growth % | -178.59% | -1.58% | 16.36% | 21.49% | -18.78% | -19.69% | 0.63% | -97.81% | -110.64% | -26.88% | -232.79% | 7.07% | 60.81% | -7.44% | - |
| Net Income | -205.35M | -196.54M | -260.6M | -184.68M | -181.12M | -69.61M | -134M | -140.73M | -74.06M | -33.71M | -25.87M | -11.07M | -6.49M | -21.43M | -18.13M |
| Depreciation & Amortization | 1.33M | 1.34M | 1.56M | 1.76M | 1.67M | 1.16M | 690K | 834K | 442K | 223K | 144K | 0 | 0 | 20K | 17K |
| Stock-Based Compensation | 110.33M | 66.82M | 39.68M | 32.55M | 19.83M | 20.8M | 17.45M | 11.88M | 6.39M | 2.28M | 1.17M | 298K | 66K | 127K | 0 |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | -100M | 0 | 0 | 0 | 1.86M | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 20.74M | 13.68M | 94.9M | 9.4M | 5.91M | -250K | -234K | 203K | 4.51M | -76K | 11K | 1.42M | -280K | 255K | 82K |
| Working Capital Changes | -20.95M | -968K | 10.57M | 4.81M | -19.72M | 1.9M | -5.89M | 5.07M | 667K | -39K | 1.33M | 2.38M | -801K | 2M | 201K |
| Change in Receivables | -22.86M | -7.57M | -3.65M | -8.64M | -5.2M | -1.25M | 0 | 0 | 0 | 0 | 0 | -60K | 0 | 0 | 0 |
| Change in Inventory | -15.89M | -7.47M | -10.12M | -5.71M | -2.81M | -11K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 17.49M | 21.89M | 21.92M | 14.77M | 1.54M | 18.31M | -6.45M | 10.51M | 6.95M | 1.95M | 467K | 3.84M | 0 | -780K | 1.58M |
| Cash from Investing | -87.88M | -137.15M | -48.17M | -5.67M | 28.03M | -62.16M | 158.53M | -27.97M | -87.15M | -110.04M | -5.11M | -17K | 0 | -5.13M | -5.27M |
| Capital Expenditures | -953K | -953K | 0 | -47K | -4.28M | -5.43M | -214K | -3.38M | -722K | -133K | -1.06M | -17K | 0 | 0 | 0 |
| CapEx % of Revenue | 0.4% | 0.5% | - | 0.06% | 18.11% | 172.29% | - | - | - | - | - | - | - | - | - |
| Acquisitions | 0 | 0 | 0 | 0 | 4M | 100M | 0 | 24.59M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | -40M | -40M | -40.5M | -5.67M | -4M | 7M | 0 | -24.59M | -86.43M | -109.91M | -4.05M | 0 | 0 | 0 | 0 |
| Cash from Financing | 174.39M | 217.96M | 191.24M | 74.37M | 213.83M | 166.48M | 2.01M | 163.47M | 164.69M | 167.2M | 0 | 41.71M | 7.42M | 19.88M | 22.44M |
| Debt Issued (Net) | -20.88M | 0 | -12.9M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Equity Issued (Net) | 212.8M | 237.88M | 195.24M | 48.88M | 131.11M | 161.73M | 0 | 161.35M | 162.88M | 166.5M | 0 | 39.62M | 0 | 19.88M | 22.44M |
| Dividends Paid | 0 | 0 | -3.97M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | -17.53M | -19.92M | 12.87M | 25.49M | 82.72M | 4.75M | 2.01M | 2.12M | 1.81M | 700K | 0 | 2.09M | 7.42M | 0 | 0 |
| Net Change in Cash | -61.91M | -34.78M | 29.19M | -67.6M | 68.43M | -41.68M | 38.56M | 12.75M | 15.48M | 27.7M | -28.33M | 34.72M | -89K | -4.4M | -660K |
| Free Cash Flow | -150.49M | -116.63M | -113.88M | -136.2M | -177.71M | -151.44M | -122.19M | -126.14M | -62.78M | -29.59M | -24.28M | -6.99M | -7.51M | -19.16M | -17.83M |
| FCF Margin % | -62.72% | -61.46% | -87.51% | -175.91% | -751.79% | -4801.43% | - | - | - | - | - | - | - | - | - |
| FCF Growth % | -39.7% | -2.41% | 16.39% | 23.36% | -17.35% | -23.93% | 3.12% | -100.92% | -112.14% | -21.9% | -247.1% | 6.85% | 60.81% | -7.44% | - |
| FCF per Share | -2.19 | -1.79 | -1.87 | -2.36 | -3.41 | -3.05 | -2.77 | -3.46 | -2.02 | -1.11 | -1.45 | -0.69 | -0.74 | -0.38 | -0.35 |
| FCF Conversion (FCF/Net Income) | 0.73x | 0.59x | 0.44x | 0.74x | 0.96x | 2.10x | 0.93x | 0.91x | 0.84x | 0.87x | 0.90x | 0.63x | 1.16x | 0.89x | 0.98x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quick answers to the most common questions about buying RYTM stock.
Rhythm Pharmaceuticals, Inc. (RYTM) generated $-115.7M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Rhythm Pharmaceuticals, Inc. (RYTM) reported negative free cash flow of $116.6M in 2025, indicating capital requirements exceeded cash from operations.
Rhythm Pharmaceuticals, Inc. (RYTM) spent $1.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.
Key Metrics
Top Statement Risk
Cash runway and dilution risk
Metrics are mathematically derived from official filings.
Cash Conversion Distorted by SBC
RYTM's operating cash flow has consistently exceeded net losses, with OCF/NI averaging 0.79 over the last four quarters, but stock-based compensation of $49.2M in Q2 2026 inflates the gap, per recent filings.
The reported OCF/NI ratio above 1.0 in Q2 2026 suggests that operating cash burn is actually less severe than net income implies, but this is largely due to non-cash stock-based compensation. Excluding SBC, cash burn would be significantly higher, indicating that the quality of earnings is poor and the company is still consuming cash at an unsustainable rate.
FCF Burn Intensifies Despite Revenue Growth
Free cash flow deteriorated to -$53.3M in Q2 2026 from -$23.3M a year earlier, with FCF margin falling to -74.9% from -48.1%, as reported in quarterly statements.
The widening FCF deficit despite 45.8% revenue growth indicates that operating expenses are scaling faster than gross profit, and the company has not yet achieved the operating leverage needed to narrow cash burn. With TTM FCF of approximately -$190M against a cash balance of $54.3M, the trajectory suggests an imminent need for external financing.
Minimal Capex Reflects Asset-Light Model
Capital expenditures have been negligible, averaging less than 2% of revenue over the past year, with no capex in Q2 2026, according to cash flow data.
The near-zero capex underscores a business model that relies on outsourced manufacturing and a commercial infrastructure that is largely variable. This means that the primary cash drain is operating expenses, particularly SG&A and R&D, rather than fixed asset investment, which could allow for faster margin improvement if revenue growth continues.
Working Capital Swings Add Volatility
Working capital changes have swung from +$10.2M in Q4 2024 to -$17.0M in Q1 2026, indicating lumpy cash flows tied to collections and payables, as per quarterly filings.
The volatility in working capital suggests that revenue recognition and cash collection are not perfectly aligned, possibly due to gross-to-net adjustments and international reimbursement timing. While the swings are not large relative to total cash burn, they add unpredictability to quarterly cash flow and warrant monitoring for any deterioration in collection efficiency.
No Capital Returns, All Cash to Operations
RYTM has paid no dividends and made no buybacks over the past ten quarters, with all cash directed toward funding operations and R&D, as reported in cash flow statements.
The absence of capital returns is typical for a pre-profit biotech, but it highlights that the company is entirely dependent on external financing to sustain its burn. With a debt/equity ratio of 0.01, the company has not leveraged its balance sheet, but the low cash balance suggests that equity dilution is the likely path to funding future operations.
Cumulative Losses Outpace Cash Burn
Over the last ten quarters, cumulative net losses of $562M exceed cumulative operating cash outflow of $327M, a $235M gap driven by non-cash charges, per financial statements.
The divergence between net income and operating cash flow is primarily due to stock-based compensation and depreciation, which are non-cash but represent real economic costs to shareholders. This suggests that the company's cash runway is longer than net income alone would imply, but the dilution from SBC is a hidden cost that investors should factor into their valuation.
What Could Invalidate the Base Case
Despite 45.8% revenue growth, RYTM's TTM operating cash burn of $190M against a cash balance of $54.3M suggests imminent dilution, while SBC of $49.2M in Q2 2026 masks true cash consumption, per financial statements.
The cash flow statement obscures the full cost of stock-based compensation, which is a real economic cost to shareholders even though it is non-cash. Additionally, the minimal capex may understate future capital needs if the company must invest in manufacturing or infrastructure to support label expansion. Investors should monitor whether the company can achieve positive operating cash flow before exhausting its cash runway, or if further equity dilution is inevitable.