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Spero Therapeutics, Inc. (SPRO) Price Target Analysis

Wall Street analyst price targets, ratings consensus & upside potential

Current Price
$2.17
Market reference
Price Target
—
— Upside
Target Range
— — —
Analyst Rating
Buy
13 analysts
Forward P/E3.2x
Trailing P/E-1.7x
Forward PEG—
Implied Growth+186.0%
Median Target—
Analyst Spread—

Price Forecast (1 Year)

Last 12 months price action with 12-month analyst target path

Current$2.17
Consensus—
High—
Low—
Bear Case
$—
—
Consensus
$—
—
Bull Case
$—
—

Analyst Ratings Distribution

Breakdown of 13 published analyst recommendations for SPRO

38% hold / mixed conviction
+15
BearishBullish
Weighted analyst sentiment score based on 13 ratings
ConsensusBuy
Coverage13 Analysts
Net Score+15
Bull / Bear46% / 15%
Strong Buy00%
Buy646%
Hold538%
Sell215%
Strong Sell00%
Strong Buy
00%
Buy
646%
Hold
538%
Sell
215%
Strong Sell
00%
Recommendation Mix46% Buy · 38% Hold · 15% Sell
Buy (6)Hold (5)Sell (2)

SPRO Price Target Analysis

Updated March 1, 2026

As of March 1, 2026, Spero Therapeutics, Inc. (SPRO) has a Wall Street consensus price target of N/A, based on estimates from 13 covering analysts. The company has a market capitalization of $122M.

Analyst price targets range from a low of N/A to a high of N/A.

The current analyst consensus rating is Buy, with 6 analysts rating the stock as a Buy or Strong Buy,5 rating it Hold, and 2 rating it Sell or Strong Sell. The mixed ratings reflect uncertainty about near-term direction.

From a valuation perspective, SPRO trades at a trailing P/E of -1.7x and forward P/E of 3.2x. Analysts expect EPS to grow +186.0% over the next year.

Investment Context: Price targets represent analyst expectations for the next 12 months and should be considered alongside your own research. Targets are based on analysts' assumptions about earnings growth, margins, and market conditions which may change. For sector-specific context, view other Healthcare stocks.

Analyst Sentiment Comparison

Industry Peer Analysis
Avg Peer Upside+71.8%
Avg Forward P/E—
Peers with Coverage9 / 10
CompanyMarket CapPriceTargetUpsideRatingFwd P/EAnalysts
BNTXBioNTech SE$27.7B$110.23$136.80+24.1%Buy—24
MRNAModerna, Inc.$20.9B$53.57$34.89-34.9%Hold—27
SMMTSummit Therapeutics Inc.$12.9B$16.59$26.00+56.7%Buy—20
PCVXVaxcyte, Inc.$8.1B$61.74$83.00+34.4%Buy—11
CDTXCidara Therapeutics, Inc.$7.0B$221.38$177.88-19.6%Buy—11
SCNIScinai Immunotherapeutics Ltd.$3.0B$0.89—————
NVAXNovavax, Inc.$1.7B$10.14$14.50+43.0%Buy—23
VIRVir Biotechnology, Inc.$1.3B$9.09$20.57+126.3%Buy—12
CVACCureVac N.V.$1.0B$4.66$21.00+350.6%Hold—8
VALNValneva SE$963M$11.09$18.33+65.3%Buy—2

Upside Potential Comparison

CVAC
+350.6%
VIR
+126.3%
VALN
+65.3%
SMMT
+56.7%
NVAX
+43.0%
PCVX
+34.4%
BNTX
+24.1%
CDTX
-19.6%

See SPRO's True Return

Price is only half the story. See total return with reinvested dividends.

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Is SPRO Undervalued?

See our Bear / Base / Bull DCF models and intrinsic value estimates.

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Compare SPRO vs AGIO

See how SPRO stacks up against sector leader Agios Pharmaceuticals, Inc..

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Frequently Asked Questions

What is the SPRO stock price target for 2026?

The consensus price target for SPRO is $N/A, close to the current price of $2.17 (N/A% implied move). Based on 13 analyst estimates, the stock appears fairly valued near current levels.

Is SPRO a buy, sell, or hold?

SPRO has a consensus rating of "Buy" based on 13 Wall Street analysts. The rating breakdown is mixed, with 5 Hold ratings making up the largest segment. The consensus 12-month price target of $N/A implies N/A% upside from current levels.

Is SPRO stock overvalued or undervalued?

With a forward P/E of 3.2388x, SPRO trades at a relatively low valuation. The consensus target of $N/A implies N/A% appreciation, suggesting the market may be pricing in risks.

How high can SPRO stock go?

The most bullish Wall Street analyst has a price target of $N/A for SPRO, while the most conservative target is $N/A. The consensus of $N/A represents the median expectation. These targets typically reflect 12-month expectations.

How many analysts cover SPRO stock?

SPRO is moderately covered, with 13 analysts providing price targets and ratings. Of these, 0 have Strong Buy ratings, 6 have Buy ratings, 5 recommend Hold, and 2 have Sell or Strong Sell ratings. Higher analyst coverage generally indicates greater institutional interest and more reliable consensus estimates.

What is the SPRO stock forecast?

The 12-month SPRO stock forecast based on 13 Wall Street analysts shows a consensus price target of $N/A, with estimates ranging from $N/A (bear case) to $N/A (bull case). The median consensus rating is "Buy".

What is SPRO's forward P/E ratio?

SPRO trades at a forward P/E ratio of 3.2x based on next-twelve-months earnings estimates. The higher forward P/E suggests near-term earnings pressure. A forward P/E is useful for comparing valuations when earnings are expected to change significantly.

Should I buy SPRO stock?

SPRO appears fairly valued according to analysts, with a "Buy" rating and minimal upside to the $N/A target. Consider your investment thesis and risk tolerance. This information is for educational purposes only. Always conduct your own research, consider your financial situation, and consult a financial advisor before making investment decisions.

Why do SPRO price targets vary so much?

SPRO analyst price targets range from $N/A to $N/A, a NaN% tight range reflecting strong analyst consensus. Differences stem from varying assumptions about revenue growth, profit margins, competitive dynamics, and valuation multiples. The $N/A consensus represents the middle ground.

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