Spero Therapeutics, Inc. (SPRO) P/E Ratio History
Historical price-to-earnings valuation from 2023 to 2024
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Valuation Context
How does the current P/E compare to historical and market benchmarks?
P/E Ratio Analysis
As of March 2, 2026, Spero Therapeutics, Inc. (SPRO) trades at a price-to-earnings ratio of -1.7x, with a stock price of $2.17 and trailing twelve-month earnings per share of $-0.78.
The current P/E is 112% below its 5-year average of 14.4x. Over the past five years, SPRO's P/E has ranged from a low of 3.3x to a high of 41.4x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 23.7x, SPRO trades at a 107% discount to its sector peers. The sector includes 224 companies with P/E ratios ranging from 0.0x to 184.4x.
Relative to the broader market, SPRO trades at a notable discount to the S&P 500 median P/E of 26.2x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our SPRO DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
Peer Comparison
P/E metrics vs. Vaccines and Infectious Disease peers
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
SCNIScinai Immunotherapeutics Ltd. | $3B | 0.1Lowest | -Best | +136% |
NVAXNovavax, Inc. | $2B | 3.9 | -Best | +310%Best |
CVACCureVac N.V. | $1B | 6.5 | -Best | +161% |
Peers sorted by market capitalization. P/E below peers may indicate undervaluation or lower growth expectations. Consider PEG ratio for growth-adjusted comparison.
Historical P/E Data
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Date | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2024 Q3 | Mon Sep 30 2024 00:00:00 GM | $1.34 | $0.07 | 19.1x | +33% |
| FY2024 Q2 | Sun Jun 30 2024 00:00:00 GM | $1.30 | $0.33 | 3.9x | -73% |
| FY2024 Q1 | Sun Mar 31 2024 00:00:00 GM | $1.72 | $0.43 | 4.0x | -72% |
| FY2023 Q4 | Sun Dec 31 2023 00:00:00 GM | $1.47 | $0.44 | 3.3x | -77% |
| FY2023 Q3 | Sat Sep 30 2023 00:00:00 GM | $1.21 | $0.03 | 41.4x | +188% |
Average P/E for displayed period: 14.4x
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Start ComparisonFrequently Asked Questions
Is SPRO stock overvalued or undervalued?
SPRO trades at -1.7x P/E, below its 5-year average of 14.4x. At the N/A percentile of historical range, the stock is priced at a discount to its own history.
How does SPRO's valuation compare to peers?
Spero Therapeutics, Inc. P/E of -1.7x compares to sector median of 23.7x. The discount suggests lower growth expectations or higher risk.
What is SPRO's PEG ratio?
SPRO PEG ratio is N/A. Above 2.0 indicates premium valuation relative to growth rate. Historical P/E data spans 2023-2024.