Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in STOK held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | 5.6M | $183.1M | +1.4% | 9.029% | 1.82% |
| 2 | BlackRock, Inc. | 5.4M | $175.4M | +3.3% | 8.647% | 0.00% |
| 3 | FMR LLC | 5.4M | $175.3M | -3.9% | 8.644% | 0.01% |
| 4 | Lynx1 Capital Management LP | 4.8M | $155.1M | -11.9% | 7.649% | 24.51% |
| 5 | Redmile Group, LLC | 4.2M | $135.6M | +3.2% | 6.686% | 8.98% |
| 6 | MORGAN STANLEY | 3.4M | $111.5M | -3.5% | 5.496% | 0.01% |
| 7 | BAKER BROS. ADVISORS LP | 3.3M | $108.6M | 0.0% | 5.357% | 0.62% |
| 8 | TORONTO DOMINION BANK | 3.2M | $103.3M | 0.0% | 5.095% | 0.15% |
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 3.1M | $100.8M | +320.7% | 4.970% | 0.02% |
| 10 | BVF INC/IL | 2.5M | $82.9M | +12.4% | 4.090% | 2.64% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 2.4M | $76.7M | — | 3.782% | 0.00% |
| 12 | STATE STREET CORP | 2.3M | $74.1M | -8.9% | 3.655% | 0.00% |
| 13 | Siren, L.L.C. | 2.0M | $65.0M | -11.2% | 3.204% | 1.80% |
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 1.8M | $59.4M | 0.0% | 2.928% | 0.70% |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 1.3M | $43.1M | +13.4% | 2.123% | 0.00% |
| 16 | Polar Capital Holdings Plc | 1.1M | $36.9M | -10.8% | 1.818% | 0.13% |
| 17 | DIMENSIONAL FUND ADVISORS LP | 990K | $32.2M | +19.7% | 1.589% | 0.01% |
| 18 | Assenagon Asset Management S.A. | 907K | $29.5M | -26.1% | 1.456% | 0.05% |
| 19 | GOLDMAN SACHS GROUP INC | 831K | $27.0M | -27.3% | 1.334% | 0.00% |
| 20 | MPM Oncology Impact Management LP | 767K | $25.0M | -0.4% | 1.232% | 1.93% |
| 21 | Opaleye Management Inc. | 700K | $22.8M | +0.7% | 1.124% | 3.00% |
| 22 | Troluce Capital Advisors LLC | 653K | $21.3M | — | 1.048% | 2.25% |
| 23 | BAILLIE GIFFORD & CO | 575K | $18.7M | +133.0% | 0.923% | 0.02% |
| 24 | BANK OF AMERICA CORP /DE/ | 543K | $17.7M | +163.4% | 0.872% | 0.00% |
| 25 | Candriam Luxembourg S.C.A. | 502K | $16.3M | +12.4% | 0.806% | 0.08% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in STOK — a direct measure of their conviction.
Filings activity in STOK during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 193 | +5.5% | 116.96% | +3.12 pp | $2.17B | +2.7% |
| Q4 2025 | 183 | +24% | 113.84% | +29.37 pp | $2.11B | +35% |
| Q3 2025 | 148 | +9.6% | 84.47% | +44.54 pp | $1.57B | +112% |
| Q2 2025 | 135 | +5.5% | 39.93% | +17.28 pp | $742M | +76% |
| Q1 2025 | 128 | 0.8% | 22.65% | 11.69 pp | $421M | 34% |
| Q4 2024 | 129 | +8.4% | 34.34% | 15.31 pp | $638M | 31% |
| Q3 2024 | 119 | +4.4% | 49.65% | +5.19 pp | $922M | +12% |
| Q2 2024 | 114 | — | 44.46% | — | $826M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying STOK stock.
Based on Q1 2026 13F filings, institutional ownership of Stoke Therapeutics, Inc. stands at 117.0%, held across 193 reporting institutions.
RTW INVESTMENTS, LP is the largest reported institutional holder of STOK, with approximately 5,623,525 shares worth $0.18B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of STOK.
Our composite Smart Money Score for STOK is 49 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
43 institutions opened new positions in STOK during Q1 2026, while 33 fully exited. 99 added to existing positions and 51 trimmed.
STOK institutional ownership rose by 3.12 percentage points quarter-over-quarter, with a net change of +10 holders.
The top 10 institutions account for 61.3% of all reported 13F value in STOK, and the top 25 account for 87.3%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Stoke Therapeutics, Inc. (STOK) Institutional Ownership