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Avenue Therapeutics, Inc. (ATXI) Total Return Calculator with Dividends Reinvested

Avenue Therapeutics, Inc.

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The total return for Avenue Therapeutics, Inc. (ATXI) stock is +150.09% over the past 12 months. So far it's down 19.78% this year. The 5-year total return is -99.99%, meaning $10,000 invested in ATXI stock 5 years ago would be worth $1 today. Total return includes price appreciation plus reinvesting any dividends paid out.

If you invested $10,000 in ATXI 1 year ago, it would be worth $24,998 today — you'd have gained $14,998.

With Dividends Reinvested$24,998+149.98%

Price Only (No DRIP)$24,998+149.98%

Period2025-05-08 → 2026-05-07

Price

Total Return (DRIP)

S&P 500

If You Invested $10,000 in ATXI

1Y$25,009+$15,009 (+150.1%)150.1% CAGR

3Y$72-$9,928 (-99.3%)-80.7% CAGR

5Y$1-$9,999 (-100.0%)-83.9% CAGR

10Y$1-$9,999 (-100.0%)-62.2% CAGR

15Y$1-$9,999 (-100.0%)-47.8% CAGR

20Y$1-$9,999 (-100.0%)-38.5% CAGR

30Y$1-$9,999 (-100.0%)-27.7% CAGR

Avenue Therapeutics, Inc. did not pay dividends during this period. Total return = price return.

Loading ATXI total return...

As of 2026-05-08

Returns at a Glance

Period	Total Return	CAGR	Price Only	Div. Contrib.	$10K →
YTD	-19.78%	—	-19.78%	—	$8,022
1Y	+150.09%	150.09%	+150.09%	—	$25,009
3Y	-99.28%	-80.70%	-99.28%	—	$72
5Y	-99.99%	-83.91%	-99.99%	—	$1
10Y	-99.99%	-62.24%	-99.99%	—	$1
15Y	-99.99%	-47.75%	-99.99%	—	$1
20Y	-99.99%	-38.55%	-99.99%	—	$1
30Y	-99.99%	-27.72%	-99.99%	—	$1

Risk & Highlights

Best Year+72.97%2019

Worst Year-91.95%2022

Max Drawdown-83.80%2025-10-21 → 2026-02-11

Annual Returns

Year	Total Return	Price Return	Div.	S&P 500	vs S&P
2026YTD	-72.30%	-72.30%	—	+0.41%	-72.7pp
2025	-64.76%	-64.76%	—	+16.64%	-81.4pp
2024	-83.33%	-83.33%	—	+24.00%	-107.3pp
2023	-86.25%	-86.25%	—	+24.81%	-111.1pp
2022	-91.95%	-91.95%	—	-19.95%	-72.0pp

ATXI outperformed the S&P 500 by 119.72pp over the past year (+150.09% vs +30.37%).

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ATXI Peers' Total Return

Accurate peer set · 10 comparable names

Name	Mkt Cap	30D Rtn	YTD Total Rtn	1Y Total Rtn	Div Contrib	3Y Total Rtn	5Y Total Rtn	10Y Total Rtn
ATXIAvenue Therapeutics, Inc.	$2M	+57.2%	-19.8%	+150.1%	—	-99.3%	-100.0%	-100.0%
PCRXPacira BioSciences, Inc.	$930M	+4.9%	-3.4%	-6.1%	—	-44.1%	-62.6%	-51.2%
COLLCollegium Pharmaceutical, Inc.	$1.3B	+20.0%	-13.6%	+45.4%	—	+67.9%	+71.0%	+153.1%
MNKDMannKind Corporation	$1.1B	+38.1%	-36.6%	-26.8%	—	-8.5%	-17.2%	-46.2%
XTLBXTL Biopharmaceuticals Ltd.	$293,767	+12.2%	+11.3%	-50.9%	—	-45.7%	-80.4%	-87.3%
NKTRNektar Therapeutics	$1.7B	+9.4%	+92.0%	+818.2%	—	+621.8%	-72.3%	-59.1%
PRGOPerrigo Company plc	$1.6B	+11.0%	-13.5%	-51.2%	+4.4pp	-58.1%	-60.1%	-77.7%
INVAInnoviva, Inc.	$1.9B	-2.1%	+14.7%	+21.7%	—	+95.2%	+94.4%	+94.9%
MCKMcKesson Corporation	$92.1B	-12.2%	-8.5%	+4.6%	+0.4pp	+106.4%	+286.9%	+348.1%
CAHCardinal Health, Inc.	$43.6B	-12.9%	-9.5%	+22.0%	+1.3pp	+127.3%	+235.7%	+160.8%
ATHAAthira Pharma, Inc.	$17M	—	-37.6%	+81.6%	—	-84.8%	-97.7%	-97.5%

Compare:ATXI vs PCRX ATXI vs COLL ATXI vs MNKD ATXI vs PCRX vs COLL

About ATXI Dividend Returns

Avenue Therapeutics, Inc. (ATXI) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends.

How We Calculate Total Return

Our total return calculator simulates dividend reinvestment (DRIP) by assuming each dividend payment is used to purchase additional shares at the closing price on the ex-dividend date. This methodology provides an accurate representation of how a dividend reinvestment plan would perform.

Frequently Asked Questions

Q1What is the total return of ATXI over the past year?

Avenue Therapeutics, Inc. (ATXI) delivered a return of 150.09% over the past year. Since ATXI does not currently pay dividends, the total return equals the price-only return.

Q2How much would $10,000 invested in ATXI be worth today?

A $10,000 investment in Avenue Therapeutics, Inc. one year ago would be worth $25,009 today, representing a gain of $15,009.

Q3Does ATXI pay dividends?

Avenue Therapeutics, Inc. (ATXI) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For ATXI, the total return equals the price-only return.

Q4Did ATXI beat the S&P 500?

Yes, Avenue Therapeutics, Inc. (ATXI) outperformed the S&P 500 by 119.72 percentage points over the past year. ATXI delivered a total return of 150.09%, compared to the S&P 500's 30.37%. This 119.72pp alpha means investors in ATXI earned more than a passive S&P 500 index fund.

Q5What is ATXI's worst drawdown?

Avenue Therapeutics, Inc. (ATXI) experienced a maximum drawdown of -83.80% over the past year, declining from its peak on 2025-10-21 to its trough on 2026-02-11. The stock has not yet fully recovered to its prior peak. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Q6What is ATXI's long-term total return over 10, 20, or 30 years?

Here are Avenue Therapeutics, Inc. (ATXI)'s long-term returns with dividends reinvested. Over 10 years, the total return is -100.0% (-62.2% CAGR) — $10,000 would have grown to $1. Over 20 years: -100.0% total return (-38.5% CAGR) — $10,000 → $1. Over 30 years: -100.0% total return (-27.7% CAGR) — $10,000 → $1. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.

Q7What was ATXI's best and worst year?

Avenue Therapeutics, Inc.'s best calendar year was 2019 with a total return of 73.0%. Its worst year was 2022 with a total return of -91.9%. This range shows the volatility investors should expect — the difference between the best and worst year is 164.9 percentage points.