Synlogic, Inc. (SYBX) P/E Ratio History
Historical price-to-earnings valuation from 2025 to 2025
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Valuation Context
How does the current P/E compare to historical and market benchmarks?
P/E Ratio Analysis
As of March 4, 2026, Synlogic, Inc. (SYBX) trades at a price-to-earnings ratio of -0.3x, with a stock price of $0.59 and trailing twelve-month earnings per share of $-0.26.
The current P/E is 103% below its 5-year average of 10.7x. Over the past five years, SYBX's P/E has ranged from a low of 10.7x to a high of 10.7x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 23.3x, SYBX trades at a 101% discount to its sector peers. The sector includes 225 companies with P/E ratios ranging from 0.0x to 190.3x.
Relative to the broader market, SYBX trades at a notable discount to the S&P 500 median P/E of 26.1x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our SYBX DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
Historical P/E Data
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Date | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2025 Q1 | Mon Mar 31 2025 00:00:00 GM | $1.24 | $0.12 | 10.7x | +0% |
Average P/E for displayed period: 10.7x
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Start ComparisonFrequently Asked Questions
Is SYBX stock overvalued or undervalued?
SYBX trades at -0.3x P/E, below its 5-year average of 10.7x. At the N/A percentile of historical range, the stock is priced at a discount to its own history.
How does SYBX's valuation compare to peers?
Synlogic, Inc. P/E of -0.3x compares to sector median of 23.3x. The discount suggests lower growth expectations or higher risk.
What is SYBX's PEG ratio?
SYBX PEG ratio is N/A. Above 2.0 indicates premium valuation relative to growth rate. Historical P/E data spans 2025-2025.